Training-free Detection and 6D Pose Estimation of Unseen Surgical Instruments

Purpose: Accurate detection and 6D pose estimation of surgical instruments are crucial for many computer-assisted interventions. However, supervised methods lack flexibility for new or unseen tools and require extensive annotated data. This work introduces a training-free pipeline for accurate multi-view 6D pose estimation of unseen surgical instruments, which only requires a textured CAD model as prior knowledge. Methods: Our pipeline consists of two main stages. First, for detection, we generate object mask proposals in each view and score their similarity to rendered templates using a pre-trained feature extractor. Detections are matched across views, triangulated into 3D instance candidates, and filtered using multi-view geometric consistency. Second, for pose estimation, a set of pose hypotheses is iteratively refined and scored using feature-metric scores with cross-view attention. The best hypothesis undergoes a final refinement using a novel multi-view, occlusion-aware contour registration, which minimizes reprojection errors of unoccluded contour points. Results: The proposed method was rigorously evaluated on real-world surgical data from the MVPSP dataset. The method achieves millimeter-accurate pose estimates that are on par with supervised methods under controlled conditions, while maintaining full generalization to unseen instruments. These results demonstrate the feasibility of training-free, marker-less detection and tracking in surgical scenes, and highlight the unique challenges in surgical environments. Conclusion: We present a novel and flexible pipeline that effectively combines state-of-the-art foundational models, multi-view geometry, and contour-based refinement for high-accuracy 6D pose estimation of surgical instruments without task-specific training. This approach enables robust instrument tracking and scene understanding in dynamic clinical environments.

Towards Comprehensive Real-Time Scene Understanding in Ophthalmic Surgery through Multimodal Image Fusion

Purpose: The integration of multimodal imaging into operating rooms paves the way for comprehensive surgical scene understanding. In ophthalmic surgery, by now, two complementary imaging modalities are available: operating microscope (OPMI) imaging and real-time intraoperative optical coherence tomography (iOCT). This first work toward temporal OPMI and iOCT feature fusion demonstrates the potential of multimodal image processing for multi-head prediction through the example of precise instrument tracking in vitreoretinal surgery. Methods: We propose a multimodal, temporal, real-time capable network architecture to perform joint instrument detection, keypoint localization, and tool-tissue distance estimation. Our network design integrates a cross-attention fusion module to merge OPMI and iOCT image features, which are efficiently extracted via a YoloNAS and a CNN encoder, respectively. Furthermore, a region-based recurrent module leverages temporal coherence. Results: Our experiments demonstrate reliable instrument localization and keypoint detection (95.79% mAP50) and show that the incorporation of iOCT significantly improves tool-tissue distance estimation, while achieving real-time processing rates of 22.5 ms per frame. Especially for close distances to the retina (below 1 mm), the distance estimation accuracy improved from 284 $μm$ (OPMI only) to 33 $μm$ (multimodal). Conclusion: Feature fusion of multimodal imaging can enhance multi-task prediction accuracy compared to single-modality processing and real-time processing performance can be achieved through tailored network design. While our results demonstrate the potential of multi-modal processing for image-guided vitreoretinal surgery, they also underline key challenges that motivate future research toward more reliable, consistent, and comprehensive surgical scene understanding.

Real-time Rendering-based Surgical Instrument Tracking via Evolutionary Optimization

Accurate and efficient tracking of surgical instruments is fundamental for Robot-Assisted Minimally Invasive Surgery. Although vision-based robot pose estimation has enabled markerless calibration without tedious physical setups, reliable tool tracking for surgical robots still remains challenging due to partial visibility and specialized articulation design of surgical instruments. Previous works in the field are usually prone to unreliable feature detections under degraded visual quality and data scarcity, whereas rendering-based methods often struggle with computational costs and suboptimal convergence. In this work, we incorporate CMA-ES, an evolutionary optimization strategy, into a versatile tracking pipeline that jointly estimates surgical instrument pose and joint configurations. Using batch rendering to efficiently evaluate multiple pose candidates in parallel, the method significantly reduces inference time and improves convergence robustness. The proposed framework further generalizes to joint angle-free and bi-manual tracking settings, making it suitable for both vision feedback control and online surgery video calibration. Extensive experiments on synthetic and real-world datasets demonstrate that the proposed method significantly outperforms prior approaches in both accuracy and runtime.

