On the Fly Robotic-Assisted Medical Instrument Planning and Execution Using Mixed Reality

Robotic-assisted medical systems (RAMS) have gained significant attention for their advantages in alleviating surgeons' fatigue and improving patients' outcomes. These systems comprise a range of human-computer interactions, including medical scene monitoring, anatomical target planning, and robot manipulation. However, despite its versatility and effectiveness, RAMS demands expertise in robotics, leading to a high learning cost for the operator. In this work, we introduce a novel framework using mixed reality technologies to ease the use of RAMS. The proposed framework achieves real-time planning and execution of medical instruments by providing 3D anatomical image overlay, human-robot collision detection, and robot programming interface. These features, integrated with an easy-to-use calibration method for head-mounted display, improve the effectiveness of human-robot interactions. To assess the feasibility of the framework, two medical applications are presented in this work: 1) coil placement during transcranial magnetic stimulation and 2) drill and injector device positioning during femoroplasty. Results from these use cases demonstrate its potential to extend to a wider range of medical scenarios.

GBEC: Geometry-Based Hand-Eye Calibration

Hand-eye calibration is the problem of solving the transformation from the end-effector of a robot to the sensor attached to it. Commonly employed techniques, such as AXXB or AXZB formulations, rely on regression methods that require collecting pose data from different robot configurations, which can produce low accuracy and repeatability. However, the derived transformation should solely depend on the geometry of the end-effector and the sensor attachment. We propose Geometry-Based End-Effector Calibration (GBEC) that enhances the repeatability and accuracy of the derived transformation compared to traditional hand-eye calibrations. To demonstrate improvements, we apply the approach to two different robot-assisted procedures: Transcranial Magnetic Stimulation (TMS) and femoroplasty. We also discuss the generalizability of GBEC for camera-in-hand and marker-in-hand sensor mounting methods. In the experiments, we perform GBEC between the robot end-effector and an optical tracker's rigid body marker attached to the TMS coil or femoroplasty drill guide. Previous research documents low repeatability and accuracy of the conventional methods for robot-assisted TMS hand-eye calibration. When compared to some existing methods, the proposed method relies solely on the geometry of the flange and the pose of the rigid-body marker, making it independent of workspace constraints or robot accuracy, without sacrificing the orthogonality of the rotation matrix. Our results validate the accuracy and applicability of the approach, providing a new and generalizable methodology for obtaining the transformation from the end-effector to a sensor.

Segment Any Medical Model Extended

The Segment Anything Model (SAM) has drawn significant attention from researchers who work on medical image segmentation because of its generalizability. However, researchers have found that SAM may have limited performance on medical images compared to state-of-the-art non-foundation models. Regardless, the community sees potential in extending, fine-tuning, modifying, and evaluating SAM for analysis of medical imaging. An increasing number of works have been published focusing on the mentioned four directions, where variants of SAM are proposed. To this end, a unified platform helps push the boundary of the foundation model for medical images, facilitating the use, modification, and validation of SAM and its variants in medical image segmentation. In this work, we introduce SAMM Extended (SAMME), a platform that integrates new SAM variant models, adopts faster communication protocols, accommodates new interactive modes, and allows for fine-tuning of subcomponents of the models. These features can expand the potential of foundation models like SAM, and the results can be translated to applications such as image-guided therapy, mixed reality interaction, robotic navigation, and data augmentation.

Realtime Robust Shape Estimation of Deformable Linear Object

Realtime shape estimation of continuum objects and manipulators is essential for developing accurate planning and control paradigms. The existing methods that create dense point clouds from camera images, and/or use distinguishable markers on a deformable body have limitations in realtime tracking of large continuum objects/manipulators. The physical occlusion of markers can often compromise accurate shape estimation. We propose a robust method to estimate the shape of linear deformable objects in realtime using scattered and unordered key points. By utilizing a robust probability-based labeling algorithm, our approach identifies the true order of the detected key points and then reconstructs the shape using piecewise spline interpolation. The approach only relies on knowing the number of the key points and the interval between two neighboring points. We demonstrate the robustness of the method when key points are partially occluded. The proposed method is also integrated into a simulation in Unity for tracking the shape of a cable with a length of 1m and a radius of 5mm. The simulation results show that our proposed approach achieves an average length error of 1.07% over the continuum's centerline and an average cross-section error of 2.11mm. The real-world experiments of tracking and estimating a heavy-load cable prove that the proposed approach is robust under occlusion and complex entanglement scenarios.

