Virtual Biopsy for Intracranial Tumors Diagnosis on MRI

Deep intracranial tumors situated in eloquent brain regions controlling vital functions present critical diagnostic challenges. Clinical practice has shifted toward stereotactic biopsy for pathological confirmation before treatment. Yet biopsy carries inherent risks of hemorrhage and neurological deficits and struggles with sampling bias due to tumor spatial heterogeneity, because pathological changes are typically region-selective rather than tumor-wide. Therefore, advancing non-invasive MRI-based pathology prediction is essential for holistic tumor assessment and modern clinical decision-making. The primary challenge lies in data scarcity: low tumor incidence requires long collection cycles, and annotation demands biopsy-verified pathology from neurosurgical experts. Additionally, tiny lesion volumes lacking segmentation masks cause critical features to be overwhelmed by background noise. To address these challenges, we construct the ICT-MRI dataset - the first public biopsy-verified benchmark with 249 cases across four categories. We propose a Virtual Biopsy framework comprising: MRI-Processor for standardization; Tumor-Localizer employing vision-language models for coarse-to-fine localization via weak supervision; and Adaptive-Diagnoser with a Masked Channel Attention mechanism fusing local discriminative features with global contexts. Experiments demonstrate over 90% accuracy, outperforming baselines by more than 20%.

GS-CLIP: Zero-shot 3D Anomaly Detection by Geometry-Aware Prompt and Synergistic View Representation Learning

Zero-shot 3D Anomaly Detection is an emerging task that aims to detect anomalies in a target dataset without any target training data, which is particularly important in scenarios constrained by sample scarcity and data privacy concerns. While current methods adapt CLIP by projecting 3D point clouds into 2D representations, they face challenges. The projection inherently loses some geometric details, and the reliance on a single 2D modality provides an incomplete visual understanding, limiting their ability to detect diverse anomaly types. To address these limitations, we propose the Geometry-Aware Prompt and Synergistic View Representation Learning (GS-CLIP) framework, which enables the model to identify geometric anomalies through a two-stage learning process. In stage 1, we dynamically generate text prompts embedded with 3D geometric priors. These prompts contain global shape context and local defect information distilled by our Geometric Defect Distillation Module (GDDM). In stage 2, we introduce Synergistic View Representation Learning architecture that processes rendered and depth images in parallel. A Synergistic Refinement Module (SRM) subsequently fuses the features of both streams, capitalizing on their complementary strengths. Comprehensive experimental results on four large-scale public datasets show that GS-CLIP achieves superior performance in detection. Code can be available at https://github.com/zhushengxinyue/GS-CLIP.

ProxyFL: A Proxy-Guided Framework for Federated Semi-Supervised Learning

Federated Semi-Supervised Learning (FSSL) aims to collaboratively train a global model across clients by leveraging partially-annotated local data in a privacy-preserving manner. In FSSL, data heterogeneity is a challenging issue, which exists both across clients and within clients. External heterogeneity refers to the data distribution discrepancy across different clients, while internal heterogeneity represents the mismatch between labeled and unlabeled data within clients. Most FSSL methods typically design fixed or dynamic parameter aggregation strategies to collect client knowledge on the server (external) and / or filter out low-confidence unlabeled samples to reduce mistakes in local client (internal). But, the former is hard to precisely fit the ideal global distribution via direct weights, and the latter results in fewer data participation into FL training. To this end, we propose a proxy-guided framework called ProxyFL that focuses on simultaneously mitigating external and internal heterogeneity via a unified proxy. I.e., we consider the learnable weights of classifier as proxy to simulate the category distribution both locally and globally. For external, we explicitly optimize global proxy against outliers instead of direct weights; for internal, we re-include the discarded samples into training by a positive-negative proxy pool to mitigate the impact of potentially-incorrect pseudo-labels. Insight experiments & theoretical analysis show our significant performance and convergence in FSSL.

