Learning latent progression states from spatial heterogeneity in uterine histopathology

Tumor progression is accompanied by changes in architecture, morphology and microenvironmental organization, yet progression-associated heterogeneity is usually compressed into static diagnostic categories in histopathology. Here we present SpaTIE, a uterus-specific computational pathology framework that learns morphology-aware representations and organizes spatial histopathological heterogeneity into progression-associated tumor states. SpaTIE was developed using 10,426 uterine hematoxylin and eosin whole-slide images and evaluated in TCGA-UCEC and TCGA-UCS cohorts. The learned representations formed morphology manifolds, supported diagnostic, molecular and survival-related prediction tasks, and localized attention to informative tumor regions. Beyond supervised prediction, SpaTIE inferred tumor-state axes from cross-sectional morphology without temporal or molecular supervision. These morphology-derived states were spatially coherent and showed associations with clinicopathological variables and survival outcomes, while not simply recapitulating staging or diagnostic labels. Integrative multi-omics analyses linked the inferred states to DNA methylation, somatic copy-number variation, mutation, RNA-seq and RPPA profiles, highlighting molecular programs related to chromatin regulation, copy-number-associated structural variation, receptor tyrosine kinase signaling, cell adhesion, extracellular-matrix remodeling and metabolic adaptation. Progression-guided virtual perturbation further prioritized molecular features coupled to the morphology-derived state organization. Together, these findings suggest that uterine histopathology contains recoverable progression-associated tumor-state information and establish SpaTIE as a framework for connecting spatial morphology with multi-omics-informed tumor-state discovery.

Trustworthy Protein-Ligand Binding Affinity Prediction via Reliability-Aware Multi-Engine Fusion

Accurate protein-ligand binding affinity prediction is central to computational drug discovery, yet modern docking engines frequently disagree without indicating which prediction to trust. Consensus scoring and ensemble methods improve mean accuracy but treat all predictions identically without interpretable confidence measures or uncertainty decomposition, ignoring the chemical context of each protein-ligand pair. To address this limitation, we introduce RELIABLE-BA (RELIABiLity-aware Evidential fusion for Binding Affinity), an evidential framework for multi-engine binding affinity prediction. Our model comprises three steps: (1) modeling each engine as an evidential expert via Normal-Inverse-Gamma distributions, (2) scaling epistemic uncertainty through learned reliability from molecular context while preserving each expert's predictive mean, and (3) fusing experts through closed-form aggregation that captures both individual uncertainty and inter-engine disagreement. Experiments on the PDBBind and BDB2020+ benchmarks demonstrate competitive point prediction with substantially improved uncertainty calibration, and additional validation on the SARS-CoV-2 Mpro dataset and 5HT2A receptor demonstrates applicability to clinically relevant drug targets. Crucially, these uncertainty estimates enable reliable filtering of protein-ligand pairs, reducing prediction error by up to 25% when retaining only high-confidence pairs. To our knowledge, RELIABLE-BA is the first multi-engine binding affinity prediction framework to combine evidential fusion with context-dependent reliability, offering a principled path toward trustworthy AI-guided drug discovery. Our code is publicly available at https://github.com/yongchand/RELIABLE-BA.

HCSU: A Dataset and Benchmark for Fine-Grained Historical Calligraphy Style Understanding

Automated fine-grained perception of calligraphy styles--a task vital to cultural heritage preservation--remains a critical challenge for Large Vision-Language Models (LVLMs), largely constrained by existing datasets that suffer from modal mixture and flattened labels. To bridge this gap, we introduce HCSU, the first comprehensive dataset tailored for fine-grained Historical Calligraphy Style Understanding. HCSU comprises 39,307 meticulously curated character images from 49 historically prominent calligraphers across 10 dynasties, systematically decoupling authentic ink manuscripts (Tie) from stone rubbings (Bei) to resolve the long-standing modal mixture problem. Moving beyond conventional flattened labels, HCSU provides hierarchical expert-written aesthetic descriptions, enabling two rigorous evaluation protocols: fine-grained style discrimination and interpretable aesthetic reasoning. Extensive evaluations reveal a persistent gap between calligraphy-related knowledge and visually grounded style perception: state-of-the-art LVLMs show non-trivial performance but remain sensitive to script-level, textual, and source-specific cues, and often struggle to ground aesthetic judgments in fine-grained brushwork evidence. Ultimately, the HCSU benchmark exposes fundamental limitations in current multimodal architectures, aiming to inspire the evolution of expert-level visual reasoning for cultural heritage preservation. The dataset is available at https://huggingface.co/datasets/Tongji209/HCSU.

