ePointDA: An End-to-End Simulation-to-Real Domain Adaptation Framework for LiDAR Point Cloud Segmentation

Due to its robust and precise distance measurements, LiDAR plays an important role in scene understanding for autonomous driving. Training deep neural networks (DNNs) on LiDAR data requires large-scale point-wise annotations, which are time-consuming and expensive to obtain. Instead, simulation-to-real domain adaptation (SRDA) trains a DNN using unlimited synthetic data with automatically generated labels and transfers the learned model to real scenarios. Existing SRDA methods for LiDAR point cloud segmentation mainly employ a multi-stage pipeline and focus on feature-level alignment. They require prior knowledge of real-world statistics and ignore the pixel-level dropout noise gap and the spatial feature gap between different domains. In this paper, we propose a novel end-to-end framework, named ePointDA, to address the above issues. Specifically, ePointDA consists of three components: self-supervised dropout noise rendering, statistics-invariant and spatially-adaptive feature alignment, and transferable segmentation learning. The joint optimization enables ePointDA to bridge the domain shift at the pixel-level by explicitly rendering dropout noise for synthetic LiDAR and at the feature-level by spatially aligning the features between different domains, without requiring the real-world statistics. Extensive experiments adapting from synthetic GTA-LiDAR to real KITTI and SemanticKITTI demonstrate the superiority of ePointDA for LiDAR point cloud segmentation.

Learning-based Computer-aided Prescription Model for Parkinson's Disease: A Data-driven Perspective

In this paper, we study a novel problem: "automatic prescription recommendation for PD patients." To realize this goal, we first build a dataset by collecting 1) symptoms of PD patients, and 2) their prescription drug provided by neurologists. Then, we build a novel computer-aided prescription model by learning the relation between observed symptoms and prescription drug. Finally, for the new coming patients, we could recommend (predict) suitable prescription drug on their observed symptoms by our prescription model. From the methodology part, our proposed model, namely Prescription viA Learning lAtent Symptoms (PALAS), could recommend prescription using the multi-modality representation of the data. In PALAS, a latent symptom space is learned to better model the relationship between symptoms and prescription drug, as there is a large semantic gap between them. Moreover, we present an efficient alternating optimization method for PALAS. We evaluated our method using the data collected from 136 PD patients at Nanjing Brain Hospital, which can be regarded as a large dataset in PD research community. The experimental results demonstrate the effectiveness and clinical potential of our method in this recommendation task, if compared with other competing methods.

Unsupervised Domain Attention Adaptation Network for Caricature Attribute Recognition

Caricature attributes provide distinctive facial features to help research in Psychology and Neuroscience. However, unlike the facial photo attribute datasets that have a quantity of annotated images, the annotations of caricature attributes are rare. To facility the research in attribute learning of caricatures, we propose a caricature attribute dataset, namely WebCariA. Moreover, to utilize models that trained by face attributes, we propose a novel unsupervised domain adaptation framework for cross-modality (i.e., photos to caricatures) attribute recognition, with an integrated inter- and intra-domain consistency learning scheme. Specifically, the inter-domain consistency learning scheme consisting an image-to-image translator to first fill the domain gap between photos and caricatures by generating intermediate image samples, and a label consistency learning module to align their semantic information. The intra-domain consistency learning scheme integrates the common feature consistency learning module with a novel attribute-aware attention-consistency learning module for a more efficient alignment. We did an extensive ablation study to show the effectiveness of the proposed method. And the proposed method also outperforms the state-of-the-art methods by a margin. The implementation of the proposed method is available at https://github.com/KeleiHe/DAAN.

Synergistic Learning of Lung Lobe Segmentation and Hierarchical Multi-Instance Classification for Automated Severity Assessment of COVID-19 in CT Images

Understanding chest CT imaging of the coronavirus disease 2019 (COVID-19) will help detect infections early and assess the disease progression. Especially, automated severity assessment of COVID-19 in CT images plays an essential role in identifying cases that are in great need of intensive clinical care. However, it is often challenging to accurately assess the severity of this disease in CT images, due to variable infection regions in the lungs, similar imaging biomarkers, and large inter-case variations. To this end, we propose a synergistic learning framework for automated severity assessment of COVID-19 in 3D CT images, by jointly performing lung lobe segmentation and multi-instance classification. Considering that only a few infection regions in a CT image are related to the severity assessment, we first represent each input image by a bag that contains a set of 2D image patches (with each cropped from a specific slice). A multi-task multi-instance deep network (called M$^2$UNet) is then developed to assess the severity of COVID-19 patients and also segment the lung lobe simultaneously. Our M$^2$UNet consists of a patch-level encoder, a segmentation sub-network for lung lobe segmentation, and a classification sub-network for severity assessment (with a unique hierarchical multi-instance learning strategy). Here, the context information provided by segmentation can be implicitly employed to improve the performance of severity assessment. Extensive experiments were performed on a real COVID-19 CT image dataset consisting of 666 chest CT images, with results suggesting the effectiveness of our proposed method compared to several state-of-the-art methods.

