A Robust Deep Learning Method with Uncertainty Estimation for the Pathological Classification of Renal Cell Carcinoma based on CT Images

Objectives To develop and validate a deep learning-based diagnostic model incorporating uncertainty estimation so as to facilitate radiologists in the preoperative differentiation of the pathological subtypes of renal cell carcinoma (RCC) based on CT images. Methods Data from 668 consecutive patients, pathologically proven RCC, were retrospectively collected from Center 1. By using five-fold cross-validation, a deep learning model incorporating uncertainty estimation was developed to classify RCC subtypes into clear cell RCC (ccRCC), papillary RCC (pRCC), and chromophobe RCC (chRCC). An external validation set of 78 patients from Center 2 further evaluated the model's performance. Results In the five-fold cross-validation, the model's area under the receiver operating characteristic curve (AUC) for the classification of ccRCC, pRCC, and chRCC was 0.868 (95% CI: 0.826-0.923), 0.846 (95% CI: 0.812-0.886), and 0.839 (95% CI: 0.802-0.88), respectively. In the external validation set, the AUCs were 0.856 (95% CI: 0.838-0.882), 0.787 (95% CI: 0.757-0.818), and 0.793 (95% CI: 0.758-0.831) for ccRCC, pRCC, and chRCC, respectively. Conclusions The developed deep learning model demonstrated robust performance in predicting the pathological subtypes of RCC, while the incorporated uncertainty emphasized the importance of understanding model confidence, which is crucial for assisting clinical decision-making for patients with renal tumors. Clinical relevance statement Our deep learning approach, integrated with uncertainty estimation, offers clinicians a dual advantage: accurate RCC subtype predictions complemented by diagnostic confidence references, promoting informed decision-making for patients with RCC.

Joint Beamforming for RIS Aided Full-Duplex Integrated Sensing and Uplink Communication

This paper studies integrated sensing and communication (ISAC) technology in a full-duplex (FD) uplink communication system. As opposed to the half-duplex system, where sensing is conducted in a first-emit-then-listen manner, FD ISAC system emits and listens simultaneously and hence conducts uninterrupted target sensing. Besides, impressed by the recently emerging reconfigurable intelligent surface (RIS) technology, we also employ RIS to improve the self-interference (SI) suppression and signal processing gain. As will be seen, the joint beamforming, RIS configuration and mobile users' power allocation is a difficult optimization problem. To resolve this challenge, via leveraging the cutting-the-edge majorization-minimization (MM) and penalty-dual-decomposition (PDD) methods, we develop an iterative solution that optimizes all variables via using convex optimization techniques. Numerical results demonstrate the effectiveness of our proposed solution and the great benefit of employing RIS in the FD ISAC system.

Joint Beamforming and Power Allocation for RIS Aided Full-Duplex Integrated Sensing and Uplink Communication System

Integrated sensing and communication (ISAC) capability is envisioned as one key feature for future cellular networks. Classical half-duplex (HD) radar sensing is conducted in a "first-emit-then-listen" manner. One challenge to realize HD ISAC lies in the discrepancy of the two systems' time scheduling for transmitting and receiving. This difficulty can be overcome by full-duplex (FD) transceivers. Besides, ISAC generally has to comprise its communication rate due to realizing sensing functionality. This loss can be compensated by the emerging reconfigurable intelligent surface (RIS) technology. This paper considers the joint design of beamforming, power allocation and signal processing in a FD uplink communication system aided by RIS, which is a highly nonconvex problem. To resolve this challenge, via leveraging the cutting-the-edge majorization-minimization (MM) and penalty-dual-decomposition (PDD) methods, we develop an iterative solution that optimizes all variables via using convex optimization techniques. Besides, by wisely exploiting alternative direction method of multipliers (ADMM) and optimality analysis, we further develop a low complexity solution that updates all variables analytically and runs highly efficiently. Numerical results are provided to verify the effectiveness and efficiency of our proposed algorithms and demonstrate the significant performance boosting by employing RIS in the FD ISAC system.

Artistic Glyph Image Synthesis via One-Stage Few-Shot Learning

Automatic generation of artistic glyph images is a challenging task that attracts many research interests. Previous methods either are specifically designed for shape synthesis or focus on texture transfer. In this paper, we propose a novel model, AGIS-Net, to transfer both shape and texture styles in one-stage with only a few stylized samples. To achieve this goal, we first disentangle the representations for content and style by using two encoders, ensuring the multi-content and multi-style generation. Then we utilize two collaboratively working decoders to generate the glyph shape image and its texture image simultaneously. In addition, we introduce a local texture refinement loss to further improve the quality of the synthesized textures. In this manner, our one-stage model is much more efficient and effective than other multi-stage stacked methods. We also propose a large-scale dataset with Chinese glyph images in various shape and texture styles, rendered from 35 professional-designed artistic fonts with 7,326 characters and 2,460 synthetic artistic fonts with 639 characters, to validate the effectiveness and extendability of our method. Extensive experiments on both English and Chinese artistic glyph image datasets demonstrate the superiority of our model in generating high-quality stylized glyph images against other state-of-the-art methods.

Accelerated Experimental Design for Pairwise Comparisons

Pairwise comparison labels are more informative and less variable than class labels, but generating them poses a challenge: their number grows quadratically in the dataset size. We study a natural experimental design objective, namely, D-optimality, that can be used to identify which $K$ pairwise comparisons to generate. This objective is known to perform well in practice, and is submodular, making the selection approximable via the greedy algorithm. A na\"ive greedy implementation has $O(N^2d^2K)$ complexity, where $N$ is the dataset size, $d$ is the feature space dimension, and $K$ is the number of generated comparisons. We show that, by exploiting the inherent geometry of the dataset--namely, that it consists of pairwise comparisons--the greedy algorithm's complexity can be reduced to $O(N^2(K+d)+N(dK+d^2) +d^2K).$ We apply the same acceleration also to the so-called lazy greedy algorithm. When combined, the above improvements lead to an execution time of less than 1 hour for a dataset with $10^8$ comparisons; the na\"ive greedy algorithm on the same dataset would require more than 10 days to terminate.