Cognitive World Models for Process-Level Social Influence Evaluation

Social influence dialogue changes user behavior by altering internal cognitive states. The central evaluation question is whether the user's beliefs, desires, intentions, and emotions measurably change over the course of conversation, a process-oriented criterion that neither surface-level text metrics (BLEU/ROUGE) nor single-score LLM judgments can capture. We propose the \textbf{Cog}nitive \textbf{W}orld \textbf{M}odel \textbf{(CogWM)}, an LLM-based user model that reframes multi-turn dialogue evaluation from ``what did the user say'' to ``how did the user's internal cognitive state evolves.'' CogWM jointly predicts BDI/E cognitive states and user utterances and serves as both a user simulator and an evaluation platform, using a three-tier evaluation framework that covers turn-level fidelity, trajectory-level state dynamics, and task-level composite scoring. Trained via our \textbf{S}ummarize-\textbf{a}nd-\textbf{A}llocate \textbf{(SaA)} annotation pipeline on 150,454 user-turn samples across four social influence scenarios, CogWM achieves 77.6\% emotion accuracy (2.1$\times$ over GPT-5.5). In 3600 multi-agent discrimination trials, it distinguishes six commercial agents by their cognitive influence, with Llama-4-Scout ranking first (CTS +0.233). CogWM moves social influence dialogue evaluation from terminal judgment to process tracking. We have released our code\footnote{\scriptsize Code: https://github.com/lucianma05-create/CogWM} and models\footnote{Model: https://www.modelscope.cn/models/LucianMa/CogWM-14B}.

Speaking Numbers to LLMs: Multi-Wavelet Number Embeddings for Time Series Forecasting

Large language models (LLMs) are attractive for context-aware time series forecasting because they can integrate heterogeneous textual signals, yet their discrete, language-oriented tokenization and embedding interfaces are misaligned with continuous numerical values, often harming numerical ordering and forecasting reliability. We propose TempoWave, a plug-and-play temporal wavelet digit interface that maps each scalar observation into digit-wise embeddings constructed from multi-wavelet, multi-scale coefficients. By directly overriding standard token representations, TempoWave seamlessly exposes both fine-grained local fluctuations and macro global structures in a transformer-compatible form, ensuring that precise numerical formatting, distinct digit identity, and robustness to common normalization operations are maintained throughout the LLM pipeline. Experiments across five context-enriched forecasting benchmarks demonstrate that TempoWave consistently improves LLM-based forecasters over standard numeric tokenization and alternative embedding interfaces, achieving a new state-of-the-art. These results highlight the numeric interface as a key bottleneck and suggest that principled multi-resolution embeddings can better couple LLMs' contextual reasoning with precise forecasting. Our code is available at https://github.com/DC-research/TempoWAVE and our model can be accessed at https://huggingface.co/Melady/TempoWAVE.

GLACIER: A Multimodal Student-Teacher Foundation Model for Molecular Property Prediction

Deep learning models facilitate the discovery of molecules with tailored properties among billions of candidate compounds. However, the computational burden to develop and deploy state-of-the-art models continuously increases, limiting their scalability. Most large-scale models are unimodal in nature and overlook the potential to leverage complementary molecular data modalities. To address these shortcomings, this paper introduces the Graph-Language Alignment for Chemical Inference and Exploration using Representations (GLACIER) model, a student-teacher framework that integrates molecular graphs, SMILES strings, and physicochemical descriptors to learn rich molecular embeddings. Our framework consists of three stages: (1) we pretrain three student encoders on 100,000 drug-like molecules: a message-passing neural network for molecular graphs, a transformer-based encoder for SMILES strings, and a multilayer perceptron for physicochemical descriptors, (2) we fuse these student modalities using a novel Finsler geometry-aware module, and (3) distill complementary knowledge from large teacher models, including MiniMol and MolFormer, into a single lightweight model via contrastive learning. We demonstrate that GLACIER is a robust framework that delivers high predictive performance and computational efficiency in complex molecular property prediction tasks. Our code is publicly available at https://github.com/eemokey/glacier.

Projecting the Emerging Mindset of SWE Agent by Launching a Wild Code Understanding Journey

Software engineering agents (SWE agents) increasingly work through tool-mediated trajectories in real repositories, yet their behavior remains difficult to characterize in concrete, observable terms. These trajectories record tool use, intermediate reasoning, evidence selection, and self-directed stopping, but they do not by themselves explain why particular moves were chosen, what evidence was trusted, or when understanding was judged sufficient. This tension makes trajectory data both limited and valuable: faithful, replayable traces can become an empirical substrate for studying agent behavior when interpreted through disciplined observation. We introduce Ada, a scoped apparatus for repository-level code understanding. Ada enters real codebases through a bounded tool interface, allowing open-ended exploration to remain recordable as finite trajectories. Across this wild-but-bounded setting, Ada chooses where to look, what to read closely, when to consolidate partial understanding, and when to close its account of the repository. We project Ada's think-action chains through observation lenses that make navigation, evidence selection, synthesis, grounding, and stopping visible without reducing behavior to raw tool counts or speculating about hidden intent. Read together, these lenses produce behavioral profiles grounded in recorded movement through software worlds. Across 408 trajectories, spanning multiple models, repositories, task families, and launch conditions, the study shows how faithful digital traces can be transformed into disciplined, comparable projections of emerging SWE-agent mindset. The results expose differences in efficiency, trajectory diversity, epistemic grounding, and the limits of intervention, while providing a methodological foundation for observing SWE agent behavior in real codebases.

