HGTDP-DTA: Hybrid Graph-Transformer with Dynamic Prompt for Drug-Target Binding Affinity Prediction

Drug target binding affinity (DTA) is a key criterion for drug screening. Existing experimental methods are time-consuming and rely on limited structural and domain information. While learning-based methods can model sequence and structural information, they struggle to integrate contextual data and often lack comprehensive modeling of drug-target interactions. In this study, we propose a novel DTA prediction method, termed HGTDP-DTA, which utilizes dynamic prompts within a hybrid Graph-Transformer framework. Our method generates context-specific prompts for each drug-target pair, enhancing the model's ability to capture unique interactions. The introduction of prompt tuning further optimizes the prediction process by filtering out irrelevant noise and emphasizing task-relevant information, dynamically adjusting the input features of the molecular graph. The proposed hybrid Graph-Transformer architecture combines structural information from Graph Convolutional Networks (GCNs) with sequence information captured by Transformers, facilitating the interaction between global and local information. Additionally, we adopted the multi-view feature fusion method to project molecular graph views and affinity subgraph views into a common feature space, effectively combining structural and contextual information. Experiments on two widely used public datasets, Davis and KIBA, show that HGTDP-DTA outperforms state-of-the-art DTA prediction methods in both prediction performance and generalization ability.

Effects of Exponential Gaussian Distribution on (Double Sampling) Randomized Smoothing

Randomized Smoothing (RS) is currently a scalable certified defense method providing robustness certification against adversarial examples. Although significant progress has been achieved in providing defenses against $\ell_p$ adversaries, the interaction between the smoothing distribution and the robustness certification still remains vague. In this work, we comprehensively study the effect of two families of distributions, named Exponential Standard Gaussian (ESG) and Exponential General Gaussian (EGG) distributions, on Randomized Smoothing and Double Sampling Randomized Smoothing (DSRS). We derive an analytic formula for ESG's certified radius, which converges to the origin formula of RS as the dimension $d$ increases. Additionally, we prove that EGG can provide tighter constant factors than DSRS in providing $\Omega(\sqrt{d})$ lower bounds of $\ell_2$ certified radius, and thus further addresses the curse of dimensionality in RS. Our experiments on real-world datasets confirm our theoretical analysis of the ESG distributions, that they provide almost the same certification under different exponents $\eta$ for both RS and DSRS. In addition, EGG

MGCP: A Multi-Grained Correlation based Prediction Network for Multivariate Time Series

Multivariate time series prediction is widely used in daily life, which poses significant challenges due to the complex correlations that exist at multi-grained levels. Unfortunately, the majority of current time series prediction models fail to simultaneously learn the correlations of multivariate time series at multi-grained levels, resulting in suboptimal performance. To address this, we propose a Multi-Grained Correlations-based Prediction (MGCP) Network, which simultaneously considers the correlations at three granularity levels to enhance prediction performance. Specifically, MGCP utilizes Adaptive Fourier Neural Operators and Graph Convolutional Networks to learn the global spatiotemporal correlations and inter-series correlations, enabling the extraction of potential features from multivariate time series at fine-grained and medium-grained levels. Additionally, MGCP employs adversarial training with an attention mechanism-based predictor and conditional discriminator to optimize prediction results at coarse-grained level, ensuring high fidelity between the generated forecast results and the actual data distribution. Finally, we compare MGCP with several state-of-the-art time series prediction algorithms on real-world benchmark datasets, and our results demonstrate the generality and effectiveness of the proposed model.

