AdaFusion: Prompt-Guided Inference with Adaptive Fusion of Pathology Foundation Models

Pathology foundation models (PFMs) have demonstrated strong representational capabilities through self-supervised pre-training on large-scale, unannotated histopathology image datasets. However, their diverse yet opaque pretraining contexts, shaped by both data-related and structural/training factors, introduce latent biases that hinder generalisability and transparency in downstream applications. In this paper, we propose AdaFusion, a novel prompt-guided inference framework that, to our knowledge, is among the very first to dynamically integrate complementary knowledge from multiple PFMs. Our method compresses and aligns tile-level features from diverse models and employs a lightweight attention mechanism to adaptively fuse them based on tissue phenotype context. We evaluate AdaFusion on three real-world benchmarks spanning treatment response prediction, tumour grading, and spatial gene expression inference. Our approach consistently surpasses individual PFMs across both classification and regression tasks, while offering interpretable insights into each model's biosemantic specialisation. These results highlight AdaFusion's ability to bridge heterogeneous PFMs, achieving both enhanced performance and interpretability of model-specific inductive biases.

GenderAlign: An Alignment Dataset for Mitigating Gender Bias in Large Language Models

Large Language Models (LLMs) are prone to generating content that exhibits gender biases, raising significant ethical concerns. Alignment, the process of fine-tuning LLMs to better align with desired behaviors, is recognized as an effective approach to mitigate gender biases. Although proprietary LLMs have made significant strides in mitigating gender bias, their alignment datasets are not publicly available. The commonly used and publicly available alignment dataset, HH-RLHF, still exhibits gender bias to some extent. There is a lack of publicly available alignment datasets specifically designed to address gender bias. Hence, we developed a new dataset named GenderAlign, aiming at mitigating a comprehensive set of gender biases in LLMs. This dataset comprises 8k single-turn dialogues, each paired with a "chosen" and a "rejected" response. Compared to the "rejected" responses, the "chosen" responses demonstrate lower levels of gender bias and higher quality. Furthermore, we categorized the gender biases in the "rejected" responses of GenderAlign into 4 principal categories. The experimental results show the effectiveness of GenderAlign in reducing gender bias in LLMs.