Remote Medication Status Prediction for Individuals with Parkinson's Disease using Time-series Data from Smartphones

Medication for neurological diseases such as the Parkinson's disease usually happens remotely at home, away from hospitals. Such out-of-lab environments pose challenges in collecting timely and accurate health status data using the limited professional care devices for health condition analysis, medication adherence measurement and future dose or treatment planning. Individual differences in behavioral signals collected from wearable sensors also lead to difficulties in adopting current general machine learning analysis pipelines. To address these challenges, we present a method for predicting medication status of Parkinson's disease patients using the public mPower dataset, which contains 62,182 remote multi-modal test records collected on smartphones from 487 patients. The proposed method shows promising results in predicting three medication status objectively: Before Medication (AUC=0.95), After Medication (AUC=0.958), and Another Time (AUC=0.976) by examining patient-wise historical records with the attention weights learned through a Transformer model. We believe our method provides an innovative way for personalized remote health sensing in a timely and objective fashion which could benefit a broad range of similar applications.

Bi-Calibration Networks for Weakly-Supervised Video Representation Learning

The leverage of large volumes of web videos paired with the searched queries or surrounding texts (e.g., title) offers an economic and extensible alternative to supervised video representation learning. Nevertheless, modeling such weakly visual-textual connection is not trivial due to query polysemy (i.e., many possible meanings for a query) and text isomorphism (i.e., same syntactic structure of different text). In this paper, we introduce a new design of mutual calibration between query and text to boost weakly-supervised video representation learning. Specifically, we present Bi-Calibration Networks (BCN) that novelly couples two calibrations to learn the amendment from text to query and vice versa. Technically, BCN executes clustering on all the titles of the videos searched by an identical query and takes the centroid of each cluster as a text prototype. The query vocabulary is built directly on query words. The video-to-text/video-to-query projections over text prototypes/query vocabulary then start the text-to-query or query-to-text calibration to estimate the amendment to query or text. We also devise a selection scheme to balance the two corrections. Two large-scale web video datasets paired with query and title for each video are newly collected for weakly-supervised video representation learning, which are named as YOVO-3M and YOVO-10M, respectively. The video features of BCN learnt on 3M web videos obtain superior results under linear model protocol on downstream tasks. More remarkably, BCN trained on the larger set of 10M web videos with further fine-tuning leads to 1.6%, and 1.8% gains in top-1 accuracy on Kinetics-400, and Something-Something V2 datasets over the state-of-the-art TDN, and ACTION-Net methods with ImageNet pre-training. Source code and datasets are available at \url{https://github.com/FuchenUSTC/BCN}.

Stand-Alone Inter-Frame Attention in Video Models

Motion, as the uniqueness of a video, has been critical to the development of video understanding models. Modern deep learning models leverage motion by either executing spatio-temporal 3D convolutions, factorizing 3D convolutions into spatial and temporal convolutions separately, or computing self-attention along temporal dimension. The implicit assumption behind such successes is that the feature maps across consecutive frames can be nicely aggregated. Nevertheless, the assumption may not always hold especially for the regions with large deformation. In this paper, we present a new recipe of inter-frame attention block, namely Stand-alone Inter-Frame Attention (SIFA), that novelly delves into the deformation across frames to estimate local self-attention on each spatial location. Technically, SIFA remoulds the deformable design via re-scaling the offset predictions by the difference between two frames. Taking each spatial location in the current frame as the query, the locally deformable neighbors in the next frame are regarded as the keys/values. Then, SIFA measures the similarity between query and keys as stand-alone attention to weighted average the values for temporal aggregation. We further plug SIFA block into ConvNets and Vision Transformer, respectively, to devise SIFA-Net and SIFA-Transformer. Extensive experiments conducted on four video datasets demonstrate the superiority of SIFA-Net and SIFA-Transformer as stronger backbones. More remarkably, SIFA-Transformer achieves an accuracy of 83.1% on Kinetics-400 dataset. Source code is available at \url{https://github.com/FuchenUSTC/SIFA}.

