Multimodal Integrated Knowledge Transfer to Large Language Models through Preference Optimization with Biomedical Applications

The scarcity of high-quality multimodal biomedical data limits the ability to effectively fine-tune pretrained Large Language Models (LLMs) for specialized biomedical tasks. To address this challenge, we introduce MINT (Multimodal Integrated kNowledge Transfer), a framework that aligns unimodal large decoder models with domain-specific decision patterns from multimodal biomedical data through preference optimization. While MINT supports different optimization techniques, we primarily implement it with the Odds Ratio Preference Optimization (ORPO) framework as its backbone. This strategy enables the aligned LLMs to perform predictive tasks using text-only or image-only inputs while retaining knowledge learnt from multimodal data. MINT leverages an upstream multimodal machine learning (MML) model trained on high-quality multimodal data to transfer domain-specific insights to downstream text-only or image-only LLMs. We demonstrate its effectiveness through two key applications: (1) Rare genetic disease prediction from texts, where MINT uses a multimodal encoder model, trained on facial photos and clinical notes, to generate a preference dataset for aligning a lightweight Llama 3.2-3B-Instruct. Despite relying on text input only, the MINT-derived model outperforms models trained with SFT, RAG, or DPO, and even outperforms Llama 3.1-405B-Instruct. (2) Tissue type classification using cell nucleus images, where MINT uses a vision-language foundation model as the preference generator, containing knowledge learnt from both text and histopathological images to align downstream image-only models. The resulting MINT-derived model significantly improves the performance of Llama 3.2-Vision-11B-Instruct on tissue type classification. In summary, MINT provides an effective strategy to align unimodal LLMs with high-quality multimodal expertise through preference optimization.

My Emotion on your face: The use of Facial Keypoint Detection to preserve Emotions in Latent Space Editing

Generative Adversarial Network approaches such as StyleGAN/2 provide two key benefits: the ability to generate photo-realistic face images and possessing a semantically structured latent space from which these images are created. Many approaches have emerged for editing images derived from vectors in the latent space of a pre-trained StyleGAN/2 models by identifying semantically meaningful directions (e.g., gender or age) in the latent space. By moving the vector in a specific direction, the ideal result would only change the target feature while preserving all the other features. Providing an ideal data augmentation approach for gesture research as it could be used to generate numerous image variations whilst keeping the facial expressions intact. However, entanglement issues, where changing one feature inevitably affects other features, impacts the ability to preserve facial expressions. To address this, we propose the use of an addition to the loss function of a Facial Keypoint Detection model to restrict changes to the facial expressions. Building on top of an existing model, adding the proposed Human Face Landmark Detection (HFLD) loss, provided by a pre-trained Facial Keypoint Detection model, to the original loss function. We quantitatively and qualitatively evaluate the existing and our extended model, showing the effectiveness of our approach in addressing the entanglement issue and maintaining the facial expression. Our approach achieves up to 49% reduction in the change of emotion in our experiments. Moreover, we show the benefit of our approach by comparing with state-of-the-art models. By increasing the ability to preserve the facial gesture and expression during facial transformation, we present a way to create human face images with fixed expression but different appearances, making it a reliable data augmentation approach for Facial Gesture and Expression research.

MonetGPT: Solving Puzzles Enhances MLLMs' Image Retouching Skills

Retouching is an essential task in post-manipulation of raw photographs. Generative editing, guided by text or strokes, provides a new tool accessible to users but can easily change the identity of the original objects in unacceptable and unpredictable ways. In contrast, although traditional procedural edits, as commonly supported by photoediting tools (e.g., Gimp, Lightroom), are conservative, they are still preferred by professionals. Unfortunately, professional quality retouching involves many individual procedural editing operations that is challenging to plan for most novices. In this paper, we ask if a multimodal large language model (MLLM) can be taught to critique raw photographs, suggest suitable remedies, and finally realize them with a given set of pre-authored procedural image operations. We demonstrate that MLLMs can be first made aware of the underlying image processing operations, by training them to solve specially designed visual puzzles. Subsequently, such an operation-aware MLLM can both plan and propose edit sequences. To facilitate training, given a set of expert-edited photos, we synthesize a reasoning dataset by procedurally manipulating the expert edits and then grounding a pretrained LLM on the visual adjustments, to synthesize reasoning for finetuning. The proposed retouching operations are, by construction, understandable by the users, preserve object details and resolution, and can be optionally overridden. We evaluate our setup on a variety of test examples and show advantages, in terms of explainability and identity preservation, over existing generative and other procedural alternatives. Code, data, models, and supplementary results can be found via our project website at https://monetgpt.github.io.

