Trusted Multi-View Classification

Multi-view classification (MVC) generally focuses on improving classification accuracy by using information from different views, typically integrating them into a unified comprehensive representation for downstream tasks. However, it is also crucial to dynamically assess the quality of a view for different samples in order to provide reliable uncertainty estimations, which indicate whether predictions can be trusted. To this end, we propose a novel multi-view classification method, termed trusted multi-view classification, which provides a new paradigm for multi-view learning by dynamically integrating different views at an evidence level. The algorithm jointly utilizes multiple views to promote both classification reliability and robustness by integrating evidence from each view. To achieve this, the Dirichlet distribution is used to model the distribution of the class probabilities, parameterized with evidence from different views and integrated with the Dempster-Shafer theory. The unified learning framework induces accurate uncertainty and accordingly endows the model with both reliability and robustness for out-of-distribution samples. Extensive experimental results validate the effectiveness of the proposed model in accuracy, reliability and robustness.

Deep Triplet Hashing Network for Case-based Medical Image Retrieval

Deep hashing methods have been shown to be the most efficient approximate nearest neighbor search techniques for large-scale image retrieval. However, existing deep hashing methods have a poor small-sample ranking performance for case-based medical image retrieval. The top-ranked images in the returned query results may be as a different class than the query image. This ranking problem is caused by classification, regions of interest (ROI), and small-sample information loss in the hashing space. To address the ranking problem, we propose an end-to-end framework, called Attention-based Triplet Hashing (ATH) network, to learn low-dimensional hash codes that preserve the classification, ROI, and small-sample information. We embed a spatial-attention module into the network structure of our ATH to focus on ROI information. The spatial-attention module aggregates the spatial information of feature maps by utilizing max-pooling, element-wise maximum, and element-wise mean operations jointly along the channel axis. The triplet cross-entropy loss can help to map the classification information of images and similarity between images into the hash codes. Extensive experiments on two case-based medical datasets demonstrate that our proposed ATH can further improve the retrieval performance compared to the state-of-the-art deep hashing methods and boost the ranking performance for small samples. Compared to the other loss methods, the triplet cross-entropy loss can enhance the classification performance and hash code-discriminability

Applications of Deep Learning in Fundus Images: A Review

The use of fundus images for the early screening of eye diseases is of great clinical importance. Due to its powerful performance, deep learning is becoming more and more popular in related applications, such as lesion segmentation, biomarkers segmentation, disease diagnosis and image synthesis. Therefore, it is very necessary to summarize the recent developments in deep learning for fundus images with a review paper. In this review, we introduce 143 application papers with a carefully designed hierarchy. Moreover, 33 publicly available datasets are presented. Summaries and analyses are provided for each task. Finally, limitations common to all tasks are revealed and possible solutions are given. We will also release and regularly update the state-of-the-art results and newly-released datasets at https://github.com/nkicsl/Fundus Review to adapt to the rapid development of this field.

Colonoscopy Polyp Detection: Domain Adaptation From Medical Report Images to Real-time Videos

Automatic colorectal polyp detection in colonoscopy video is a fundamental task, which has received a lot of attention. Manually annotating polyp region in a large scale video dataset is time-consuming and expensive, which limits the development of deep learning techniques. A compromise is to train the target model by using labeled images and infer on colonoscopy videos. However, there are several issues between the image-based training and video-based inference, including domain differences, lack of positive samples, and temporal smoothness. To address these issues, we propose an Image-video-joint polyp detection network (Ivy-Net) to address the domain gap between colonoscopy images from historical medical reports and real-time videos. In our Ivy-Net, a modified mixup is utilized to generate training data by combining the positive images and negative video frames at the pixel level, which could learn the domain adaptive representations and augment the positive samples. Simultaneously, a temporal coherence regularization (TCR) is proposed to introduce the smooth constraint on feature-level in adjacent frames and improve polyp detection by unlabeled colonoscopy videos. For evaluation, a new large colonoscopy polyp dataset is collected, which contains 3056 images from historical medical reports of 889 positive patients and 7.5-hour videos of 69 patients (28 positive). The experiments on the collected dataset demonstrate that our Ivy-Net achieves the state-of-the-art result on colonoscopy video.

Deep Partial Multi-View Learning

Although multi-view learning has made signifificant progress over the past few decades, it is still challenging due to the diffificulty in modeling complex correlations among different views, especially under the context of view missing. To address the challenge, we propose a novel framework termed Cross Partial Multi-View Networks (CPM-Nets), which aims to fully and flflexibly take advantage of multiple partial views. We fifirst provide a formal defifinition of completeness and versatility for multi-view representation and then theoretically prove the versatility of the learned latent representations. For completeness, the task of learning latent multi-view representation is specififically translated to a degradation process by mimicking data transmission, such that the optimal tradeoff between consistency and complementarity across different views can be implicitly achieved. Equipped with adversarial strategy, our model stably imputes missing views, encoding information from all views for each sample to be encoded into latent representation to further enhance the completeness. Furthermore, a nonparametric classifification loss is introduced to produce structured representations and prevent overfifitting, which endows the algorithm with promising generalization under view-missing cases. Extensive experimental results validate the effectiveness of our algorithm over existing state of the arts for classifification, representation learning and data imputation.

