Protocol generalisation for brain tissue microstructure estimation via hypernetwork-controlled geometric deep learning

Brain tissue microstructure estimation with machine learning provides higher computational efficiency than conventional fitting. However, machine learning still presents important limitations that hamper its clinical utility. Specifically, current models typically lack generalisation across diffusion MRI acquisition protocols and require retraining whenever b-vectors or b-values change. Moreover, the recent machine learning methods that were developed to address protocol generalisation lack rotational equivariance. Particularly suitable for dMRI parameter estimation is a geometric deep learning model known as spherical convolutional neural network (SCNN), which guarantees rotational equivariance and b-vector generalisation. However, this architecture currently does not account for b-values. Therefore, obtaining a model that combines protocol generalisation and rotational equivariance remains an open challenge. In this paper, we directly address this issue by incorporating explicit b-value dependence into an SCNN architecture via a hypernetwork. This new approach is illustrated using NODDI as an example forward model for estimating brain tissue microstructure. To evaluate b-value generalisation, the original and newly proposed SCNN architectures are trained on synthetic data and tested on both synthetic and real data across different b-value pairs. Results demonstrate that the proposed method achieves reduced RMSE and bias on synthetic data, as well as higher agreement with conventional NODDI fitting on real data, indicating improved robustness to unseen b-values and a reduced need for retraining. By combining generalisation across b-values with generalisation across b-vectors and rotational equivariance, the proposed framework enhances the applicability of deep learning to clinical diffusion MRI parameter estimation. Code available at https://github.com/aerdnairo/arXiv\_generalisedSCNN.

UniCross: Unified Cross-Skill Dexterous Manipulation Synthesis

Many dexterous manipulation tasks require the object to remain securely held throughout the interaction. From the perspective of hand-object relational motion, such manipulation comprises four canonical skills: grasping, relocation, in-hand rotation, and in-hand translation. Human hands flexibly compose these skills to accomplish complex tasks. Existing approaches, however, model these skills separately with skill-specific action constraints, objectives, or even dedicated hand morphologies, which breaks the compatibility and continuity required for long-horizon composition. In this work, we present a unified framework that models all four skills in a single formulation that shares the same state and action spaces and a common objective structure. This formulation enables straightforward distillation of a single cross-skill policy that performs strongly on every skill, generalizes to unseen objects, stays robust to disturbances, and chains skills seamlessly into long-horizon manipulation. The framework also transfers effectively across different hand morphologies. Overall, our results suggest that different dexterous manipulation skills can be viewed as instantiations of a shared task formulation, revealing the intrinsic consistency across different behaviors.

Eddeep: a deep-learning framework for fast eddy-current distortion correction in diffusion MRI

Diffusion MRI (dMRI) relies on diffusion-weighted echo-planar imaging, which is highly susceptible to eddy-current-induced geometric distortions. These distortions vary across diffusion volumes according to gradient strength and direction, causing between-volume misalignment that can bias downstream microstructural analyses. Current state-of-the-art correction methods, such as FSL Eddy, achieve high-quality correction through iterative prediction-correction schemes but are computationally expensive. We propose Eddeep, a deep-learning framework for fast eddy-current distortion correction in dMRI. Eddeep decomposes the problem into two stages. First, a supervised image translation network standardises the appearance of diffusion-weighted and b=0 images, removing contrast differences that hinder reliable registration. Second, an unsupervised registration network estimates both eddy-current distortion and between-volume head motion parameters under a physics-constrained quadratic distortion model, enabling correction in a single forward pass. The method was trained on UK Biobank data and evaluated on both in-domain (UK Biobank) and out-of-domain (Memodyn) datasets. Across a range of complementary metrics, including between-volume jitter, diffusion kurtosis imaging residuals, signal irregularity, and mutual information, Eddeep achieved correction quality comparable to that of FSL Eddy while substantially reducing inference time. These results demonstrate that deep learning can provide accurate and efficient eddy-current distortion correction without relying on iterative optimisation, supporting the development of faster diffusion MRI processing pipelines for large-scale studies and clinical deployment. The code is available at: https://github.com/CIG-UCL/eddeep.

