Can Large Language Models Logically Predict Myocardial Infarction? Evaluation based on UK Biobank Cohort

Background: Large language models (LLMs) have seen extraordinary advances with applications in clinical decision support. However, high-quality evidence is urgently needed on the potential and limitation of LLMs in providing accurate clinical decisions based on real-world medical data. Objective: To evaluate quantitatively whether universal state-of-the-art LLMs (ChatGPT and GPT-4) can predict the incidence risk of myocardial infarction (MI) with logical inference, and to further make comparison between various models to assess the performance of LLMs comprehensively. Methods: In this retrospective cohort study, 482,310 participants recruited from 2006 to 2010 were initially included in UK Biobank database and later on resampled into a final cohort of 690 participants. For each participant, tabular data of the risk factors of MI were transformed into standardized textual descriptions for ChatGPT recognition. Responses were generated by asking ChatGPT to select a score ranging from 0 to 10 representing the risk. Chain of Thought (CoT) questioning was used to evaluate whether LLMs make prediction logically. The predictive performance of ChatGPT was compared with published medical indices, traditional machine learning models and other large language models. Conclusions: Current LLMs are not ready to be applied in clinical medicine fields. Future medical LLMs are suggested to be expert in medical domain knowledge to understand both natural languages and quantified medical data, and further make logical inferences.

Anisotropic Diffusion Probabilistic Model for Imbalanced Image Classification

Real-world data often has a long-tailed distribution, where the scarcity of tail samples significantly limits the model's generalization ability. Denoising Diffusion Probabilistic Models (DDPM) are generative models based on stochastic differential equation theory and have demonstrated impressive performance in image classification tasks. However, existing diffusion probabilistic models do not perform satisfactorily in classifying tail classes. In this work, we propose the Anisotropic Diffusion Probabilistic Model (ADPM) for imbalanced image classification problems. We utilize the data distribution to control the diffusion speed of different class samples during the forward process, effectively improving the classification accuracy of the denoiser in the reverse process. Specifically, we provide a theoretical strategy for selecting noise levels for different categories in the diffusion process based on error analysis theory to address the imbalanced classification problem. Furthermore, we integrate global and local image prior in the forward process to enhance the model's discriminative ability in the spatial dimension, while incorporate semantic-level contextual information in the reverse process to boost the model's discriminative power and robustness. Through comparisons with state-of-the-art methods on four medical benchmark datasets, we validate the effectiveness of the proposed method in handling long-tail data. Our results confirm that the anisotropic diffusion model significantly improves the classification accuracy of rare classes while maintaining the accuracy of head classes. On the skin lesion datasets, PAD-UFES and HAM10000, the F1-scores of our method improved by 4% and 3%, respectively compared to the original diffusion probabilistic model.

SAFETY-J: Evaluating Safety with Critique

The deployment of Large Language Models (LLMs) in content generation raises significant safety concerns, particularly regarding the transparency and interpretability of content evaluations. Current methods, primarily focused on binary safety classifications, lack mechanisms for detailed critique, limiting their utility for model improvement and user trust. To address these limitations, we introduce SAFETY-J, a bilingual generative safety evaluator for English and Chinese with critique-based judgment. SAFETY-J utilizes a robust training dataset that includes diverse dialogues and augmented query-response pairs to assess safety across various scenarios comprehensively. We establish an automated meta-evaluation benchmark that objectively assesses the quality of critiques with minimal human intervention, facilitating scalable and continuous improvement. Additionally, SAFETY-J employs an iterative preference learning technique to dynamically refine safety assessments based on meta-evaluations and critiques. Our evaluations demonstrate that SAFETY-J provides more nuanced and accurate safety evaluations, thereby enhancing both critique quality and predictive reliability in complex content scenarios. To facilitate further research and application, we open-source SAFETY-J's training protocols, datasets, and code at \url{https://github.com/GAIR-NLP/Safety-J}.

BeHonest: Benchmarking Honesty of Large Language Models

Previous works on Large Language Models (LLMs) have mainly focused on evaluating their helpfulness or harmlessness. However, honesty, another crucial alignment criterion, has received relatively less attention. Dishonest behaviors in LLMs, such as spreading misinformation and defrauding users, eroding user trust, and causing real-world harm, present severe risks that intensify as these models approach superintelligence levels. Enhancing honesty in LLMs addresses critical deficiencies and helps uncover latent capabilities that are not readily expressed. This underscores the urgent need for reliable methods and benchmarks to effectively ensure and evaluate the honesty of LLMs. In this paper, we introduce BeHonest, a pioneering benchmark specifically designed to assess honesty in LLMs comprehensively. BeHonest evaluates three essential aspects of honesty: awareness of knowledge boundaries, avoidance of deceit, and consistency in responses. Building on this foundation, we designed 10 scenarios to evaluate and analyze 9 popular LLMs on the market, including both closed-source and open-source models from different model families with varied model sizes. Our findings indicate that there is still significant room for improvement in the honesty of LLMs. We also encourage the AI community to prioritize honesty alignment in LLMs. Our benchmark and code can be found at: \url{https://github.com/GAIR-NLP/BeHonest}.

