Beyond attention: deriving biologically interpretable insights from weakly-supervised multiple-instance learning models

Recent advances in attention-based multiple instance learning (MIL) have improved our insights into the tissue regions that models rely on to make predictions in digital pathology. However, the interpretability of these approaches is still limited. In particular, they do not report whether high-attention regions are positively or negatively associated with the class labels or how well these regions correspond to previously established clinical and biological knowledge. We address this by introducing a post-training methodology to analyse MIL models. Firstly, we introduce prediction-attention-weighted (PAW) maps by combining tile-level attention and prediction scores produced by a refined encoder, allowing us to quantify the predictive contribution of high-attention regions. Secondly, we introduce a biological feature instantiation technique by integrating PAW maps with nuclei segmentation masks. This further improves interpretability by providing biologically meaningful features related to the cellular organisation of the tissue and facilitates comparisons with known clinical features. We illustrate the utility of our approach by comparing PAW maps obtained for prostate cancer diagnosis (i.e. samples containing malignant tissue, 381/516 tissue samples) and prognosis (i.e. samples from patients with biochemical recurrence following surgery, 98/663 tissue samples) in a cohort of patients from the international cancer genome consortium (ICGC UK Prostate Group). Our approach reveals that regions that are predictive of adverse prognosis do not tend to co-locate with the tumour regions, indicating that non-cancer cells should also be studied when evaluating prognosis.

Regularized Robust MDPs and Risk-Sensitive MDPs: Equivalence, Policy Gradient, and Sample Complexity

This paper focuses on reinforcement learning for the regularized robust Markov decision process (MDP) problem, an extension of the robust MDP framework. We first introduce the risk-sensitive MDP and establish the equivalence between risk-sensitive MDP and regularized robust MDP. This equivalence offers an alternative perspective for addressing the regularized RMDP and enables the design of efficient learning algorithms. Given this equivalence, we further derive the policy gradient theorem for the regularized robust MDP problem and prove the global convergence of the exact policy gradient method under the tabular setting with direct parameterization. We also propose a sample-based offline learning algorithm, namely the robust fitted-Z iteration (RFZI), for a specific regularized robust MDP problem with a KL-divergence regularization term and analyze the sample complexity of the algorithm. Our results are also supported by numerical simulations.

Catch-Up Distillation: You Only Need to Train Once for Accelerating Sampling

Diffusion Probability Models (DPMs) have made impressive advancements in various machine learning domains. However, achieving high-quality synthetic samples typically involves performing a large number of sampling steps, which impedes the possibility of real-time sample synthesis. Traditional accelerated sampling algorithms via knowledge distillation rely on pre-trained model weights and discrete time step scenarios, necessitating additional training sessions to achieve their goals. To address these issues, we propose the Catch-Up Distillation (CUD), which encourages the current moment output of the velocity estimation model ``catch up'' with its previous moment output. Specifically, CUD adjusts the original Ordinary Differential Equation (ODE) training objective to align the current moment output with both the ground truth label and the previous moment output, utilizing Runge-Kutta-based multi-step alignment distillation for precise ODE estimation while preventing asynchronous updates. Furthermore, we investigate the design space for CUDs under continuous time-step scenarios and analyze how to determine the suitable strategies. To demonstrate CUD's effectiveness, we conduct thorough ablation and comparison experiments on CIFAR-10, MNIST, and ImageNet-64. On CIFAR-10, we obtain a FID of 2.80 by sampling in 15 steps under one-session training and the new state-of-the-art FID of 3.37 by sampling in one step with additional training. This latter result necessitated only 62w iterations with a batch size of 128, in contrast to Consistency Distillation, which demanded 210w iterations with a larger batch size of 256. Our code is released at https://anonymous.4open.science/r/Catch-Up-Distillation-E31F.

A Dynamic-Neighbor Particle Swarm Optimizer for Accurate Latent Factor Analysis

High-Dimensional and Incomplete matrices, which usually contain a large amount of valuable latent information, can be well represented by a Latent Factor Analysis model. The performance of an LFA model heavily rely on its optimization process. Thereby, some prior studies employ the Particle Swarm Optimization to enhance an LFA model's optimization process. However, the particles within the swarm follow the static evolution paths and only share the global best information, which limits the particles' searching area to cause sub-optimum issue. To address this issue, this paper proposes a Dynamic-neighbor-cooperated Hierarchical PSO-enhanced LFA model with two-fold main ideas. First is the neighbor-cooperated strategy, which enhances the randomly chosen neighbor's velocity for particles' evolution. Second is the dynamic hyper-parameter tunning. Extensive experiments on two benchmark datasets are conducted to evaluate the proposed DHPL model. The results substantiate that DHPL achieves a higher accuracy without hyper-parameters tunning than the existing PSO-incorporated LFA models in representing an HDI matrix.