PVminer: A Domain-Specific Tool to Detect the Patient Voice in Patient Generated Data

Patient-generated text such as secure messages, surveys, and interviews contains rich expressions of the patient voice (PV), reflecting communicative behaviors and social determinants of health (SDoH). Traditional qualitative coding frameworks are labor intensive and do not scale to large volumes of patient-authored messages across health systems. Existing machine learning (ML) and natural language processing (NLP) approaches provide partial solutions but often treat patient-centered communication (PCC) and SDoH as separate tasks or rely on models not well suited to patient-facing language. We introduce PVminer, a domain-adapted NLP framework for structuring patient voice in secure patient-provider communication. PVminer formulates PV detection as a multi-label, multi-class prediction task integrating patient-specific BERT encoders (PV-BERT-base and PV-BERT-large), unsupervised topic modeling for thematic augmentation (PV-Topic-BERT), and fine-tuned classifiers for Code, Subcode, and Combo-level labels. Topic representations are incorporated during fine-tuning and inference to enrich semantic inputs. PVminer achieves strong performance across hierarchical tasks and outperforms biomedical and clinical pre-trained baselines, achieving F1 scores of 82.25% (Code), 80.14% (Subcode), and up to 77.87% (Combo). An ablation study further shows that author identity and topic-based augmentation each contribute meaningful gains. Pre-trained models, source code, and documentation will be publicly released, with annotated datasets available upon request for research use.

CREM: Compression-Driven Representation Enhancement for Multimodal Retrieval and Comprehension

Multimodal Large Language Models (MLLMs) have shown remarkable success in comprehension tasks such as visual description and visual question answering. However, their direct application to embedding-based tasks like retrieval remains challenging due to the discrepancy between output formats and optimization objectives. Previous approaches often employ contrastive fine-tuning to adapt MLLMs for retrieval, but at the cost of losing their generative capabilities. We argue that both generative and embedding tasks fundamentally rely on shared cognitive mechanisms, specifically cross-modal representation alignment and contextual comprehension. To this end, we propose CREM (Compression-driven Representation Enhanced Model), with a unified framework that enhances multimodal representations for retrieval while preserving generative ability. Specifically, we introduce a compression-based prompt design with learnable chorus tokens to aggregate multimodal semantics and a compression-driven training strategy that integrates contrastive and generative objectives through compression-aware attention. Extensive experiments demonstrate that CREM achieves state-of-the-art retrieval performance on MMEB while maintaining strong generative performance on multiple comprehension benchmarks. Our findings highlight that generative supervision can further improve the representational quality of MLLMs under the proposed compression-driven paradigm.

Conv-FinRe: A Conversational and Longitudinal Benchmark for Utility-Grounded Financial Recommendation

Most recommendation benchmarks evaluate how well a model imitates user behavior. In financial advisory, however, observed actions can be noisy or short-sighted under market volatility and may conflict with a user's long-term goals. Treating what users chose as the sole ground truth, therefore, conflates behavioral imitation with decision quality. We introduce Conv-FinRe, a conversational and longitudinal benchmark for stock recommendation that evaluates LLMs beyond behavior matching. Given an onboarding interview, step-wise market context, and advisory dialogues, models must generate rankings over a fixed investment horizon. Crucially, Conv-FinRe provides multi-view references that distinguish descriptive behavior from normative utility grounded in investor-specific risk preferences, enabling diagnosis of whether an LLM follows rational analysis, mimics user noise, or is driven by market momentum. We build the benchmark from real market data and human decision trajectories, instantiate controlled advisory conversations, and evaluate a suite of state-of-the-art LLMs. Results reveal a persistent tension between rational decision quality and behavioral alignment: models that perform well on utility-based ranking often fail to match user choices, whereas behaviorally aligned models can overfit short-term noise. The dataset is publicly released on Hugging Face, and the codebase is available on GitHub.

FRAPPE: Infusing World Modeling into Generalist Policies via Multiple Future Representation Alignment

Enabling VLA models to predict environmental dynamics, known as world modeling, has been recognized as essential for improving robotic reasoning and generalization. However, current approaches face two main issues: 1. The training objective forces models to over-emphasize pixel-level reconstruction, which constrains semantic learning and generalization 2. Reliance on predicted future observations during inference often leads to error accumulation. To address these challenges, we introduce Future Representation Alignment via Parallel Progressive Expansion (FRAPPE). Our method adopts a two-stage fine-tuning strategy: In the mid-training phase, the model learns to predict the latent representations of future observations; In the post-training phase, we expand the computational workload in parallel and align the representation simultaneously with multiple different visual foundation models. By significantly improving fine-tuning efficiency and reducing dependence on action-annotated data, FRAPPE provides a scalable and data-efficient pathway to enhance world-awareness in generalist robotic policies. Experiments on the RoboTwin benchmark and real-world tasks demonstrate that FRAPPE outperforms state-of-the-art approaches and shows strong generalization in long-horizon and unseen scenarios.