CS2-Net: Deep Learning Segmentation of Curvilinear Structures in Medical Imaging

Automated detection of curvilinear structures, e.g., blood vessels or nerve fibres, from medical and biomedical images is a crucial early step in automatic image interpretation associated to the management of many diseases. Precise measurement of the morphological changes of these curvilinear organ structures informs clinicians for understanding the mechanism, diagnosis, and treatment of e.g. cardiovascular, kidney, eye, lung, and neurological conditions. In this work, we propose a generic and unified convolution neural network for the segmentation of curvilinear structures and illustrate in several 2D/3D medical imaging modalities. We introduce a new curvilinear structure segmentation network (CS2-Net), which includes a self-attention mechanism in the encoder and decoder to learn rich hierarchical representations of curvilinear structures. Two types of attention modules - spatial attention and channel attention - are utilized to enhance the inter-class discrimination and intra-class responsiveness, to further integrate local features with their global dependencies and normalization, adaptively. Furthermore, to facilitate the segmentation of curvilinear structures in medical images, we employ a 1x3 and a 3x1 convolutional kernel to capture boundary features. ...

M3Lung-Sys: A Deep Learning System for Multi-Class Lung Pneumonia Screening from CT Imaging

To counter the outbreak of COVID-19, the accurate diagnosis of suspected cases plays a crucial role in timely quarantine, medical treatment, and preventing the spread of the pandemic. Considering the limited training cases and resources (e.g, time and budget), we propose a Multi-task Multi-slice Deep Learning System (M3Lung-Sys) for multi-class lung pneumonia screening from CT imaging, which only consists of two 2D CNN networks, i.e., slice- and patient-level classification networks. The former aims to seek the feature representations from abundant CT slices instead of limited CT volumes, and for the overall pneumonia screening, the latter one could recover the temporal information by feature refinement and aggregation between different slices. In addition to distinguish COVID-19 from Healthy, H1N1, and CAP cases, our M 3 Lung-Sys also be able to locate the areas of relevant lesions, without any pixel-level annotation. To further demonstrate the effectiveness of our model, we conduct extensive experiments on a chest CT imaging dataset with a total of 734 patients (251 healthy people, 245 COVID-19 patients, 105 H1N1 patients, and 133 CAP patients). The quantitative results with plenty of metrics indicate the superiority of our proposed model on both slice- and patient-level classification tasks. More importantly, the generated lesion location maps make our system interpretable and more valuable to clinicians.

Adversarial Exposure Attack on Diabetic Retinopathy Imagery

Diabetic retinopathy (DR) is a leading cause of vision loss in the world and numerous cutting-edge works have built powerful deep neural networks (DNNs) to automatically classify the DR cases via the retinal fundus images (RFIs). However, RFIs are usually affected by the widely existing camera exposure while the robustness of DNNs to the exposure is rarely explored. In this paper, we study this problem from the viewpoint of adversarial attack and identify a totally new task, i.e., adversarial exposure attack generating adversarial images by tuning image exposure to mislead the DNNs with significantly high transferability. To this end, we first implement a straightforward method, i.e., multiplicative-perturbation-based exposure attack, and reveal the big challenges of this new task. Then, to make the adversarial image naturalness, we propose the adversarial bracketed exposure fusion that regards the exposure attack as an element-wise bracketed exposure fusion problem in the Laplacian-pyramid space. Moreover, to realize high transferability, we further propose the convolutional bracketed exposure fusion where the element-wise multiplicative operation is extended to the convolution. We validate our method on the real public DR dataset with the advanced DNNs, e.g., ResNet50, MobileNet, and EfficientNet, showing our method can achieve high image quality and success rate of the transfer attack. Our method reveals the potential threats to the DNN-based DR automated diagnosis and can definitely benefit the development of exposure-robust automated DR diagnosis method in the future.

NuI-Go: Recursive Non-Local Encoder-Decoder Network for Retinal Image Non-Uniform Illumination Removal

Retinal images have been widely used by clinicians for early diagnosis of ocular diseases. However, the quality of retinal images is often clinically unsatisfactory due to eye lesions and imperfect imaging process. One of the most challenging quality degradation issues in retinal images is non-uniform which hinders the pathological information and further impairs the diagnosis of ophthalmologists and computer-aided analysis.To address this issue, we propose a non-uniform illumination removal network for retinal image, called NuI-Go, which consists of three Recursive Non-local Encoder-Decoder Residual Blocks (NEDRBs) for enhancing the degraded retinal images in a progressive manner. Each NEDRB contains a feature encoder module that captures the hierarchical feature representations, a non-local context module that models the context information, and a feature decoder module that recovers the details and spatial dimension. Additionally, the symmetric skip-connections between the encoder module and the decoder module provide long-range information compensation and reuse. Extensive experiments demonstrate that the proposed method can effectively remove the non-uniform illumination on retinal images while well preserving the image details and color. We further demonstrate the advantages of the proposed method for improving the accuracy of retinal vessel segmentation.

Retinal Image Segmentation with a Structure-Texture Demixing Network

Retinal image segmentation plays an important role in automatic disease diagnosis. This task is very challenging because the complex structure and texture information are mixed in a retinal image, and distinguishing the information is difficult. Existing methods handle texture and structure jointly, which may lead biased models toward recognizing textures and thus results in inferior segmentation performance. To address it, we propose a segmentation strategy that seeks to separate structure and texture components and significantly improve the performance. To this end, we design a structure-texture demixing network (STD-Net) that can process structures and textures differently and better. Extensive experiments on two retinal image segmentation tasks (i.e., blood vessel segmentation, optic disc and cup segmentation) demonstrate the effectiveness of the proposed method.