A Self-Evolving Agentic System for Automated Generation and Execution of Biological Protocols

Autonomous wet-lab experimentation requires more than plausible protocol text: biological intent, quantitative procedures, device constraints and experimental feedback must remain aligned from protocol and SOP design to code and physical execution. We developed ProtoPilot, a self-evolving multi-agent system, together with an expert-grounded benchmark and evaluation framework for testing this conversion as an experimental automation problem. The framework spans 294 synthetic-biology and molecular-biology tasks derived from 98 gold-standard protocols, wet-lab expert rubrics, device-level validity gates and real experimental tests. ProtoPilot incorporates layer-wise verifiability, multi-agent orchestration and a runtime-updated skill library to generate protocols, expand SOPs, synthesize SDK-compliant code and revise workflows from wet-lab feedback. It achieved a Top@3 expert-preference rate of 90.2%, an overall protocol-to-code gate pass rate of 89.5% and an Opentrons pass rate of 88.24%, compared with 32.35% for OpenTrons-AI. Wet-lab validation produced interpretable readouts, Sanger-confirmed products and feedback-corrected PCA-assembled DNA targets, establishing a verifiable route to autonomous experimentation. Together, these results show that the evaluation framework captures execution-relevant requirements for autonomous wet-lab automation, and that ProtoPilot can meet them by converting protocol and code generation into validated execution and feedback-guided revision.

SyncCache: Exploiting Asymmetric Dynamics for Fast Audio-Driven Portrait Animation

Diffusion Transformers (DiTs) have significantly advanced audio-driven portrait animation, but their high computational cost leads to substantial inference latency. Although training-free diffusion caching accelerates inference significant, existing methods are primarily developed for text-conditioned generation and overlook the spatial and modality imbalances inherent in audio-driven portrait animation. In this paper, we propose SyncCache, a training-free caching acceleration method tailored for DiT-based portrait animation that explicitly exploits asymmetric dynamics. Specifically, high-frequency dynamics driven by audio conditions and concentrated in human regions are more challenging and critical to cache and reuse than the low-frequency visual background in portrait animation. First, we introduce Spatially-Asymmetric Probing to prioritize error sensitivity in dynamic human region. Second, through Modality-Decoupled Caching, we bypass heavy DiT block by reusing stable inter-block residuals, while continuously recomputing lightweight audio blocks to preserve precise lip synchronization. Furthermore, we introduce a cache ratio to control cache capacity and formulate memory-adaptive cache selection as an offline dynamic programming problem without online overhead. Extensive experiments demonstrate that SyncCache achieves superior speed-quality trade-offs, delivering up to 4.12x acceleration on HunyuanVideo-Avatar and 3.75x on Wan-S2V with near-lossless visual fidelity and precise audio alignment.

MBench: A Comprehensive Benchmark on Memory Capability for Video World Models

Recent advancements in video-based world models have demonstrated an unprecedented ability to synthesize high-fidelity visual sequences. However, a fundamental gap persists between visually plausible video generation and the functional requirements of a world model, particularly in maintaining a stable and reasonable internal state over extended temporal horizons. While existing benchmarks primarily emphasize visual quality, motion coherence, and text-video alignment, they largely overlook memory, the core capability of a world model to preserve consistency across long-term horizons and complex interactions. To address this gap, we present \textbf{MBench}, a comprehensive benchmark dedicated to quantifying and evaluating the memory capability of video world models. We systematically decompose the memory capability of video world models into three hierarchical and complementary core dimensions: entity consistency, environment consistency, and causal consistency, which are further refined into 12 quantifiable sub-dimensions for comprehensive characterization of long-term memory. Our benchmark is built upon rigorously curated real-captured long videos, and evaluated by rule-based quantitative matrices and VLM to enable objective and comprehensive consistency assessment. Extensive evaluations of mainstream state-of-the-art video world models reveal critical systemic limitations of existing methods in long-term state retention, providing a standardized benchmark and clear research direction to advance the field.

Enhancing Spatial Understanding in Image Generation via Reward Modeling

Recent progress in text-to-image generation has greatly advanced visual fidelity and creativity, but it has also imposed higher demands on prompt complexity-particularly in encoding intricate spatial relationships. In such cases, achieving satisfactory results often requires multiple sampling attempts. To address this challenge, we introduce a novel method that strengthens the spatial understanding of current image generation models. We first construct the SpatialReward-Dataset with over 80k preference pairs. Building on this dataset, we build SpatialScore, a reward model designed to evaluate the accuracy of spatial relationships in text-to-image generation, achieving performance that even surpasses leading proprietary models on spatial evaluation. We further demonstrate that this reward model effectively enables online reinforcement learning for the complex spatial generation. Extensive experiments across multiple benchmarks show that our specialized reward model yields significant and consistent gains in spatial understanding for image generation.

Scaling Speech Tokenizers with Diffusion Autoencoders

Speech tokenizers are foundational to speech language models, yet existing approaches face two major challenges: (1) balancing trade-offs between encoding semantics for understanding and acoustics for reconstruction, and (2) achieving low bit rates and low token rates. We propose Speech Diffusion Tokenizer (SiTok), a diffusion autoencoder that jointly learns semantic-rich representations through supervised learning and enables high-fidelity audio reconstruction with diffusion. We scale SiTok to 1.6B parameters and train it on 2 million hours of speech. Experiments show that SiTok outperforms strong baselines on understanding, reconstruction and generation tasks, at an extremely low token rate of $12.5$ Hz and a bit-rate of 200 bits-per-second.