DriveFine: Refining-Augmented Masked Diffusion VLA for Precise and Robust Driving

Vision-Language-Action (VLA) models for autonomous driving increasingly adopt generative planners trained with imitation learning followed by reinforcement learning. Diffusion-based planners suffer from modality alignment difficulties, low training efficiency, and limited generalization. Token-based planners are plagued by cumulative causal errors and irreversible decoding. In summary, the two dominant paradigms exhibit complementary strengths and weaknesses. In this paper, we propose DriveFine, a masked diffusion VLA model that combines flexible decoding with self-correction capabilities. In particular, we design a novel plug-and-play block-MoE, which seamlessly injects a refinement expert on top of the generation expert. By enabling explicit expert selection during inference and gradient blocking during training, the two experts are fully decoupled, preserving the foundational capabilities and generic patterns of the pretrained weights, which highlights the flexibility and extensibility of the block-MoE design. Furthermore, we design a hybrid reinforcement learning strategy that encourages effective exploration of refinement expert while maintaining training stability. Extensive experiments on NAVSIM v1, v2, and Navhard benchmarks demonstrate that DriveFine exhibits strong efficacy and robustness. The code will be released at https://github.com/MSunDYY/DriveFine.

ReBA-Pred-Net: Weakly-Supervised Regional Brain Age Prediction on MRI

Brain age has become a prominent biomarker of brain health. Yet most prior work targets whole brain age (WBA), a coarse paradigm that struggles to support tasks such as disease characterization and research on development and aging patterns, because relevant changes are typically region-selective rather than brain-wide. Therefore, robust regional brain age (ReBA) estimation is critical, yet a widely generalizable model has yet to be established. In this paper, we propose the Regional Brain Age Prediction Network (ReBA-Pred-Net), a Teacher-Student framework designed for fine-grained brain age estimation. The Teacher produces soft ReBA to guide the Student to yield reliable ReBA estimates with a clinical-prior consistency constraint (regions within the same function should change similarly). For rigorous evaluation, we introduce two indirect metrics: Healthy Control Similarity (HCS), which assesses statistical consistency by testing whether regional brain-age-gap (ReBA minus chronological age) distributions align between training and unseen HC; and Neuro Disease Correlation (NDC), which assesses factual consistency by checking whether clinically confirmed patients show elevated brain-age-gap in disease-associated regions. Experiments across multiple backbones demonstrate the statistical and factual validity of our method.

The Pensieve Paradigm: Stateful Language Models Mastering Their Own Context

In the world of Harry Potter, when Dumbledore's mind is overburdened, he extracts memories into a Pensieve to be revisited later. In the world of AI, while we possess the Pensieve-mature databases and retrieval systems, our models inexplicably lack the "wand" to operate it. They remain like a Dumbledore without agency, passively accepting a manually engineered context as their entire memory. This work finally places the wand in the model's hand. We introduce StateLM, a new class of foundation models endowed with an internal reasoning loop to manage their own state. We equip our model with a suite of memory tools, such as context pruning, document indexing, and note-taking, and train it to actively manage these tools. By learning to dynamically engineering its own context, our model breaks free from the architectural prison of a fixed window. Experiments across various model sizes demonstrate StateLM's effectiveness across diverse scenarios. On long-document QA tasks, StateLMs consistently outperform standard LLMs across all model scales; on the chat memory task, they achieve absolute accuracy improvements of 10% to 20% over standard LLMs. On the deep research task BrowseComp-Plus, the performance gap becomes even more pronounced: StateLM achieves up to 52% accuracy, whereas standard LLM counterparts struggle around 5%. Ultimately, our approach shifts LLMs from passive predictors to state-aware agents where reasoning becomes a stateful and manageable process.