Training Small Multimodal Models to Bridge Biomedical Competency Gap: A Case Study in Radiology Imaging

The scaling laws and extraordinary performance of large foundation models motivate the development and utilization of such large models in biomedicine. However, despite early promising results on some biomedical benchmarks, there are still major challenges that need to be addressed before these models can be used in real-world applications. Frontier models such as GPT-4V still have major competency gaps in multimodal capabilities for biomedical applications. Moreover, pragmatic issues such as access, cost, latency, and compliance make it hard for clinicians to use privately-hosted state-of-the-art large models directly on private patient data. In this paper, we explore training open-source small multimodal models (SMMs) to bridge biomedical competency gaps for unmet clinical needs. To maximize data efficiency, we adopt a modular approach by incorporating state-of-the-art pre-trained models for image and text modalities, and focusing on training a lightweight adapter to ground each modality to the text embedding space. We conduct a comprehensive study of this approach on radiology imaging. For training, we assemble a large dataset with over 1 million image-text pairs. For evaluation, we propose a clinically driven novel approach using GPT-4 and demonstrate its parity with expert evaluation. We also study grounding qualitatively using attention. For best practice, we conduct a systematic ablation study on various choices in data engineering and multimodal training. The resulting LLaVA-Rad (7B) model attains state-of-the-art results on radiology tasks such as report generation and cross-modal retrieval, even outperforming much larger models such as GPT-4V and Med-PaLM M (84B). LLaVA-Rad is fast and can be run on a single V100 GPU in private settings, offering a promising state-of-the-art tool for real-world clinical applications.

Depth-guided NeRF Training via Earth Mover's Distance

Neural Radiance Fields (NeRFs) are trained to minimize the rendering loss of predicted viewpoints. However, the photometric loss often does not provide enough information to disambiguate between different possible geometries yielding the same image. Previous work has thus incorporated depth supervision during NeRF training, leveraging dense predictions from pre-trained depth networks as pseudo-ground truth. While these depth priors are assumed to be perfect once filtered for noise, in practice, their accuracy is more challenging to capture. This work proposes a novel approach to uncertainty in depth priors for NeRF supervision. Instead of using custom-trained depth or uncertainty priors, we use off-the-shelf pretrained diffusion models to predict depth and capture uncertainty during the denoising process. Because we know that depth priors are prone to errors, we propose to supervise the ray termination distance distribution with Earth Mover's Distance instead of enforcing the rendered depth to replicate the depth prior exactly through L2-loss. Our depth-guided NeRF outperforms all baselines on standard depth metrics by a large margin while maintaining performance on photometric measures.

Just Shift It: Test-Time Prototype Shifting for Zero-Shot Generalization with Vision-Language Models

Advancements in vision-language models (VLMs) have propelled the field of computer vision, particularly in the zero-shot learning setting. Despite their promise, the effectiveness of these models often diminishes due to domain shifts in test environments. To address this, we introduce the Test-Time Prototype Shifting (TPS) framework, a pioneering approach designed to adapt VLMs to test datasets using unlabeled test inputs. Our method is based on the notion of modulating per-class prototypes in the shared embedding space. By pre-computing and caching prototypes generated with the pre-trained text encoder, TPS not only facilitates optimization-free prototype reuse for subsequent predictions but also enables seamless integration with current advancements in prompt engineering. At test-time, TPS dynamically learns shift vectors for each prototype based solely on the given test sample, effectively bridging the domain gap and enhancing classification accuracy. A notable aspect of our framework is its significantly reduced memory and computational demands when compared to conventional text-prompt tuning methods. Extensive evaluations across 15 datasets involving natural distribution shifts and cross-dataset generalization demonstrate TPS's superior performance, achieving state-of-the-art results while reducing resource requirements.

VideoAgent: Long-form Video Understanding with Large Language Model as Agent

Long-form video understanding represents a significant challenge within computer vision, demanding a model capable of reasoning over long multi-modal sequences. Motivated by the human cognitive process for long-form video understanding, we emphasize interactive reasoning and planning over the ability to process lengthy visual inputs. We introduce a novel agent-based system, VideoAgent, that employs a large language model as a central agent to iteratively identify and compile crucial information to answer a question, with vision-language foundation models serving as tools to translate and retrieve visual information. Evaluated on the challenging EgoSchema and NExT-QA benchmarks, VideoAgent achieves 54.1% and 71.3% zero-shot accuracy with only 8.4 and 8.2 frames used on average. These results demonstrate superior effectiveness and efficiency of our method over the current state-of-the-art methods, highlighting the potential of agent-based approaches in advancing long-form video understanding.

