Causal Inference via Nonlinear Variable Decorrelation for Healthcare Applications

Causal inference and model interpretability research are gaining increasing attention, especially in the domains of healthcare and bioinformatics. Despite recent successes in this field, decorrelating features under nonlinear environments with human interpretable representations has not been adequately investigated. To address this issue, we introduce a novel method with a variable decorrelation regularizer to handle both linear and nonlinear confounding. Moreover, we employ association rules as new representations using association rule mining based on the original features to further proximate human decision patterns to increase model interpretability. Extensive experiments are conducted on four healthcare datasets (one synthetically generated and three real-world collections on different diseases). Quantitative results in comparison to baseline approaches on parameter estimation and causality computation indicate the model's superior performance. Furthermore, expert evaluation given by healthcare professionals validates the effectiveness and interpretability of the proposed model.

Remote Medication Status Prediction for Individuals with Parkinson's Disease using Time-series Data from Smartphones

Medication for neurological diseases such as the Parkinson's disease usually happens remotely at home, away from hospitals. Such out-of-lab environments pose challenges in collecting timely and accurate health status data using the limited professional care devices for health condition analysis, medication adherence measurement and future dose or treatment planning. Individual differences in behavioral signals collected from wearable sensors also lead to difficulties in adopting current general machine learning analysis pipelines. To address these challenges, we present a method for predicting medication status of Parkinson's disease patients using the public mPower dataset, which contains 62,182 remote multi-modal test records collected on smartphones from 487 patients. The proposed method shows promising results in predicting three medication status objectively: Before Medication (AUC=0.95), After Medication (AUC=0.958), and Another Time (AUC=0.976) by examining patient-wise historical records with the attention weights learned through a Transformer model. We believe our method provides an innovative way for personalized remote health sensing in a timely and objective fashion which could benefit a broad range of similar applications.

Product Information Browsing Support System Using Analytic Hierarchy Process

Large-scale e-commerce sites can collect and analyze a large number of user preferences and behaviors, and thus can recommend highly trusted products to users. However, it is very difficult for individuals or non-corporate groups to obtain large-scale user data. Therefore, we consider whether knowledge of the decision-making domain can be used to obtain user preferences and combine it with content-based filtering to design an information retrieval system. This study describes the process of building a product information browsing support system with high satisfaction based on product similarity and multiple other perspectives about products on the Internet. We present the architecture of the proposed system and explain the working principle of its constituent modules. Finally, we demonstrate the effectiveness of the proposed system through an evaluation experiment and a questionnaire.

Learning Bias-Invariant Representation by Cross-Sample Mutual Information Minimization

Deep learning algorithms mine knowledge from the training data and thus would likely inherit the dataset's bias information. As a result, the obtained model would generalize poorly and even mislead the decision process in real-life applications. We propose to remove the bias information misused by the target task with a cross-sample adversarial debiasing (CSAD) method. CSAD explicitly extracts target and bias features disentangled from the latent representation generated by a feature extractor and then learns to discover and remove the correlation between the target and bias features. The correlation measurement plays a critical role in adversarial debiasing and is conducted by a cross-sample neural mutual information estimator. Moreover, we propose joint content and local structural representation learning to boost mutual information estimation for better performance. We conduct thorough experiments on publicly available datasets to validate the advantages of the proposed method over state-of-the-art approaches.

ConTNet: Why not use convolution and transformer at the same time?

Although convolutional networks (ConvNets) have enjoyed great success in computer vision (CV), it suffers from capturing global information crucial to dense prediction tasks such as object detection and segmentation. In this work, we innovatively propose ConTNet (ConvolutionTransformer Network), combining transformer with ConvNet architectures to provide large receptive fields. Unlike the recently-proposed transformer-based models (e.g., ViT, DeiT) that are sensitive to hyper-parameters and extremely dependent on a pile of data augmentations when trained from scratch on a midsize dataset (e.g., ImageNet1k), ConTNet can be optimized like normal ConvNets (e.g., ResNet) and preserve an outstanding robustness. It is also worth pointing that, given identical strong data augmentations, the performance improvement of ConTNet is more remarkable than that of ResNet. We present its superiority and effectiveness on image classification and downstream tasks. For example, our ConTNet achieves 81.8% top-1 accuracy on ImageNet which is the same as DeiT-B with less than 40% computational complexity. ConTNet-M also outperforms ResNet50 as the backbone of both Faster-RCNN (by 2.6%) and Mask-RCNN (by 3.2%) on COCO2017 dataset. We hope that ConTNet could serve as a useful backbone for CV tasks and bring new ideas for model design

Scalable Semi-supervised Landmark Localization for X-ray Images using Few-shot Deep Adaptive Graph

Landmark localization plays an important role in medical image analysis. Learning based methods, including CNN and GCN, have demonstrated the state-of-the-art performance. However, most of these methods are fully-supervised and heavily rely on manual labeling of a large training dataset. In this paper, based on a fully-supervised graph-based method, DAG, we proposed a semi-supervised extension of it, termed few-shot DAG, \ie five-shot DAG. It first trains a DAG model on the labeled data and then fine-tunes the pre-trained model on the unlabeled data with a teacher-student SSL mechanism. In addition to the semi-supervised loss, we propose another loss using JS divergence to regulate the consistency of the intermediate feature maps. We extensively evaluated our method on pelvis, hand and chest landmark detection tasks. Our experiment results demonstrate consistent and significant improvements over previous methods.

Contour Transformer Network for One-shot Segmentation of Anatomical Structures

Accurate segmentation of anatomical structures is vital for medical image analysis. The state-of-the-art accuracy is typically achieved by supervised learning methods, where gathering the requisite expert-labeled image annotations in a scalable manner remains a main obstacle. Therefore, annotation-efficient methods that permit to produce accurate anatomical structure segmentation are highly desirable. In this work, we present Contour Transformer Network (CTN), a one-shot anatomy segmentation method with a naturally built-in human-in-the-loop mechanism. We formulate anatomy segmentation as a contour evolution process and model the evolution behavior by graph convolutional networks (GCNs). Training the CTN model requires only one labeled image exemplar and leverages additional unlabeled data through newly introduced loss functions that measure the global shape and appearance consistency of contours. On segmentation tasks of four different anatomies, we demonstrate that our one-shot learning method significantly outperforms non-learning-based methods and performs competitively to the state-of-the-art fully supervised deep learning methods. With minimal human-in-the-loop editing feedback, the segmentation performance can be further improved to surpass the fully supervised methods.