scKDGM: KAN-guided Dynamic Graph Masked Learning for Single-Cell RNA-seq Clustering

Single-cell RNA sequencing (scRNA-seq) clustering is essential for identifying cell types, but high dimensionality, sparsity, dropout, and technical noise hinder robust expression representation and cell graph construction. Existing masked autoencoders mainly use expression recovery for feature reconstruction, while graph clustering methods usually depend on fixed KNN graphs and do not feed recovered expression back into graph optimization. We propose scKDGM, a KAN-guided dynamic graph masked learning framework for scRNA-seq clustering. scKDGM uses graph-aware distribution preserving gene masking (GDP-Mask) to perturb cell identity, a KAN-based TAKGCN encoder to learn masked-view representations, mask-guided expression recovery to construct a dynamic graph, and cross-view contrastive learning to transfer recovery signals into topology updates. A ZINB loss models overdispersion and zero inflation. Experiments on 12 real scRNA-seq datasets show that scKDGM outperforms 10 baselines in average NMI and ARI.

NVIDIA Isaac Sim: Enabling Scalable, GPU-Accelerated Simulation for Robotics

Simulation has become a core infrastructure for robotics research. Unlike previous simulators, NVIDIA Isaac Sim leverages GPU acceleration to enable large-scale parallel training and physics-accurate modeling. Its synthetic data generation pipeline alleviates the scarcity of high-quality training data, supporting data-driven robot learning and large-scale simulation-centric experimentation. However, existing surveys often treat it as one simulator among many, without a systematic analysis of its architectural characteristics, usage patterns, and limitations. This survey reviews Isaac Sim from system and application perspectives, outlining its architecture and comparing it with widely used simulators. We analyze representative studies across five major domains and summarize common usage patterns, particularly in data generation and high-fidelity simulation. We also outline key future directions and challenges, including physics open-world learning, simulation-centric training and practical usability constraints.

Reinforcement Learning for Follow-the-Leader Robotic Endoscopic Navigation via Synthetic Data

Autonomous navigation is crucial for both medical and industrial endoscopic robots, enabling safe and efficient exploration of narrow tubular environments without continuous human intervention, where avoiding contact with the inner walls has been a longstanding challenge for prior approaches. We present a follow-the-leader endoscopic robot based on a flexible continuum structure designed to minimize contact between the endoscope body and intestinal walls, thereby reducing patient discomfort. To achieve this objective, we propose a vision-based deep reinforcement learning framework guided by monocular depth estimation. A realistic intestinal simulation environment was constructed in \textit{NVIDIA Omniverse} to train and evaluate autonomous navigation strategies. Furthermore, thousands of synthetic intraluminal images were generated using NVIDIA Replicator to fine-tune the Depth Anything model, enabling dense three-dimensional perception of the intestinal environment with a single monocular camera. Subsequently, we introduce a geometry-aware reward and penalty mechanism to enable accurate lumen tracking. Compared with the original Depth Anything model, our method improves $δ_{1}$ depth accuracy by 39.2% and reduces the navigation J-index by 0.67 relative to the second-best method, demonstrating the robustness and effectiveness of the proposed approach.