JoyNexus: Service-Oriented Multi-Tenant Post-Training for VLA Models

The post-training of Vision-Language-Action (VLA) models is essential due to the diversity of simulators, robot embodiments, and task objectives. Existing compute services, whether offered as direct accelerator rental or batch-workload submission, typically allocate an exclusive set of GPU and CPU resources to a single tenant. While this paradigm maximizes client flexibility, it burdens users with infrastructure adaptation, and the fixed card-hour accounting model renders short or bursty workloads both expensive for tenants and inefficient for the service provider. To address these challenges, we present JoyNexus, a unified service for multi-tenant VLA supervised fine-tuning, reinforcement learning, and evaluation. JoyNexus decouples the Training Model Service, Inference Model Service, and Environment Service, each accessed through APIs and backed by resident shared base models with tenant-specific slots. Tenants can directly invoke high-level semantic APIs for training, rollout, and evaluation, or compose custom algorithms using lower-level APIs and their assigned endpoints. Multiple tenants submit workloads concurrently; their action modules, optimizers, rollout records, and policy versions remain isolated, and the service is scheduled by the global Training Queue and Inference Queue. To further improve multi-tenant training efficiency, JoyNexus introduces group batching for heterogeneous VLA data schemas that share a compatible model-facing prefix, enabling a single shared backbone forward pass over grouped samples. Finally, we evaluate JoyNexus through workload simulation and a group-batching pipeline in a realistic embodied scenario. Results show that, compared with isolated single-tenant execution, JoyNexus reduces aggregate GPU time and improves service utilization via cross-tenant scheduling on shared resources.

PAKE: Learning Whole-Body Loco-Manipulation with Partial Kinematic Embeddings

Loco-manipulation has recently shown promising capabilities; however, achieving high-precision control, managing the high-dimensional action space induced by many degrees of freedom (DoFs), and fully exploiting the inherent redundancy of whole-body systems remain challenging. In this paper, we propose a novel whole-body control framework that effectively addresses these challenges by decomposing the complex loco-manipulation problem into partial reference motion generation and low-level imitation control. We introduce a new Kinematic Normalizing Flow (KNF) model, trained on a large-scale kinematic dataset, that generates diverse yet feasible partial reference motions. A high-level controller is then trained to navigate the KNF's latent space to exploit redundant solutions, while a low-level controller ensures physically feasible and accurate motion execution. We validate our approach on the quadrupedal robot equipped with a six-DoF robotic arm. In simulation, experimental results show that our approach significantly outperforms state-of-the-art methods in terms of tracking accuracy and feasible workspace coverage. For hardware deployment, we evaluate the system over 24 episodes across 8 different mobile loco-manipulation tasks. The system achieves end-effector pose-tracking errors of 4.5 cm and 0.14 rad, while maintaining accurate locomotion tracking with linear and angular velocity errors of 0.1 m/s and 0.01 rad/s, respectively, outperforming competitive baselines. Our method represents a practical and powerful solution for accurate and generalized whole-body loco-manipulation in high-DoF robotic systems, with promising potential for diverse downstream robotic tasks.

Align and Segment: Unsupervised Learning for Building Segmentation From Misaligned Labels

Supervised learning for image segmentation typically requires spatially aligned image and label sets. When images and labels originate from different sources, the pairing may be misaligned, which can significantly deteriorate the performance of the learned models. This is especially common in remote sensing, when aerial or satellite images are co-registered with labels from another source (e.g., OpenStreetMap). In this work, we propose a novel approach for training on misaligned labels, where we simultaneously learn the label alignment. Our align and segment (AnS) approach builds on the spatial transformer module to transform the misaligned labels using an affine transformation to provide a better learning target for a canonical semantic segmentation network. We prevent shortcut learning of misaligned labels in these semantic segmentation networks through a self-supervised regularization loss and show that it is complementary to data augmentation, especially for systematically misaligned training data. A decisive characteristic of our AnS approach is that it learns without requiring any golden labels. We experimentally show on both synthetic and real-world data from different cities that our approach enables high-quality building segmentation and precise label-image alignment at the same time. Code and derived datasets are available at https://github.com/venkanna37/align-and-segment

Unpaired Joint Distribution Modeling via Multi-Scale Image Representations

This paper studies the problem of learning a joint distribution from marginal observations, which is inherently ill-posed due to the ambiguity of feasible couplings. We propose LUD-MSR, a latent-variable probabilistic framework that models the joint distribution via auxiliary representations and optimizes evidence lower bounds using only marginal data. Under mild assumptions, we establish an upper bound on the distribution approximation error. This analysis reveals a trade-off in representation learning between domain consistency and information preservation. To address this trade-off, we introduce a Multi-Scale image Representation (MSR) mapping that exploits structural similarity at coarse scales while suppressing domain-specific variations. We show that MSR achieves a more favorable balance of this trade-off compared to existing approaches. Experiments on real-world denoising benchmarks, including cryo-electron microscopy (cryo-EM), demonstrate the effectiveness of the proposed framework.

