The best performance in the CARE 2025 -- Liver Task (LiSeg-Contrast): Contrast-Aware Semi-Supervised Segmentation with Domain Generalization and Test-Time Adaptation

Accurate liver segmentation from contrast-enhanced MRI is essential for diagnosis, treatment planning, and disease monitoring. However, it remains challenging due to limited annotated data, heterogeneous enhancement protocols, and significant domain shifts across scanners and institutions. Traditional image-to-image translation frameworks have made great progress in domain generalization, but their application is not straightforward. For example, Pix2Pix requires image registration, and cycle-GAN cannot be integrated seamlessly into segmentation pipelines. Meanwhile, these methods are originally used to deal with cross-modality scenarios, and often introduce structural distortions and suffer from unstable training, which may pose drawbacks in our single-modality scenario. To address these challenges, we propose CoSSeg-TTA, a compact segmentation framework for the GED4 (Gd-EOB-DTPA enhanced hepatobiliary phase MRI) modality built upon nnU-Netv2 and enhanced with a semi-supervised mean teacher scheme to exploit large amounts of unlabeled volumes. A domain adaptation module, incorporating a randomized histogram-based style appearance transfer function and a trainable contrast-aware network, enriches domain diversity and mitigates cross-center variability. Furthermore, a continual test-time adaptation strategy is employed to improve robustness during inference. Extensive experiments demonstrate that our framework consistently outperforms the nnU-Netv2 baseline, achieving superior Dice score and Hausdorff Distance while exhibiting strong generalization to unseen domains under low-annotation conditions.

Rethinking Alignment and Uniformity in Unsupervised Image Semantic Segmentation

Unsupervised image semantic segmentation(UISS) aims to match low-level visual features with semantic-level representations without outer supervision. In this paper, we address the critical properties from the view of feature alignments and feature uniformity for UISS models. We also make a comparison between UISS and image-wise representation learning. Based on the analysis, we argue that the existing MI-based methods in UISS suffer from representation collapse. By this, we proposed a robust network called Semantic Attention Network(SAN), in which a new module Semantic Attention(SEAT) is proposed to generate pixel-wise and semantic features dynamically. Experimental results on multiple semantic segmentation benchmarks show that our unsupervised segmentation framework specializes in catching semantic representations, which outperforms all the unpretrained and even several pretrained methods.