ANX: Protocol-First Design for AI Agent Interaction with a Supporting 3EX Decoupled Architecture

AI agents, autonomous digital actors, need agent-native protocols; existing methods include GUI automation and MCP-based skills, with defects of high token consumption, fragmented interaction, inadequate security, due to lacking a unified top-level framework and key components, each independent module flawed. To address these issues, we present ANX, an open, extensible, verifiable agent-native protocol and top-level framework integrating CLI, Skill, MCP, resolving pain points via protocol innovation, architectural optimization and tool supplementation. Its four core innovations: 1) Agent-native design (ANX Config, Markup, CLI) with high information density, flexibility and strong adaptability to reduce tokens and eliminate inconsistencies; 2) Human-agent interaction combining Skill's flexibility for dual rendering as agent-executable instructions and human-readable UI; 3) MCP-supported on-demand lightweight apps without pre-registration; 4) ANX Markup-enabled machine-executable SOPs eliminating ambiguity for reliable long-horizon tasks and multi-agent collaboration. As the first in a series, we focus on ANX's design, present its 3EX decoupled architecture with ANXHub and preliminary feasibility analysis and experimental validation. ANX ensures native security: LLM-bypassed UI-to-Core communication keeps sensitive data out of agent context; human-only confirmation prevents automated misuse. Form-filling experiments with Qwen3.5-plus/GPT-4o show ANX reduces tokens by 47.3% (Qwen3.5-plus) and 55.6% (GPT-4o) vs MCP-based skills, 57.1% (Qwen3.5-plus) and 66.3% (GPT-4o) vs GUI automation, and shortens execution time by 58.1% and 57.7% vs MCP-based skills.

Effective Dataset Distillation for Spatio-Temporal Forecasting with Bi-dimensional Compression

Spatio-temporal time series are widely used in real-world applications, including traffic prediction and weather forecasting. They are sequences of observations over extensive periods and multiple locations, naturally represented as multidimensional data. Forecasting is a central task in spatio-temporal analysis, and numerous deep learning methods have been developed to address it. However, as dataset sizes and model complexities continue to grow in practice, training deep learning models has become increasingly time- and resource-intensive. A promising solution to this challenge is dataset distillation, which synthesizes compact datasets that can effectively replace the original data for model training. Although successful in various domains, including time series analysis, existing dataset distillation methods compress only one dimension, making them less suitable for spatio-temporal datasets, where both spatial and temporal dimensions jointly contribute to the large data volume. To address this limitation, we propose STemDist, the first dataset distillation method specialized for spatio-temporal time series forecasting. A key idea of our solution is to compress both temporal and spatial dimensions in a balanced manner, reducing training time and memory. We further reduce the distillation cost by performing distillation at the cluster level rather than the individual location level, and we complement this coarse-grained approach with a subset-based granular distillation technique that enhances forecasting performance. On five real-world datasets, we show empirically that, compared to both general and time-series dataset distillation methods, datasets distilled by our STemDist method enable model training (1) faster (up to 6X) (2) more memory-efficient (up to 8X), and (3) more effective (with up to 12% lower prediction error).

Cluster-Specific Predictive Modeling: A Scalable Solution for Resource-Constrained Wi-Fi Controllers

This manuscript presents a comprehensive analysis of predictive modeling optimization in managed Wi-Fi networks through the integration of clustering algorithms and model evaluation techniques. The study addresses the challenges of deploying forecasting algorithms in large-scale environments managed by a central controller constrained by memory and computational resources. Feature-based clustering, supported by Principal Component Analysis (PCA) and advanced feature engineering, is employed to group time series data based on shared characteristics, enabling the development of cluster-specific predictive models. Comparative evaluations between global models (GMs) and cluster-specific models demonstrate that cluster-specific models consistently achieve superior accuracy in terms of Mean Absolute Error (MAE) values in high-activity clusters. The trade-offs between model complexity (and accuracy) and resource utilization are analyzed, highlighting the scalability of tailored modeling approaches. The findings advocate for adaptive network management strategies that optimize resource allocation through selective model deployment, enhance predictive accuracy, and ensure scalable operations in large-scale, centrally managed Wi-Fi environments.

