for the Alzheimer's Disease Neuroimaging Initiative
Abstract:Vision Language Action (VLA) models promise an open-vocabulary interface that can translate perceptual ambiguity into semantically grounded driving decisions, yet they still treat language as a static prior fixed at inference time. As a result, the model must infer continuously shifting objectives from pixels alone, yielding delayed or overly conservative maneuvers. We argue that effective VLAs for autonomous driving need an online channel in which users can influence driving with specific intentions. To this end, we present EchoVLA, a user-aware VLA that couples camera streams with in situ audio instructions. We augment the nuScenes dataset with temporally aligned, intent-specific speech commands generated by converting ego-motion descriptions into synthetic audios. Further, we compose emotional speech-trajectory pairs into a multimodal Chain-of-Thought (CoT) for fine-tuning a Multimodal Large Model (MLM) based on Qwen2.5-Omni. Specifically, we synthesize the audio-augmented dataset with different emotion types paired with corresponding driving behaviors, leveraging the emotional cues embedded in tone, pitch, and speech tempo to reflect varying user states, such as urgent or hesitant intentions, thus enabling our EchoVLA to interpret not only the semantic content but also the emotional context of audio commands for more nuanced and emotionally adaptive driving behavior. In open-loop benchmarks, our approach reduces the average L2 error by $59.4\%$ and the collision rate by $74.4\%$ compared to the baseline of vision-only perception. More experiments on nuScenes dataset validate that EchoVLA not only steers the trajectory through audio instructions, but also modulates driving behavior in response to the emotions detected in the user's speech.
Abstract:Scientific compound figures combine multiple labeled panels into a single image, but captions in real pipelines are often missing or only provide figure-level summaries, making panel-level understanding difficult. In this paper, we propose FigEx2, visual-conditioned framework that localizes panels and generates panel-wise captions directly from the compound figure. To mitigate the impact of diverse phrasing in open-ended captioning, we introduce a noise-aware gated fusion module that adaptively filters token-level features to stabilize the detection query space. Furthermore, we employ a staged optimization strategy combining supervised learning with reinforcement learning (RL), utilizing CLIP-based alignment and BERTScore-based semantic rewards to enforce strict multimodal consistency. To support high-quality supervision, we curate BioSci-Fig-Cap, a refined benchmark for panel-level grounding, alongside cross-disciplinary test suites in physics and chemistry. Experimental results demonstrate that FigEx2 achieves a superior 0.726 mAP@0.5:0.95 for detection and significantly outperforms Qwen3-VL-8B by 0.51 in METEOR and 0.24 in BERTScore. Notably, FigEx2 exhibits remarkable zero-shot transferability to out-of-distribution scientific domains without any fine-tuning.
Abstract:Multimodal Large Language Models (MLLMs) have shown strong potential for radiology report generation, yet their clinical translation is hindered by architectural heterogeneity and the prevalence of factual hallucinations. Standard supervised fine-tuning often fails to strictly align linguistic outputs with visual evidence, while existing reinforcement learning approaches struggle with either prohibitive computational costs or limited exploration. To address these challenges, we propose a comprehensive framework for self-consistent radiology report generation. First, we conduct a systematic evaluation to identify optimal vision encoder and LLM backbone configurations for medical imaging. Building on this foundation, we introduce a novel "Reason-then-Summarize" architecture optimized via Group Relative Policy Optimization (GRPO). This framework restructures generation into two distinct components: a think block for detailed findings and an answer block for structured disease labels. By utilizing a multi-dimensional composite reward function, we explicitly penalize logical discrepancies between the generated narrative and the final diagnosis. Extensive experiments on the MIMIC-CXR benchmark demonstrate that our method achieves state-of-the-art performance in clinical efficacy metrics and significantly reduces hallucinations compared to strong supervised baselines.
Abstract:Early detection of Alzheimer's disease (AD) requires models capable of integrating macro-scale neuroanatomical alterations with micro-scale genetic susceptibility, yet existing multimodal approaches struggle to align these heterogeneous signals. We introduce R-GenIMA, an interpretable multimodal large language model that couples a novel ROI-wise vision transformer with genetic prompting to jointly model structural MRI and single nucleotide polymorphisms (SNPs) variations. By representing each anatomically parcellated brain region as a visual token and encoding SNP profiles as structured text, the framework enables cross-modal attention that links regional atrophy patterns to underlying genetic factors. Applied to the ADNI cohort, R-GenIMA achieves state-of-the-art performance in four-way classification across normal cognition (NC), subjective memory concerns (SMC), mild cognitive impairment (MCI), and AD. Beyond predictive accuracy, the model yields biologically meaningful explanations by identifying stage-specific brain regions and gene signatures, as well as coherent ROI-Gene association patterns across the disease continuum. Attention-based attribution revealed genes consistently enriched for established GWAS-supported AD risk loci, including APOE, BIN1, CLU, and RBFOX1. Stage-resolved neuroanatomical signatures identified shared vulnerability hubs across disease stages alongside stage-specific patterns: striatal involvement in subjective decline, frontotemporal engagement during prodromal impairment, and consolidated multimodal network disruption in AD. These results demonstrate that interpretable multimodal AI can synthesize imaging and genetics to reveal mechanistic insights, providing a foundation for clinically deployable tools that enable earlier risk stratification and inform precision therapeutic strategies in Alzheimer's disease.
