ADAM Challenge: Detecting Age-related Macular Degeneration from Fundus Images

Age-related macular degeneration (AMD) is the leading cause of visual impairment among elderly in the world. Early detection of AMD is of great importance as the vision loss caused by AMD is irreversible and permanent. Color fundus photography is the most cost-effective imaging modality to screen for retinal disorders. \textcolor{red}{Recently, some algorithms based on deep learning had been developed for fundus image analysis and automatic AMD detection. However, a comprehensive annotated dataset and a standard evaluation benchmark are still missing.} To deal with this issue, we set up the Automatic Detection challenge on Age-related Macular degeneration (ADAM) for the first time, held as a satellite event of the ISBI 2020 conference. The ADAM challenge consisted of four tasks which cover the main topics in detecting AMD from fundus images, including classification of AMD, detection and segmentation of optic disc, localization of fovea, and detection and segmentation of lesions. The ADAM challenge has released a comprehensive dataset of 1200 fundus images with the category labels of AMD, the pixel-wise segmentation masks of the full optic disc and lesions (drusen, exudate, hemorrhage, scar, and other), as well as the location coordinates of the macular fovea. A uniform evaluation framework has been built to make a fair comparison of different models. During the ADAM challenge, 610 results were submitted for online evaluation, and finally, 11 teams participated in the onsite challenge. This paper introduces the challenge, dataset, and evaluation methods, as well as summarizes the methods and analyzes the results of the participating teams of each task. In particular, we observed that ensembling strategy and clinical prior knowledge can better improve the performances of the deep learning models.

REFUGE2 Challenge: Treasure for Multi-Domain Learning in Glaucoma Assessment

Glaucoma is the second leading cause of blindness and is the leading cause of irreversible blindness disease in the world. Early screening for glaucoma in the population is significant. Color fundus photography is the most cost effective imaging modality to screen for ocular diseases. Deep learning network is often used in color fundus image analysis due to its powful feature extraction capability. However, the model training of deep learning method needs a large amount of data, and the distribution of data should be abundant for the robustness of model performance. To promote the research of deep learning in color fundus photography and help researchers further explore the clinical application signification of AI technology, we held a REFUGE2 challenge. This challenge released 2,000 color fundus images of four models, including Zeiss, Canon, Kowa and Topcon, which can validate the stabilization and generalization of algorithms on multi-domain. Moreover, three sub-tasks were designed in the challenge, including glaucoma classification, cup/optic disc segmentation, and macular fovea localization. These sub-tasks technically cover the three main problems of computer vision and clinicly cover the main researchs of glaucoma diagnosis. Over 1,300 international competitors joined the REFUGE2 challenge, 134 teams submitted more than 3,000 valid preliminary results, and 22 teams reached the final. This article summarizes the methods of some of the finalists and analyzes their results. In particular, we observed that the teams using domain adaptation strategies had high and robust performance on the dataset with multi-domain. This indicates that UDA and other multi-domain related researches will be the trend of deep learning field in the future, and our REFUGE2 datasets will play an important role in these researches.

CUGE: A Chinese Language Understanding and Generation Evaluation Benchmark

Realizing general-purpose language intelligence has been a longstanding goal for natural language processing, where standard evaluation benchmarks play a fundamental and guiding role. We argue that for general-purpose language intelligence evaluation, the benchmark itself needs to be comprehensive and systematic. To this end, we propose CUGE, a Chinese Language Understanding and Generation Evaluation benchmark with the following features: (1) Hierarchical benchmark framework, where datasets are principally selected and organized with a language capability-task-dataset hierarchy. (2) Multi-level scoring strategy, where different levels of model performance are provided based on the hierarchical framework. To facilitate CUGE, we provide a public leaderboard that can be customized to support flexible model judging criteria. Evaluation results on representative pre-trained language models indicate ample room for improvement towards general-purpose language intelligence. CUGE is publicly available at cuge.baai.ac.cn.

Model Uncertainty-Aware Knowledge Amalgamation for Pre-Trained Language Models

As many fine-tuned pre-trained language models~(PLMs) with promising performance are generously released, investigating better ways to reuse these models is vital as it can greatly reduce the retraining computational cost and the potential environmental side-effects. In this paper, we explore a novel model reuse paradigm, Knowledge Amalgamation~(KA) for PLMs. Without human annotations available, KA aims to merge the knowledge from different teacher-PLMs, each of which specializes in a different classification problem, into a versatile student model. The achieve this, we design a Model Uncertainty--aware Knowledge Amalgamation~(MUKA) framework, which identifies the potential adequate teacher using Monte-Carlo Dropout for approximating the golden supervision to guide the student. Experimental results demonstrate that MUKA achieves substantial improvements over baselines on benchmark datasets. Further analysis shows that MUKA can generalize well under several complicate settings with multiple teacher models, heterogeneous teachers, and even cross-dataset teachers.