FreqCycle: A Multi-Scale Time-Frequency Analysis Method for Time Series Forecasting

Mining time-frequency features is critical for time series forecasting. Existing research has predominantly focused on modeling low-frequency patterns, where most time series energy is concentrated. The overlooking of mid to high frequency continues to limit further performance gains in deep learning models. We propose FreqCycle, a novel framework integrating: (i) a Filter-Enhanced Cycle Forecasting (FECF) module to extract low-frequency features by explicitly learning shared periodic patterns in the time domain, and (ii) a Segmented Frequency-domain Pattern Learning (SFPL) module to enhance mid to high frequency energy proportion via learnable filters and adaptive weighting. Furthermore, time series data often exhibit coupled multi-periodicity, such as intertwined weekly and daily cycles. To address coupled multi-periodicity as well as long lookback window challenges, we extend FreqCycle hierarchically into MFreqCycle, which decouples nested periodic features through cross-scale interactions. Extensive experiments on seven diverse domain benchmarks demonstrate that FreqCycle achieves state-of-the-art accuracy while maintaining faster inference speeds, striking an optimal balance between performance and efficiency.

A Practical Guide Towards Interpreting Time-Series Deep Clinical Predictive Models: A Reproducibility Study

Clinical decisions are high-stakes and require explicit justification, making model interpretability essential for auditing deep clinical models prior to deployment. As the ecosystem of model architectures and explainability methods expands, critical questions remain: Do architectural features like attention improve explainability? Do interpretability approaches generalize across clinical tasks? While prior benchmarking efforts exist, they often lack extensibility and reproducibility, and critically, fail to systematically examine how interpretability varies across the interplay of clinical tasks and model architectures. To address these gaps, we present a comprehensive benchmark evaluating interpretability methods across diverse clinical prediction tasks and model architectures. Our analysis reveals that: (1) attention when leveraged properly is a highly efficient approach for faithfully interpreting model predictions; (2) black-box interpreters like KernelSHAP and LIME are computationally infeasible for time-series clinical prediction tasks; and (3) several interpretability approaches are too unreliable to be trustworthy. From our findings, we discuss several guidelines on improving interpretability within clinical predictive pipelines. To support reproducibility and extensibility, we provide our implementations via PyHealth, a well-documented open-source framework: https://github.com/sunlabuiuc/PyHealth.

KairosVL: Orchestrating Time Series and Semantics for Unified Reasoning

Driven by the increasingly complex and decision-oriented demands of time series analysis, we introduce the Semantic-Conditional Time Series Reasoning task, which extends conventional time series analysis beyond purely numerical modeling to incorporate contextual and semantic understanding. To further enhance the mode's reasoning capabilities on complex time series problems, we propose a two-round reinforcement learning framework: the first round strengthens the mode's perception of fundamental temporal primitives, while the second focuses on semantic-conditioned reasoning. The resulting model, KairosVL, achieves competitive performance across both synthetic and real-world tasks. Extensive experiments and ablation studies demonstrate that our framework not only boosts performance but also preserves intrinsic reasoning ability and significantly improves generalization to unseen scenarios. To summarize, our work highlights the potential of combining semantic reasoning with temporal modeling and provides a practical framework for real-world time series intelligence, which is in urgent demand.

Sense4HRI: A ROS 2 HRI Framework for Physiological Sensor Integration and Synchronized Logging

Physiological signals are increasingly relevant to estimate the mental states of users in human-robot interaction (HRI), yet ROS 2-based HRI frameworks still lack reusable support to integrate such data streams in a standardized way. Therefore, we propose Sense4HRI, an adapted framework for human-robot interaction in ROS 2 that integrates physiological measurements and derived user-state indicators. The framework is designed to be extensible, allowing the integration of additional physiological sensors, their interpretation, and multimodal fusion to provide a robust assessment of the mental states of users. In addition, it introduces reusable interfaces for timestamped physiological time-series data and supports synchronized logging of physiological signals together with experiment context, enabling interoperable and traceable multimodal analysis within ROS 2-based HRI systems.