Abstract:With the rapid progress of large language models (LLMs), advanced multimodal large language models (MLLMs) have demonstrated impressive zero-shot capabilities on vision-language tasks. In the biomedical domain, however, even state-of-the-art MLLMs struggle with basic Medical Decision Making (MDM) tasks. We investigate this limitation using two challenging datasets: (1) three-stage Alzheimer's disease (AD) classification (normal, mild cognitive impairment, dementia), where category differences are visually subtle, and (2) MIMIC-CXR chest radiograph classification with 14 non-mutually exclusive conditions. Our empirical study shows that text-only reasoning consistently outperforms vision-only or vision-text settings, with multimodal inputs often performing worse than text alone. To mitigate this, we explore three strategies: (1) in-context learning with reason-annotated exemplars, (2) vision captioning followed by text-only inference, and (3) few-shot fine-tuning of the vision tower with classification supervision. These findings reveal that current MLLMs lack grounded visual understanding and point to promising directions for improving multimodal decision making in healthcare.
Abstract:Large Language Models (LLMs) excel at many tasks but struggle with ambiguous scenarios where multiple valid responses exist, often yielding unreliable results. Conversely, Small Language Models (SLMs) demonstrate robustness in such scenarios but are susceptible to misleading or adversarial inputs. We observed that LLMs handle negative examples effectively, while SLMs excel with positive examples. To leverage their complementary strengths, we introduce SLIDE (Small and Large Integrated for Dialogue Evaluation), a method integrating SLMs and LLMs via adaptive weighting. Building on SLIDE, we further propose a Dual-Refinement Evaluation (DRE) method to enhance SLM-LLM integration: (1) SLM-generated insights guide the LLM to produce initial evaluations; (2) SLM-derived adjustments refine the LLM's scores for improved accuracy. Experiments demonstrate that DRE outperforms existing methods, showing stronger alignment with human judgment across diverse benchmarks. This work illustrates how combining small and large models can yield more reliable evaluation tools, particularly for open-ended tasks such as dialogue evaluation.

Abstract:Motion prediction plays an important role in autonomous driving. This study presents LMFormer, a lane-aware transformer network for trajectory prediction tasks. In contrast to previous studies, our work provides a simple mechanism to dynamically prioritize the lanes and shows that such a mechanism introduces explainability into the learning behavior of the network. Additionally, LMFormer uses the lane connection information at intersections, lane merges, and lane splits, in order to learn long-range dependency in lane structure. Moreover, we also address the issue of refining the predicted trajectories and propose an efficient method for iterative refinement through stacked transformer layers. For benchmarking, we evaluate LMFormer on the nuScenes dataset and demonstrate that it achieves SOTA performance across multiple metrics. Furthermore, the Deep Scenario dataset is used to not only illustrate cross-dataset network performance but also the unification capabilities of LMFormer to train on multiple datasets and achieve better performance.
Abstract:Creating a realistic animatable avatar from a single static portrait remains challenging. Existing approaches often struggle to capture subtle facial expressions, the associated global body movements, and the dynamic background. To address these limitations, we propose a novel framework that leverages a pretrained video diffusion transformer model to generate high-fidelity, coherent talking portraits with controllable motion dynamics. At the core of our work is a dual-stage audio-visual alignment strategy. In the first stage, we employ a clip-level training scheme to establish coherent global motion by aligning audio-driven dynamics across the entire scene, including the reference portrait, contextual objects, and background. In the second stage, we refine lip movements at the frame level using a lip-tracing mask, ensuring precise synchronization with audio signals. To preserve identity without compromising motion flexibility, we replace the commonly used reference network with a facial-focused cross-attention module that effectively maintains facial consistency throughout the video. Furthermore, we integrate a motion intensity modulation module that explicitly controls expression and body motion intensity, enabling controllable manipulation of portrait movements beyond mere lip motion. Extensive experimental results show that our proposed approach achieves higher quality with better realism, coherence, motion intensity, and identity preservation. Ours project page: https://fantasy-amap.github.io/fantasy-talking/.
Abstract:Wireless sensing systems, particularly those using mmWave technology, offer distinct advantages over traditional vision-based approaches, such as enhanced privacy and effectiveness in poor lighting conditions. These systems, leveraging FMCW signals, have shown success in human-centric applications like localization, gesture recognition, and so on. However, comprehensive mmWave datasets for diverse applications are scarce, often constrained by pre-processed signatures (e.g., point clouds or RA heatmaps) and inconsistent annotation formats. To overcome these limitations, we propose mmGen, a novel and generalized framework tailored for full-scene mmWave signal generation. By constructing physical signal transmission models, mmGen synthesizes human-reflected and environment-reflected mmWave signals from the constructed 3D meshes. Additionally, we incorporate methods to account for material properties, antenna gains, and multipath reflections, enhancing the realism of the synthesized signals. We conduct extensive experiments using a prototype system with commercial mmWave devices and Kinect sensors. The results show that the average similarity of Range-Angle and micro-Doppler signatures between the synthesized and real-captured signals across three different environments exceeds 0.91 and 0.89, respectively, demonstrating the effectiveness and practical applicability of mmGen.




Abstract:Traditional Mixture-of-Experts (MoE) networks benefit from utilizing multiple smaller expert models as opposed to a single large network. However, these experts typically operate independently, leaving a question open about whether interconnecting these models could enhance the performance of MoE networks. In response, we introduce GRAPHMOE, a novel method aimed at augmenting the cognitive depth of language models via a self-rethinking mechanism constructed on Pseudo GraphMoE networks. GRAPHMOE employs a recurrent routing strategy to simulate iterative thinking steps, thereby facilitating the flow of information among expert nodes. We implement the GRAPHMOE architecture using Low-Rank Adaptation techniques (LoRA) and conduct extensive experiments on various benchmark datasets. The experimental results reveal that GRAPHMOE outperforms other LoRA based models, achieving state-of-the-art (SOTA) performance. Additionally, this study explores a novel recurrent routing strategy that may inspire further advancements in enhancing the reasoning capabilities of language models.