Project Imaging-X: A Survey of 1000+ Open-Access Medical Imaging Datasets for Foundation Model Development

Foundation models have demonstrated remarkable success across diverse domains and tasks, primarily due to the thrive of large-scale, diverse, and high-quality datasets. However, in the field of medical imaging, the curation and assembling of such medical datasets are highly challenging due to the reliance on clinical expertise and strict ethical and privacy constraints, resulting in a scarcity of large-scale unified medical datasets and hindering the development of powerful medical foundation models. In this work, we present the largest survey to date of medical image datasets, covering over 1,000 open-access datasets with a systematic catalog of their modalities, tasks, anatomies, annotations, limitations, and potential for integration. Our analysis exposes a landscape that is modest in scale, fragmented across narrowly scoped tasks, and unevenly distributed across organs and modalities, which in turn limits the utility of existing medical image datasets for developing versatile and robust medical foundation models. To turn fragmentation into scale, we propose a metadata-driven fusion paradigm (MDFP) that integrates public datasets with shared modalities or tasks, thereby transforming multiple small data silos into larger, more coherent resources. Building on MDFP, we release an interactive discovery portal that enables end-to-end, automated medical image dataset integration, and compile all surveyed datasets into a unified, structured table that clearly summarizes their key characteristics and provides reference links, offering the community an accessible and comprehensive repository. By charting the current terrain and offering a principled path to dataset consolidation, our survey provides a practical roadmap for scaling medical imaging corpora, supporting faster data discovery, more principled dataset creation, and more capable medical foundation models.

CellFluxRL: Biologically-Constrained Virtual Cell Modeling via Reinforcement Learning

Building virtual cells with generative models to simulate cellular behavior in silico is emerging as a promising paradigm for accelerating drug discovery. However, prior image-based generative approaches can produce implausible cell images that violate basic physical and biological constraints. To address this, we propose to post-train virtual cell models with reinforcement learning (RL), leveraging biologically meaningful evaluators as reward functions. We design seven rewards spanning three categories-biological function, structural validity, and morphological correctness-and optimize the state-of-the-art CellFlux model to yield CellFluxRL. CellFluxRL consistently improves over CellFlux across all rewards, with further performance boosts from test-time scaling. Overall, our results present a virtual cell modeling framework that enforces physically-based constraints through RL, advancing beyond "visually realistic" generations towards "biologically meaningful" ones.

Uncertainty Quantification for Distribution-to-Distribution Flow Matching in Scientific Imaging

Distribution-to-distribution generative models support scientific imaging tasks ranging from modeling cellular perturbation responses to translating medical images across conditions. Trustworthy generation requires both reliability (generalization across labs, devices, and experimental conditions) and accountability (detecting out-of-distribution cases where predictions may be unreliable). Uncertainty quantification (UQ) based approaches serve as promising candidates for these tasks, yet UQ for distribution-to-distribution generative models remains underexplored. We present a unified UQ framework, Bayesian Stochastic Flow Matching (BSFM), that disentangles aleatoric and epistemic uncertainty. The Stochastic Flow Matching (SFM) component augments deterministic flows with a diffusion term to improve model generalization to unseen scenarios. For UQ, we develop a scalable Bayesian approach -- MCD-Antithetic -- that combines Monte Carlo Dropout with sample-efficient antithetic sampling to produce effective anomaly scores for out-of-distribution detection. Experiments on cellular imaging (BBBC021, JUMP) and brain fMRI (Theory of Mind) across diverse scenarios show that SFM improves reliability while MCD-Antithetic enhances accountability.

Fine-tuning MLLMs Without Forgetting Is Easier Than You Think

The paper demonstrate that simple adjustments of the fine-tuning recipes of multimodal large language models (MLLM) are sufficient to mitigate catastrophic forgetting. On visual question answering, we design a 2x2 experimental framework to assess model performance across in-distribution and out-of-distribution image and text inputs. Our results show that appropriate regularization, such as constraining the number of trainable parameters or adopting a low learning rate, effectively prevents forgetting when dealing with out-of-distribution images. However, we uncover a distinct form of forgetting in settings with in-distribution images and out-of-distribution text. We attribute this forgetting as task-specific overfitting and address this issue by introducing a data-hybrid training strategy that combines datasets and tasks. Finally, we demonstrate that this approach naturally extends to continual learning, outperforming existing methods with complex auxiliary mechanisms. In general, our findings challenge the prevailing assumptions by highlighting the inherent robustness of MLLMs and providing practical guidelines for adapting them while preserving their general capabilities.

Tool Verification for Test-Time Reinforcement Learning

Test-time reinforcement learning (TTRL) has emerged as a promising paradigm for self-evolving large reasoning models (LRMs), enabling online adaptation on unlabeled test inputs via self-induced rewards through majority voting. However, a spurious yet high-frequency unverified consensus can become a biased and reinforced reward signal, leading to incorrect mode collapse. We address this failure mode with T^3RL (Tool-Verification for Test-Time Reinforcement Learning), which introduces test-time tool verification into reward estimation. Concretely, a verifier uses an external tool as evidence (e.g., from code execution) to upweight verified rollouts in a verification-aware voting, producing more reliable pseudo-labels for training. Across various math difficulties (MATH-500, AMC, and AIME 2024) and diverse backbone types, T^3RL significantly improves over TTRL, with larger gains on harder problems. More broadly, T^3RL can be viewed as verified online data synthesis, highlighting test-time tool verification as a key mechanism for stabilizing self-evolution.