GroundedSurg: A Multi-Procedure Benchmark for Language-Conditioned Surgical Tool Segmentation

Clinically reliable perception of surgical scenes is essential for advancing intelligent, context-aware intraoperative assistance such as instrument handoff guidance, collision avoidance, and workflow-aware robotic support. Existing surgical tool benchmarks primarily evaluate category-level segmentation, requiring models to detect all instances of predefined instrument classes. However, real-world clinical decisions often require resolving references to a specific instrument instance based on its functional role, spatial relation, or anatomical interaction capabilities not captured by current evaluation paradigms. We introduce GroundedSurg, the first language-conditioned, instance-level surgical grounding benchmark. Each instance pairs a surgical image with a natural-language description targeting a single instrument, accompanied by structured spatial grounding annotations including bounding boxes and point-level anchors. The dataset spans ophthalmic, laparoscopic, robotic, and open procedures, encompassing diverse instrument types, imaging conditions, and operative complexities. By jointly evaluating linguistic reference resolution and pixel-level localization, GroundedSurg enables a systematic and realistic evaluation of vision-language models in clinically realistic multi-instrument scenes. Extensive experiments demonstrate substantial performance gaps across modern segmentation and VLMs, highlighting the urgent need for clinically grounded vision-language reasoning in surgical AI systems. Code and data are publicly available at https://github.com/gaash-lab/GroundedSurg

Evaluating Large Vision-language Models for Surgical Tool Detection

Surgery is a highly complex process, and artificial intelligence has emerged as a transformative force in supporting surgical guidance and decision-making. However, the unimodal nature of most current AI systems limits their ability to achieve a holistic understanding of surgical workflows. This highlights the need for general-purpose surgical AI systems capable of comprehensively modeling the interrelated components of surgical scenes. Recent advances in large vision-language models that integrate multimodal data processing offer strong potential for modeling surgical tasks and providing human-like scene reasoning and understanding. Despite their promise, systematic investigations of VLMs in surgical applications remain limited. In this study, we evaluate the effectiveness of large VLMs for the fundamental surgical vision task of detecting surgical tools. Specifically, we investigate three state-of-the-art VLMs, Qwen2.5, LLaVA1.5, and InternVL3.5, on the GraSP robotic surgery dataset under both zero-shot and parameter-efficient LoRA fine-tuning settings. Our results demonstrate that Qwen2.5 consistently achieves superior detection performance in both configurations among the evaluated VLMs. Furthermore, compared with the open-set detection baseline Grounding DINO, Qwen2.5 exhibits stronger zero-shot generalization and comparable fine-tuned performance. Notably, Qwen2.5 shows superior instrument recognition, while Grounding DINO demonstrates stronger localization.

Towards Autonomous Instrument Tray Assembly for Sterile Processing Applications

The Sterile Processing and Distribution (SPD) department is responsible for cleaning, disinfecting, inspecting, and assembling surgical instruments between surgeries. Manual inspection and preparation of instrument trays is a time-consuming, error-prone task, often prone to contamination and instrument breakage. In this work, we present a fully automated robotic system that sorts and structurally packs surgical instruments into sterile trays, focusing on automation of the SPD assembly stage. A custom dataset comprising 31 surgical instruments and 6,975 annotated images was collected to train a hybrid perception pipeline using YOLO12 for detection and a cascaded ResNet-based model for fine-grained classification. The system integrates a calibrated vision module, a 6-DOF Staubli TX2-60L robotic arm with a custom dual electromagnetic gripper, and a rule-based packing algorithm that reduces instrument collisions during transport. The packing framework uses 3D printed dividers and holders to physically isolate instruments, reducing collision and friction during transport. Experimental evaluations show high perception accuracy and statistically significant reduction in tool-to-tool collisions compared to human-assembled trays. This work serves as the scalable first step toward automating SPD workflows, improving safety, and consistency of surgical preparation while reducing SPD processing times.

On-the-fly hand-eye calibration for the da Vinci surgical robot

In Robot-Assisted Minimally Invasive Surgery (RMIS), accurate tool localization is crucial to ensure patient safety and successful task execution. However, this remains challenging for cable-driven robots, such as the da Vinci robot, because erroneous encoder readings lead to pose estimation errors. In this study, we propose a calibration framework to produce accurate tool localization results through computing the hand-eye transformation matrix on-the-fly. The framework consists of two interrelated algorithms: the feature association block and the hand-eye calibration block, which provide robust correspondences for key points detected on monocular images without pre-training, and offer the versatility to accommodate various surgical scenarios by adopting an array of filter approaches, respectively. To validate its efficacy, we test the framework extensively on publicly available video datasets that feature multiple surgical instruments conducting tasks in both in vitro and ex vivo scenarios, under varying illumination conditions and with different levels of key point measurement accuracy. The results show a significant reduction in tool localization errors under the proposed calibration framework, with accuracies comparable to other state-of-the-art methods while being more time-efficient.