Multi-turn Consistent Image Editing

Many real-world applications, such as interactive photo retouching, artistic content creation, and product design, require flexible and iterative image editing. However, existing image editing methods primarily focus on achieving the desired modifications in a single step, which often struggles with ambiguous user intent, complex transformations, or the need for progressive refinements. As a result, these methods frequently produce inconsistent outcomes or fail to meet user expectations. To address these challenges, we propose a multi-turn image editing framework that enables users to iteratively refine their edits, progressively achieving more satisfactory results. Our approach leverages flow matching for accurate image inversion and a dual-objective Linear Quadratic Regulators (LQR) for stable sampling, effectively mitigating error accumulation. Additionally, by analyzing the layer-wise roles of transformers, we introduce a adaptive attention highlighting method that enhances editability while preserving multi-turn coherence. Extensive experiments demonstrate that our framework significantly improves edit success rates and visual fidelity compared to existing methods.

Towards Smart Point-and-Shoot Photography

Hundreds of millions of people routinely take photos using their smartphones as point and shoot (PAS) cameras, yet very few would have the photography skills to compose a good shot of a scene. While traditional PAS cameras have built-in functions to ensure a photo is well focused and has the right brightness, they cannot tell the users how to compose the best shot of a scene. In this paper, we present a first of its kind smart point and shoot (SPAS) system to help users to take good photos. Our SPAS proposes to help users to compose a good shot of a scene by automatically guiding the users to adjust the camera pose live on the scene. We first constructed a large dataset containing 320K images with camera pose information from 4000 scenes. We then developed an innovative CLIP-based Composition Quality Assessment (CCQA) model to assign pseudo labels to these images. The CCQA introduces a unique learnable text embedding technique to learn continuous word embeddings capable of discerning subtle visual quality differences in the range covered by five levels of quality description words {bad, poor, fair, good, perfect}. And finally we have developed a camera pose adjustment model (CPAM) which first determines if the current view can be further improved and if so it outputs the adjust suggestion in the form of two camera pose adjustment angles. The two tasks of CPAM make decisions in a sequential manner and each involves different sets of training samples, we have developed a mixture-of-experts model with a gated loss function to train the CPAM in an end-to-end manner. We will present extensive results to demonstrate the performances of our SPAS system using publicly available image composition datasets.

Advancing Conversational Diagnostic AI with Multimodal Reasoning

Large Language Models (LLMs) have demonstrated great potential for conducting diagnostic conversations but evaluation has been largely limited to language-only interactions, deviating from the real-world requirements of remote care delivery. Instant messaging platforms permit clinicians and patients to upload and discuss multimodal medical artifacts seamlessly in medical consultation, but the ability of LLMs to reason over such data while preserving other attributes of competent diagnostic conversation remains unknown. Here we advance the conversational diagnosis and management performance of the Articulate Medical Intelligence Explorer (AMIE) through a new capability to gather and interpret multimodal data, and reason about this precisely during consultations. Leveraging Gemini 2.0 Flash, our system implements a state-aware dialogue framework, where conversation flow is dynamically controlled by intermediate model outputs reflecting patient states and evolving diagnoses. Follow-up questions are strategically directed by uncertainty in such patient states, leading to a more structured multimodal history-taking process that emulates experienced clinicians. We compared AMIE to primary care physicians (PCPs) in a randomized, blinded, OSCE-style study of chat-based consultations with patient actors. We constructed 105 evaluation scenarios using artifacts like smartphone skin photos, ECGs, and PDFs of clinical documents across diverse conditions and demographics. Our rubric assessed multimodal capabilities and other clinically meaningful axes like history-taking, diagnostic accuracy, management reasoning, communication, and empathy. Specialist evaluation showed AMIE to be superior to PCPs on 7/9 multimodal and 29/32 non-multimodal axes (including diagnostic accuracy). The results show clear progress in multimodal conversational diagnostic AI, but real-world translation needs further research.

