CheXGenBench: A Unified Benchmark For Fidelity, Privacy and Utility of Synthetic Chest Radiographs

We introduce CheXGenBench, a rigorous and multifaceted evaluation framework for synthetic chest radiograph generation that simultaneously assesses fidelity, privacy risks, and clinical utility across state-of-the-art text-to-image generative models. Despite rapid advancements in generative AI for real-world imagery, medical domain evaluations have been hindered by methodological inconsistencies, outdated architectural comparisons, and disconnected assessment criteria that rarely address the practical clinical value of synthetic samples. CheXGenBench overcomes these limitations through standardised data partitioning and a unified evaluation protocol comprising over 20 quantitative metrics that systematically analyse generation quality, potential privacy vulnerabilities, and downstream clinical applicability across 11 leading text-to-image architectures. Our results reveal critical inefficiencies in the existing evaluation protocols, particularly in assessing generative fidelity, leading to inconsistent and uninformative comparisons. Our framework establishes a standardised benchmark for the medical AI community, enabling objective and reproducible comparisons while facilitating seamless integration of both existing and future generative models. Additionally, we release a high-quality, synthetic dataset, SynthCheX-75K, comprising 75K radiographs generated by the top-performing model (Sana 0.6B) in our benchmark to support further research in this critical domain. Through CheXGenBench, we establish a new state-of-the-art and release our framework, models, and SynthCheX-75K dataset at https://raman1121.github.io/CheXGenBench/

VolE: A Point-cloud Framework for Food 3D Reconstruction and Volume Estimation

Accurate food volume estimation is crucial for medical nutrition management and health monitoring applications, but current food volume estimation methods are often limited by mononuclear data, leveraging single-purpose hardware such as 3D scanners, gathering sensor-oriented information such as depth information, or relying on camera calibration using a reference object. In this paper, we present VolE, a novel framework that leverages mobile device-driven 3D reconstruction to estimate food volume. VolE captures images and camera locations in free motion to generate precise 3D models, thanks to AR-capable mobile devices. To achieve real-world measurement, VolE is a reference- and depth-free framework that leverages food video segmentation for food mask generation. We also introduce a new food dataset encompassing the challenging scenarios absent in the previous benchmarks. Our experiments demonstrate that VolE outperforms the existing volume estimation techniques across multiple datasets by achieving 2.22 % MAPE, highlighting its superior performance in food volume estimation.

A systematic review of challenges and proposed solutions in modeling multimodal data

Multimodal data modeling has emerged as a powerful approach in clinical research, enabling the integration of diverse data types such as imaging, genomics, wearable sensors, and electronic health records. Despite its potential to improve diagnostic accuracy and support personalized care, modeling such heterogeneous data presents significant technical challenges. This systematic review synthesizes findings from 69 studies to identify common obstacles, including missing modalities, limited sample sizes, dimensionality imbalance, interpretability issues, and finding the optimal fusion techniques. We highlight recent methodological advances, such as transfer learning, generative models, attention mechanisms, and neural architecture search that offer promising solutions. By mapping current trends and innovations, this review provides a comprehensive overview of the field and offers practical insights to guide future research and development in multimodal modeling for medical applications.

Towards user-centered interactive medical image segmentation in VR with an assistive AI agent

Crucial in disease analysis and surgical planning, manual segmentation of volumetric medical scans (e.g. MRI, CT) is laborious, error-prone, and challenging to master, while fully automatic algorithms can benefit from user feedback. Therefore, with the complementary power of the latest radiological AI foundation models and virtual reality (VR)'s intuitive data interaction, we propose SAMIRA, a novel conversational AI agent that assists users with localizing, segmenting, and visualizing 3D medical concepts in VR. Through speech-based interaction, the agent helps users understand radiological features, locate clinical targets, and generate segmentation masks that can be refined with just a few point prompts. The system also supports true-to-scale 3D visualization of segmented pathology to enhance patient-specific anatomical understanding. Furthermore, to determine the optimal interaction paradigm under near-far attention-switching for refining segmentation masks in an immersive, human-in-the-loop workflow, we compare VR controller pointing, head pointing, and eye tracking as input modes. With a user study, evaluations demonstrated a high usability score (SUS=90.0 $\pm$ 9.0), low overall task load, as well as strong support for the proposed VR system's guidance, training potential, and integration of AI in radiological segmentation tasks.