On the Role of Depth in Surgical Vision Foundation Models: An Empirical Study of RGB-D Pre-training

Vision foundation models (VFMs) have emerged as powerful tools for surgical scene understanding. However, current approaches predominantly rely on unimodal RGB pre-training, overlooking the complex 3D geometry inherent to surgical environments. Although several architectures support multimodal or geometry-aware inputs in general computer vision, the benefits of incorporating depth information in surgical settings remain underexplored. We conduct a large-scale empirical study comparing eight ViT-based VFMs that differ in pre-training domain, learning objective, and input modality (RGB vs. RGB-D). For pre-training, we use a curated dataset of 1.4 million robotic surgical images paired with depth maps generated from an off-the-shelf network. We evaluate these models under both frozen-backbone and end-to-end fine-tuning protocols across eight surgical datasets spanning object detection, segmentation, depth estimation, and pose estimation. Our experiments yield several consistent findings. Models incorporating explicit geometric tokenization, such as MultiMAE, substantially outperform unimodal baselines across all tasks. Notably, geometric-aware pre-training enables remarkable data efficiency: models fine-tuned on just 25% of labeled data consistently surpass RGB-only models trained on the full dataset. Importantly, these gains require no architectural or runtime changes at inference; depth is used only during pre-training, making adoption straightforward. These findings suggest that multimodal pre-training offers a viable path towards building more capable surgical vision systems.

Neural Collision Detection for Multi-arm Laparoscopy Surgical Robots Through Learning-from-Simulation

This study presents an integrated framework for enhancing the safety and operational efficiency of robotic arms in laparoscopic surgery by addressing key challenges in collision detection and minimum distance estimation. By combining analytical modeling, real-time simulation, and machine learning, the framework offers a robust solution for ensuring safe robotic operations. An analytical model was developed to estimate the minimum distances between robotic arms based on their joint configurations, offering precise theoretical calculations that serve as both a validation tool and a benchmark. To complement this, a 3D simulation environment was created to model two 7-DOF Kinova robotic arms, generating a diverse dataset of configurations for collision detection and distance estimation. Using these insights, a deep neural network model was trained with joint actuators of robot arms and relative positions as inputs, achieving a mean absolute error of 282.2 mm and an R-squared value of 0.85. The close alignment between predicted and actual distances highlights the network's accuracy and its ability to generalize spatial relationships. This work demonstrates the effectiveness of combining analytical precision with machine learning algorithms to enhance the precision and reliability of robotic systems.

H-CNN-ViT: A Hierarchical Gated Attention Multi-Branch Model for Bladder Cancer Recurrence Prediction

Bladder cancer is one of the most prevalent malignancies worldwide, with a recurrence rate of up to 78%, necessitating accurate post-operative monitoring for effective patient management. Multi-sequence contrast-enhanced MRI is commonly used for recurrence detection; however, interpreting these scans remains challenging, even for experienced radiologists, due to post-surgical alterations such as scarring, swelling, and tissue remodeling. AI-assisted diagnostic tools have shown promise in improving bladder cancer recurrence prediction, yet progress in this field is hindered by the lack of dedicated multi-sequence MRI datasets for recurrence assessment study. In this work, we first introduce a curated multi-sequence, multi-modal MRI dataset specifically designed for bladder cancer recurrence prediction, establishing a valuable benchmark for future research. We then propose H-CNN-ViT, a new Hierarchical Gated Attention Multi-Branch model that enables selective weighting of features from the global (ViT) and local (CNN) paths based on contextual demands, achieving a balanced and targeted feature fusion. Our multi-branch architecture processes each modality independently, ensuring that the unique properties of each imaging channel are optimally captured and integrated. Evaluated on our dataset, H-CNN-ViT achieves an AUC of 78.6%, surpassing state-of-the-art models. Our model is publicly available at https://github.com/XLIAaron/H-CNN-ViT.