Complementary Information Mutual Learning for Multimodality Medical Image Segmentation

Radiologists must utilize multiple modal images for tumor segmentation and diagnosis due to the limitations of medical imaging and the diversity of tumor signals. This leads to the development of multimodal learning in segmentation. However, the redundancy among modalities creates challenges for existing subtraction-based joint learning methods, such as misjudging the importance of modalities, ignoring specific modal information, and increasing cognitive load. These thorny issues ultimately decrease segmentation accuracy and increase the risk of overfitting. This paper presents the complementary information mutual learning (CIML) framework, which can mathematically model and address the negative impact of inter-modal redundant information. CIML adopts the idea of addition and removes inter-modal redundant information through inductive bias-driven task decomposition and message passing-based redundancy filtering. CIML first decomposes the multimodal segmentation task into multiple subtasks based on expert prior knowledge, minimizing the information dependence between modalities. Furthermore, CIML introduces a scheme in which each modality can extract information from other modalities additively through message passing. To achieve non-redundancy of extracted information, the redundant filtering is transformed into complementary information learning inspired by the variational information bottleneck. The complementary information learning procedure can be efficiently solved by variational inference and cross-modal spatial attention. Numerical results from the verification task and standard benchmarks indicate that CIML efficiently removes redundant information between modalities, outperforming SOTA methods regarding validation accuracy and segmentation effect.

Can language agents be alternatives to PPO? A Preliminary Empirical Study On OpenAI Gym

The formidable capacity for zero- or few-shot decision-making in language agents encourages us to pose a compelling question: Can language agents be alternatives to PPO agents in traditional sequential decision-making tasks? To investigate this, we first take environments collected in OpenAI Gym as our testbeds and ground them to textual environments that construct the TextGym simulator. This allows for straightforward and efficient comparisons between PPO agents and language agents, given the widespread adoption of OpenAI Gym. To ensure a fair and effective benchmarking, we introduce $5$ levels of scenario for accurate domain-knowledge controlling and a unified RL-inspired framework for language agents. Additionally, we propose an innovative explore-exploit-guided language (EXE) agent to solve tasks within TextGym. Through numerical experiments and ablation studies, we extract valuable insights into the decision-making capabilities of language agents and make a preliminary evaluation of their potential to be alternatives to PPO in classical sequential decision-making problems. This paper sheds light on the performance of language agents and paves the way for future research in this exciting domain. Our code is publicly available at~\url{https://github.com/mail-ecnu/Text-Gym-Agents}.

Temporally-Extended Prompts Optimization for SAM in Interactive Medical Image Segmentation

The Segmentation Anything Model (SAM) has recently emerged as a foundation model for addressing image segmentation. Owing to the intrinsic complexity of medical images and the high annotation cost, the medical image segmentation (MIS) community has been encouraged to investigate SAM's zero-shot capabilities to facilitate automatic annotation. Inspired by the extraordinary accomplishments of interactive medical image segmentation (IMIS) paradigm, this paper focuses on assessing the potential of SAM's zero-shot capabilities within the IMIS paradigm to amplify its benefits in the MIS domain. Regrettably, we observe that SAM's vulnerability to prompt forms (e.g., points, bounding boxes) becomes notably pronounced in IMIS. This leads us to develop a framework that adaptively offers suitable prompt forms for human experts. We refer to the framework above as temporally-extended prompts optimization (TEPO) and model it as a Markov decision process, solvable through reinforcement learning. Numerical experiments on the standardized benchmark BraTS2020 demonstrate that the learned TEPO agent can further enhance SAM's zero-shot capability in the MIS context.

Negotiated Reasoning: On Provably Addressing Relative Over-Generalization

Over-generalization is a thorny issue in cognitive science, where people may become overly cautious due to past experiences. Agents in multi-agent reinforcement learning (MARL) also have been found to suffer relative over-generalization (RO) as people do and stuck to sub-optimal cooperation. Recent methods have shown that assigning reasoning ability to agents can mitigate RO algorithmically and empirically, but there has been a lack of theoretical understanding of RO, let alone designing provably RO-free methods. This paper first proves that RO can be avoided when the MARL method satisfies a consistent reasoning requirement under certain conditions. Then we introduce a novel reasoning framework, called negotiated reasoning, that first builds the connection between reasoning and RO with theoretical justifications. After that, we propose an instantiated algorithm, Stein variational negotiated reasoning (SVNR), which uses Stein variational gradient descent to derive a negotiation policy that provably avoids RO in MARL under maximum entropy policy iteration. The method is further parameterized with neural networks for amortized learning, making computation efficient. Numerical experiments on many RO-challenged environments demonstrate the superiority and efficiency of SVNR compared to state-of-the-art methods in addressing RO.

Semantically Aligned Task Decomposition in Multi-Agent Reinforcement Learning

The difficulty of appropriately assigning credit is particularly heightened in cooperative MARL with sparse reward, due to the concurrent time and structural scales involved. Automatic subgoal generation (ASG) has recently emerged as a viable MARL approach inspired by utilizing subgoals in intrinsically motivated reinforcement learning. However, end-to-end learning of complex task planning from sparse rewards without prior knowledge, undoubtedly requires massive training samples. Moreover, the diversity-promoting nature of existing ASG methods can lead to the "over-representation" of subgoals, generating numerous spurious subgoals of limited relevance to the actual task reward and thus decreasing the sample efficiency of the algorithm. To address this problem and inspired by the disentangled representation learning, we propose a novel "disentangled" decision-making method, Semantically Aligned task decomposition in MARL (SAMA), that prompts pretrained language models with chain-of-thought that can suggest potential goals, provide suitable goal decomposition and subgoal allocation as well as self-reflection-based replanning. Additionally, SAMA incorporates language-grounded RL to train each agent's subgoal-conditioned policy. SAMA demonstrates considerable advantages in sample efficiency compared to state-of-the-art ASG methods, as evidenced by its performance on two challenging sparse-reward tasks, Overcooked and MiniRTS.

