Robust Polyp Detection and Diagnosis through Compositional Prompt-Guided Diffusion Models

Colorectal cancer (CRC) is a significant global health concern, and early detection through screening plays a critical role in reducing mortality. While deep learning models have shown promise in improving polyp detection, classification, and segmentation, their generalization across diverse clinical environments, particularly with out-of-distribution (OOD) data, remains a challenge. Multi-center datasets like PolypGen have been developed to address these issues, but their collection is costly and time-consuming. Traditional data augmentation techniques provide limited variability, failing to capture the complexity of medical images. Diffusion models have emerged as a promising solution for generating synthetic polyp images, but the image generation process in current models mainly relies on segmentation masks as the condition, limiting their ability to capture the full clinical context. To overcome these limitations, we propose a Progressive Spectrum Diffusion Model (PSDM) that integrates diverse clinical annotations-such as segmentation masks, bounding boxes, and colonoscopy reports-by transforming them into compositional prompts. These prompts are organized into coarse and fine components, allowing the model to capture both broad spatial structures and fine details, generating clinically accurate synthetic images. By augmenting training data with PSDM-generated samples, our model significantly improves polyp detection, classification, and segmentation. For instance, on the PolypGen dataset, PSDM increases the F1 score by 2.12% and the mean average precision by 3.09%, demonstrating superior performance in OOD scenarios and enhanced generalization.

Exploring Task-Level Optimal Prompts for Visual In-Context Learning

With the development of Vision Foundation Models (VFMs) in recent years, Visual In-Context Learning (VICL) has become a better choice compared to modifying models in most scenarios. Different from retraining or fine-tuning model, VICL does not require modifications to the model's weights or architecture, and only needs a prompt with demonstrations to teach VFM how to solve tasks. Currently, significant computational cost for finding optimal prompts for every test sample hinders the deployment of VICL, as determining which demonstrations to use for constructing prompts is very costly. In this paper, however, we find a counterintuitive phenomenon that most test samples actually achieve optimal performance under the same prompts, and searching for sample-level prompts only costs more time but results in completely identical prompts. Therefore, we propose task-level prompting to reduce the cost of searching for prompts during the inference stage and introduce two time-saving yet effective task-level prompt search strategies. Extensive experimental results show that our proposed method can identify near-optimal prompts and reach the best VICL performance with a minimal cost that prior work has never achieved.

Transformer-based toxin-protein interaction analysis prioritizes airborne particulate matter components with potential adverse health effects

Air pollution, particularly airborne particulate matter (PM), poses a significant threat to public health globally. It is crucial to comprehend the association between PM-associated toxic components and their cellular targets in humans to understand the mechanisms by which air pollution impacts health and to establish causal relationships between air pollution and public health consequences. Although many studies have explored the impact of PM on human health, the understanding of the association between toxins and the associated targets remain limited. Leveraging cutting-edge deep learning technologies, we developed tipFormer (toxin-protein interaction prediction based on transformer), a novel deep-learning tool for identifying toxic components capable of penetrating human cells and instigating pathogenic biological activities and signaling cascades. Experimental results show that tipFormer effectively captures interactions between proteins and toxic components. It incorporates dual pre-trained language models to encode protein sequences and chemicals. It employs a convolutional encoder to assimilate the sequential attributes of proteins and chemicals. It then introduces a learning module with a cross-attention mechanism to decode and elucidate the multifaceted interactions pivotal for the hotspots binding proteins and chemicals. Experimental results show that tipFormer effectively captures interactions between proteins and toxic components. This approach offers significant value to air quality and toxicology researchers by allowing high-throughput identification and prioritization of hazards. It supports more targeted laboratory studies and field measurements, ultimately enhancing our understanding of how air pollution impacts human health.