Think Thrice Before You Speak: Dual knowledge-enhanced Theory-of-Mind Reasoning for Persuasive Agents

Persuasive dialogue requires reasoning about others' latent mental states, a capability known as Theory of Mind (ToM). However, due to reliance on simple prompting strategies and insufficient ToM knowledge, existing LLMs often fail to capture the intrinsic dependencies among mental states, leading to fragmented representations and unstable reasoning. To address these challenges, we introduce the ToM-based Persuasive Dialogue (ToM-PD) task, grounded in the Belief-Desire-Intention (BDI) framework, which explicitly models the sequential dependencies among mental states in multi-turn dialogues. To facilitate research on this task, we construct a large-scale annotated dataset, ToM-based Broad Persuasive Dialogues (ToM-BPD), capturing fine-grained mental states and corresponding persuasive strategies. We further propose Think Thrice Before You Speak (TTBYS), a knowledge-enhanced stepwise reasoning framework that leverages both explicit and implicit prior experiences to improve LLMs' inference of desires, beliefs, and persuasive strategies. Experimental results demonstrate that Qwen3-8B equipped with TTBYS outperforms GPT-5 by 1.20%, 22.80%, and 16.97% in predicting desires, beliefs, and persuasive strategies, respectively. Case studies further show that our approach enhances interpretability and consistency in reasoning.

ZID-Net: Zero-Inference Diffusion Prior Decoupling Network for Single Image Dehazing

Single image dehazing is often constrained by a trade-off between restoration quality and computational efficiency. While efficient, CNN networks struggle to learn robust priors for dense and non-homogeneous haze. Conversely, diffusion models provide strong generative priors but suffer from severe inference latency and sampling instability. To address these limitations, we propose ZID-Net, a novel framework that explicitly decouples diffusion supervision from feed-forward inference. For efficient inference, we design a frequency-spatial decoupled feed-forward backbone. Within this backbone, a Channel-Spatial Laplacian Mask (CSLM) filters haze-amplified noise to extract purified structural details, while Lightweight Global Context Blocks (LGCBs) establish long-range spatial dependencies to capture the global variations of haze. A Dynamic Feature Arbitration Block (DFAB) then adaptively fuses these semantic and structural features for robust reconstruction. To provide this backbone with physical priors without the inference cost, we introduce a Zero-Inference Prior Propagation Head (ZI-PPH) during training. ZI-PPH leverages a conditional diffusion process to predict residual noise, providing degradation-aware structural supervision to the backbone. By discarding the diffusion branch at test time, ZID-Net integrates diffusion priors into a pure feed-forward architecture for accurate and efficient restoration. ZID-Net achieves 40.75 dB PSNR on the synthetic RESIDE dataset and outperforms existing methods with a 1.13 dB gain on real-world datasets. Additionally, it yields a 3.06 dB PSNR gain on the StateHaze1k remote sensing dataset with an inference time of just 19.35 ms. The project code is available at: https://github.com/XoomitLXH/ZID-Net.

Beyond Compliance: A Resistance-Informed Motivation Reasoning Framework for Challenging Psychological Client Simulation

Psychological client simulators have emerged as a scalable solution for training and evaluating counselor trainees and psychological LLMs. Yet existing simulators exhibit unrealistic over-compliance, leaving counselors underprepared for the challenging behaviors common in real-world practice. To bridge this gap, we present ResistClient, which systematically models challenging client behaviors grounded in Client Resistance Theory by integrating external behaviors with underlying motivational mechanisms. To this end, we propose Resistance-Informed Motivation Reasoning (RIMR), a two-stage training framework. First, RIMR mitigates compliance bias via supervised fine-tuning on RPC, a large-scale resistance-oriented psychological conversation dataset covering diverse client profiles. Second, beyond surface-level response imitation, RIMR models psychologically coherent motivation reasoning before response generation, jointly optimizing motivation authenticity and response consistency via process-supervised reinforcement learning. Extensive automatic and expert evaluations show that ResistClient substantially outperforms existing simulators in challenge fidelity, behavioral plausibility, and reasoning coherence. Moreover, ResistClient facilities evaluation of psychological LLMs under challenging conditions, offering new optimization directions for mental health dialogue systems.