Deep Autocorrelation Modeling for Time-Series Forecasting: Progress and Prospects

Autocorrelation is a defining characteristic of time-series data, where each observation is statistically dependent on its predecessors. In the context of deep time-series forecasting, autocorrelation arises in both the input history and the label sequences, presenting two central research challenges: (1) designing neural architectures that model autocorrelation in history sequences, and (2) devising learning objectives that model autocorrelation in label sequences. Recent studies have made strides in tackling these challenges, but a systematic survey examining both aspects remains lacking. To bridge this gap, this paper provides a comprehensive review of deep time-series forecasting from the perspective of autocorrelation modeling. In contrast to existing surveys, this work makes two distinctive contributions. First, it proposes a novel taxonomy that encompasses recent literature on both model architectures and learning objectives -- whereas prior surveys neglect or inadequately discuss the latter aspect. Second, it offers a thorough analysis of the motivations, insights, and progression of the surveyed literature from a unified, autocorrelation-centric perspective, providing a holistic overview of the evolution of deep time-series forecasting. The full list of papers and resources is available at https://github.com/Master-PLC/Awesome-TSF-Papers.

AIVV: Neuro-Symbolic LLM Agent-Integrated Verification and Validation for Trustworthy Autonomous Systems

Deep learning models excel at detecting anomaly patterns in normal data. However, they do not provide a direct solution for anomaly classification and scalability across diverse control systems, frequently failing to distinguish genuine faults from nuisance faults caused by noise or the control system's large transient response. Consequently, because algorithmic fault validation remains unscalable, full Verification and Validation (V\&V) operations are still managed by Human-in-the-Loop (HITL) analysis, resulting in an unsustainable manual workload. To automate this essential oversight, we propose Agent-Integrated Verification and Validation (AIVV), a hybrid framework that deploys Large Language Models (LLMs) as a deliberative outer loop. Because rigorous system verification strictly depends on accurate validation, AIVV escalates mathematically flagged anomalies to a role-specialized LLM council. The council agents perform collaborative validation by semantically validating nuisance and true failures based on natural-language (NL) requirements to secure a high-fidelity system-verification baseline. Building on this foundation, the council then performs system verification by assessing post-fault responses against NL operational tolerances, ultimately generating actionable V\&V artifacts, such as gain-tuning proposals. Experiments on a time-series simulator for Unmanned Underwater Vehicles (UUVs) demonstrate that AIVV successfully digitizes the HITL V\&V process, overcoming the limitations of rule-based fault classification and offering a scalable blueprint for LLM-mediated oversight in time-series data domains.

Evaluating Interactive 2D Visualization as a Sample Selection Strategy for Biomedical Time-Series Data Annotation

Reliable machine-learning models in biomedical settings depend on accurate labels, yet annotating biomedical time-series data remains challenging. Algorithmic sample selection may support annotation, but evidence from studies involving real human annotators is scarce. Consequently, we compare three sample selection methods for annotation: random sampling (RND), farthest-first traversal (FAFT), and a graphical user interface-based method enabling exploration of complementary 2D visualizations (2DVs) of high-dimensional data. We evaluated the methods across four classification tasks in infant motility assessment (IMA) and speech emotion recognition (SER). Twelve annotators, categorized as experts or non-experts, performed data annotation under a limited annotation budget, and post-annotation experiments were conducted to evaluate the sampling methods. Across all classification tasks, 2DV performed best when aggregating labels across annotators. In IMA, 2DV most effectively captured rare classes, but also exhibited greater annotator-to-annotator label distribution variability resulting from the limited annotation budget, decreasing classification performance when models were trained on individual annotators' labels; in these cases, FAFT excelled. For SER, 2DV outperformed the other methods among expert annotators and matched their performance for non-experts in the individual-annotator setting. A failure risk analysis revealed that RND was the safest choice when annotator count or annotator expertise was uncertain, whereas 2DV had the highest risk due to its greater label distribution variability. Furthermore, post-experiment interviews indicated that 2DV made the annotation task more interesting and enjoyable. Overall, 2DV-based sampling appears promising for biomedical time-series data annotation, particularly when the annotation budget is not highly constrained.