Exact: Exploring Space-Time Perceptive Clues for Weakly Supervised Satellite Image Time Series Semantic Segmentation

Automated crop mapping through Satellite Image Time Series (SITS) has emerged as a crucial avenue for agricultural monitoring and management. However, due to the low resolution and unclear parcel boundaries, annotating pixel-level masks is exceptionally complex and time-consuming in SITS. This paper embraces the weakly supervised paradigm (i.e., only image-level categories available) to liberate the crop mapping task from the exhaustive annotation burden. The unique characteristics of SITS give rise to several challenges in weakly supervised learning: (1) noise perturbation from spatially neighboring regions, and (2) erroneous semantic bias from anomalous temporal periods. To address the above difficulties, we propose a novel method, termed exploring space-time perceptive clues (Exact). First, we introduce a set of spatial clues to explicitly capture the representative patterns of different crops from the most class-relative regions. Besides, we leverage the temporal-to-class interaction of the model to emphasize the contributions of pivotal clips, thereby enhancing the model perception for crop regions. Build upon the space-time perceptive clues, we derive the clue-based CAMs to effectively supervise the SITS segmentation network. Our method demonstrates impressive performance on various SITS benchmarks. Remarkably, the segmentation network trained on Exact-generated masks achieves 95% of its fully supervised performance, showing the bright promise of weakly supervised paradigm in crop mapping scenario. Our code will be publicly available.

EndoFinder: Online Image Retrieval for Explainable Colorectal Polyp Diagnosis

Determining the necessity of resecting malignant polyps during colonoscopy screen is crucial for patient outcomes, yet challenging due to the time-consuming and costly nature of histopathology examination. While deep learning-based classification models have shown promise in achieving optical biopsy with endoscopic images, they often suffer from a lack of explainability. To overcome this limitation, we introduce EndoFinder, a content-based image retrieval framework to find the 'digital twin' polyp in the reference database given a newly detected polyp. The clinical semantics of the new polyp can be inferred referring to the matched ones. EndoFinder pioneers a polyp-aware image encoder that is pre-trained on a large polyp dataset in a self-supervised way, merging masked image modeling with contrastive learning. This results in a generic embedding space ready for different downstream clinical tasks based on image retrieval. We validate the framework on polyp re-identification and optical biopsy tasks, with extensive experiments demonstrating that EndoFinder not only achieves explainable diagnostics but also matches the performance of supervised classification models. EndoFinder's reliance on image retrieval has the potential to support diverse downstream decision-making tasks during real-time colonoscopy procedures.

User Welfare Optimization in Recommender Systems with Competing Content Creators

Driven by the new economic opportunities created by the creator economy, an increasing number of content creators rely on and compete for revenue generated from online content recommendation platforms. This burgeoning competition reshapes the dynamics of content distribution and profoundly impacts long-term user welfare on the platform. However, the absence of a comprehensive picture of global user preference distribution often traps the competition, especially the creators, in states that yield sub-optimal user welfare. To encourage creators to best serve a broad user population with relevant content, it becomes the platform's responsibility to leverage its information advantage regarding user preference distribution to accurately signal creators. In this study, we perform system-side user welfare optimization under a competitive game setting among content creators. We propose an algorithmic solution for the platform, which dynamically computes a sequence of weights for each user based on their satisfaction of the recommended content. These weights are then utilized to design mechanisms that adjust the recommendation policy or the post-recommendation rewards, thereby influencing creators' content production strategies. To validate the effectiveness of our proposed method, we report our findings from a series of experiments, including: 1. a proof-of-concept negative example illustrating how creators' strategies converge towards sub-optimal states without platform intervention; 2. offline experiments employing our proposed intervention mechanisms on diverse datasets; and 3. results from a three-week online experiment conducted on a leading short-video recommendation platform.