SARM: LLM-Augmented Semantic Anchor for End-to-End Live-Streaming Ranking

Large-scale live-streaming recommendation requires precise modeling of non-stationary content semantics under strict real-time serving constraints. In industrial deployment, two common approaches exhibit fundamental limitations: discrete semantic abstractions sacrifice descriptive precision through clustering, while dense multimodal embeddings are extracted independently and remain weakly aligned with ranking optimization, limiting fine-grained content-aware ranking. To address these limitations, we propose \textbf{SARM}, an end-to-end ranking architecture that integrates natural-language semantic anchors directly into ranking optimization, enabling fine-grained author representations conditioned on multimodal content. Each semantic anchor is represented as learnable text tokens jointly optimized with ranking features, allowing the model to adapt content descriptions to ranking objectives. A lightweight dual-token gated design captures domain-specific live-streaming semantics, while an asymmetric deployment strategy preserves low-latency online training and serving. Extensive offline evaluation and large-scale A/B tests show consistent improvements over production baselines. SARM is fully deployed and serves over 400 million users daily.

Do VLMs Perceive or Recall? Probing Visual Perception vs. Memory with Classic Visual Illusions

Large Vision-Language Models (VLMs) often answer classic visual illusions "correctly" on original images, yet persist with the same responses when illusion factors are inverted, even though the visual change is obvious to humans. This raises a fundamental question: do VLMs perceive visual changes or merely recall memorized patterns? While several studies have noted this phenomenon, the underlying causes remain unclear. To move from observations to systematic understanding, this paper introduces VI-Probe, a controllable visual-illusion framework with graded perturbations and matched visual controls (without illusion inducer) that disentangles visually grounded perception from language-driven recall. Unlike prior work that focuses on averaged accuracy, we measure stability and sensitivity using Polarity-Flip Consistency, Template Fixation Index, and an illusion multiplier normalized against matched controls. Experiments across different families reveal that response persistence arises from heterogeneous causes rather than a single mechanism. For instance, GPT-5 exhibits memory override, Claude-Opus-4.1 shows perception-memory competition, while Qwen variants suggest visual-processing limits. Our findings challenge single-cause views and motivate probing-based evaluation that measures both knowledge and sensitivity to controlled visual change. Data and code are available at https://sites.google.com/view/vi-probe/.

PaperSearchQA: Learning to Search and Reason over Scientific Papers with RLVR

Search agents are language models (LMs) that reason and search knowledge bases (or the web) to answer questions; recent methods supervise only the final answer accuracy using reinforcement learning with verifiable rewards (RLVR). Most RLVR search agents tackle general-domain QA, which limits their relevance to technical AI systems in science, engineering, and medicine. In this work we propose training agents to search and reason over scientific papers -- this tests technical question-answering, it is directly relevant to real scientists, and the capabilities will be crucial to future AI Scientist systems. Concretely, we release a search corpus of 16 million biomedical paper abstracts and construct a challenging factoid QA dataset called PaperSearchQA with 60k samples answerable from the corpus, along with benchmarks. We train search agents in this environment to outperform non-RL retrieval baselines; we also perform further quantitative analysis and observe interesting agent behaviors like planning, reasoning, and self-verification. Our corpus, datasets, and benchmarks are usable with the popular Search-R1 codebase for RLVR training and released on https://huggingface.co/collections/jmhb/papersearchqa. Finally, our data creation methods are scalable and easily extendable to other scientific domains.

RadDiff: Describing Differences in Radiology Image Sets with Natural Language

Understanding how two radiology image sets differ is critical for generating clinical insights and for interpreting medical AI systems. We introduce RadDiff, a multimodal agentic system that performs radiologist-style comparative reasoning to describe clinically meaningful differences between paired radiology studies. RadDiff builds on a proposer-ranker framework from VisDiff, and incorporates four innovations inspired by real diagnostic workflows: (1) medical knowledge injection through domain-adapted vision-language models; (2) multimodal reasoning that integrates images with their clinical reports; (3) iterative hypothesis refinement across multiple reasoning rounds; and (4) targeted visual search that localizes and zooms in on salient regions to capture subtle findings. To evaluate RadDiff, we construct RadDiffBench, a challenging benchmark comprising 57 expert-validated radiology study pairs with ground-truth difference descriptions. On RadDiffBench, RadDiff achieves 47% accuracy, and 50% accuracy when guided by ground-truth reports, significantly outperforming the general-domain VisDiff baseline. We further demonstrate RadDiff's versatility across diverse clinical tasks, including COVID-19 phenotype comparison, racial subgroup analysis, and discovery of survival-related imaging features. Together, RadDiff and RadDiffBench provide the first method-and-benchmark foundation for systematically uncovering meaningful differences in radiological data.

Intelligent recognition of GPR road hidden defect images based on feature fusion and attention mechanism

Ground Penetrating Radar (GPR) has emerged as a pivotal tool for non-destructive evaluation of subsurface road defects. However, conventional GPR image interpretation remains heavily reliant on subjective expertise, introducing inefficiencies and inaccuracies. This study introduces a comprehensive framework to address these limitations: (1) A DCGAN-based data augmentation strategy synthesizes high-fidelity GPR images to mitigate data scarcity while preserving defect morphology under complex backgrounds; (2) A novel Multi-modal Chain and Global Attention Network (MCGA-Net) is proposed, integrating Multi-modal Chain Feature Fusion (MCFF) for hierarchical multi-scale defect representation and Global Attention Mechanism (GAM) for context-aware feature enhancement; (3) MS COCO transfer learning fine-tunes the backbone network, accelerating convergence and improving generalization. Ablation and comparison experiments validate the framework's efficacy. MCGA-Net achieves Precision (92.8%), Recall (92.5%), and mAP@50 (95.9%). In the detection of Gaussian noise, weak signals and small targets, MCGA-Net maintains robustness and outperforms other models. This work establishes a new paradigm for automated GPR-based defect detection, balancing computational efficiency with high accuracy in complex subsurface environments.