Abstract:Point cloud completion is inherently ill-posed due to severe sparsity and ambiguity in partial observations. Existing multi-view methods alleviate this by incorporating 2D semantics, but often rely on learned attention and fixed fusion, which lack geometric consistency and adaptability. We propose ProjFormer, a cross-modal framework that enforces geometry-consistent 2D-3D interaction through explicit projection and adaptive feature routing. A Projective Guided View Attention module aligns 3D points with multi-view features via deterministic projection, enabling efficient and geometrically consistent aggregation. Building on this, a geometry-aware routing network performs point-wise adaptive fusion of structural and observation-driven features for progressive refinement. Experiments show that, under a lightweight design, ProjFormer delivers competitive performance with improved structural completeness.
Abstract:Quantitative drug-induced sleep endoscopy (DISE) requires reliable airway boundaries at specific anatomical levels. Pixel-level DISE annotations are scarce, and manual contouring limits the scalability of quantitative assessment. To address this limitation, we developed ASTRA-Net for known-plane DISE segmentation with limited real annotations. Stage 1 aligned intermediate ConvNeXt-Base representations from 14,250 unlabeled virtual endoscopy frames derived from computed tomography and real DISE frames. Virtual images were used only for feature alignment. Stage 2 fine-tuned four independent UNet++ decoders on 401 real annotated frames. Structured zero-mask supervision constrained incompatible plane outputs and invalid frames. Six alignment configurations used maximum mean discrepancy, domain adversarial learning, or both objectives. On a hold-out evaluation set of 100 frames, the five-model MMD-only segmentation ensemble achieved a mean Dice of 0.8927, with a 95% image-level bootstrap interval of 0.8631 to 0.9160. The mean intersection over union was 0.8239. A classification- enabled variant of the same alignment configuration reached a restricted four-plane top-1 accuracy of 0.92 on the same hold-out frames. These results indicate that ASTRA-Net can support frame-level, plane-specific DISE boundary delineation when real annotations are limited.
Abstract:Robot imitation learning for manipulation should preserve demonstrated task geometry while producing dynamically admissible robot motions. Existing pipelines often learn task-dependent trajectories and impose execution limits afterward through filtering, smoothing, clipping, or time scaling, which may distort task-critical end-effector paths. We propose the Spectral Movement Primitive (SMP), a frequency-domain imitation learning framework that couples task-space skill generation with joint-space execution regulation. Demonstrations are represented by truncated finite-horizon Fourier coefficients. An empirically selected low-frequency task band captures the dominant motion geometry, while higher harmonics contribute disproportionately to derivative growth. A frame-aware context-conditioned GMM/GMR prior predicts the task-band coefficients in a canonical task frame, and the resulting Cartesian trajectory is mapped to joint space through sequential inverse kinematics. A phase-coupled regulator then limits the requested phase progression without modifying the spectral coefficients, thereby enforcing joint velocity and acceleration limits while preserving the represented path. Experiments evaluate task-band reconstruction, robustness to composite demonstration corruption, out-of-distribution cross-board generalization, joint-space dynamic admissibility, end-effector path preservation, and deployment on a Franka Panda robot. Results show compact geometric reconstruction, consistent transfer across unseen task frames, substantial reductions in dynamic violations and jerk, and preservation of the intended end-effector path during phase regulation.
Abstract:Multimodal large language models are increasingly deployed as long-horizon agents, where memory must do more than recall: it must track an evolving world, revise what has gone stale, and surface the right evidence at decision time. Existing benchmarks measure recall over static dialogue, collapse memory into a single end-of-task accuracy, and reduce visual observations to captions, leaving us unable to localize failures to writing, maintenance, retrieval, or use. The rise of agent harnesses that author their own memory sharpens this gap, since we have no principled way to compare hand-designed pipelines with self-managing alternatives. To close these gaps, we formulate multimodal agent memory as an Action-World Interaction Loop with an observable four-stage lifecycle, and instantiate it in WorldMemArena: 400 multi-session multimodal tasks spanning Lifelong Evolution (evolving personal and task states) and Agentic Execution (memory from real observations, actions, and feedback), annotated with gold memory points, updates, distractors, and evidence chains for stage-level diagnosis. This enables the first head-to-head comparison of long-context, manually designed (RAG and external memory systems), and harness-based memory agents. Results show that: (1) better memory writing and storage do not guarantee better performance; (2) multimodal memory still struggles to fully use visual evidence; (3) systems are unstable across domains and degrade on realistic agentic trajectories; and (4) harness memory is more flexible but remains costly and less reliable.
