APTOS-2024 challenge report: Generation of synthetic 3D OCT images from fundus photographs

Optical Coherence Tomography (OCT) provides high-resolution, 3D, and non-invasive visualization of retinal layers in vivo, serving as a critical tool for lesion localization and disease diagnosis. However, its widespread adoption is limited by equipment costs and the need for specialized operators. In comparison, 2D color fundus photography offers faster acquisition and greater accessibility with less dependence on expensive devices. Although generative artificial intelligence has demonstrated promising results in medical image synthesis, translating 2D fundus images into 3D OCT images presents unique challenges due to inherent differences in data dimensionality and biological information between modalities. To advance generative models in the fundus-to-3D-OCT setting, the Asia Pacific Tele-Ophthalmology Society (APTOS-2024) organized a challenge titled Artificial Intelligence-based OCT Generation from Fundus Images. This paper details the challenge framework (referred to as APTOS-2024 Challenge), including: the benchmark dataset, evaluation methodology featuring two fidelity metrics-image-based distance (pixel-level OCT B-scan similarity) and video-based distance (semantic-level volumetric consistency), and analysis of top-performing solutions. The challenge attracted 342 participating teams, with 42 preliminary submissions and 9 finalists. Leading methodologies incorporated innovations in hybrid data preprocessing or augmentation (cross-modality collaborative paradigms), pre-training on external ophthalmic imaging datasets, integration of vision foundation models, and model architecture improvement. The APTOS-2024 Challenge is the first benchmark demonstrating the feasibility of fundus-to-3D-OCT synthesis as a potential solution for improving ophthalmic care accessibility in under-resourced healthcare settings, while helping to expedite medical research and clinical applications.

Optimal Transport Driven Asymmetric Image-to-Image Translation for Nuclei Segmentation of Histological Images

Segmentation of nuclei regions from histological images enables morphometric analysis of nuclei structures, which in turn helps in the detection and diagnosis of diseases under consideration. To develop a nuclei segmentation algorithm, applicable to different types of target domain representations, image-to-image translation networks can be considered as they are invariant to target domain image representations. One of the important issues with image-to-image translation models is that they fail miserably when the information content between two image domains are asymmetric in nature. In this regard, the paper introduces a new deep generative model for segmenting nuclei structures from histological images. The proposed model considers an embedding space for handling information-disparity between information-rich histological image space and information-poor segmentation map domain. Integrating judiciously the concepts of optimal transport and measure theory, the model develops an invertible generator, which provides an efficient optimization framework with lower network complexity. The concept of invertible generator automatically eliminates the need of any explicit cycle-consistency loss. The proposed model also introduces a spatially-constrained squeeze operation within the framework of invertible generator to maintain spatial continuity within the image patches. The model provides a better trade-off between network complexity and model performance compared to other existing models having complex network architectures. The performance of the proposed deep generative model, along with a comparison with state-of-the-art nuclei segmentation methods, is demonstrated on publicly available histological image data sets.

SAR2Struct: Extracting 3D Semantic Structural Representation of Aircraft Targets from Single-View SAR Image

To translate synthetic aperture radar (SAR) image into interpretable forms for human understanding is the ultimate goal of SAR advanced information retrieval. Existing methods mainly focus on 3D surface reconstruction or local geometric feature extraction of targets, neglecting the role of structural modeling in capturing semantic information. This paper proposes a novel task: SAR target structure recovery, which aims to infer the components of a target and the structural relationships between its components, specifically symmetry and adjacency, from a single-view SAR image. Through learning the structural consistency and geometric diversity across the same type of targets as observed in different SAR images, it aims to derive the semantic representation of target directly from its 2D SAR image. To solve this challenging task, a two-step algorithmic framework based on structural descriptors is developed. Specifically, in the training phase, it first detects 2D keypoints from real SAR images, and then learns the mapping from these keypoints to 3D hierarchical structures using simulated data. During the testing phase, these two steps are integrated to infer the 3D structure from real SAR images. Experimental results validated the effectiveness of each step and demonstrated, for the first time, that 3D semantic structural representation of aircraft targets can be directly derived from a single-view SAR image.

