A Flexible 2.5D Medical Image Segmentation Approach with In-Slice and Cross-Slice Attention

Deep learning has become the de facto method for medical image segmentation, with 3D segmentation models excelling in capturing complex 3D structures and 2D models offering high computational efficiency. However, segmenting 2.5D images, which have high in-plane but low through-plane resolution, is a relatively unexplored challenge. While applying 2D models to individual slices of a 2.5D image is feasible, it fails to capture the spatial relationships between slices. On the other hand, 3D models face challenges such as resolution inconsistencies in 2.5D images, along with computational complexity and susceptibility to overfitting when trained with limited data. In this context, 2.5D models, which capture inter-slice correlations using only 2D neural networks, emerge as a promising solution due to their reduced computational demand and simplicity in implementation. In this paper, we introduce CSA-Net, a flexible 2.5D segmentation model capable of processing 2.5D images with an arbitrary number of slices through an innovative Cross-Slice Attention (CSA) module. This module uses the cross-slice attention mechanism to effectively capture 3D spatial information by learning long-range dependencies between the center slice (for segmentation) and its neighboring slices. Moreover, CSA-Net utilizes the self-attention mechanism to understand correlations among pixels within the center slice. We evaluated CSA-Net on three 2.5D segmentation tasks: (1) multi-class brain MRI segmentation, (2) binary prostate MRI segmentation, and (3) multi-class prostate MRI segmentation. CSA-Net outperformed leading 2D and 2.5D segmentation methods across all three tasks, demonstrating its efficacy and superiority. Our code is publicly available at https://github.com/mirthAI/CSA-Net.

RetinaRegNet: A Versatile Approach for Retinal Image Registration

We introduce the RetinaRegNet model, which can achieve state-of-the-art performance across various retinal image registration tasks. RetinaRegNet does not require training on any retinal images. It begins by establishing point correspondences between two retinal images using image features derived from diffusion models. This process involves the selection of feature points from the moving image using the SIFT algorithm alongside random point sampling. For each selected feature point, a 2D correlation map is computed by assessing the similarity between the feature vector at that point and the feature vectors of all pixels in the fixed image. The pixel with the highest similarity score in the correlation map corresponds to the feature point in the moving image. To remove outliers in the estimated point correspondences, we first applied an inverse consistency constraint, followed by a transformation-based outlier detector. This method proved to outperform the widely used random sample consensus (RANSAC) outlier detector by a significant margin. To handle large deformations, we utilized a two-stage image registration framework. A homography transformation was used in the first stage and a more accurate third-order polynomial transformation was used in the second stage. The model's effectiveness was demonstrated across three retinal image datasets: color fundus images, fluorescein angiography images, and laser speckle flowgraphy images. RetinaRegNet outperformed current state-of-the-art methods in all three datasets. It was especially effective for registering image pairs with large displacement and scaling deformations. This innovation holds promise for various applications in retinal image analysis. Our code is publicly available at https://github.com/mirthAI/RetinaRegNet.

HQ-Edit: A High-Quality Dataset for Instruction-based Image Editing

This study introduces HQ-Edit, a high-quality instruction-based image editing dataset with around 200,000 edits. Unlike prior approaches relying on attribute guidance or human feedback on building datasets, we devise a scalable data collection pipeline leveraging advanced foundation models, namely GPT-4V and DALL-E 3. To ensure its high quality, diverse examples are first collected online, expanded, and then used to create high-quality diptychs featuring input and output images with detailed text prompts, followed by precise alignment ensured through post-processing. In addition, we propose two evaluation metrics, Alignment and Coherence, to quantitatively assess the quality of image edit pairs using GPT-4V. HQ-Edits high-resolution images, rich in detail and accompanied by comprehensive editing prompts, substantially enhance the capabilities of existing image editing models. For example, an HQ-Edit finetuned InstructPix2Pix can attain state-of-the-art image editing performance, even surpassing those models fine-tuned with human-annotated data. The project page is https://thefllood.github.io/HQEdit_web.

