Data-Efficient Brain Connectome Analysis via Multi-Task Meta-Learning

Brain networks characterize complex connectivities among brain regions as graph structures, which provide a powerful means to study brain connectomes. In recent years, graph neural networks have emerged as a prevalent paradigm of learning with structured data. However, most brain network datasets are limited in sample sizes due to the relatively high cost of data acquisition, which hinders the deep learning models from sufficient training. Inspired by meta-learning that learns new concepts fast with limited training examples, this paper studies data-efficient training strategies for analyzing brain connectomes in a cross-dataset setting. Specifically, we propose to meta-train the model on datasets of large sample sizes and transfer the knowledge to small datasets. In addition, we also explore two brain-network-oriented designs, including atlas transformation and adaptive task reweighing. Compared to other pre-training strategies, our meta-learning-based approach achieves higher and stabler performance, which demonstrates the effectiveness of our proposed solutions. The framework is also able to derive new insights regarding the similarities among datasets and diseases in a data-driven fashion.

FBNETGEN: Task-aware GNN-based fMRI Analysis via Functional Brain Network Generation

Functional magnetic resonance imaging (fMRI) is one of the most common imaging modalities to investigate brain functions. Recent studies in neuroscience stress the great potential of functional brain networks constructed from fMRI data for clinical predictions. Traditional functional brain networks, however, are noisy and unaware of downstream prediction tasks, while also incompatible with the deep graph neural network (GNN) models. In order to fully unleash the power of GNNs in network-based fMRI analysis, we develop FBNETGEN, a task-aware and interpretable fMRI analysis framework via deep brain network generation. In particular, we formulate (1) prominent region of interest (ROI) features extraction, (2) brain networks generation, and (3) clinical predictions with GNNs, in an end-to-end trainable model under the guidance of particular prediction tasks. Along with the process, the key novel component is the graph generator which learns to transform raw time-series features into task-oriented brain networks. Our learnable graphs also provide unique interpretations by highlighting prediction-related brain regions. Comprehensive experiments on two datasets, i.e., the recently released and currently largest publicly available fMRI dataset Adolescent Brain Cognitive Development (ABCD), and the widely-used fMRI dataset PNC, prove the superior effectiveness and interpretability of FBNETGEN. The implementation is available at https://github.com/Wayfear/FBNETGEN.

Identifying Critical LMS Features for Predicting At-risk Students

Learning management systems (LMSs) have become essential in higher education and play an important role in helping educational institutions to promote student success. Traditionally, LMSs have been used by postsecondary institutions in administration, reporting, and delivery of educational content. In this paper, we present an additional use of LMS by using its data logs to perform data-analytics and identify academically at-risk students. The data-driven insights would allow educational institutions and educators to develop and implement pedagogical interventions targeting academically at-risk students. We used anonymized data logs created by Brightspace LMS during fall 2019, spring 2020, and fall 2020 semesters at our college. Supervised machine learning algorithms were used to predict the final course performance of students, and several algorithms were found to perform well with accuracy above 90%. SHAP value method was used to assess the relative importance of features used in the predictive models. Unsupervised learning was also used to group students into different clusters based on the similarities in their interaction/involvement with LMS. In both of supervised and unsupervised learning, we identified two most-important features (Number_Of_Assignment_Submissions and Content_Completed). More importantly, our study lays a foundation and provides a framework for developing a real-time data analytics metric that may be incorporated into a LMS.

Unrestricted Adversarial Attacks on ImageNet Competition

Many works have investigated the adversarial attacks or defenses under the settings where a bounded and imperceptible perturbation can be added to the input. However in the real-world, the attacker does not need to comply with this restriction. In fact, more threats to the deep model come from unrestricted adversarial examples, that is, the attacker makes large and visible modifications on the image, which causes the model classifying mistakenly, but does not affect the normal observation in human perspective. Unrestricted adversarial attack is a popular and practical direction but has not been studied thoroughly. We organize this competition with the purpose of exploring more effective unrestricted adversarial attack algorithm, so as to accelerate the academical research on the model robustness under stronger unbounded attacks. The competition is held on the TianChi platform (\url{https://tianchi.aliyun.com/competition/entrance/531853/introduction}) as one of the series of AI Security Challengers Program.

