APCyc: Property-Informed Design of Cyclic Peptides via Automated Cyclization

Cyclic peptides represent a promising class of therapeutic compounds in modern drug discovery, often offering improved stability and binding affinity. However, the de novo design of cyclic peptides remains challenging because methods must identify pocket-adaptive cyclization patterns and linkage sites while simultaneously controlling drug-relevant properties. This challenge is particularly pronounced for recent generative models trained predominantly on linear peptide data, which may fail to capture cyclization-specific constraints. To address the limitation, we introduce APCyc, a target-aware de novo cyclic peptide generation framework that explicitly models cyclization and jointly optimizes multiple essential physicochemical properties. By using an expanded residue vocabulary and explicitly encoding cyclization-site and linkage-type information, APCyc learns cyclization-aware representations and leverages Bayesian posterior guidance to steer sampling toward cyclic peptides satisfying multiple property objectives. Experimental results demonstrate that our model learns target-dependent cyclization preferences, and enables effective and controllable multi-property optimization for cyclic peptide design. The source code of this paper is available at https://github.com/HKUSTGZ-ML4Health-Lab/APCyc.

Adapting Vision-Language Models from Iconic to Inclusive for Multi-Label Recognition Without Labels

Understanding multi-label images remains a challenging task in computer vision. With the rapid progress of vision-language multimodal learning, vision-language models (VLMs) enable zero-shot recognition without labeled data. However, due to their intrinsic design, these models often prioritize the most iconic object and omit other contextual positives. This intrinsic bias conflicts with the nature of multi-label learning, thereby limiting their applicability. In this work, we propose an unsupervised framework that adapts VLMs from iconic recognition toward inclusive understanding, enabling label-free multi-label image recognition. Our approach consists of two key stages, ``cutting'' and ``sewing'': In the cutting stage, we present the multi-sampling response estimator to prevent the model from concentrating only on one single object. In the second sewing stage, the multi-object blend adaptation is introduced to adjust the labels to better conform to the multi-label distribution while preserving the intrinsic characteristics of the original model within only one epoch. Extensive experiments show that our framework significantly outperforms existing unsupervised approaches on four public datasets, even surpassing several representative weakly supervised baselines. These results demonstrate the potential of adapting pre-trained VLMs for more comprehensive visual understanding without manual annotations. Our code is publicly available at https://github.com/iCVTEAM/TailorCLIP.

TVIR: Building Deep Research Agents Towards Text--Visual Interleaved Report Generation

Deep Research Agents have shown strong capability in multi-step information retrieval, reasoning, and long-form report generation, but existing benchmarks and systems remain predominantly text-centric, with limited evaluation of whether visual elements are factually reliable and well aligned with the surrounding analysis. To address this gap, we introduce TVIR (Text--Visual Interleaved Report Generation), which includes TVIR-Bench, a benchmark of 100 expert-curated multimodal deep research tasks that require visual elements to serve specific analytical sub-goals, and TVIR-Agent, a hierarchical multi-agent framework that serves as a strong baseline for constructing outlines, retrieving images, generating charts with traceable sources, and composing reports through context-aware sequential writing. We further develop a dual-path evaluation framework that combines Textual Assessment and Visual Assessment. Experiments across nine deep research systems show that TVIR-Agent achieves strong overall performance, underscoring the importance of explicit multimodal design and evaluation for evidence-driven report generation.

The Right Inference Strategy Is All You Need: Nearly Training-Free Domain-Wise Inference for EgoCross Challenge