SPC to 3D: Novel View Synthesis from Binary SPC via I2I translation

Single Photon Avalanche Diodes (SPADs) represent a cutting-edge imaging technology, capable of detecting individual photons with remarkable timing precision. Building on this sensitivity, Single Photon Cameras (SPCs) enable image capture at exceptionally high speeds under both low and high illumination. Enabling 3D reconstruction and radiance field recovery from such SPC data holds significant promise. However, the binary nature of SPC images leads to severe information loss, particularly in texture and color, making traditional 3D synthesis techniques ineffective. To address this challenge, we propose a modular two-stage framework that converts binary SPC images into high-quality colorized novel views. The first stage performs image-to-image (I2I) translation using generative models such as Pix2PixHD, converting binary SPC inputs into plausible RGB representations. The second stage employs 3D scene reconstruction techniques like Neural Radiance Fields (NeRF) or Gaussian Splatting (3DGS) to generate novel views. We validate our two-stage pipeline (Pix2PixHD + Nerf/3DGS) through extensive qualitative and quantitative experiments, demonstrating significant improvements in perceptual quality and geometric consistency over the alternative baseline.

DragNeXt: Rethinking Drag-Based Image Editing

Drag-Based Image Editing (DBIE), which allows users to manipulate images by directly dragging objects within them, has recently attracted much attention from the community. However, it faces two key challenges: (\emph{\textcolor{magenta}{i}}) point-based drag is often highly ambiguous and difficult to align with users' intentions; (\emph{\textcolor{magenta}{ii}}) current DBIE methods primarily rely on alternating between motion supervision and point tracking, which is not only cumbersome but also fails to produce high-quality results. These limitations motivate us to explore DBIE from a new perspective -- redefining it as deformation, rotation, and translation of user-specified handle regions. Thereby, by requiring users to explicitly specify both drag areas and types, we can effectively address the ambiguity issue. Furthermore, we propose a simple-yet-effective editing framework, dubbed \textcolor{SkyBlue}{\textbf{DragNeXt}}. It unifies DBIE as a Latent Region Optimization (LRO) problem and solves it through Progressive Backward Self-Intervention (PBSI), simplifying the overall procedure of DBIE while further enhancing quality by fully leveraging region-level structure information and progressive guidance from intermediate drag states. We validate \textcolor{SkyBlue}{\textbf{DragNeXt}} on our NextBench, and extensive experiments demonstrate that our proposed method can significantly outperform existing approaches. Code will be released on github.

LoopDB: A Loop Closure Dataset for Large Scale Simultaneous Localization and Mapping

In this study, we introduce LoopDB, which is a challenging loop closure dataset comprising over 1000 images captured across diverse environments, including parks, indoor scenes, parking spaces, as well as centered around individual objects. Each scene is represented by a sequence of five consecutive images. The dataset was collected using a high resolution camera, providing suitable imagery for benchmarking the accuracy of loop closure algorithms, typically used in simultaneous localization and mapping. As ground truth information, we provide computed rotations and translations between each consecutive images. Additional to its benchmarking goal, the dataset can be used to train and fine-tune loop closure methods based on deep neural networks. LoopDB is publicly available at https://github.com/RovisLab/LoopDB.

Design and Evaluation of Deep Learning-Based Dual-Spectrum Image Fusion Methods

Visible images offer rich texture details, while infrared images emphasize salient targets. Fusing these complementary modalities enhances scene understanding, particularly for advanced vision tasks under challenging conditions. Recently, deep learning-based fusion methods have gained attention, but current evaluations primarily rely on general-purpose metrics without standardized benchmarks or downstream task performance. Additionally, the lack of well-developed dual-spectrum datasets and fair algorithm comparisons hinders progress. To address these gaps, we construct a high-quality dual-spectrum dataset captured in campus environments, comprising 1,369 well-aligned visible-infrared image pairs across four representative scenarios: daytime, nighttime, smoke occlusion, and underpasses. We also propose a comprehensive and fair evaluation framework that integrates fusion speed, general metrics, and object detection performance using the lang-segment-anything model to ensure fairness in downstream evaluation. Extensive experiments benchmark several state-of-the-art fusion algorithms under this framework. Results demonstrate that fusion models optimized for downstream tasks achieve superior performance in target detection, especially in low-light and occluded scenes. Notably, some algorithms that perform well on general metrics do not translate to strong downstream performance, highlighting limitations of current evaluation practices and validating the necessity of our proposed framework. The main contributions of this work are: (1)a campus-oriented dual-spectrum dataset with diverse and challenging scenes; (2) a task-aware, comprehensive evaluation framework; and (3) thorough comparative analysis of leading fusion methods across multiple datasets, offering insights for future development.

