Single-Image-Based Deep Learning for Segmentation of Early Esophageal Cancer Lesions

Accurate segmentation of lesions is crucial for diagnosis and treatment of early esophageal cancer (EEC). However, neither traditional nor deep learning-based methods up to today can meet the clinical requirements, with the mean Dice score - the most important metric in medical image analysis - hardly exceeding 0.75. In this paper, we present a novel deep learning approach for segmenting EEC lesions. Our approach stands out for its uniqueness, as it relies solely on a single image coming from one patient, forming the so-called "You-Only-Have-One" (YOHO) framework. On one hand, this "one-image-one-network" learning ensures complete patient privacy as it does not use any images from other patients as the training data. On the other hand, it avoids nearly all generalization-related problems since each trained network is applied only to the input image itself. In particular, we can push the training to "over-fitting" as much as possible to increase the segmentation accuracy. Our technical details include an interaction with clinical physicians to utilize their expertise, a geometry-based rendering of a single lesion image to generate the training set (the \emph{biggest} novelty), and an edge-enhanced UNet. We have evaluated YOHO over an EEC data-set created by ourselves and achieved a mean Dice score of 0.888, which represents a significant advance toward clinical applications.

Securing Deep Generative Models with Universal Adversarial Signature

Recent advances in deep generative models have led to the development of methods capable of synthesizing high-quality, realistic images. These models pose threats to society due to their potential misuse. Prior research attempted to mitigate these threats by detecting generated images, but the varying traces left by different generative models make it challenging to create a universal detector capable of generalizing to new, unseen generative models. In this paper, we propose to inject a universal adversarial signature into an arbitrary pre-trained generative model, in order to make its generated contents more detectable and traceable. First, the imperceptible optimal signature for each image can be found by a signature injector through adversarial training. Subsequently, the signature can be incorporated into an arbitrary generator by fine-tuning it with the images processed by the signature injector. In this way, the detector corresponding to the signature can be reused for any fine-tuned generator for tracking the generator identity. The proposed method is validated on the FFHQ and ImageNet datasets with various state-of-the-art generative models, consistently showing a promising detection rate. Code will be made publicly available at \url{https://github.com/zengxianyu/genwm}.

SceneComposer: Any-Level Semantic Image Synthesis

We propose a new framework for conditional image synthesis from semantic layouts of any precision levels, ranging from pure text to a 2D semantic canvas with precise shapes. More specifically, the input layout consists of one or more semantic regions with free-form text descriptions and adjustable precision levels, which can be set based on the desired controllability. The framework naturally reduces to text-to-image (T2I) at the lowest level with no shape information, and it becomes segmentation-to-image (S2I) at the highest level. By supporting the levels in-between, our framework is flexible in assisting users of different drawing expertise and at different stages of their creative workflow. We introduce several novel techniques to address the challenges coming with this new setup, including a pipeline for collecting training data; a precision-encoded mask pyramid and a text feature map representation to jointly encode precision level, semantics, and composition information; and a multi-scale guided diffusion model to synthesize images. To evaluate the proposed method, we collect a test dataset containing user-drawn layouts with diverse scenes and styles. Experimental results show that the proposed method can generate high-quality images following the layout at given precision, and compares favorably against existing methods. Project page \url{https://zengxianyu.github.io/scenec/}

Shape-guided Object Inpainting

Previous works on image inpainting mainly focus on inpainting background or partially missing objects, while the problem of inpainting an entire missing object remains unexplored. This work studies a new image inpainting task, i.e. shape-guided object inpainting. Given an incomplete input image, the goal is to fill in the hole by generating an object based on the context and implicit guidance given by the hole shape. Since previous methods for image inpainting are mainly designed for background inpainting, they are not suitable for this task. Therefore, we propose a new data preparation method and a novel Contextual Object Generator (CogNet) for the object inpainting task. On the data side, we incorporate object priors into training data by using object instances as holes. The CogNet has a two-stream architecture that combines the standard bottom-up image completion process with a top-down object generation process. A predictive class embedding module bridges the two streams by predicting the class of the missing object from the bottom-up features, from which a semantic object map is derived as the input of the top-down stream. Experiments demonstrate that the proposed method can generate realistic objects that fit the context in terms of both visual appearance and semantic meanings. Code can be found at the project page \url{https://zengxianyu.github.io/objpaint}

SketchEdit: Mask-Free Local Image Manipulation with Partial Sketches

Sketch-based image manipulation is an interactive image editing task to modify an image based on input sketches from users. Existing methods typically formulate this task as a conditional inpainting problem, which requires users to draw an extra mask indicating the region to modify in addition to sketches. The masked regions are regarded as holes and filled by an inpainting model conditioned on the sketch. With this formulation, paired training data can be easily obtained by randomly creating masks and extracting edges or contours. Although this setup simplifies data preparation and model design, it complicates user interaction and discards useful information in masked regions. To this end, we investigate a new paradigm of sketch-based image manipulation: mask-free local image manipulation, which only requires sketch inputs from users and utilizes the entire original image. Given an image and sketch, our model automatically predicts the target modification region and encodes it into a structure agnostic style vector. A generator then synthesizes the new image content based on the style vector and sketch. The manipulated image is finally produced by blending the generator output into the modification region of the original image. Our model can be trained in a self-supervised fashion by learning the reconstruction of an image region from the style vector and sketch. The proposed method offers simpler and more intuitive user workflows for sketch-based image manipulation and provides better results than previous approaches. More results, code and interactive demo will be available at \url{https://zengxianyu.github.io/sketchedit}.