CoLa-Diff: Conditional Latent Diffusion Model for Multi-Modal MRI Synthesis

MRI synthesis promises to mitigate the challenge of missing MRI modality in clinical practice. Diffusion model has emerged as an effective technique for image synthesis by modelling complex and variable data distributions. However, most diffusion-based MRI synthesis models are using a single modality. As they operate in the original image domain, they are memory-intensive and less feasible for multi-modal synthesis. Moreover, they often fail to preserve the anatomical structure in MRI. Further, balancing the multiple conditions from multi-modal MRI inputs is crucial for multi-modal synthesis. Here, we propose the first diffusion-based multi-modality MRI synthesis model, namely Conditioned Latent Diffusion Model (CoLa-Diff). To reduce memory consumption, we design CoLa-Diff to operate in the latent space. We propose a novel network architecture, e.g., similar cooperative filtering, to solve the possible compression and noise in latent space. To better maintain the anatomical structure, brain region masks are introduced as the priors of density distributions to guide diffusion process. We further present auto-weight adaptation to employ multi-modal information effectively. Our experiments demonstrate that CoLa-Diff outperforms other state-of-the-art MRI synthesis methods, promising to serve as an effective tool for multi-modal MRI synthesis.

Boundary-aware Supervoxel-level Iteratively Refined Interactive 3D Image Segmentation with Multi-agent Reinforcement Learning

Interactive segmentation has recently been explored to effectively and efficiently harvest high-quality segmentation masks by iteratively incorporating user hints. While iterative in nature, most existing interactive segmentation methods tend to ignore the dynamics of successive interactions and take each interaction independently. We here propose to model iterative interactive image segmentation with a Markov decision process (MDP) and solve it with reinforcement learning (RL) where each voxel is treated as an agent. Considering the large exploration space for voxel-wise prediction and the dependence among neighboring voxels for the segmentation tasks, multi-agent reinforcement learning is adopted, where the voxel-level policy is shared among agents. Considering that boundary voxels are more important for segmentation, we further introduce a boundary-aware reward, which consists of a global reward in the form of relative cross-entropy gain, to update the policy in a constrained direction, and a boundary reward in the form of relative weight, to emphasize the correctness of boundary predictions. To combine the advantages of different types of interactions, i.e., simple and efficient for point-clicking, and stable and robust for scribbles, we propose a supervoxel-clicking based interaction design. Experimental results on four benchmark datasets have shown that the proposed method significantly outperforms the state-of-the-arts, with the advantage of fewer interactions, higher accuracy, and enhanced robustness.

Learning Roles with Emergent Social Value Orientations

Social dilemmas can be considered situations where individual rationality leads to collective irrationality. The multi-agent reinforcement learning community has leveraged ideas from social science, such as social value orientations (SVO), to solve social dilemmas in complex cooperative tasks. In this paper, by first introducing the typical "division of labor or roles" mechanism in human society, we provide a promising solution for intertemporal social dilemmas (ISD) with SVOs. A novel learning framework, called Learning Roles with Emergent SVOs (RESVO), is proposed to transform the learning of roles into the social value orientation emergence, which is symmetrically solved by endowing agents with altruism to share rewards with other agents. An SVO-based role embedding space is then constructed by individual conditioning policies on roles with a novel rank regularizer and mutual information maximizer. Experiments show that RESVO achieves a stable division of labor and cooperation in ISDs with different complexity.

Decentralized Entropic Optimal Transport for Privacy-preserving Distributed Distribution Comparison

Privacy-preserving distributed distribution comparison measures the distance between the distributions whose data are scattered across different agents in a distributed system and cannot be shared among the agents. In this study, we propose a novel decentralized entropic optimal transport (EOT) method, which provides a privacy-preserving and communication-efficient solution to this problem with theoretical guarantees. In particular, we design a mini-batch randomized block-coordinate descent (MRBCD) scheme to optimize the decentralized EOT distance in its dual form. The dual variables are scattered across different agents and updated locally and iteratively with limited communications among partial agents. The kernel matrix involved in the gradients of the dual variables is estimated by a distributed kernel approximation method, and each agent only needs to approximate and store a sub-kernel matrix by one-shot communication and without sharing raw data. We analyze our method's communication complexity and provide a theoretical bound for the approximation error caused by the convergence error, the approximated kernel, and the mismatch between the storage and communication protocols. Experiments on synthetic data and real-world distributed domain adaptation tasks demonstrate the effectiveness of our method.

ReAssigner: A Plug-and-Play Virtual Machine Scheduling Intensifier for Heterogeneous Requests

With the rapid development of cloud computing, virtual machine scheduling has become one of the most important but challenging issues for the cloud computing community, especially for practical heterogeneous request sequences. By analyzing the impact of request heterogeneity on some popular heuristic schedulers, it can be found that existing scheduling algorithms can not handle the request heterogeneity properly and efficiently. In this paper, a plug-and-play virtual machine scheduling intensifier, called Resource Assigner (ReAssigner), is proposed to enhance the scheduling efficiency of any given scheduler for heterogeneous requests. The key idea of ReAssigner is to pre-assign roles to physical resources and let resources of the same role form a virtual cluster to handle homogeneous requests. ReAssigner can cooperate with arbitrary schedulers by restricting their scheduling space to virtual clusters. With evaluations on the real dataset from Huawei Cloud, the proposed ReAssigner achieves significant scheduling performance improvement compared with some state-of-the-art scheduling methods.