Eye-gaze Guided Multi-modal Alignment Framework for Radiology

In multi-modal frameworks, the alignment of cross-modal features presents a significant challenge. The predominant approach in multi-modal pre-training emphasizes either global or local alignment between modalities, utilizing extensive datasets. This bottom-up driven method often suffers from a lack of interpretability, a critical concern in radiology. Previous studies have integrated high-level labels in medical images or text, but these still rely on manual annotation, a costly and labor-intensive process. Our work introduces a novel approach by using eye-gaze data, collected synchronously by radiologists during diagnostic evaluations. This data, indicating radiologists' focus areas, naturally links chest X-rays to diagnostic texts. We propose the Eye-gaze Guided Multi-modal Alignment (EGMA) framework to harness eye-gaze data for better alignment of image and text features, aiming to reduce reliance on manual annotations and thus cut training costs. Our model demonstrates robust performance, outperforming other state-of-the-art methods in zero-shot classification and retrieval tasks. The incorporation of easily-obtained eye-gaze data during routine radiological diagnoses signifies a step towards minimizing manual annotation dependency. Additionally, we explore the impact of varying amounts of eye-gaze data on model performance, highlighting the feasibility and utility of integrating this auxiliary data into multi-modal pre-training.

Prompt-enhanced Federated Content Representation Learning for Cross-domain Recommendation

Cross-domain Recommendation (CDR) as one of the effective techniques in alleviating the data sparsity issues has been widely studied in recent years. However, previous works may cause domain privacy leakage since they necessitate the aggregation of diverse domain data into a centralized server during the training process. Though several studies have conducted privacy preserving CDR via Federated Learning (FL), they still have the following limitations: 1) They need to upload users' personal information to the central server, posing the risk of leaking user privacy. 2) Existing federated methods mainly rely on atomic item IDs to represent items, which prevents them from modeling items in a unified feature space, increasing the challenge of knowledge transfer among domains. 3) They are all based on the premise of knowing overlapped users between domains, which proves impractical in real-world applications. To address the above limitations, we focus on Privacy-preserving Cross-domain Recommendation (PCDR) and propose PFCR as our solution. For Limitation 1, we develop a FL schema by exclusively utilizing users' interactions with local clients and devising an encryption method for gradient encryption. For Limitation 2, we model items in a universal feature space by their description texts. For Limitation 3, we initially learn federated content representations, harnessing the generality of natural language to establish bridges between domains. Subsequently, we craft two prompt fine-tuning strategies to tailor the pre-trained model to the target domain. Extensive experiments on two real-world datasets demonstrate the superiority of our PFCR method compared to the SOTA approaches.

MCRPL: A Pretrain, Prompt & Fine-tune Paradigm for Non-overlapping Many-to-one Cross-domain Recommendation

Cross-domain Recommendation (CR) is the task that tends to improve the recommendations in the sparse target domain by leveraging the information from other rich domains. Existing methods of cross-domain recommendation mainly focus on overlapping scenarios by assuming users are totally or partially overlapped, which are taken as bridges to connect different domains. However, this assumption does not always hold since it is illegal to leak users' identity information to other domains. Conducting Non-overlapping MCR (NMCR) is challenging since 1) The absence of overlapping information prevents us from directly aligning different domains, and this situation may get worse in the MCR scenario. 2) The distribution between source and target domains makes it difficult for us to learn common information across domains. To overcome the above challenges, we focus on NMCR, and devise MCRPL as our solution. To address Challenge 1, we first learn shared domain-agnostic and domain-dependent prompts, and pre-train them in the pre-training stage. To address Challenge 2, we further update the domain-dependent prompts with other parameters kept fixed to transfer the domain knowledge to the target domain. We conduct experiments on five real-world domains, and the results show the advance of our MCRPL method compared with several recent SOTA baselines.

SutraNets: Sub-series Autoregressive Networks for Long-Sequence, Probabilistic Forecasting

We propose SutraNets, a novel method for neural probabilistic forecasting of long-sequence time series. SutraNets use an autoregressive generative model to factorize the likelihood of long sequences into products of conditional probabilities. When generating long sequences, most autoregressive approaches suffer from harmful error accumulation, as well as challenges in modeling long-distance dependencies. SutraNets treat long, univariate prediction as multivariate prediction over lower-frequency sub-series. Autoregression proceeds across time and across sub-series in order to ensure coherent multivariate (and, hence, high-frequency univariate) outputs. Since sub-series can be generated using fewer steps, SutraNets effectively reduce error accumulation and signal path distances. We find SutraNets to significantly improve forecasting accuracy over competitive alternatives on six real-world datasets, including when we vary the number of sub-series and scale up the depth and width of the underlying sequence models.

C2FAR: Coarse-to-Fine Autoregressive Networks for Precise Probabilistic Forecasting

We present coarse-to-fine autoregressive networks (C2FAR), a method for modeling the probability distribution of univariate, numeric random variables. C2FAR generates a hierarchical, coarse-to-fine discretization of a variable autoregressively; progressively finer intervals of support are generated from a sequence of binned distributions, where each distribution is conditioned on previously-generated coarser intervals. Unlike prior (flat) binned distributions, C2FAR can represent values with exponentially higher precision, for only a linear increase in complexity. We use C2FAR for probabilistic forecasting via a recurrent neural network, thus modeling time series autoregressively in both space and time. C2FAR is the first method to simultaneously handle discrete and continuous series of arbitrary scale and distribution shape. This flexibility enables a variety of time series use cases, including anomaly detection, interpolation, and compression. C2FAR achieves improvements over the state-of-the-art on several benchmark forecasting datasets.