Fine-tuning Pre-trained Language Models with Noise Stability Regularization

The advent of large-scale pre-trained language models has contributed greatly to the recent progress in natural language processing. Many state-of-the-art language models are first trained on a large text corpus and then fine-tuned on downstream tasks. Despite its recent success and wide adoption, fine-tuning a pre-trained language model often suffers from overfitting, which leads to poor generalizability due to the extremely high complexity of the model and the limited training samples from downstream tasks. To address this problem, we propose a novel and effective fine-tuning framework, named Layerwise Noise Stability Regularization (LNSR). Specifically, we propose to inject the standard Gaussian noise or In-manifold noise and regularize hidden representations of the fine-tuned model. We first provide theoretical analyses to support the efficacy of our method. We then demonstrate the advantages of the proposed method over other state-of-the-art algorithms including L2-SP, Mixout and SMART. While these previous works only verify the effectiveness of their methods on relatively simple text classification tasks, we also verify the effectiveness of our method on question answering tasks, where the target problem is much more difficult and more training examples are available. Furthermore, extensive experimental results indicate that the proposed algorithm can not only enhance the in-domain performance of the language models but also improve the domain generalization performance on out-of-domain data.

Automatic Relation-aware Graph Network Proliferation

Graph neural architecture search has sparked much attention as Graph Neural Networks (GNNs) have shown powerful reasoning capability in many relational tasks. However, the currently used graph search space overemphasizes learning node features and neglects mining hierarchical relational information. Moreover, due to diverse mechanisms in the message passing, the graph search space is much larger than that of CNNs. This hinders the straightforward application of classical search strategies for exploring complicated graph search space. We propose Automatic Relation-aware Graph Network Proliferation (ARGNP) for efficiently searching GNNs with a relation-guided message passing mechanism. Specifically, we first devise a novel dual relation-aware graph search space that comprises both node and relation learning operations. These operations can extract hierarchical node/relational information and provide anisotropic guidance for message passing on a graph. Second, analogous to cell proliferation, we design a network proliferation search paradigm to progressively determine the GNN architectures by iteratively performing network division and differentiation. The experiments on six datasets for four graph learning tasks demonstrate that GNNs produced by our method are superior to the current state-of-the-art hand-crafted and search-based GNNs. Codes are available at https://github.com/phython96/ARGNP.

Localized Adversarial Domain Generalization

Deep learning methods can struggle to handle domain shifts not seen in training data, which can cause them to not generalize well to unseen domains. This has led to research attention on domain generalization (DG), which aims to the model's generalization ability to out-of-distribution. Adversarial domain generalization is a popular approach to DG, but conventional approaches (1) struggle to sufficiently align features so that local neighborhoods are mixed across domains; and (2) can suffer from feature space over collapse which can threaten generalization performance. To address these limitations, we propose localized adversarial domain generalization with space compactness maintenance~(LADG) which constitutes two major contributions. First, we propose an adversarial localized classifier as the domain discriminator, along with a principled primary branch. This constructs a min-max game whereby the aim of the featurizer is to produce locally mixed domains. Second, we propose to use a coding-rate loss to alleviate feature space over collapse. We conduct comprehensive experiments on the Wilds DG benchmark to validate our approach, where LADG outperforms leading competitors on most datasets.

Deep Federated Anomaly Detection for Multivariate Time Series Data

Despite the fact that many anomaly detection approaches have been developed for multivariate time series data, limited effort has been made on federated settings in which multivariate time series data are heterogeneously distributed among different edge devices while data sharing is prohibited. In this paper, we investigate the problem of federated unsupervised anomaly detection and present a Federated Exemplar-based Deep Neural Network (Fed-ExDNN) to conduct anomaly detection for multivariate time series data on different edge devices. Specifically, we first design an Exemplar-based Deep Neural network (ExDNN) to learn local time series representations based on their compatibility with an exemplar module which consists of hidden parameters learned to capture varieties of normal patterns on each edge device. Next, a constrained clustering mechanism (FedCC) is employed on the centralized server to align and aggregate the parameters of different local exemplar modules to obtain a unified global exemplar module. Finally, the global exemplar module is deployed together with a shared feature encoder to each edge device and anomaly detection is conducted by examining the compatibility of testing data to the exemplar module. Fed-ExDNN captures local normal time series patterns with ExDNN and aggregates these patterns by FedCC, and thus can handle the heterogeneous data distributed over different edge devices simultaneously. Thoroughly empirical studies on six public datasets show that ExDNN and Fed-ExDNN can outperform state-of-the-art anomaly detection algorithms and federated learning techniques.