Unsupervised Domain Adaptation via Deep Hierarchical Optimal Transport

Unsupervised domain adaptation is a challenging task that aims to estimate a transferable model for unlabeled target domain by exploiting source labeled data. Optimal Transport (OT) based methods recently have been proven to be a promising direction for domain adaptation due to their competitive performance. However, most of these methods coarsely aligned source and target distributions, leading to the over-aligned problem where the category-discriminative information is mixed up although domain-invariant representations can be learned. In this paper, we propose a Deep Hierarchical Optimal Transport method (DeepHOT) for unsupervised domain adaptation. The main idea is to use hierarchical optimal transport to learn both domain-invariant and category-discriminative representations by mining the rich structural correlations among domain data. The DeepHOT framework consists of a domain-level OT and an image-level OT, where the latter is used as the ground distance metric for the former. The image-level OT captures structural associations of local image regions that are beneficial to image classification, while the domain-level OT learns domain-invariant representations by leveraging the underlying geometry of domains. However, due to the high computational complexity, the optimal transport based models are limited in some scenarios. To this end, we propose a robust and efficient implementation of the DeepHOT framework by approximating origin OT with sliced Wasserstein distance in image-level OT and using a mini-batch unbalanced optimal transport for domain-level OT. Extensive experiments show that DeepHOT surpasses the state-of-the-art methods in four benchmark datasets. Code will be released on GitHub.

Brief Industry Paper: The Necessity of Adaptive Data Fusion in Infrastructure-Augmented Autonomous Driving System

This paper is the first to provide a thorough system design overview along with the fusion methods selection criteria of a real-world cooperative autonomous driving system, named Infrastructure-Augmented Autonomous Driving or IAAD. We present an in-depth introduction of the IAAD hardware and software on both road-side and vehicle-side computing and communication platforms. We extensively characterize the IAAD system in the context of real-world deployment scenarios and observe that the network condition that fluctuates along the road is currently the main technical roadblock for cooperative autonomous driving. To address this challenge, we propose new fusion methods, dubbed "inter-frame fusion" and "planning fusion" to complement the current state-of-the-art "intra-frame fusion". We demonstrate that each fusion method has its own benefit and constraint.

Two-Dimensional Weisfeiler-Lehman Graph Neural Networks for Link Prediction

Link prediction is one important application of graph neural networks (GNNs). Most existing GNNs for link prediction are based on one-dimensional Weisfeiler-Lehman (1-WL) test. 1-WL-GNNs first compute node representations by iteratively passing neighboring node features to the center, and then obtain link representations by aggregating the pairwise node representations. As pointed out by previous works, this two-step procedure results in low discriminating power, as 1-WL-GNNs by nature learn node-level representations instead of link-level. In this paper, we study a completely different approach which can directly obtain node pair (link) representations based on \textit{two-dimensional Weisfeiler-Lehman (2-WL) tests}. 2-WL tests directly use links (2-tuples) as message passing units instead of nodes, and thus can directly obtain link representations. We theoretically analyze the expressive power of 2-WL tests to discriminate non-isomorphic links, and prove their superior link discriminating power than 1-WL. Based on different 2-WL variants, we propose a series of novel 2-WL-GNN models for link prediction. Experiments on a wide range of real-world datasets demonstrate their competitive performance to state-of-the-art baselines and superiority over plain 1-WL-GNNs.

NTIRE 2022 Challenge on High Dynamic Range Imaging: Methods and Results

This paper reviews the challenge on constrained high dynamic range (HDR) imaging that was part of the New Trends in Image Restoration and Enhancement (NTIRE) workshop, held in conjunction with CVPR 2022. This manuscript focuses on the competition set-up, datasets, the proposed methods and their results. The challenge aims at estimating an HDR image from multiple respective low dynamic range (LDR) observations, which might suffer from under- or over-exposed regions and different sources of noise. The challenge is composed of two tracks with an emphasis on fidelity and complexity constraints: In Track 1, participants are asked to optimize objective fidelity scores while imposing a low-complexity constraint (i.e. solutions can not exceed a given number of operations). In Track 2, participants are asked to minimize the complexity of their solutions while imposing a constraint on fidelity scores (i.e. solutions are required to obtain a higher fidelity score than the prescribed baseline). Both tracks use the same data and metrics: Fidelity is measured by means of PSNR with respect to a ground-truth HDR image (computed both directly and with a canonical tonemapping operation), while complexity metrics include the number of Multiply-Accumulate (MAC) operations and runtime (in seconds).

Attention-based CNN-LSTM and XGBoost hybrid model for stock prediction

Stock market plays an important role in the economic development. Due to the complex volatility of the stock market, the research and prediction on the change of the stock price, can avoid the risk for the investors. The traditional time series model ARIMA can not describe the nonlinearity, and can not achieve satisfactory results in the stock prediction. As neural networks are with strong nonlinear generalization ability, this paper proposes an attention-based CNN-LSTM and XGBoost hybrid model to predict the stock price. The model constructed in this paper integrates the time series model, the Convolutional Neural Networks with Attention mechanism, the Long Short-Term Memory network, and XGBoost regressor in a non-linear relationship, and improves the prediction accuracy. The model can fully mine the historical information of the stock market in multiple periods. The stock data is first preprocessed through ARIMA. Then, the deep learning architecture formed in pretraining-finetuning framework is adopted. The pre-training model is the Attention-based CNN-LSTM model based on sequence-to-sequence framework. The model first uses convolution to extract the deep features of the original stock data, and then uses the Long Short-Term Memory networks to mine the long-term time series features. Finally, the XGBoost model is adopted for fine-tuning. The results show that the hybrid model is more effective and the prediction accuracy is relatively high, which can help investors or institutions to make decisions and achieve the purpose of expanding return and avoiding risk. Source code is available at https://github.com/zshicode/Attention-CLX-stock-prediction.