Effective and Interpretable fMRI Analysis via Functional Brain Network Generation

Recent studies in neuroscience show great potential of functional brain networks constructed from fMRI data for popularity modeling and clinical predictions. However, existing functional brain networks are noisy and unaware of downstream prediction tasks, while also incompatible with recent powerful machine learning models of GNNs. In this work, we develop an end-to-end trainable pipeline to extract prominent fMRI features, generate brain networks, and make predictions with GNNs, all under the guidance of downstream prediction tasks. Preliminary experiments on the PNC fMRI data show the superior effectiveness and unique interpretability of our framework.

Improving Adversarial Transferability with Gradient Refining

Deep neural networks are vulnerable to adversarial examples, which are crafted by adding human-imperceptible perturbations to original images. Most existing adversarial attack methods achieve nearly 100% attack success rates under the white-box setting, but only achieve relatively low attack success rates under the black-box setting. To improve the transferability of adversarial examples for the black-box setting, several methods have been proposed, e.g., input diversity, translation-invariant attack, and momentum-based attack. In this paper, we propose a method named Gradient Refining, which can further improve the adversarial transferability by correcting useless gradients introduced by input diversity through multiple transformations. Our method is generally applicable to many gradient-based attack methods combined with input diversity. Extensive experiments are conducted on the ImageNet dataset and our method can achieve an average transfer success rate of 82.07% for three different models under single-model setting, which outperforms the other state-of-the-art methods by a large margin of 6.0% averagely. And we have applied the proposed method to the competition CVPR 2021 Unrestricted Adversarial Attacks on ImageNet organized by Alibaba and won the second place in attack success rates among 1558 teams.

Meaningful Adversarial Stickers for Face Recognition in Physical World

Face recognition (FR) systems have been widely applied in safety-critical fields with the introduction of deep learning. However, the existence of adversarial examples brings potential security risks to FR systems. To identify their vulnerability and help improve their robustness, in this paper, we propose Meaningful Adversarial Stickers, a physically feasible and easily implemented attack method by using meaningful real stickers existing in our life, where the attackers manipulate the pasting parameters of stickers on the face, instead of designing perturbation patterns and then printing them like most existing works. We conduct attacks in the black-box setting with limited information which is more challenging and practical. To effectively solve the pasting position, rotation angle, and other parameters of the stickers, we design Region based Heuristic Differential Algorithm, which utilizes the inbreeding strategy based on regional aggregation of effective solutions and the adaptive adjustment strategy of evaluation criteria. Extensive experiments are conducted on two public datasets including LFW and CelebA with respective to three representative FR models like FaceNet, SphereFace, and CosFace, achieving attack success rates of 81.78%, 72.93%, and 79.26% respectively with only hundreds of queries. The results in the physical world confirm the effectiveness of our method in complex physical conditions. When continuously changing the face posture of testers, the method can still perform successful attacks up to 98.46%, 91.30% and 86.96% in the time series.

LOCUS: A Novel Decomposition Method for Brain Network Connectivity Matrices using Low-rank Structure with Uniform Sparsity

Network-oriented research has been increasingly popular in many scientific areas. In neuroscience research, imaging-based network connectivity measures have become the key for understanding brain organizations, potentially serving as individual neural fingerprints. There are major challenges in analyzing connectivity matrices including the high dimensionality of brain networks, unknown latent sources underlying the observed connectivity, and the large number of brain connections leading to spurious findings. In this paper, we propose a novel blind source separation method with low-rank structure and uniform sparsity (LOCUS) as a fully data-driven decomposition method for network measures. Compared with the existing method that vectorizes connectivity matrices ignoring brain network topology, LOCUS achieves more efficient and accurate source separation for connectivity matrices using low-rank structure. We propose a novel angle-based uniform sparsity regularization that demonstrates better performance than the existing sparsity controls for low-rank tensor methods. We propose a highly efficient iterative Node-Rotation algorithm that exploits the block multi-convexity of the objective function to solve the non-convex optimization problem for learning LOCUS. We illustrate the advantage of LOCUS through extensive simulation studies. Application of LOCUS to Philadelphia Neurodevelopmental Cohort neuroimaging study reveals biologically insightful connectivity traits which are not found using the existing method.