MINT-1T: Scaling Open-Source Multimodal Data by 10x: A Multimodal Dataset with One Trillion Tokens

Multimodal interleaved datasets featuring free-form interleaved sequences of images and text are crucial for training frontier large multimodal models (LMMs). Despite the rapid progression of open-source LMMs, there remains a pronounced scarcity of large-scale, diverse open-source multimodal interleaved datasets. In response, we introduce MINT-1T, the most extensive and diverse open-source Multimodal INTerleaved dataset to date. MINT-1T comprises one trillion text tokens and three billion images, a 10x scale-up from existing open-source datasets. Additionally, we include previously untapped sources such as PDFs and ArXiv papers. As scaling multimodal interleaved datasets requires substantial engineering effort, sharing the data curation process and releasing the dataset greatly benefits the community. Our experiments show that LMMs trained on MINT-1T rival the performance of models trained on the previous leading dataset, OBELICS. Our data and code will be released at https://github.com/mlfoundations/MINT-1T.

TACCO: Task-guided Co-clustering of Clinical Concepts and Patient Visits for Disease Subtyping based on EHR Data

The growing availability of well-organized Electronic Health Records (EHR) data has enabled the development of various machine learning models towards disease risk prediction. However, existing risk prediction methods overlook the heterogeneity of complex diseases, failing to model the potential disease subtypes regarding their corresponding patient visits and clinical concept subgroups. In this work, we introduce TACCO, a novel framework that jointly discovers clusters of clinical concepts and patient visits based on a hypergraph modeling of EHR data. Specifically, we develop a novel self-supervised co-clustering framework that can be guided by the risk prediction task of specific diseases. Furthermore, we enhance the hypergraph model of EHR data with textual embeddings and enforce the alignment between the clusters of clinical concepts and patient visits through a contrastive objective. Comprehensive experiments conducted on the public MIMIC-III dataset and Emory internal CRADLE dataset over the downstream clinical tasks of phenotype classification and cardiovascular risk prediction demonstrate an average 31.25% performance improvement compared to traditional ML baselines and a 5.26% improvement on top of the vanilla hypergraph model without our co-clustering mechanism. In-depth model analysis, clustering results analysis, and clinical case studies further validate the improved utilities and insightful interpretations delivered by TACCO. Code is available at https://github.com/PericlesHat/TACCO.

MobileAIBench: Benchmarking LLMs and LMMs for On-Device Use Cases

The deployment of Large Language Models (LLMs) and Large Multimodal Models (LMMs) on mobile devices has gained significant attention due to the benefits of enhanced privacy, stability, and personalization. However, the hardware constraints of mobile devices necessitate the use of models with fewer parameters and model compression techniques like quantization. Currently, there is limited understanding of quantization's impact on various task performances, including LLM tasks, LMM tasks, and, critically, trust and safety. There is a lack of adequate tools for systematically testing these models on mobile devices. To address these gaps, we introduce MobileAIBench, a comprehensive benchmarking framework for evaluating mobile-optimized LLMs and LMMs. MobileAIBench assesses models across different sizes, quantization levels, and tasks, measuring latency and resource consumption on real devices. Our two-part open-source framework includes a library for running evaluations on desktops and an iOS app for on-device latency and hardware utilization measurements. Our thorough analysis aims to accelerate mobile AI research and deployment by providing insights into the performance and feasibility of deploying LLMs and LMMs on mobile platforms.

From Basic to Extra Features: Hypergraph Transformer Pretrain-then-Finetuning for Balanced Clinical Predictions on EHR

Electronic Health Records (EHRs) contain rich patient information and are crucial for clinical research and practice. In recent years, deep learning models have been applied to EHRs, but they often rely on massive features, which may not be readily available for all patients. We propose HTP-Star, which leverages hypergraph structures with a pretrain-then-finetune framework for modeling EHR data, enabling seamless integration of additional features. Additionally, we design two techniques, namely (1) Smoothness-inducing Regularization and (2) Group-balanced Reweighting, to enhance the model's robustness during fine-tuning. Through experiments conducted on two real EHR datasets, we demonstrate that HTP-Star consistently outperforms various baselines while striking a balance between patients with basic and extra features.

Decomposing the Neurons: Activation Sparsity via Mixture of Experts for Continual Test Time Adaptation

Continual Test-Time Adaptation (CTTA), which aims to adapt the pre-trained model to ever-evolving target domains, emerges as an important task for vision models. As current vision models appear to be heavily biased towards texture, continuously adapting the model from one domain distribution to another can result in serious catastrophic forgetting. Drawing inspiration from the human visual system's adeptness at processing both shape and texture according to the famous Trichromatic Theory, we explore the integration of a Mixture-of-Activation-Sparsity-Experts (MoASE) as an adapter for the CTTA task. Given the distinct reaction of neurons with low/high activation to domain-specific/agnostic features, MoASE decomposes the neural activation into high-activation and low-activation components with a non-differentiable Spatial Differentiate Dropout (SDD). Based on the decomposition, we devise a multi-gate structure comprising a Domain-Aware Gate (DAG) that utilizes domain information to adaptive combine experts that process the post-SDD sparse activations of different strengths, and the Activation Sparsity Gate (ASG) that adaptively assigned feature selection threshold of the SDD for different experts for more precise feature decomposition. Finally, we introduce a Homeostatic-Proximal (HP) loss to bypass the error accumulation problem when continuously adapting the model. Extensive experiments on four prominent benchmarks substantiate that our methodology achieves state-of-the-art performance in both classification and segmentation CTTA tasks. Our code is now available at https://github.com/RoyZry98/MoASE-Pytorch.