Cycle-YOLO: A Efficient and Robust Framework for Pavement Damage Detection

With the development of modern society, traffic volume continues to increase in most countries worldwide, leading to an increase in the rate of pavement damage Therefore, the real-time and highly accurate pavement damage detection and maintenance have become the current need. In this paper, an enhanced pavement damage detection method with CycleGAN and improved YOLOv5 algorithm is presented. We selected 7644 self-collected images of pavement damage samples as the initial dataset and augmented it by CycleGAN. Due to a substantial difference between the images generated by CycleGAN and real road images, we proposed a data enhancement method based on an improved Scharr filter, CycleGAN, and Laplacian pyramid. To improve the target recognition effect on a complex background and solve the problem that the spatial pyramid pooling-fast module in the YOLOv5 network cannot handle multiscale targets, we introduced the convolutional block attention module attention mechanism and proposed the atrous spatial pyramid pooling with squeeze-and-excitation structure. In addition, we optimized the loss function of YOLOv5 by replacing the CIoU with EIoU. The experimental results showed that our algorithm achieved a precision of 0.872, recall of 0.854, and mean average precision@0.5 of 0.882 in detecting three main types of pavement damage: cracks, potholes, and patching. On the GPU, its frames per second reached 68, meeting the requirements for real-time detection. Its overall performance even exceeded the current more advanced YOLOv7 and achieved good results in practical applications, providing a basis for decision-making in pavement damage detection and prevention.

Disentangled Representation with Cross Experts Covariance Loss for Multi-Domain Recommendation

Multi-domain learning (MDL) has emerged as a prominent research area aimed at enhancing the quality of personalized services. The key challenge in MDL lies in striking a balance between learning commonalities across domains while preserving the distinct characteristics of each domain. However, this gives rise to a challenging dilemma. On one hand, a model needs to leverage domain-specific modules, such as experts or embeddings, to preserve the uniqueness of each domain. On the other hand, due to the long-tailed distributions observed in real-world domains, some tail domains may lack sufficient samples to fully learn their corresponding modules. Unfortunately, existing approaches have not adequately addressed this dilemma. To address this issue, we propose a novel model called Crocodile, which stands for Cross-experts Covariance Loss for Disentangled Learning. Crocodile adopts a multi-embedding paradigm to facilitate model learning and employs a Covariance Loss on these embeddings to disentangle them. This disentanglement enables the model to capture diverse user interests across domains effectively. Additionally, we introduce a novel gating mechanism to further enhance the capabilities of Crocodile. Through empirical analysis, we demonstrate that our proposed method successfully resolves these two challenges and outperforms all state-of-the-art methods on publicly available datasets. We firmly believe that the analytical perspectives and design concept of disentanglement presented in our work can pave the way for future research in the field of MDL.

Multi-dimension Transformer with Attention-based Filtering for Medical Image Segmentation

The accurate segmentation of medical images is crucial for diagnosing and treating diseases. Recent studies demonstrate that vision transformer-based methods have significantly improved performance in medical image segmentation, primarily due to their superior ability to establish global relationships among features and adaptability to various inputs. However, these methods struggle with the low signal-to-noise ratio inherent to medical images. Additionally, the effective utilization of channel and spatial information, which are essential for medical image segmentation, is limited by the representation capacity of self-attention. To address these challenges, we propose a multi-dimension transformer with attention-based filtering (MDT-AF), which redesigns the patch embedding and self-attention mechanism for medical image segmentation. MDT-AF incorporates an attention-based feature filtering mechanism into the patch embedding blocks and employs a coarse-to-fine process to mitigate the impact of low signal-to-noise ratio. To better capture complex structures in medical images, MDT-AF extends the self-attention mechanism to incorporate spatial and channel dimensions, enriching feature representation. Moreover, we introduce an interaction mechanism to improve the feature aggregation between spatial and channel dimensions. Experimental results on three public medical image segmentation benchmarks show that MDT-AF achieves state-of-the-art (SOTA) performance.

PMG : Personalized Multimodal Generation with Large Language Models

The emergence of large language models (LLMs) has revolutionized the capabilities of text comprehension and generation. Multi-modal generation attracts great attention from both the industry and academia, but there is little work on personalized generation, which has important applications such as recommender systems. This paper proposes the first method for personalized multimodal generation using LLMs, showcases its applications and validates its performance via an extensive experimental study on two datasets. The proposed method, Personalized Multimodal Generation (PMG for short) first converts user behaviors (e.g., clicks in recommender systems or conversations with a virtual assistant) into natural language to facilitate LLM understanding and extract user preference descriptions. Such user preferences are then fed into a generator, such as a multimodal LLM or diffusion model, to produce personalized content. To capture user preferences comprehensively and accurately, we propose to let the LLM output a combination of explicit keywords and implicit embeddings to represent user preferences. Then the combination of keywords and embeddings are used as prompts to condition the generator. We optimize a weighted sum of the accuracy and preference scores so that the generated content has a good balance between them. Compared to a baseline method without personalization, PMG has a significant improvement on personalization for up to 8% in terms of LPIPS while retaining the accuracy of generation.