Unleashing the Potential of SAM for Medical Adaptation via Hierarchical Decoding

The Segment Anything Model (SAM) has garnered significant attention for its versatile segmentation abilities and intuitive prompt-based interface. However, its application in medical imaging presents challenges, requiring either substantial training costs and extensive medical datasets for full model fine-tuning or high-quality prompts for optimal performance. This paper introduces H-SAM: a prompt-free adaptation of SAM tailored for efficient fine-tuning of medical images via a two-stage hierarchical decoding procedure. In the initial stage, H-SAM employs SAM's original decoder to generate a prior probabilistic mask, guiding a more intricate decoding process in the second stage. Specifically, we propose two key designs: 1) A class-balanced, mask-guided self-attention mechanism addressing the unbalanced label distribution, enhancing image embedding; 2) A learnable mask cross-attention mechanism spatially modulating the interplay among different image regions based on the prior mask. Moreover, the inclusion of a hierarchical pixel decoder in H-SAM enhances its proficiency in capturing fine-grained and localized details. This approach enables SAM to effectively integrate learned medical priors, facilitating enhanced adaptation for medical image segmentation with limited samples. Our H-SAM demonstrates a 4.78% improvement in average Dice compared to existing prompt-free SAM variants for multi-organ segmentation using only 10% of 2D slices. Notably, without using any unlabeled data, H-SAM even outperforms state-of-the-art semi-supervised models relying on extensive unlabeled training data across various medical datasets. Our code is available at https://github.com/Cccccczh404/H-SAM.

3D-TransUNet for Brain Metastases Segmentation in the BraTS2023 Challenge

Segmenting brain tumors is complex due to their diverse appearances and scales. Brain metastases, the most common type of brain tumor, are a frequent complication of cancer. Therefore, an effective segmentation model for brain metastases must adeptly capture local intricacies to delineate small tumor regions while also integrating global context to understand broader scan features. The TransUNet model, which combines Transformer self-attention with U-Net's localized information, emerges as a promising solution for this task. In this report, we address brain metastases segmentation by training the 3D-TransUNet model on the Brain Tumor Segmentation (BraTS-METS) 2023 challenge dataset. Specifically, we explored two architectural configurations: the Encoder-only 3D-TransUNet, employing Transformers solely in the encoder, and the Decoder-only 3D-TransUNet, utilizing Transformers exclusively in the decoder. For Encoder-only 3D-TransUNet, we note that Masked-Autoencoder pre-training is required for a better initialization of the Transformer Encoder and thus accelerates the training process. We identify that the Decoder-only 3D-TransUNet model should offer enhanced efficacy in the segmentation of brain metastases, as indicated by our 5-fold cross-validation on the training set. However, our use of the Encoder-only 3D-TransUNet model already yield notable results, with an average lesion-wise Dice score of 59.8\% on the test set, securing second place in the BraTS-METS 2023 challenge.

MicroDiffusion: Implicit Representation-Guided Diffusion for 3D Reconstruction from Limited 2D Microscopy Projections

Volumetric optical microscopy using non-diffracting beams enables rapid imaging of 3D volumes by projecting them axially to 2D images but lacks crucial depth information. Addressing this, we introduce MicroDiffusion, a pioneering tool facilitating high-quality, depth-resolved 3D volume reconstruction from limited 2D projections. While existing Implicit Neural Representation (INR) models often yield incomplete outputs and Denoising Diffusion Probabilistic Models (DDPM) excel at capturing details, our method integrates INR's structural coherence with DDPM's fine-detail enhancement capabilities. We pretrain an INR model to transform 2D axially-projected images into a preliminary 3D volume. This pretrained INR acts as a global prior guiding DDPM's generative process through a linear interpolation between INR outputs and noise inputs. This strategy enriches the diffusion process with structured 3D information, enhancing detail and reducing noise in localized 2D images. By conditioning the diffusion model on the closest 2D projection, MicroDiffusion substantially enhances fidelity in resulting 3D reconstructions, surpassing INR and standard DDPM outputs with unparalleled image quality and structural fidelity. Our code and dataset are available at https://github.com/UCSC-VLAA/MicroDiffusion.

CIS-UNet: Multi-Class Segmentation of the Aorta in Computed Tomography Angiography via Context-Aware Shifted Window Self-Attention