A Roadmap Towards Automated and Regulated Robotic Systems

The rapid development of generative technology opens up possibility for higher level of automation, and artificial intelligence (AI) embodiment in robotic systems is imminent. However, due to the blackbox nature of the generative technology, the generation of the knowledge and workflow scheme is uncontrolled, especially in a dynamic environment and a complex scene. This poses challenges to regulations in safety-demanding applications such as medical scenes. We argue that the unregulated generative processes from AI is fitted for low level end tasks, but intervention in the form of manual or automated regulation should happen post-workflow-generation and pre-robotic-execution. To address this, we propose a roadmap that can lead to fully automated and regulated robotic systems. In this paradigm, the high level policies are generated as structured graph data, enabling regulatory oversight and reusability, while the code base for lower level tasks is generated by generative models. Our approach aims the transitioning from expert knowledge to regulated action, akin to the iterative processes of study, practice, scrutiny, and execution in human tasks. We identify the generative and deterministic processes in a design cycle, where generative processes serve as a text-based world simulator and the deterministic processes generate the executable system. We propose State Machine Seralization Language (SMSL) to be the conversion point between text simulator and executable workflow control. From there, we analyze the modules involved based on the current literature, and discuss human in the loop. As a roadmap, this work identifies the current possible implementation and future work. This work does not provide an implemented system but envisions to inspire the researchers working on the direction in the roadmap. We implement the SMSL and D-SFO paradigm that serve as the starting point of the roadmap.

SM4Depth: Seamless Monocular Metric Depth Estimation across Multiple Cameras and Scenes by One Model

The generalization of monocular metric depth estimation (MMDE) has been a longstanding challenge. Recent methods made progress by combining relative and metric depth or aligning input image focal length. However, they are still beset by challenges in camera, scene, and data levels: (1) Sensitivity to different cameras; (2) Inconsistent accuracy across scenes; (3) Reliance on massive training data. This paper proposes SM4Depth, a seamless MMDE method, to address all the issues above within a single network. First, we reveal that a consistent field of view (FOV) is the key to resolve ``metric ambiguity'' across cameras, which guides us to propose a more straightforward preprocessing unit. Second, to achieve consistently high accuracy across scenes, we explicitly model the metric scale determination as discretizing the depth interval into bins and propose variation-based unnormalized depth bins. This method bridges the depth gap of diverse scenes by reducing the ambiguity of the conventional metric bin. Third, to reduce the reliance on massive training data, we propose a ``divide and conquer" solution. Instead of estimating directly from the vast solution space, the correct metric bins are estimated from multiple solution sub-spaces for complexity reduction. Finally, with just 150K RGB-D pairs and a consumer-grade GPU for training, SM4Depth achieves state-of-the-art performance on most previously unseen datasets, especially surpassing ZoeDepth and Metric3D on mRI$_\theta$. The code can be found at https://github.com/1hao-Liu/SM4Depth.