MedAdapter: Efficient Test-Time Adaptation of Large Language Models towards Medical Reasoning

Despite their improved capabilities in generation and reasoning, adapting large language models (LLMs) to the biomedical domain remains challenging due to their immense size and corporate privacy. In this work, we propose MedAdapter, a unified post-hoc adapter for test-time adaptation of LLMs towards biomedical applications. Instead of fine-tuning the entire LLM, MedAdapter effectively adapts the original model by fine-tuning only a small BERT-sized adapter to rank candidate solutions generated by LLMs. Experiments demonstrate that MedAdapter effectively adapts both white-box and black-box LLMs in biomedical reasoning, achieving average performance improvements of 25.48% and 11.31%, respectively, without requiring extensive computational resources or sharing data with third parties. MedAdapter also yields superior performance when combined with train-time adaptation, highlighting a flexible and complementary solution to existing adaptation methods. Faced with the challenges of balancing model performance, computational resources, and data privacy, MedAdapter provides an efficient, privacy-preserving, cost-effective, and transparent solution for adapting LLMs to the biomedical domain.

BMRetriever: Tuning Large Language Models as Better Biomedical Text Retrievers

Developing effective biomedical retrieval models is important for excelling at knowledge-intensive biomedical tasks but still challenging due to the deficiency of sufficient publicly annotated biomedical data and computational resources. We present BMRetriever, a series of dense retrievers for enhancing biomedical retrieval via unsupervised pre-training on large biomedical corpora, followed by instruction fine-tuning on a combination of labeled datasets and synthetic pairs. Experiments on 5 biomedical tasks across 11 datasets verify BMRetriever's efficacy on various biomedical applications. BMRetriever also exhibits strong parameter efficiency, with the 410M variant outperforming baselines up to 11.7 times larger, and the 2B variant matching the performance of models with over 5B parameters. The training data and model checkpoints are released at \url{https://huggingface.co/BMRetriever} to ensure transparency, reproducibility, and application to new domains.

SQ-LLaVA: Self-Questioning for Large Vision-Language Assistant

Recent advancements in the vision-language model have shown notable generalization in vision-language tasks after visual instruction tuning. However, bridging the gap between the pre-trained vision encoder and the large language models becomes the whole network's bottleneck. To improve cross-modality alignment, existing works usually consider more visual instruction data covering a broader range of vision tasks to fine-tune the model for question-answering, which are costly to obtain. However, the image contains rich contextual information that has been largely under-explored. This paper first attempts to harness this overlooked context within visual instruction data, training the model to self-supervised `learning' how to ask high-quality questions. In this way, we introduce a novel framework named SQ-LLaVA: Self-Questioning for Large Vision-Language Assistant. SQ-LLaVA exhibits proficiency in generating flexible and meaningful image-related questions while analyzing the visual clue and prior language knowledge, signifying an advanced level of generalized visual understanding. Moreover, fine-tuning SQ-LLaVA on higher-quality instruction data shows a consistent performance improvement compared with traditional visual-instruction tuning methods. This improvement highlights the efficacy of self-questioning techniques in achieving a deeper and more nuanced comprehension of visual content across various contexts.

NaturalVLM: Leveraging Fine-grained Natural Language for Affordance-Guided Visual Manipulation

Enabling home-assistant robots to perceive and manipulate a diverse range of 3D objects based on human language instructions is a pivotal challenge. Prior research has predominantly focused on simplistic and task-oriented instructions, i.e., "Slide the top drawer open". However, many real-world tasks demand intricate multi-step reasoning, and without human instructions, these will become extremely difficult for robot manipulation. To address these challenges, we introduce a comprehensive benchmark, NrVLM, comprising 15 distinct manipulation tasks, containing over 4500 episodes meticulously annotated with fine-grained language instructions. We split the long-term task process into several steps, with each step having a natural language instruction. Moreover, we propose a novel learning framework that completes the manipulation task step-by-step according to the fine-grained instructions. Specifically, we first identify the instruction to execute, taking into account visual observations and the end-effector's current state. Subsequently, our approach facilitates explicit learning through action-prompts and perception-prompts to promote manipulation-aware cross-modality alignment. Leveraging both visual observations and linguistic guidance, our model outputs a sequence of actionable predictions for manipulation, including contact points and end-effector poses. We evaluate our method and baselines using the proposed benchmark NrVLM. The experimental results demonstrate the effectiveness of our approach. For additional details, please refer to https://sites.google.com/view/naturalvlm.

FOFO: A Benchmark to Evaluate LLMs' Format-Following Capability

This paper presents FoFo, a pioneering benchmark for evaluating large language models' (LLMs) ability to follow complex, domain-specific formats, a crucial yet underexamined capability for their application as AI agents. Despite LLMs' advancements, existing benchmarks fail to assess their format-following proficiency adequately. FoFo fills this gap with a diverse range of real-world formats and instructions, developed through an AI-Human collaborative method. Our evaluation across both open-source (e.g., Llama 2, WizardLM) and closed-source (e.g., GPT-4, PALM2, Gemini) LLMs highlights three key findings: open-source models significantly lag behind closed-source ones in format adherence; LLMs' format-following performance is independent of their content generation quality; and LLMs' format proficiency varies across different domains. These insights suggest the need for specialized tuning for format-following skills and highlight FoFo's role in guiding the selection of domain-specific AI agents. FoFo is released here at https://github.com/SalesforceAIResearch/FoFo.