LocalStyleFool: Regional Video Style Transfer Attack Using Segment Anything Model

Previous work has shown that well-crafted adversarial perturbations can threaten the security of video recognition systems. Attackers can invade such models with a low query budget when the perturbations are semantic-invariant, such as StyleFool. Despite the query efficiency, the naturalness of the minutia areas still requires amelioration, since StyleFool leverages style transfer to all pixels in each frame. To close the gap, we propose LocalStyleFool, an improved black-box video adversarial attack that superimposes regional style-transfer-based perturbations on videos. Benefiting from the popularity and scalably usability of Segment Anything Model (SAM), we first extract different regions according to semantic information and then track them through the video stream to maintain the temporal consistency. Then, we add style-transfer-based perturbations to several regions selected based on the associative criterion of transfer-based gradient information and regional area. Perturbation fine adjustment is followed to make stylized videos adversarial. We demonstrate that LocalStyleFool can improve both intra-frame and inter-frame naturalness through a human-assessed survey, while maintaining competitive fooling rate and query efficiency. Successful experiments on the high-resolution dataset also showcase that scrupulous segmentation of SAM helps to improve the scalability of adversarial attacks under high-resolution data.

Understanding the Ranking Loss for Recommendation with Sparse User Feedback

Click-through rate (CTR) prediction holds significant importance in the realm of online advertising. While many existing approaches treat it as a binary classification problem and utilize binary cross entropy (BCE) as the optimization objective, recent advancements have indicated that combining BCE loss with ranking loss yields substantial performance improvements. However, the full efficacy of this combination loss remains incompletely understood. In this paper, we uncover a new challenge associated with BCE loss in scenarios with sparse positive feedback, such as CTR prediction: the gradient vanishing for negative samples. Subsequently, we introduce a novel perspective on the effectiveness of ranking loss in CTR prediction, highlighting its ability to generate larger gradients on negative samples, thereby mitigating their optimization issues and resulting in improved classification ability. Our perspective is supported by extensive theoretical analysis and empirical evaluation conducted on publicly available datasets. Furthermore, we successfully deployed the ranking loss in Tencent's online advertising system, achieving notable lifts of 0.70% and 1.26% in Gross Merchandise Value (GMV) for two main scenarios. The code for our approach is openly accessible at the following GitHub repository: https://github.com/SkylerLinn/Understanding-the-Ranking-Loss.

CLAP: Learning Transferable Binary Code Representations with Natural Language Supervision

Binary code representation learning has shown significant performance in binary analysis tasks. But existing solutions often have poor transferability, particularly in few-shot and zero-shot scenarios where few or no training samples are available for the tasks. To address this problem, we present CLAP (Contrastive Language-Assembly Pre-training), which employs natural language supervision to learn better representations of binary code (i.e., assembly code) and get better transferability. At the core, our approach boosts superior transfer learning capabilities by effectively aligning binary code with their semantics explanations (in natural language), resulting a model able to generate better embeddings for binary code. To enable this alignment training, we then propose an efficient dataset engine that could automatically generate a large and diverse dataset comprising of binary code and corresponding natural language explanations. We have generated 195 million pairs of binary code and explanations and trained a prototype of CLAP. The evaluations of CLAP across various downstream tasks in binary analysis all demonstrate exceptional performance. Notably, without any task-specific training, CLAP is often competitive with a fully supervised baseline, showing excellent transferability. We release our pre-trained model and code at https://github.com/Hustcw/CLAP.