Invariant Test-Time Adaptation for Vision-Language Model Generalization

Vision-language foundation models have exhibited remarkable success across a multitude of downstream tasks due to their scalability on extensive image-text paired datasets. However, these models display significant limitations when applied to long-tail tasks, such as fine-grained image classification, as a result of "decision shortcuts" that hinders their generalization capabilities. In this work, we find that the CLIP model possesses a rich set of features, encompassing both \textit{desired invariant causal features} and \textit{undesired decision shortcuts}. Moreover, the underperformance of CLIP on downstream tasks originates from its inability to effectively utilize pre-trained features in accordance with specific task requirements. To address this challenge, this paper introduces a test-time prompt tuning paradigm that optimizes a learnable prompt, thereby compelling the model to exploit genuine causal invariant features while disregarding decision shortcuts during the inference phase. The proposed method effectively alleviates excessive dependence on potentially misleading, task-irrelevant contextual information, while concurrently emphasizing critical, task-related visual cues. We conduct comparative analysis of the proposed method against various approaches which validates its effectiveness.

SportQA: A Benchmark for Sports Understanding in Large Language Models

A deep understanding of sports, a field rich in strategic and dynamic content, is crucial for advancing Natural Language Processing (NLP). This holds particular significance in the context of evaluating and advancing Large Language Models (LLMs), given the existing gap in specialized benchmarks. To bridge this gap, we introduce SportQA, a novel benchmark specifically designed for evaluating LLMs in the context of sports understanding. SportQA encompasses over 70,000 multiple-choice questions across three distinct difficulty levels, each targeting different aspects of sports knowledge from basic historical facts to intricate, scenario-based reasoning tasks. We conducted a thorough evaluation of prevalent LLMs, mainly utilizing few-shot learning paradigms supplemented by chain-of-thought (CoT) prompting. Our results reveal that while LLMs exhibit competent performance in basic sports knowledge, they struggle with more complex, scenario-based sports reasoning, lagging behind human expertise. The introduction of SportQA marks a significant step forward in NLP, offering a tool for assessing and enhancing sports understanding in LLMs.

MaskClustering: View Consensus based Mask Graph Clustering for Open-Vocabulary 3D Instance Segmentation

Open-vocabulary 3D instance segmentation has emerged as a frontier topic due to its capability to segment 3D instances beyond a predefined set of categories. However, compared to significant progress in the 2D domain, methods for 3D open-vocabulary instance segmentation are hindered by the limited scale of high-quality annotated 3D data. To harness the capabilities of 2D models, recent efforts have focused on merging 2D masks based on metrics such as geometric and semantic similarity to form 3D instances. In contrast to these local metrics, we propose a novel metric called view consensus to better exploit multi-view observation. The key insight is that two 2D masks should be considered as belonging to the same instance if a considerable number of other 2D masks from other views contain both these two masks. Based on this metric, we build a global mask graph and iteratively cluster masks, prioritizing mask pairs with solid view consensus. The corresponding 3D points cluster of these 2D mask clusters can be regarded as 3D instances, along with the fused open-vocabulary features from clustered 2D masks. Through this multi-view verification and fusion mechanism, our method effectively leverages the prior instance knowledge from massive 2D masks predicted by visual foundation models, eliminating the need for training on 3D data. Experiments on publicly available datasets, including ScanNet200 and MatterPort3D, demonstrate that our method achieves state-of-the-art performance in both open-vocabulary instance segmentation and class-agnostic mask generation. Our project page is at https://pku-epic.github.io/MaskClustering.

Flexible Error Mitigation of Quantum Processes with Data Augmentation Empowered Neural Model

Neural networks have shown their effectiveness in various tasks in the realm of quantum computing. However, their application in quantum error mitigation, a crucial step towards realizing practical quantum advancements, has been restricted by reliance on noise-free statistics. To tackle this critical challenge, we propose a data augmentation empowered neural model for error mitigation (DAEM). Our model does not require any prior knowledge about the specific noise type and measurement settings and can estimate noise-free statistics solely from the noisy measurement results of the target quantum process, rendering it highly suitable for practical implementation. In numerical experiments, we show the model's superior performance in mitigating various types of noise, including Markovian noise and Non-Markovian noise, compared with previous error mitigation methods. We further demonstrate its versatility by employing the model to mitigate errors in diverse types of quantum processes, including those involving large-scale quantum systems and continuous-variable quantum states. This powerful data augmentation-empowered neural model for error mitigation establishes a solid foundation for realizing more reliable and robust quantum technologies in practical applications.