The Llama 4 Herd: Architecture, Training, Evaluation, and Deployment Notes

This document consolidates publicly reported technical details about Metas Llama 4 model family. It summarizes (i) released variants (Scout and Maverick) and the broader herd context including the previewed Behemoth teacher model, (ii) architectural characteristics beyond a high-level MoE description covering routed/shared-expert structure, early-fusion multimodality, and long-context design elements reported for Scout (iRoPE and length generalization strategies), (iii) training disclosures spanning pre-training, mid-training for long-context extension, and post-training methodology (lightweight SFT, online RL, and lightweight DPO) as described in release materials, (iv) developer-reported benchmark results for both base and instruction-tuned checkpoints, and (v) practical deployment constraints observed across major serving environments, including provider-specific context limits and quantization packaging. The manuscript also summarizes licensing obligations relevant to redistribution and derivative naming, and reviews publicly described safeguards and evaluation practices. The goal is to provide a compact technical reference for researchers and practitioners who need precise, source-backed facts about Llama 4.

SCP: Accelerating Discovery with a Global Web of Autonomous Scientific Agents

We introduce SCP: the Science Context Protocol, an open-source standard designed to accelerate discovery by enabling a global network of autonomous scientific agents. SCP is built on two foundational pillars: (1) Unified Resource Integration: At its core, SCP provides a universal specification for describing and invoking scientific resources, spanning software tools, models, datasets, and physical instruments. This protocol-level standardization enables AI agents and applications to discover, call, and compose capabilities seamlessly across disparate platforms and institutional boundaries. (2) Orchestrated Experiment Lifecycle Management: SCP complements the protocol with a secure service architecture, which comprises a centralized SCP Hub and federated SCP Servers. This architecture manages the complete experiment lifecycle (registration, planning, execution, monitoring, and archival), enforces fine-grained authentication and authorization, and orchestrates traceable, end-to-end workflows that bridge computational and physical laboratories. Based on SCP, we have constructed a scientific discovery platform that offers researchers and agents a large-scale ecosystem of more than 1,600 tool resources. Across diverse use cases, SCP facilitates secure, large-scale collaboration between heterogeneous AI systems and human researchers while significantly reducing integration overhead and enhancing reproducibility. By standardizing scientific context and tool orchestration at the protocol level, SCP establishes essential infrastructure for scalable, multi-institution, agent-driven science.

InvCoSS: Inversion-driven Continual Self-supervised Learning in Medical Multi-modal Image Pre-training

Continual self-supervised learning (CSSL) in medical imaging trains a foundation model sequentially, alleviating the need for collecting multi-modal images for joint training and offering promising improvements in downstream performance while preserving data privacy. However, most existing methods still rely on replaying data from previous stages to prevent catastrophic forgetting, which compromises privacy and limits their applicability in real-world scenarios where data transfer across sites is often restricted. In this work, we propose InvCoSS, an inversion-driven continual self-supervised learning framework for medical multi-modal image pre-training. Specifically, after training on a previous task, InvCoSS inverts the pre-trained self-supervised model to generate synthetic images that approximate the original training distribution. These synthetic images are then combined with data from the new task for joint optimization, which effectively mitigates catastrophic forgetting while strictly adhering to the constraint of no access to previous real data. Furthermore, to improve the fidelity of synthetic images, we introduce a novel InvUNet with a multi-scale fusion architecture to restore both high- and low-frequency components of the inverted images. To enhance diversity and prevent mode collapse, we design a repulsive representation-learning mechanism that encourages a diverse feature space for synthetic images without class guidance. Extensive experiments across nine downstream tasks validate the effectiveness of InvCoSS, achieving performance comparable to or even superior to prior data-replay methods while significantly reducing storage requirements and eliminating data privacy constraints.

E-4DGS: High-Fidelity Dynamic Reconstruction from the Multi-view Event Cameras

Novel view synthesis and 4D reconstruction techniques predominantly rely on RGB cameras, thereby inheriting inherent limitations such as the dependence on adequate lighting, susceptibility to motion blur, and a limited dynamic range. Event cameras, offering advantages of low power, high temporal resolution and high dynamic range, have brought a new perspective to addressing the scene reconstruction challenges in high-speed motion and low-light scenes. To this end, we propose E-4DGS, the first event-driven dynamic Gaussian Splatting approach, for novel view synthesis from multi-view event streams with fast-moving cameras. Specifically, we introduce an event-based initialization scheme to ensure stable training and propose event-adaptive slicing splatting for time-aware reconstruction. Additionally, we employ intensity importance pruning to eliminate floating artifacts and enhance 3D consistency, while incorporating an adaptive contrast threshold for more precise optimization. We design a synthetic multi-view camera setup with six moving event cameras surrounding the object in a 360-degree configuration and provide a benchmark multi-view event stream dataset that captures challenging motion scenarios. Our approach outperforms both event-only and event-RGB fusion baselines and paves the way for the exploration of multi-view event-based reconstruction as a novel approach for rapid scene capture.

GS2E: Gaussian Splatting is an Effective Data Generator for Event Stream Generation

We introduce GS2E (Gaussian Splatting to Event), a large-scale synthetic event dataset for high-fidelity event vision tasks, captured from real-world sparse multi-view RGB images. Existing event datasets are often synthesized from dense RGB videos, which typically lack viewpoint diversity and geometric consistency, or depend on expensive, difficult-to-scale hardware setups. GS2E overcomes these limitations by first reconstructing photorealistic static scenes using 3D Gaussian Splatting, and subsequently employing a novel, physically-informed event simulation pipeline. This pipeline generally integrates adaptive trajectory interpolation with physically-consistent event contrast threshold modeling. Such an approach yields temporally dense and geometrically consistent event streams under diverse motion and lighting conditions, while ensuring strong alignment with underlying scene structures. Experimental results on event-based 3D reconstruction demonstrate GS2E's superior generalization capabilities and its practical value as a benchmark for advancing event vision research.