Explainable Fairness in Recommendation

Existing research on fairness-aware recommendation has mainly focused on the quantification of fairness and the development of fair recommendation models, neither of which studies a more substantial problem--identifying the underlying reason of model disparity in recommendation. This information is critical for recommender system designers to understand the intrinsic recommendation mechanism and provides insights on how to improve model fairness to decision makers. Fortunately, with the rapid development of Explainable AI, we can use model explainability to gain insights into model (un)fairness. In this paper, we study the problem of explainable fairness, which helps to gain insights about why a system is fair or unfair, and guides the design of fair recommender systems with a more informed and unified methodology. Particularly, we focus on a common setting with feature-aware recommendation and exposure unfairness, but the proposed explainable fairness framework is general and can be applied to other recommendation settings and fairness definitions. We propose a Counterfactual Explainable Fairness framework, called CEF, which generates explanations about model fairness that can improve the fairness without significantly hurting the performance.The CEF framework formulates an optimization problem to learn the "minimal" change of the input features that changes the recommendation results to a certain level of fairness. Based on the counterfactual recommendation result of each feature, we calculate an explainability score in terms of the fairness-utility trade-off to rank all the feature-based explanations, and select the top ones as fairness explanations.

Breast Cancer Induced Bone Osteolysis Prediction Using Temporal Variational Auto-Encoders

Objective and Impact Statement. We adopt a deep learning model for bone osteolysis prediction on computed tomography (CT) images of murine breast cancer bone metastases. Given the bone CT scans at previous time steps, the model incorporates the bone-cancer interactions learned from the sequential images and generates future CT images. Its ability of predicting the development of bone lesions in cancer-invading bones can assist in assessing the risk of impending fractures and choosing proper treatments in breast cancer bone metastasis. Introduction. Breast cancer often metastasizes to bone, causes osteolytic lesions, and results in skeletal related events (SREs) including severe pain and even fatal fractures. Although current imaging techniques can detect macroscopic bone lesions, predicting the occurrence and progression of bone lesions remains a challenge. Methods. We adopt a temporal variational auto-encoder (T-VAE) model that utilizes a combination of variational auto-encoders and long short-term memory networks to predict bone lesion emergence on our micro-CT dataset containing sequential images of murine tibiae. Given the CT scans of murine tibiae at early weeks, our model can learn the distribution of their future states from data. Results. We test our model against other deep learning-based prediction models on the bone lesion progression prediction task. Our model produces much more accurate predictions than existing models under various evaluation metrics. Conclusion. We develop a deep learning framework that can accurately predict and visualize the progression of osteolytic bone lesions. It will assist in planning and evaluating treatment strategies to prevent SREs in breast cancer patients.

CM-GAN: Image Inpainting with Cascaded Modulation GAN and Object-Aware Training

Recent image inpainting methods have made great progress but often struggle to generate plausible image structures when dealing with large holes in complex images. This is partially due to the lack of effective network structures that can capture both the long-range dependency and high-level semantics of an image. To address these problems, we propose cascaded modulation GAN (CM-GAN), a new network design consisting of an encoder with Fourier convolution blocks that extract multi-scale feature representations from the input image with holes and a StyleGAN-like decoder with a novel cascaded global-spatial modulation block at each scale level. In each decoder block, global modulation is first applied to perform coarse semantic-aware structure synthesis, then spatial modulation is applied on the output of global modulation to further adjust the feature map in a spatially adaptive fashion. In addition, we design an object-aware training scheme to prevent the network from hallucinating new objects inside holes, fulfilling the needs of object removal tasks in real-world scenarios. Extensive experiments are conducted to show that our method significantly outperforms existing methods in both quantitative and qualitative evaluation.