EgoCross evaluates multimodal large language models on egocentric video question answering under substantial domain shift, where test videos come from surgery, industrial assembly, extreme sports, and animal-mounted cameras rather than ordinary daily-life scenes. In the source-limited track, the base model is fixed to Qwen3-VL-4B, while the official task-specific support set contains only 20 training samples. This setting makes the challenge less about model scaling and more about exposing the right visual, temporal, and answer-selection cues to a constrained model. Our key observation is that the frozen baseline model is not simply incapable of these rare scenarios; rather, it often fails to transfer its existing visual-language knowledge to the new task format without an appropriate interface. We therefore use a domain-wise inference strategy that treats the four target domains separately and designs different input, prompting, and answer-mapping procedures according to each domain's task characteristics. These strategies make the rare egocentric scenes more interpretable to the VLM by emphasizing the cues that matter for each domain. The resulting system is nearly training-free: surgery, and animal questions are answered with the base Qwen3-VL-4B model, while XSports and industry use only the official SFT checkpoint trained for two epochs on the provided 20 training samples. On the final evaluation, this simple strategy reaches 66.98\% overall accuracy, suggesting that careful domain-aware inference can compensate for limited base-model strength and recover much of the ability already present in the baseline model.

RoboStressBench: Benchmarking VLM Robustness to Physical Visual Stress in Embodied Scenes

Vision-Language Models (VLMs) have shown strong visual understanding and are increasingly deployed in embodied AI systems, where reliable perception under real conditions is essential. However, existing benchmarks assess VLMs using clean images or isolated perturbations rather than stresses caused by physical scene formation. This design has two limitations: it covers only a narrow subset of everyday visual stresses, and some perturbations rarely appear in realistic embodied scenes. This gap raises a fundamental question: how can we define visual stress in a principled way that captures the diverse factors encountered in physical environments? To address this question, we formulate visual perception from an inverse graphics perspective and introduce RoboStressBench, a benchmark for evaluating VLM robustness to physical visual stress in embodied scenes. Inspired by the physical rendering equation, RoboStressBench decomposes visual stress into four physically grounded dimensions: Material (M), Viewpoint (V), Lighting (L), and Geometry (G). This design enables RoboStressBench to cover a broad range of visual stresses in real-world environments, while allowing controlled analysis of their effects on VLM capabilities such as visual recognition, reasoning, and planning. Through comprehensive evaluations of state-of-the-art VLMs, we identify stress-specific failure modes and reveal that different physical factors degrade different embodied capabilities, which are often obscured by aggregate accuracy. We further introduce a stress-aware agentic solver that detects visual stressors and invokes visual-editing skills before reasoning, improving robustness in high-stress scenarios. Overall, RoboStressBench provides a principled evaluation framework for diagnosing and improving VLM perception under real-world physical stress, supporting the development of more reliable embodied AI systems.

Envisioning Beyond the Few: Disentangled Semantics and Primitives for Few-Shot Atypical Layout-to-Image Generation

The layout-to-image (L2I) task enables fine-grained control over image generation via object categories and spatial layouts. However, existing L2I methods yield fragmented and distorted generations under few-shot atypical settings. We term this failure as representation fragmentation, arising from a granularity mismatch that entangles semantic identity with visual details. To address this issue, we propose a representation-driven framework that disentangles semantics from primitives for robust few-shot adaptation. Specifically, Semantic Anchoring aggregates categorical semantics into anchors for stable identity, while Primitive Imbuing models recomposable primitives for robust local detail modeling. Conceptual Steering further regulates optimization with a saliency-aware objective to preserve foreground semantic consistency. Extensive experiments demonstrate consistent improvements in the 5-shot regime over state-of-the-art L2I methods in both visual fidelity and alignment across diverse atypical domains. The source code is publicly available at https://github.com/iCVTEAM/DSP.

Nautilus: An Auto-Scheduling Tensor Compiler for Efficient Tiled GPU Kernels

We present Nautilus, a novel tensor compiler that moves toward fully automated math-to-kernel optimization. Nautilus compiles a high-level algebraic specification of tensor operators into efficient tiled GPU kernels. Nautilus's successive lowering design allows high-level optimizations, expression rewrites, and tile optimizations to be jointly applied in a single end-to-end system. Nautilus presents a novel auto-scheduler that discovers sequences of high-level optimizations, while preserving the regular program structure needed by tile optimizers. Nautilus's auto-scheduler captures complex interactions and trade-offs in the high-level optimizations, including aggressive global transformations like advanced reduction fusion. Nautilus is the first end-to-end tensor compiler capable of starting from a math-like description of attention and automatically discovering FlashAttention-3-like kernels, offloading the entire burden of optimization from the programmer to the compiler. Across five transformer-based models and 150 evaluation configurations on NVIDIA GH200 and RTX 5090 GPUs, Nautilus achieves up to 23% higher throughput than state-of-the-art compilers on GH200 and up to 42% on RTX 5090, while matching or exceeding manually written cuDNN kernels on many long-sequence configurations.