Advancing COVID-19 Diagnosis with Privacy-Preserving Collaboration in Artificial Intelligence

Artificial intelligence (AI) provides a promising substitution for streamlining COVID-19 diagnoses. However, concerns surrounding security and trustworthiness impede the collection of large-scale representative medical data, posing a considerable challenge for training a well-generalised model in clinical practices. To address this, we launch the Unified CT-COVID AI Diagnostic Initiative (UCADI), where the AI model can be distributedly trained and independently executed at each host institution under a federated learning framework (FL) without data sharing. Here we show that our FL model outperformed all the local models by a large yield (test sensitivity /specificity in China: 0.973/0.951, in the UK: 0.730/0.942), achieving comparable performance with a panel of professional radiologists. We further evaluated the model on the hold-out (collected from another two hospitals leaving out the FL) and heterogeneous (acquired with contrast materials) data, provided visual explanations for decisions made by the model, and analysed the trade-offs between the model performance and the communication costs in the federated training process. Our study is based on 9,573 chest computed tomography scans (CTs) from 3,336 patients collected from 23 hospitals located in China and the UK. Collectively, our work advanced the prospects of utilising federated learning for privacy-preserving AI in digital health.

Image Inpainting with Contextual Reconstruction Loss

Convolutional neural networks (CNNs) have been observed to be inefficient in propagating information across distant spatial positions in images. Recent studies in image inpainting attempt to overcome this issue by explicitly searching reference regions throughout the entire image to fill the features from reference regions in the missing regions. This operation can be implemented as contextual attention layer (CA layer) \cite{yu2018generative}, which has been widely used in many deep learning-based methods. However, it brings significant computational overhead as it computes the pair-wise similarity of feature patches at every spatial position. Also, it often fails to find proper reference regions due to the lack of supervision in terms of the correspondence between missing regions and known regions. We propose a novel contextual reconstruction loss (CR loss) to solve these problems. First, a criterion of searching reference region is designed based on minimizing reconstruction and adversarial losses corresponding to the searched reference and the ground-truth image. Second, unlike previous approaches which integrate the computationally heavy patch searching and replacement operation in the inpainting model, CR loss encourages a vanilla CNN to simulate this behavior during training, thus no extra computations are required during inference. Experimental results demonstrate that the proposed inpainting model with the CR loss compares favourably against the state-of-the-arts in terms of quantitative and visual performance. Code is available at \url{https://github.com/zengxianyu/crfill}.

High-Resolution Image Inpainting with Iterative Confidence Feedback and Guided Upsampling

Existing image inpainting methods often produce artifacts when dealing with large holes in real applications. To address this challenge, we propose an iterative inpainting method with a feedback mechanism. Specifically, we introduce a deep generative model which not only outputs an inpainting result but also a corresponding confidence map. Using this map as feedback, it progressively fills the hole by trusting only high-confidence pixels inside the hole at each iteration and focuses on the remaining pixels in the next iteration. As it reuses partial predictions from the previous iterations as known pixels, this process gradually improves the result. In addition, we propose a guided upsampling network to enable generation of high-resolution inpainting results. We achieve this by extending the Contextual Attention module [1] to borrow high-resolution feature patches in the input image. Furthermore, to mimic real object removal scenarios, we collect a large object mask dataset and synthesize more realistic training data that better simulates user inputs. Experiments show that our method significantly outperforms existing methods in both quantitative and qualitative evaluations. More results and Web APP are available at https://zengxianyu.github.io/iic.

Joint Learning of Saliency Detection and Weakly Supervised Semantic Segmentation

Existing weakly supervised semantic segmentation (WSSS) methods usually utilize the results of pre-trained saliency detection (SD) models without explicitly modeling the connections between the two tasks, which is not the most efficient configuration. Here we propose a unified multi-task learning framework to jointly solve WSSS and SD using a single network, \ie saliency, and segmentation network (SSNet). SSNet consists of a segmentation network (SN) and a saliency aggregation module (SAM). For an input image, SN generates the segmentation result and, SAM predicts the saliency of each category and aggregating the segmentation masks of all categories into a saliency map. The proposed network is trained end-to-end with image-level category labels and class-agnostic pixel-level saliency labels. Experiments on PASCAL VOC 2012 segmentation dataset and four saliency benchmark datasets show the performance of our method compares favorably against state-of-the-art weakly supervised segmentation methods and fully supervised saliency detection methods.

Multi-source weak supervision for saliency detection

The high cost of pixel-level annotations makes it appealing to train saliency detection models with weak supervision. However, a single weak supervision source usually does not contain enough information to train a well-performing model. To this end, we propose a unified framework to train saliency detection models with diverse weak supervision sources. In this paper, we use category labels, captions, and unlabelled data for training, yet other supervision sources can also be plugged into this flexible framework. We design a classification network (CNet) and a caption generation network (PNet), which learn to predict object categories and generate captions, respectively, meanwhile highlight the most important regions for corresponding tasks. An attention transfer loss is designed to transmit supervision signal between networks, such that the network designed to be trained with one supervision source can benefit from another. An attention coherence loss is defined on unlabelled data to encourage the networks to detect generally salient regions instead of task-specific regions. We use CNet and PNet to generate pixel-level pseudo labels to train a saliency prediction network (SNet). During the testing phases, we only need SNet to predict saliency maps. Experiments demonstrate the performance of our method compares favourably against unsupervised and weakly supervised methods and even some supervised methods.