Abstract:LLM agents increasingly run inside execution harnesses that dispatch tools, allocate resources, and route messages between specialized components. However, a harness can return a correct, benign answer over a trajectory that accesses unauthorized resources or leaks context to the wrong agent. Output-level evaluation cannot see these failures, yet most safety benchmarks score only final outputs or terminal states, even though many violations occur mid-trajectory rather than at termination. The central question is whether the harness respects user intent, permission boundaries, and information-flow constraints throughout execution. To address this gap, we propose HarnessAudit, a framework that audits full execution trajectories across boundary compliance, execution fidelity, and system stability, with a focus on multi-agent harnesses where these risks are most pronounced. We further introduce HarnessAudit-Bench, a benchmark of 210 tasks across eight real-world domains, instantiated in both single-agent and multi-agent configurations with embedded safety constraints. Evaluating ten harness configurations across frontier models and three multi-agent frameworks, we find that: (i) task completion is misaligned with safe execution, and violations accumulate with trajectory length; (ii) safety risks vary across domains, task types, and agent roles; (iii) most violations concentrate in resource access and inter-agent information transfer; and (iv) multi-agent collaboration expands the safety risk surface, while harness design sets the upper bound of safe deployment.
Abstract:Whole-body Positron Emission Tomography (PET) registration is essential for multi-parametric tumor characterization and assessment of metastatic disease progression. In deep learning-based deformable registration, the dense displacement field (DDF) regularizer is crucial for stabilizing optimization and preventing unrealistic deformations in large 3D volumes. A key challenge in whole-body deformable registration is anatomical heterogeneity, rigid structures (e.g., bones) should undergo stronger regularization, whereas soft tissues require more flexible deformation and weaker constraints. In this work, we propose a simple yet effective CT-guided spatially-varying regularization strategy for whole-body cross-tracer deformable PET registration. The key idea is to use the paired CT volume from the PET/CT acquisition to construct a voxel-wise regularization map for the DDF, replacing the conventional single global regularization weight. This yields anatomy-adaptive regularization strength across rigid and soft tissues. The proposed method is evaluated on a real clinical cross-tracer PET/CT dataset of 296 patients involving 18F-PSMA and 18F-FDG, showing that the proposed method achieves statistically significant improvements over weakly-supervised registration baseline in both whole-body registration performance and organ-wise alignment.
Abstract:Video Large Language Models (VideoLLMs) excel at video understanding tasks where outputs are textual, such as Video Question Answering and Video Captioning. However, they underperform specialized embedding-based models in Retrieval tasks, such as Text-toVideo Retrieval and Moment Retrieval. We introduce ViLL-E (Video-LLM-Embed), a unified VideoLLM architecture endowed with a novel embedding generation mechanism that allows the model to "think longer" for complex videos and stop early for easy ones. We train this model with a three-stage training methodology combining generative and contrastive learning: initial large-scale pre-training with video-caption pairs; followed by continual training on a smaller, detailed-caption dataset; and concluding with task-specific fine-tuning on a novel multi-task dataset covering Video QA, Temporal Localization, Video Retrieval, and Video-Text Matching. Our model significantly improves temporal localization (on avg. 7% over other VideoLLMs) and video retrieval (up to 4% over dual encoder models), achieving performance comparable to state-of-the-art specialized embedding models while remaining competitive on VideoQA tasks. Furthermore, our joint contrastive-generative training unlocks new zero-shot capabilities, significantly outperforming state-of-the-art methods in composed video retrieval (+5% over SotA) and retrieval from long text (+2% over SotA).