Multi-Human Mesh Recovery with Transformers

Conventional approaches to human mesh recovery predominantly employ a region-based strategy. This involves initially cropping out a human-centered region as a preprocessing step, with subsequent modeling focused on this zoomed-in image. While effective for single figures, this pipeline poses challenges when dealing with images featuring multiple individuals, as different people are processed separately, often leading to inaccuracies in relative positioning. Despite the advantages of adopting a whole-image-based approach to address this limitation, early efforts in this direction have fallen short in performance compared to recent region-based methods. In this work, we advocate for this under-explored area of modeling all people at once, emphasizing its potential for improved accuracy in multi-person scenarios through considering all individuals simultaneously and leveraging the overall context and interactions. We introduce a new model with a streamlined transformer-based design, featuring three critical design choices: multi-scale feature incorporation, focused attention mechanisms, and relative joint supervision. Our proposed model demonstrates a significant performance improvement, surpassing state-of-the-art region-based and whole-image-based methods on various benchmarks involving multiple individuals.

Revisiting Active Learning in the Era of Vision Foundation Models

Foundation vision or vision-language models are trained on large unlabeled or noisy data and learn robust representations that can achieve impressive zero- or few-shot performance on diverse tasks. Given these properties, they are a natural fit for active learning (AL), which aims to maximize labeling efficiency, but the full potential of foundation models has not been explored in the context of AL, specifically in the low-budget regime. In this work, we evaluate how foundation models influence three critical components of effective AL, namely, 1) initial labeled pool selection, 2) ensuring diverse sampling, and 3) the trade-off between representative and uncertainty sampling. We systematically study how the robust representations of foundation models (DINOv2, OpenCLIP) challenge existing findings in active learning. Our observations inform the principled construction of a new simple and elegant AL strategy that balances uncertainty estimated via dropout with sample diversity. We extensively test our strategy on many challenging image classification benchmarks, including natural images as well as out-of-domain biomedical images that are relatively understudied in the AL literature. Source code will be made available.

Single-View 3D Human Digitalization with Large Reconstruction Models

In this paper, we introduce Human-LRM, a single-stage feed-forward Large Reconstruction Model designed to predict human Neural Radiance Fields (NeRF) from a single image. Our approach demonstrates remarkable adaptability in training using extensive datasets containing 3D scans and multi-view capture. Furthermore, to enhance the model's applicability for in-the-wild scenarios especially with occlusions, we propose a novel strategy that distills multi-view reconstruction into single-view via a conditional triplane diffusion model. This generative extension addresses the inherent variations in human body shapes when observed from a single view, and makes it possible to reconstruct the full body human from an occluded image. Through extensive experiments, we show that Human-LRM surpasses previous methods by a significant margin on several benchmarks.

Connect, Collapse, Corrupt: Learning Cross-Modal Tasks with Uni-Modal Data

Building cross-modal applications is challenging due to limited paired multi-modal data. Recent works have shown that leveraging a pre-trained multi-modal contrastive representation space enables cross-modal tasks to be learned from uni-modal data. This is based on the assumption that contrastive optimization makes embeddings from different modalities interchangeable. However, this assumption is under-explored due to the poorly understood geometry of the multi-modal contrastive space, where a modality gap exists. In our study, we provide a theoretical explanation of this space's geometry and introduce a three-step method, $C^3$ (Connect, Collapse, Corrupt), to bridge the modality gap, enhancing the interchangeability of embeddings. Our $C^3$ method significantly improves cross-modal learning from uni-modal data, achieving state-of-the-art results on zero-shot image / audio / video captioning and text-to-image generation.

Describing Differences in Image Sets with Natural Language

How do two sets of images differ? Discerning set-level differences is crucial for understanding model behaviors and analyzing datasets, yet manually sifting through thousands of images is impractical. To aid in this discovery process, we explore the task of automatically describing the differences between two $\textbf{sets}$ of images, which we term Set Difference Captioning. This task takes in image sets $D_A$ and $D_B$, and outputs a description that is more often true on $D_A$ than $D_B$. We outline a two-stage approach that first proposes candidate difference descriptions from image sets and then re-ranks the candidates by checking how well they can differentiate the two sets. We introduce VisDiff, which first captions the images and prompts a language model to propose candidate descriptions, then re-ranks these descriptions using CLIP. To evaluate VisDiff, we collect VisDiffBench, a dataset with 187 paired image sets with ground truth difference descriptions. We apply VisDiff to various domains, such as comparing datasets (e.g., ImageNet vs. ImageNetV2), comparing classification models (e.g., zero-shot CLIP vs. supervised ResNet), summarizing model failure modes (supervised ResNet), characterizing differences between generative models (e.g., StableDiffusionV1 and V2), and discovering what makes images memorable. Using VisDiff, we are able to find interesting and previously unknown differences in datasets and models, demonstrating its utility in revealing nuanced insights.