A Robust Deep Learning Method with Uncertainty Estimation for the Pathological Classification of Renal Cell Carcinoma based on CT Images

Objectives To develop and validate a deep learning-based diagnostic model incorporating uncertainty estimation so as to facilitate radiologists in the preoperative differentiation of the pathological subtypes of renal cell carcinoma (RCC) based on CT images. Methods Data from 668 consecutive patients, pathologically proven RCC, were retrospectively collected from Center 1. By using five-fold cross-validation, a deep learning model incorporating uncertainty estimation was developed to classify RCC subtypes into clear cell RCC (ccRCC), papillary RCC (pRCC), and chromophobe RCC (chRCC). An external validation set of 78 patients from Center 2 further evaluated the model's performance. Results In the five-fold cross-validation, the model's area under the receiver operating characteristic curve (AUC) for the classification of ccRCC, pRCC, and chRCC was 0.868 (95% CI: 0.826-0.923), 0.846 (95% CI: 0.812-0.886), and 0.839 (95% CI: 0.802-0.88), respectively. In the external validation set, the AUCs were 0.856 (95% CI: 0.838-0.882), 0.787 (95% CI: 0.757-0.818), and 0.793 (95% CI: 0.758-0.831) for ccRCC, pRCC, and chRCC, respectively. Conclusions The developed deep learning model demonstrated robust performance in predicting the pathological subtypes of RCC, while the incorporated uncertainty emphasized the importance of understanding model confidence, which is crucial for assisting clinical decision-making for patients with renal tumors. Clinical relevance statement Our deep learning approach, integrated with uncertainty estimation, offers clinicians a dual advantage: accurate RCC subtype predictions complemented by diagnostic confidence references, promoting informed decision-making for patients with RCC.

Joint Beamforming for RIS Aided Full-Duplex Integrated Sensing and Uplink Communication

This paper studies integrated sensing and communication (ISAC) technology in a full-duplex (FD) uplink communication system. As opposed to the half-duplex system, where sensing is conducted in a first-emit-then-listen manner, FD ISAC system emits and listens simultaneously and hence conducts uninterrupted target sensing. Besides, impressed by the recently emerging reconfigurable intelligent surface (RIS) technology, we also employ RIS to improve the self-interference (SI) suppression and signal processing gain. As will be seen, the joint beamforming, RIS configuration and mobile users' power allocation is a difficult optimization problem. To resolve this challenge, via leveraging the cutting-the-edge majorization-minimization (MM) and penalty-dual-decomposition (PDD) methods, we develop an iterative solution that optimizes all variables via using convex optimization techniques. Numerical results demonstrate the effectiveness of our proposed solution and the great benefit of employing RIS in the FD ISAC system.

Joint Beamforming and Power Allocation for RIS Aided Full-Duplex Integrated Sensing and Uplink Communication System

Integrated sensing and communication (ISAC) capability is envisioned as one key feature for future cellular networks. Classical half-duplex (HD) radar sensing is conducted in a "first-emit-then-listen" manner. One challenge to realize HD ISAC lies in the discrepancy of the two systems' time scheduling for transmitting and receiving. This difficulty can be overcome by full-duplex (FD) transceivers. Besides, ISAC generally has to comprise its communication rate due to realizing sensing functionality. This loss can be compensated by the emerging reconfigurable intelligent surface (RIS) technology. This paper considers the joint design of beamforming, power allocation and signal processing in a FD uplink communication system aided by RIS, which is a highly nonconvex problem. To resolve this challenge, via leveraging the cutting-the-edge majorization-minimization (MM) and penalty-dual-decomposition (PDD) methods, we develop an iterative solution that optimizes all variables via using convex optimization techniques. Besides, by wisely exploiting alternative direction method of multipliers (ADMM) and optimality analysis, we further develop a low complexity solution that updates all variables analytically and runs highly efficiently. Numerical results are provided to verify the effectiveness and efficiency of our proposed algorithms and demonstrate the significant performance boosting by employing RIS in the FD ISAC system.

Artistic Glyph Image Synthesis via One-Stage Few-Shot Learning

Automatic generation of artistic glyph images is a challenging task that attracts many research interests. Previous methods either are specifically designed for shape synthesis or focus on texture transfer. In this paper, we propose a novel model, AGIS-Net, to transfer both shape and texture styles in one-stage with only a few stylized samples. To achieve this goal, we first disentangle the representations for content and style by using two encoders, ensuring the multi-content and multi-style generation. Then we utilize two collaboratively working decoders to generate the glyph shape image and its texture image simultaneously. In addition, we introduce a local texture refinement loss to further improve the quality of the synthesized textures. In this manner, our one-stage model is much more efficient and effective than other multi-stage stacked methods. We also propose a large-scale dataset with Chinese glyph images in various shape and texture styles, rendered from 35 professional-designed artistic fonts with 7,326 characters and 2,460 synthetic artistic fonts with 639 characters, to validate the effectiveness and extendability of our method. Extensive experiments on both English and Chinese artistic glyph image datasets demonstrate the superiority of our model in generating high-quality stylized glyph images against other state-of-the-art methods.

Accelerated Experimental Design for Pairwise Comparisons

Pairwise comparison labels are more informative and less variable than class labels, but generating them poses a challenge: their number grows quadratically in the dataset size. We study a natural experimental design objective, namely, D-optimality, that can be used to identify which $K$ pairwise comparisons to generate. This objective is known to perform well in practice, and is submodular, making the selection approximable via the greedy algorithm. A na\"ive greedy implementation has $O(N^2d^2K)$ complexity, where $N$ is the dataset size, $d$ is the feature space dimension, and $K$ is the number of generated comparisons. We show that, by exploiting the inherent geometry of the dataset--namely, that it consists of pairwise comparisons--the greedy algorithm's complexity can be reduced to $O(N^2(K+d)+N(dK+d^2) +d^2K).$ We apply the same acceleration also to the so-called lazy greedy algorithm. When combined, the above improvements lead to an execution time of less than 1 hour for a dataset with $10^8$ comparisons; the na\"ive greedy algorithm on the same dataset would require more than 10 days to terminate.