SAM4Dcap: Training-free Biomechanical Twin System from Monocular Video

Quantitative biomechanical analysis is essential for clinical diagnosis and injury prevention but is often restricted to laboratories due to the high cost of optical motion capture systems. While multi-view video approaches have lowered barriers, they remain impractical for home-based scenarios requiring monocular capture. This paper presents SAM4Dcap, an open-source, end-to-end framework for estimating biomechanical metrics from monocular video without additional training. SAM4Dcap integrates the temporally consistent 4D human mesh recovery of SAM-Body4D with the OpenSim biomechanical solver. The pipeline converts reconstructed meshes into trajectory files compatible with diverse musculoskeletal models. We introduce automated prompting strategies and a Linux-native build for processing. Preliminary evaluations on walking and drop-jump tasks indicate that SAM4Dcap has the potential to achieve knee kinematic predictions comparable to multi-view systems, although some discrepancies in hip flexion and residual jitter remain. By bridging advanced computer vision with established biomechanical simulation, SAM4Dcap provides a flexible, accessible foundation for non-laboratory motion analysis.

Evaluating the Diagnostic Classification Ability of Multimodal Large Language Models: Insights from the Osteoarthritis Initiative

Multimodal large language models (MLLMs) show promising performance on medical visual question answering (VQA) and report generation, but these generation and explanation abilities do not reliably transfer to disease-specific classification. We evaluated MLLM architectures on knee osteoarthritis (OA) radiograph classification, which remains underrepresented in existing medical MLLM benchmarks, even though knee OA affects an estimated 300 to 400 million people worldwide. Through systematic ablation studies manipulating the vision encoder, the connector, and the large language model (LLM) across diverse training strategies, we measured each component's contribution to diagnostic accuracy. In our classification task, a trained vision encoder alone could outperform full MLLM pipelines in classification accuracy and fine-tuning the LLM provided no meaningful improvement over prompt-based guidance. And LoRA fine-tuning on a small, class-balanced dataset (500 images) gave better results than training on a much larger but class-imbalanced set (5,778 images), indicating that data balance and quality can matter more than raw scale for this task. These findings suggest that for domain-specific medical classification, LLMs are more effective as interpreters and report generators rather than as primary classifiers. Therefore, the MLLM architecture appears less suitable for medical image diagnostic classification tasks that demand high certainty. We recommend prioritizing vision encoder optimization and careful dataset curation when developing clinically applicable systems.