AI Agents vs. Agentic AI: A Conceptual Taxonomy, Applications and Challenge

This study critically distinguishes between AI Agents and Agentic AI, offering a structured conceptual taxonomy, application mapping, and challenge analysis to clarify their divergent design philosophies and capabilities. We begin by outlining the search strategy and foundational definitions, characterizing AI Agents as modular systems driven by Large Language Models (LLMs) and Large Image Models (LIMs) for narrow, task-specific automation. Generative AI is positioned as a precursor, with AI Agents advancing through tool integration, prompt engineering, and reasoning enhancements. In contrast, Agentic AI systems represent a paradigmatic shift marked by multi-agent collaboration, dynamic task decomposition, persistent memory, and orchestrated autonomy. Through a sequential evaluation of architectural evolution, operational mechanisms, interaction styles, and autonomy levels, we present a comparative analysis across both paradigms. Application domains such as customer support, scheduling, and data summarization are contrasted with Agentic AI deployments in research automation, robotic coordination, and medical decision support. We further examine unique challenges in each paradigm including hallucination, brittleness, emergent behavior, and coordination failure and propose targeted solutions such as ReAct loops, RAG, orchestration layers, and causal modeling. This work aims to provide a definitive roadmap for developing robust, scalable, and explainable AI agent and Agentic AI-driven systems. >AI Agents, Agent-driven, Vision-Language-Models, Agentic AI Decision Support System, Agentic-AI Applications

DDFP: Data-dependent Frequency Prompt for Source Free Domain Adaptation of Medical Image Segmentation

Domain adaptation addresses the challenge of model performance degradation caused by domain gaps. In the typical setup for unsupervised domain adaptation, labeled data from a source domain and unlabeled data from a target domain are used to train a target model. However, access to labeled source domain data, particularly in medical datasets, can be restricted due to privacy policies. As a result, research has increasingly shifted to source-free domain adaptation (SFDA), which requires only a pretrained model from the source domain and unlabeled data from the target domain data for adaptation. Existing SFDA methods often rely on domain-specific image style translation and self-supervision techniques to bridge the domain gap and train the target domain model. However, the quality of domain-specific style-translated images and pseudo-labels produced by these methods still leaves room for improvement. Moreover, training the entire model during adaptation can be inefficient under limited supervision. In this paper, we propose a novel SFDA framework to address these challenges. Specifically, to effectively mitigate the impact of domain gap in the initial training phase, we introduce preadaptation to generate a preadapted model, which serves as an initialization of target model and allows for the generation of high-quality enhanced pseudo-labels without introducing extra parameters. Additionally, we propose a data-dependent frequency prompt to more effectively translate target domain images into a source-like style. To further enhance adaptation, we employ a style-related layer fine-tuning strategy, specifically designed for SFDA, to train the target model using the prompted target domain images and pseudo-labels. Extensive experiments on cross-modality abdominal and cardiac SFDA segmentation tasks demonstrate that our proposed method outperforms existing state-of-the-art methods.

A Multimodal Multi-Agent Framework for Radiology Report Generation

Radiology report generation (RRG) aims to automatically produce diagnostic reports from medical images, with the potential to enhance clinical workflows and reduce radiologists' workload. While recent approaches leveraging multimodal large language models (MLLMs) and retrieval-augmented generation (RAG) have achieved strong results, they continue to face challenges such as factual inconsistency, hallucination, and cross-modal misalignment. We propose a multimodal multi-agent framework for RRG that aligns with the stepwise clinical reasoning workflow, where task-specific agents handle retrieval, draft generation, visual analysis, refinement, and synthesis. Experimental results demonstrate that our approach outperforms a strong baseline in both automatic metrics and LLM-based evaluations, producing more accurate, structured, and interpretable reports. This work highlights the potential of clinically aligned multi-agent frameworks to support explainable and trustworthy clinical AI applications.