From Registration Uncertainty to Segmentation Uncertainty

Understanding the uncertainty inherent in deep learning-based image registration models has been an ongoing area of research. Existing methods have been developed to quantify both transformation and appearance uncertainties related to the registration process, elucidating areas where the model may exhibit ambiguity regarding the generated deformation. However, our study reveals that neither uncertainty effectively estimates the potential errors when the registration model is used for label propagation. Here, we propose a novel framework to concurrently estimate both the epistemic and aleatoric segmentation uncertainties for image registration. To this end, we implement a compact deep neural network (DNN) designed to transform the appearance discrepancy in the warping into aleatoric segmentation uncertainty by minimizing a negative log-likelihood loss function. Furthermore, we present epistemic segmentation uncertainty within the label propagation process as the entropy of the propagated labels. By introducing segmentation uncertainty along with existing methods for estimating registration uncertainty, we offer vital insights into the potential uncertainties at different stages of image registration. We validated our proposed framework using publicly available datasets, and the results prove that the segmentation uncertainties estimated with the proposed method correlate well with errors in label propagation, all while achieving superior registration performance.

Revisiting registration-based synthesis: A focus on unsupervised MR image synthesis

Deep learning (DL) has led to significant improvements in medical image synthesis, enabling advanced image-to-image translation to generate synthetic images. However, DL methods face challenges such as domain shift and high demands for training data, limiting their generalizability and applicability. Historically, image synthesis was also carried out using deformable image registration (DIR), a method that warps moving images of a desired modality to match the anatomy of a fixed image. However, concerns about its speed and accuracy led to its decline in popularity. With the recent advances of DL-based DIR, we now revisit and reinvigorate this line of research. In this paper, we propose a fast and accurate synthesis method based on DIR. We use the task of synthesizing a rare magnetic resonance (MR) sequence, white matter nulled (WMn) T1-weighted (T1-w) images, to demonstrate the potential of our approach. During training, our method learns a DIR model based on the widely available MPRAGE sequence, which is a cerebrospinal fluid nulled (CSFn) T1-w inversion recovery gradient echo pulse sequence. During testing, the trained DIR model is first applied to estimate the deformation between moving and fixed CSFn images. Subsequently, this estimated deformation is applied to align the paired WMn counterpart of the moving CSFn image, yielding a synthetic WMn image for the fixed CSFn image. Our experiments demonstrate promising results for unsupervised image synthesis using DIR. These findings highlight the potential of our technique in contexts where supervised synthesis methods are constrained by limited training data.

Learning to See Low-Light Images via Feature Domain Adaptation

Raw low light image enhancement (LLIE) has achieved much better performance than the sRGB domain enhancement methods due to the merits of raw data. However, the ambiguity between noisy to clean and raw to sRGB mappings may mislead the single-stage enhancement networks. The two-stage networks avoid ambiguity by decoupling the two mappings but usually have large computing complexity. To solve this problem, we propose a single-stage network empowered by Feature Domain Adaptation (FDA) to decouple the denoising and color mapping tasks in raw LLIE. The denoising encoder is supervised by the clean raw image, and then the denoised features are adapted for the color mapping task by an FDA module. We propose a Lineformer to serve as the FDA, which can well explore the global and local correlations with fewer line buffers (friendly to the line-based imaging process). During inference, the raw supervision branch is removed. In this way, our network combines the advantage of a two-stage enhancement process with the efficiency of single-stage inference. Experiments on four benchmark datasets demonstrate that our method achieves state-of-the-art performance with fewer computing costs (60% FLOPs of the two-stage method DNF). Our codes will be released after the acceptance of this work.

A Comparative Study of Image Restoration Networks for General Backbone Network Design

Despite the significant progress made by deep models in various image restoration tasks, existing image restoration networks still face challenges in terms of task generality. An intuitive manifestation is that networks which excel in certain tasks often fail to deliver satisfactory results in others. To illustrate this point, we select five representative image restoration networks and conduct a comparative study on five classic image restoration tasks. First, we provide a detailed explanation of the characteristics of different image restoration tasks and backbone networks. Following this, we present the benchmark results and analyze the reasons behind the performance disparity of different models across various tasks. Drawing from this comparative study, we propose that a general image restoration backbone network needs to meet the functional requirements of diverse tasks. Based on this principle, we design a new general image restoration backbone network, X-Restormer. Extensive experiments demonstrate that X-Restormer possesses good task generality and achieves state-of-the-art performance across a variety of tasks.