Global Convergence of Online Identification for Mixed Linear Regression

Mixed linear regression (MLR) is a powerful model for characterizing nonlinear relationships by utilizing a mixture of linear regression sub-models. The identification of MLR is a fundamental problem, where most of the existing results focus on offline algorithms, rely on independent and identically distributed (i.i.d) data assumptions, and provide local convergence results only. This paper investigates the online identification and data clustering problems for two basic classes of MLRs, by introducing two corresponding new online identification algorithms based on the expectation-maximization (EM) principle. It is shown that both algorithms will converge globally without resorting to the traditional i.i.d data assumptions. The main challenge in our investigation lies in the fact that the gradient of the maximum likelihood function does not have a unique zero, and a key step in our analysis is to establish the stability of the corresponding differential equation in order to apply the celebrated Ljung's ODE method. It is also shown that the within-cluster error and the probability that the new data is categorized into the correct cluster are asymptotically the same as those in the case of known parameters. Finally, numerical simulations are provided to verify the effectiveness of our online algorithms.

Motif-Based Prompt Learning for Universal Cross-Domain Recommendation

Cross-Domain Recommendation (CDR) stands as a pivotal technology addressing issues of data sparsity and cold start by transferring general knowledge from the source to the target domain. However, existing CDR models suffer limitations in adaptability across various scenarios due to their inherent complexity. To tackle this challenge, recent advancements introduce universal CDR models that leverage shared embeddings to capture general knowledge across domains and transfer it through "Multi-task Learning" or "Pre-train, Fine-tune" paradigms. However, these models often overlook the broader structural topology that spans domains and fail to align training objectives, potentially leading to negative transfer. To address these issues, we propose a motif-based prompt learning framework, MOP, which introduces motif-based shared embeddings to encapsulate generalized domain knowledge, catering to both intra-domain and inter-domain CDR tasks. Specifically, we devise three typical motifs: butterfly, triangle, and random walk, and encode them through a Motif-based Encoder to obtain motif-based shared embeddings. Moreover, we train MOP under the "Pre-training \& Prompt Tuning" paradigm. By unifying pre-training and recommendation tasks as a common motif-based similarity learning task and integrating adaptable prompt parameters to guide the model in downstream recommendation tasks, MOP excels in transferring domain knowledge effectively. Experimental results on four distinct CDR tasks demonstrate the effectiveness of MOP than the state-of-the-art models.

ChatRadio-Valuer: A Chat Large Language Model for Generalizable Radiology Report Generation Based on Multi-institution and Multi-system Data

Radiology report generation, as a key step in medical image analysis, is critical to the quantitative analysis of clinically informed decision-making levels. However, complex and diverse radiology reports with cross-source heterogeneity pose a huge generalizability challenge to the current methods under massive data volume, mainly because the style and normativity of radiology reports are obviously distinctive among institutions, body regions inspected and radiologists. Recently, the advent of large language models (LLM) offers great potential for recognizing signs of health conditions. To resolve the above problem, we collaborate with the Second Xiangya Hospital in China and propose ChatRadio-Valuer based on the LLM, a tailored model for automatic radiology report generation that learns generalizable representations and provides a basis pattern for model adaptation in sophisticated analysts' cases. Specifically, ChatRadio-Valuer is trained based on the radiology reports from a single institution by means of supervised fine-tuning, and then adapted to disease diagnosis tasks for human multi-system evaluation (i.e., chest, abdomen, muscle-skeleton, head, and maxillofacial $\&$ neck) from six different institutions in clinical-level events. The clinical dataset utilized in this study encompasses a remarkable total of \textbf{332,673} observations. From the comprehensive results on engineering indicators, clinical efficacy and deployment cost metrics, it can be shown that ChatRadio-Valuer consistently outperforms state-of-the-art models, especially ChatGPT (GPT-3.5-Turbo) and GPT-4 et al., in terms of the diseases diagnosis from radiology reports. ChatRadio-Valuer provides an effective avenue to boost model generalization performance and alleviate the annotation workload of experts to enable the promotion of clinical AI applications in radiology reports.

Asymptotically Efficient Online Learning for Censored Regression Models Under Non-I.I.D Data

The asymptotically efficient online learning problem is investigated for stochastic censored regression models, which arise from various fields of learning and statistics but up to now still lacks comprehensive theoretical studies on the efficiency of the learning algorithms. For this, we propose a two-step online algorithm, where the first step focuses on achieving algorithm convergence, and the second step is dedicated to improving the estimation performance. Under a general excitation condition on the data, we show that our algorithm is strongly consistent and asymptotically normal by employing the stochastic Lyapunov function method and limit theories for martingales. Moreover, we show that the covariances of the estimates can achieve the Cramer-Rao (C-R) bound asymptotically, indicating that the performance of the proposed algorithm is the best possible that one can expect in general. Unlike most of the existing works, our results are obtained without resorting to the traditionally used but stringent conditions such as independent and identically distributed (i.i.d) assumption on the data, and thus our results do not exclude applications to stochastic dynamical systems with feedback. A numerical example is also provided to illustrate the superiority of the proposed online algorithm over the existing related ones in the literature.