Abstract:Modern clinical practice increasingly depends on reasoning over heterogeneous, evolving, and incomplete patient data. Although recent advances in multimodal foundation models have improved performance on various clinical tasks, most existing models remain static, opaque, and poorly aligned with real-world clinical workflows. We present Cerebra, an interactive multi-agent AI team that coordinates specialized agents for EHR, clinical notes, and medical imaging analysis. These outputs are synthesized into a clinician-facing dashboard that combines visual analytics with a conversational interface, enabling clinicians to interrogate predictions and contextualize risk at the point of care. Cerebra supports privacy-preserving deployment by operating on structured representations and remains robust when modalities are incomplete. We evaluated Cerebra using a massive multi-institutional dataset spanning 3 million patients from four independent healthcare systems. Cerebra consistently outperformed both state-of-the-art single-modality models and large multimodal language model baselines. In dementia risk prediction, it achieved AUROCs up to 0.80, compared with 0.74 for the strongest single-modality model and 0.68 for language model baselines. For dementia diagnosis, it achieved an AUROC of 0.86, and for survival prediction, a C-index of 0.81. In a reader study with experienced physicians, Cerebra significantly improved expert performance, increasing accuracy by 17.5 percentage points in prospective dementia risk estimation. These results demonstrate Cerebra's potential for interpretable, robust decision support in clinical care.
Abstract:Modern clinical practice increasingly depends on reasoning over heterogeneous, evolving, and incomplete patient data. Although recent advances in multimodal foundation models have improved performance on various clinical tasks, most existing models remain static, opaque, and poorly aligned with real-world clinical workflows. We present Cerebra, an interactive multi-agent AI team that coordinates specialized agents for EHR, clinical notes, and medical imaging analysis. These outputs are synthesized into a clinician-facing dashboard that combines visual analytics with a conversational interface, enabling clinicians to interrogate predictions and contextualize risk at the point of care. Cerebra supports privacy-preserving deployment by operating on structured representations and remains robust when modalities are incomplete. We evaluated Cerebra using a massive multi-institutional dataset spanning 3 million patients from four independent healthcare systems. Cerebra consistently outperformed both state-of-the-art single-modality models and large multimodal language model baselines. In dementia risk prediction, it achieved AUROCs up to 0.80, compared with 0.74 for the strongest single-modality model and 0.68 for language model baselines. For dementia diagnosis, it achieved an AUROC of 0.86, and for survival prediction, a C-index of 0.81. In a reader study with experienced physicians, Cerebra significantly improved expert performance, increasing accuracy by 17.5 percentage points in prospective dementia risk estimation. These results demonstrate Cerebra's potential for interpretable, robust decision support in clinical care.
Abstract:FL has emerged as a transformative paradigm for ITS, notably camera-based Road Condition Classification (RCC). However, by enabling collaboration, FL-based RCC exposes the system to adversarial participants launching Targeted Label-Flipping Attacks (TLFAs). Malicious clients (vehicles) can relabel their local training data (e.g., from an actual uneven road to a wrong smooth road), consequently compromising global model predictions and jeopardizing transportation safety. Existing countermeasures against such poisoning attacks fail to maintain resilient model performance near the necessary attack-free levels in various attack scenarios due to: 1) not tailoring poisoned local model detection to TLFAs, 2) not excluding malicious vehicular clients based on historical behavior, and 3) not remedying the already-corrupted global model after exclusion. To close this research gap, we propose FedTrident, which introduces: 1) neuron-wise analysis for local model misbehavior detection (notably including attack goal identification, critical feature extraction, and GMM-based model clustering and filtering); 2) adaptive client rating for client exclusion according to the local model detection results in each FL round; and 3) machine unlearning for corrupted global model remediation once malicious clients are excluded during FL. Extensive evaluation across diverse FL-RCC models, tasks, and configurations demonstrates that FedTrident can effectively thwart TLFAs, achieving performance comparable to that in attack-free scenarios and outperforming eight baseline countermeasures by 9.49% and 4.47% for the two most critical metrics. Moreover, FedTrident is resilient to various malicious client rates, data heterogeneity levels, complicated multi-task, and dynamic attacks.