SimPRIVE: a Simulation framework for Physical Robot Interaction with Virtual Environments

The use of machine learning in cyber-physical systems has attracted the interest of both industry and academia. However, no general solution has yet been found against the unpredictable behavior of neural networks and reinforcement learning agents. Nevertheless, the improvements of photo-realistic simulators have paved the way towards extensive testing of complex algorithms in different virtual scenarios, which would be expensive and dangerous to implement in the real world. This paper presents SimPRIVE, a simulation framework for physical robot interaction with virtual environments, which operates as a vehicle-in-the-loop platform, rendering a virtual world while operating the vehicle in the real world. Using SimPRIVE, any physical mobile robot running on ROS 2 can easily be configured to move its digital twin in a virtual world built with the Unreal Engine 5 graphic engine, which can be populated with objects, people, or other vehicles with programmable behavior. SimPRIVE has been designed to accommodate custom or pre-built virtual worlds while being light-weight to contain execution times and allow fast rendering. Its main advantage lies in the possibility of testing complex algorithms on the full software and hardware stack while minimizing the risks and costs of a test campaign. The framework has been validated by testing a reinforcement learning agent trained for obstacle avoidance on an AgileX Scout Mini rover that navigates a virtual office environment where everyday objects and people are placed as obstacles. The physical rover moves with no collision in an indoor limited space, thanks to a LiDAR-based heuristic.

CasualHDRSplat: Robust High Dynamic Range 3D Gaussian Splatting from Casually Captured Videos

Recently, photo-realistic novel view synthesis from multi-view images, such as neural radiance field (NeRF) and 3D Gaussian Splatting (3DGS), have garnered widespread attention due to their superior performance. However, most works rely on low dynamic range (LDR) images, which limits the capturing of richer scene details. Some prior works have focused on high dynamic range (HDR) scene reconstruction, typically require capturing of multi-view sharp images with different exposure times at fixed camera positions during exposure times, which is time-consuming and challenging in practice. For a more flexible data acquisition, we propose a one-stage method: \textbf{CasualHDRSplat} to easily and robustly reconstruct the 3D HDR scene from casually captured videos with auto-exposure enabled, even in the presence of severe motion blur and varying unknown exposure time. \textbf{CasualHDRSplat} contains a unified differentiable physical imaging model which first applies continuous-time trajectory constraint to imaging process so that we can jointly optimize exposure time, camera response function (CRF), camera poses, and sharp 3D HDR scene. Extensive experiments demonstrate that our approach outperforms existing methods in terms of robustness and rendering quality. Our source code will be available at https://github.com/WU-CVGL/CasualHDRSplat

A Clinician-Friendly Platform for Ophthalmic Image Analysis Without Technical Barriers

Artificial intelligence (AI) shows remarkable potential in medical imaging diagnostics, but current models typically require retraining when deployed across different clinical centers, limiting their widespread adoption. We introduce GlobeReady, a clinician-friendly AI platform that enables ocular disease diagnosis without retraining/fine-tuning or technical expertise. GlobeReady achieves high accuracy across imaging modalities: 93.9-98.5% for an 11-category fundus photo dataset and 87.2-92.7% for a 15-category OCT dataset. Through training-free local feature augmentation, it addresses domain shifts across centers and populations, reaching an average accuracy of 88.9% across five centers in China, 86.3% in Vietnam, and 90.2% in the UK. The built-in confidence-quantifiable diagnostic approach further boosted accuracy to 94.9-99.4% (fundus) and 88.2-96.2% (OCT), while identifying out-of-distribution cases at 86.3% (49 CFP categories) and 90.6% (13 OCT categories). Clinicians from multiple countries rated GlobeReady highly (average 4.6 out of 5) for its usability and clinical relevance. These results demonstrate GlobeReady's robust, scalable diagnostic capability and potential to support ophthalmic care without technical barriers.

Green Robotic Mixed Reality with Gaussian Splatting

Realizing green communication in robotic mixed reality (RoboMR) systems presents a challenge, due to the necessity of uploading high-resolution images at high frequencies through wireless channels. This paper proposes Gaussian splatting (GS) RoboMR (GSRMR), which achieves a lower energy consumption and makes a concrete step towards green RoboMR. The crux to GSRMR is to build a GS model which enables the simulator to opportunistically render a photo-realistic view from the robot's pose, thereby reducing the need for excessive image uploads. Since the GS model may involve discrepancies compared to the actual environments, a GS cross-layer optimization (GSCLO) framework is further proposed, which jointly optimizes content switching (i.e., deciding whether to upload image or not) and power allocation across different frames. The GSCLO problem is solved by an accelerated penalty optimization (APO) algorithm. Experiments demonstrate that the proposed GSRMR reduces the communication energy by over 10x compared with RoboMR. Furthermore, the proposed GSRMR with APO outperforms extensive baseline schemes, in terms of peak signal-to-noise ratio (PSNR) and structural similarity index measure (SSIM).