Building a Scalable, Reproducible, Evaluatable, and Closed-Loop Simulation Environment Foundation for Embodied Intelligence

This paper presents a cloud-native simulation infrastructure framework for embodied intelligence that supports large-scale training, standardized evaluation, and simulation-based data collection. The framework unifies simulation environment generation, task execution, trajectory collection, model evaluation, data management, and cloud services into a scalable and reproducible platform. To address the high cost, limited scalability, and poor reproducibility of real-world robotic data collection, the framework adopts cloud-native technologies including elastic resource scheduling, containerized simulation, unified data management, and service-oriented system design, enabling efficient large-scale simulation for multi-model and multi-task workloads. Built on a four-layer architecture, the framework provides standardized environment assets, automated task generation, trajectory collection, benchmark evaluation, and closed-loop data optimization. It further integrates representative systems including D-VLA, RL-VLA3, Sword, and Pre-VLA to support scalable simulation, dynamic scheduling, visual augmentation, and real-time data filtering. We argue that cloud-native simulation infrastructure provides a unified foundation for data generation, model training, standardized evaluation, and real-world deployment, and will play a key role in the future development of embodied intelligence.

A Synthetic-Driven Vision System for Assembly Step Recognition

Quality control in industrial assembly is essential, and real-time monitoring of the assembly process is crucial for preventing costly defects and ensuring production reliability. Vision-based automated inspection offers a powerful solution for such real-time monitoring. However, due to the specialized industrial components and processes, training these models typically relies on task-specific real-world data, which is costly and labor-intensive to collect and annotate. In this paper, we propose a system that automatically generates realistic assembly sequences and further trains real-time inspection models using the synthetic data. It can be efficiently applied to a given task within an hour, requiring only CAD models and simple step descriptions. Focusing on practical challenges, our system integrates a physics-based motion generation module to capture the variance of different human assembly, designs domain-randomized rendering to deal with the environmental complexity and variation, and employs an object-detection-based step recognition module for robust sim-to-real transfer, leading to 92.4% accuracy on a real-world assembly case with 46.7%, 15.8% and 61.2% performance improvement, respectively. Overall, our system provides a practical solution for industrial assembly inspection without requiring expensive real-world data collection and annotation, with the effectiveness validated on real industrial assembly tasks.

MedEvoEval: Evaluating Continual Evolution of Doctor Agents through Simulated Clinical Episodes

Doctor agents are moving beyond single-turn answer generation toward evolving clinical decision systems. Within an outpatient episode, they acquire evidence, use examination and consultation resources, and decide when to finalize a diagnosis and management plan. Across episodes, their behavior may change through memory, retrieval, reflection, or other update mechanisms. Current evaluations only partially cover this setting. Fixed-input medical QA benchmarks score final answers from complete inputs, whereas many interactive benchmarks still focus on individual encounters or fixed runs, providing limited support for evaluating how episode-level decisions interact with cross-episode experience. We introduce MedEvoEval, an executable longitudinal evaluation framework based on action-gated simulated outpatient episodes. Each source case is converted into role-specific patient, examination, and manager views; evidence is revealed only through valid actions; and each episode records a structured trace that links observations, actions, final outputs, manager scores, and optional experience write-back. We release a runnable E&D artifact with 700 processed episodes, provenance notes, schemas, an episode runner, scoring scripts, configurations, example logs, analysis code, and trajectory- and step-level derivatives. Experiments show that episode traces expose process costs hidden by final-answer scoring, show how MDT-style consultation reallocates resources, and support longitudinal analyses of memory maturation, held-out transfer, update-stage response, and backward retention. Together, these results show that MedEvoEval provides a concrete basis for evaluating whether doctor agents improve through experience, transfer useful behavior, and retain earlier capabilities over time.