RiO-DETR: DETR for Real-time Oriented Object Detection

We present RiO-DETR: DETR for Real-time Oriented Object Detection, the first real-time oriented detection transformer to the best of our knowledge. Adapting DETR to oriented bounding boxes (OBBs) poses three challenges: semantics-dependent orientation, angle periodicity that breaks standard Euclidean refinement, and an enlarged search space that slows convergence. RiO-DETR resolves these issues with task-native designs while preserving real-time efficiency. First, we propose Content-Driven Angle Estimation by decoupling angle from positional queries, together with Rotation-Rectified Orthogonal Attention to capture complementary cues for reliable orientation. Second, Decoupled Periodic Refinement combines bounded coarse-to-fine updates with a Shortest-Path Periodic Loss for stable learning across angular seams. Third, Oriented Dense O2O injects angular diversity into dense supervision to speed up angle convergence at no extra cost. Extensive experiments on DOTA-1.0, DIOR-R, and FAIR-1M-2.0 demonstrate RiO-DETR establishes a new speed--accuracy trade-off for real-time oriented detection. Code will be made publicly available.

WorldTree: Towards 4D Dynamic Worlds from Monocular Video using Tree-Chains

Dynamic reconstruction has achieved remarkable progress, but there remain challenges in monocular input for more practical applications. The prevailing works attempt to construct efficient motion representations, but lack a unified spatiotemporal decomposition framework, suffering from either holistic temporal optimization or coupled hierarchical spatial composition. To this end, we propose WorldTree, a unified framework comprising Temporal Partition Tree (TPT) that enables coarse-to-fine optimization based on the inheritance-based partition tree structure for hierarchical temporal decomposition, and Spatial Ancestral Chains (SAC) that recursively query ancestral hierarchical structure to provide complementary spatial dynamics while specializing motion representations across ancestral nodes. Experimental results on different datasets indicate that our proposed method achieves 8.26% improvement of LPIPS on NVIDIA-LS and 9.09% improvement of mLPIPS on DyCheck compared to the second-best method. Code: https://github.com/iCVTEAM/WorldTree.

LongCat-Flash-Thinking-2601 Technical Report

We introduce LongCat-Flash-Thinking-2601, a 560-billion-parameter open-source Mixture-of-Experts (MoE) reasoning model with superior agentic reasoning capability. LongCat-Flash-Thinking-2601 achieves state-of-the-art performance among open-source models on a wide range of agentic benchmarks, including agentic search, agentic tool use, and tool-integrated reasoning. Beyond benchmark performance, the model demonstrates strong generalization to complex tool interactions and robust behavior under noisy real-world environments. Its advanced capability stems from a unified training framework that combines domain-parallel expert training with subsequent fusion, together with an end-to-end co-design of data construction, environments, algorithms, and infrastructure spanning from pre-training to post-training. In particular, the model's strong generalization capability in complex tool-use are driven by our in-depth exploration of environment scaling and principled task construction. To optimize long-tailed, skewed generation and multi-turn agentic interactions, and to enable stable training across over 10,000 environments spanning more than 20 domains, we systematically extend our asynchronous reinforcement learning framework, DORA, for stable and efficient large-scale multi-environment training. Furthermore, recognizing that real-world tasks are inherently noisy, we conduct a systematic analysis and decomposition of real-world noise patterns, and design targeted training procedures to explicitly incorporate such imperfections into the training process, resulting in improved robustness for real-world applications. To further enhance performance on complex reasoning tasks, we introduce a Heavy Thinking mode that enables effective test-time scaling by jointly expanding reasoning depth and width through intensive parallel thinking.