HF-UNet: Learning Hierarchically Inter-Task Relevance in Multi-Task U-Net for Accurate Prostate Segmentation

Accurate segmentation of the prostate is a key step in external beam radiation therapy treatments. In this paper, we tackle the challenging task of prostate segmentation in CT images by a two-stage network with 1) the first stage to fast localize, and 2) the second stage to accurately segment the prostate. To precisely segment the prostate in the second stage, we formulate prostate segmentation into a multi-task learning framework, which includes a main task to segment the prostate, and an auxiliary task to delineate the prostate boundary. Here, the second task is applied to provide additional guidance of unclear prostate boundary in CT images. Besides, the conventional multi-task deep networks typically share most of the parameters (i.e., feature representations) across all tasks, which may limit their data fitting ability, as the specificities of different tasks are inevitably ignored. By contrast, we solve them by a hierarchically-fused U-Net structure, namely HF-UNet. The HF-UNet has two complementary branches for two tasks, with the novel proposed attention-based task consistency learning block to communicate at each level between the two decoding branches. Therefore, HF-UNet endows the ability to learn hierarchically the shared representations for different tasks, and preserve the specificities of learned representations for different tasks simultaneously. We did extensive evaluations of the proposed method on a large planning CT image dataset, including images acquired from 339 patients. The experimental results show HF-UNet outperforms the conventional multi-task network architectures and the state-of-the-art methods.

Manifold Alignment for Semantically Aligned Style Transfer

Given a content image and a style image, the goal of style transfer is to synthesize an output image by transferring the target style to the content image. Currently, most of the methods address the problem with global style transfer, assuming styles can be represented by global statistics, such as Gram matrices or covariance matrices. In this paper, we make a different assumption that local semantically aligned (or similar) regions between the content and style images should share similar style patterns. Based on this assumption, content features and style features are seen as two sets of manifolds and a manifold alignment based style transfer (MAST) method is proposed. MAST is a subspace learning method which learns a common subspace of the content and style features. In the common subspace, content and style features with larger feature similarity or the same semantic meaning are forced to be close. The learned projection matrices are added with orthogonality constraints so that the mapping can be bidirectional, which allows us to project the content features into the common subspace, and then into the original style space. By using a pre-trained decoder, promising stylized images are obtained. The method is further extended to allow users to specify corresponding semantic regions between content and style images or using semantic segmentation maps as guidance. Extensive experiments show the proposed MAST achieves appealing results in style transfer.

TripletUNet: Multi-Task U-Net with Online Voxel-Wise Learning for Precise CT Prostate Segmentation

Fully convolutional networks (FCNs), including U-Net and V-Net, are widely-used network architecture for semantic segmentation in recent studies. However, conventional FCNs are typically trained by the cross-entropy loss or dice loss, in which the relationships among voxels are neglected. This often results in non-smooth neighborhoods in the output segmentation map. This problem becomes more serious in CT prostate segmentation as CT images are usually of low tissue contrast. To address this problem, we propose a two-stage framework. The first stage quickly localizes the prostate region. Then, the second stage precisely segments the prostate by a multi-task FCN-based on the U-Net architecture. We introduce a novel online voxel-triplet learning module through metric learning and voxel feature embeddings in the multi-task network. The proposed network has two branches guided by two tasks: 1) a segmentation sub-network aiming to generate prostate segmentation, and 2) a triplet learning sub-network aiming to improve the quality of the learned feature space supervised by a mixed of triplet and pair-wise loss function. The triplet learning sub-network samples triplets from the inter-mediate heatmap. Unlike conventional deep triplet learning methods that generate triplets before the training phase, our proposed voxel-triplets are sampled in an online manner and operates in an end-to-end fashion via multi-task learning. To evaluate the proposed method, we implement comprehensive experiments on a CT image dataset consisting of 339 patients. The ablation studies show that our method can effectively learn more representative voxel-level features compared with the conventional FCN network. And the comparisons show that the proposed method outperforms the state-of-the-art methods by a large margin.

On the Limitations of Cross-lingual Encoders as Exposed by Reference-Free Machine Translation Evaluation

Evaluation of cross-lingual encoders is usually performed either via zero-shot cross-lingual transfer in supervised downstream tasks or via unsupervised cross-lingual textual similarity. In this paper, we concern ourselves with reference-free machine translation (MT) evaluation where we directly compare source texts to (sometimes low-quality) system translations, which represents a natural adversarial setup for multilingual encoders. Reference-free evaluation holds the promise of web-scale comparison of MT systems. We systematically investigate a range of metrics based on state-of-the-art cross-lingual semantic representations obtained with pretrained M-BERT and LASER. We find that they perform poorly as semantic encoders for reference-free MT evaluation and identify their two key limitations, namely, (a) a semantic mismatch between representations of mutual translations and, more prominently, (b) the inability to punish "translationese", i.e., low-quality literal translations. We propose two partial remedies: (1) post-hoc re-alignment of the vector spaces and (2) coupling of semantic-similarity based metrics with target-side language modeling. In segment-level MT evaluation, our best metric surpasses reference-based BLEU by 5.7 correlation points.