Deep learning image burst stacking to reconstruct high-resolution ground-based solar observations

Large aperture ground based solar telescopes allow the solar atmosphere to be resolved in unprecedented detail. However, observations are limited by Earths turbulent atmosphere, requiring post image corrections. Current reconstruction methods using short exposure bursts face challenges with strong turbulence and high computational costs. We introduce a deep learning approach that reconstructs 100 short exposure images into one high quality image in real time. Using unpaired image to image translation, our model is trained on degraded bursts with speckle reconstructions as references, improving robustness and generalization. Our method shows an improved robustness in terms of perceptual quality, especially when speckle reconstructions show artifacts. An evaluation with a varying number of images per burst demonstrates that our method makes efficient use of the combined image information and achieves the best reconstructions when provided with the full image burst.

A Culturally-diverse Multilingual Multimodal Video Benchmark & Model

Large multimodal models (LMMs) have recently gained attention due to their effectiveness to understand and generate descriptions of visual content. Most existing LMMs are in English language. While few recent works explore multilingual image LMMs, to the best of our knowledge, moving beyond the English language for cultural and linguistic inclusivity is yet to be investigated in the context of video LMMs. In pursuit of more inclusive video LMMs, we introduce a multilingual Video LMM benchmark, named ViMUL-Bench, to evaluate Video LMMs across 14 languages, including both low- and high-resource languages: English, Chinese, Spanish, French, German, Hindi, Arabic, Russian, Bengali, Urdu, Sinhala, Tamil, Swedish, and Japanese. Our ViMUL-Bench is designed to rigorously test video LMMs across 15 categories including eight culturally diverse categories, ranging from lifestyles and festivals to foods and rituals and from local landmarks to prominent cultural personalities. ViMUL-Bench comprises both open-ended (short and long-form) and multiple-choice questions spanning various video durations (short, medium, and long) with 8k samples that are manually verified by native language speakers. In addition, we also introduce a machine translated multilingual video training set comprising 1.2 million samples and develop a simple multilingual video LMM, named ViMUL, that is shown to provide a better tradeoff between high-and low-resource languages for video understanding. We hope our ViMUL-Bench and multilingual video LMM along with a large-scale multilingual video training set will help ease future research in developing cultural and linguistic inclusive multilingual video LMMs. Our proposed benchmark, video LMM and training data will be publicly released at https://mbzuai-oryx.github.io/ViMUL/.

Feature-Based Lie Group Transformer for Real-World Applications

The main goal of representation learning is to acquire meaningful representations from real-world sensory inputs without supervision. Representation learning explains some aspects of human development. Various neural network (NN) models have been proposed that acquire empirically good representations. However, the formulation of a good representation has not been established. We recently proposed a method for categorizing changes between a pair of sensory inputs. A unique feature of this approach is that transformations between two sensory inputs are learned to satisfy algebraic structural constraints. Conventional representation learning often assumes that disentangled independent feature axes is a good representation; however, we found that such a representation cannot account for conditional independence. To overcome this problem, we proposed a new method using group decomposition in Galois algebra theory. Although this method is promising for defining a more general representation, it assumes pixel-to-pixel translation without feature extraction, and can only process low-resolution images with no background, which prevents real-world application. In this study, we provide a simple method to apply our group decomposition theory to a more realistic scenario by combining feature extraction and object segmentation. We replace pixel translation with feature translation and formulate object segmentation as grouping features under the same transformation. We validated the proposed method on a practical dataset containing both real-world object and background. We believe that our model will lead to a better understanding of human development of object recognition in the real world.