Advancements in medical imaging and endovascular grafting have facilitated minimally invasive treatments for aortic diseases. Accurate 3D segmentation of the aorta and its branches is crucial for interventions, as inaccurate segmentation can lead to erroneous surgical planning and endograft construction. Previous methods simplified aortic segmentation as a binary image segmentation problem, overlooking the necessity of distinguishing between individual aortic branches. In this paper, we introduce Context Infused Swin-UNet (CIS-UNet), a deep learning model designed for multi-class segmentation of the aorta and thirteen aortic branches. Combining the strengths of Convolutional Neural Networks (CNNs) and Swin transformers, CIS-UNet adopts a hierarchical encoder-decoder structure comprising a CNN encoder, symmetric decoder, skip connections, and a novel Context-aware Shifted Window Self-Attention (CSW-SA) as the bottleneck block. Notably, CSW-SA introduces a unique utilization of the patch merging layer, distinct from conventional Swin transformers. It efficiently condenses the feature map, providing a global spatial context and enhancing performance when applied at the bottleneck layer, offering superior computational efficiency and segmentation accuracy compared to the Swin transformers. We trained our model on computed tomography (CT) scans from 44 patients and tested it on 15 patients. CIS-UNet outperformed the state-of-the-art SwinUNetR segmentation model, which is solely based on Swin transformers, by achieving a superior mean Dice coefficient of 0.713 compared to 0.697, and a mean surface distance of 2.78 mm compared to 3.39 mm. CIS-UNet's superior 3D aortic segmentation offers improved precision and optimization for planning endovascular treatments. Our dataset and code will be publicly available.

A Semantic Space is Worth 256 Language Descriptions: Make Stronger Segmentation Models with Descriptive Properties

This paper introduces ProLab, a novel approach using property-level label space for creating strong interpretable segmentation models. Instead of relying solely on category-specific annotations, ProLab uses descriptive properties grounded in common sense knowledge for supervising segmentation models. It is based on two core designs. First, we employ Large Language Models (LLMs) and carefully crafted prompts to generate descriptions of all involved categories that carry meaningful common sense knowledge and follow a structured format. Second, we introduce a description embedding model preserving semantic correlation across descriptions and then cluster them into a set of descriptive properties (e.g., 256) using K-Means. These properties are based on interpretable common sense knowledge consistent with theories of human recognition. We empirically show that our approach makes segmentation models perform stronger on five classic benchmarks (e.g., ADE20K, COCO-Stuff, Pascal Context, Cityscapes, and BDD). Our method also shows better scalability with extended training steps than category-level supervision. Our interpretable segmentation framework also emerges with the generalization ability to segment out-of-domain or unknown categories using only in-domain descriptive properties. Code is available at https://github.com/lambert-x/ProLab.

MixCon3D: Synergizing Multi-View and Cross-Modal Contrastive Learning for Enhancing 3D Representation

Contrastive learning has emerged as a promising paradigm for 3D open-world understanding, jointly with text, image, and point cloud. In this paper, we introduce MixCon3D, which combines the complementary information between 2D images and 3D point clouds to enhance contrastive learning. With the further integration of multi-view 2D images, MixCon3D enhances the traditional tri-modal representation by offering a more accurate and comprehensive depiction of real-world 3D objects and bolstering text alignment. Additionally, we pioneer the first thorough investigation of various training recipes for the 3D contrastive learning paradigm, building a solid baseline with improved performance. Extensive experiments conducted on three representative benchmarks reveal that our method renders significant improvement over the baseline, surpassing the previous state-of-the-art performance on the challenging 1,156-category Objaverse-LVIS dataset by 5.7%. We further showcase the effectiveness of our approach in more applications, including text-to-3D retrieval and point cloud captioning. The code is available at https://github.com/UCSC-VLAA/MixCon3D.

3D TransUNet: Advancing Medical Image Segmentation through Vision Transformers

Medical image segmentation plays a crucial role in advancing healthcare systems for disease diagnosis and treatment planning. The u-shaped architecture, popularly known as U-Net, has proven highly successful for various medical image segmentation tasks. However, U-Net's convolution-based operations inherently limit its ability to model long-range dependencies effectively. To address these limitations, researchers have turned to Transformers, renowned for their global self-attention mechanisms, as alternative architectures. One popular network is our previous TransUNet, which leverages Transformers' self-attention to complement U-Net's localized information with the global context. In this paper, we extend the 2D TransUNet architecture to a 3D network by building upon the state-of-the-art nnU-Net architecture, and fully exploring Transformers' potential in both the encoder and decoder design. We introduce two key components: 1) A Transformer encoder that tokenizes image patches from a convolution neural network (CNN) feature map, enabling the extraction of global contexts, and 2) A Transformer decoder that adaptively refines candidate regions by utilizing cross-attention between candidate proposals and U-Net features. Our investigations reveal that different medical tasks benefit from distinct architectural designs. The Transformer encoder excels in multi-organ segmentation, where the relationship among organs is crucial. On the other hand, the Transformer decoder proves more beneficial for dealing with small and challenging segmented targets such as tumor segmentation. Extensive experiments showcase the significant potential of integrating a Transformer-based encoder and decoder into the u-shaped medical image segmentation architecture. TransUNet outperforms competitors in various medical applications.