Recent Advances in Medical Imaging Segmentation: A Survey

Medical imaging is a cornerstone of modern healthcare, driving advancements in diagnosis, treatment planning, and patient care. Among its various tasks, segmentation remains one of the most challenging problem due to factors such as data accessibility, annotation complexity, structural variability, variation in medical imaging modalities, and privacy constraints. Despite recent progress, achieving robust generalization and domain adaptation remains a significant hurdle, particularly given the resource-intensive nature of some proposed models and their reliance on domain expertise. This survey explores cutting-edge advancements in medical image segmentation, focusing on methodologies such as Generative AI, Few-Shot Learning, Foundation Models, and Universal Models. These approaches offer promising solutions to longstanding challenges. We provide a comprehensive overview of the theoretical foundations, state-of-the-art techniques, and recent applications of these methods. Finally, we discuss inherent limitations, unresolved issues, and future research directions aimed at enhancing the practicality and accessibility of segmentation models in medical imaging. We are maintaining a \href{https://github.com/faresbougourzi/Awesome-DL-for-Medical-Imaging-Segmentation}{GitHub Repository} to continue tracking and updating innovations in this field.

Using Foundation Models as Pseudo-Label Generators for Pre-Clinical 4D Cardiac CT Segmentation

Cardiac image segmentation is an important step in many cardiac image analysis and modeling tasks such as motion tracking or simulations of cardiac mechanics. While deep learning has greatly advanced segmentation in clinical settings, there is limited work on pre-clinical imaging, notably in porcine models, which are often used due to their anatomical and physiological similarity to humans. However, differences between species create a domain shift that complicates direct model transfer from human to pig data. Recently, foundation models trained on large human datasets have shown promise for robust medical image segmentation; yet their applicability to porcine data remains largely unexplored. In this work, we investigate whether foundation models can generate sufficiently accurate pseudo-labels for pig cardiac CT and propose a simple self-training approach to iteratively refine these labels. Our method requires no manually annotated pig data, relying instead on iterative updates to improve segmentation quality. We demonstrate that this self-training process not only enhances segmentation accuracy but also smooths out temporal inconsistencies across consecutive frames. Although our results are encouraging, there remains room for improvement, for example by incorporating more sophisticated self-training strategies and by exploring additional foundation models and other cardiac imaging technologies.

ImplicitStainer: Data-Efficient Medical Image Translation for Virtual Antibody-based Tissue Staining Using Local Implicit Functions

Hematoxylin and eosin (H&E) staining is a gold standard for microscopic diagnosis in pathology. However, H&E staining does not capture all the diagnostic information that may be needed. To obtain additional molecular information, immunohistochemical (IHC) stains highlight proteins that mark specific cell types, such as CD3 for T-cells or CK8/18 for epithelial cells. While IHC stains are vital for prognosis and treatment guidance, they are typically only available at specialized centers and time consuming to acquire, leading to treatment delays for patients. Virtual staining, enabled by deep learning-based image translation models, provides a promising alternative by computationally generating IHC stains from H&E stained images. Although many GAN and diffusion based image to image (I2I) translation methods have been used for virtual staining, these models treat image patches as independent data points, which results in increased and more diverse data requirements for effective generation. We present ImplicitStainer, a novel approach that leverages local implicit functions to improve image translation, specifically virtual staining performance, by focusing on pixel-level predictions. This method enhances robustness to variations in dataset sizes, delivering high-quality results even with limited data. We validate our approach on two datasets using a comprehensive set of metrics and benchmark it against over fifteen state-of-the-art GAN- and diffusion based models. Full Code and models trained will be released publicly via Github upon acceptance.