KNAS: Green Neural Architecture Search

Many existing neural architecture search (NAS) solutions rely on downstream training for architecture evaluation, which takes enormous computations. Considering that these computations bring a large carbon footprint, this paper aims to explore a green (namely environmental-friendly) NAS solution that evaluates architectures without training. Intuitively, gradients, induced by the architecture itself, directly decide the convergence and generalization results. It motivates us to propose the gradient kernel hypothesis: Gradients can be used as a coarse-grained proxy of downstream training to evaluate random-initialized networks. To support the hypothesis, we conduct a theoretical analysis and find a practical gradient kernel that has good correlations with training loss and validation performance. According to this hypothesis, we propose a new kernel based architecture search approach KNAS. Experiments show that KNAS achieves competitive results with orders of magnitude faster than "train-then-test" paradigms on image classification tasks. Furthermore, the extremely low search cost enables its wide applications. The searched network also outperforms strong baseline RoBERTA-large on two text classification tasks. Codes are available at \url{https://github.com/Jingjing-NLP/KNAS} .

Auto-Encoding Knowledge Graph for Unsupervised Medical Report Generation

Medical report generation, which aims to automatically generate a long and coherent report of a given medical image, has been receiving growing research interests. Existing approaches mainly adopt a supervised manner and heavily rely on coupled image-report pairs. However, in the medical domain, building a large-scale image-report paired dataset is both time-consuming and expensive. To relax the dependency on paired data, we propose an unsupervised model Knowledge Graph Auto-Encoder (KGAE) which accepts independent sets of images and reports in training. KGAE consists of a pre-constructed knowledge graph, a knowledge-driven encoder and a knowledge-driven decoder. The knowledge graph works as the shared latent space to bridge the visual and textual domains; The knowledge-driven encoder projects medical images and reports to the corresponding coordinates in this latent space and the knowledge-driven decoder generates a medical report given a coordinate in this space. Since the knowledge-driven encoder and decoder can be trained with independent sets of images and reports, KGAE is unsupervised. The experiments show that the unsupervised KGAE generates desirable medical reports without using any image-report training pairs. Moreover, KGAE can also work in both semi-supervised and supervised settings, and accept paired images and reports in training. By further fine-tuning with image-report pairs, KGAE consistently outperforms the current state-of-the-art models on two datasets.

Well-classified Examples are Underestimated in Classification with Deep Neural Networks

The conventional wisdom behind learning deep classification models is to focus on bad-classified examples and ignore well-classified examples that are far from the decision boundary. For instance, when training with cross-entropy loss, examples with higher likelihoods (i.e., well-classified examples) contribute smaller gradients in back-propagation. However, we theoretically show that this common practice hinders representation learning, energy optimization, and the growth of margin. To counteract this deficiency, we propose to reward well-classified examples with additive bonuses to revive their contribution to learning. This counterexample theoretically addresses these three issues. We empirically support this claim by directly verify the theoretical results or through the significant performance improvement with our counterexample on diverse tasks, including image classification, graph classification, and machine translation. Furthermore, this paper shows that because our idea can solve these three issues, we can deal with complex scenarios, such as imbalanced classification, OOD detection, and applications under adversarial attacks. Code is available at: https://github.com/lancopku/well-classified-examples-are-underestimated.

RAP: Robustness-Aware Perturbations for Defending against Backdoor Attacks on NLP Models

Backdoor attacks, which maliciously control a well-trained model's outputs of the instances with specific triggers, are recently shown to be serious threats to the safety of reusing deep neural networks (DNNs). In this work, we propose an efficient online defense mechanism based on robustness-aware perturbations. Specifically, by analyzing the backdoor training process, we point out that there exists a big gap of robustness between poisoned and clean samples. Motivated by this observation, we construct a word-based robustness-aware perturbation to distinguish poisoned samples from clean samples to defend against the backdoor attacks on natural language processing (NLP) models. Moreover, we give a theoretical analysis about the feasibility of our robustness-aware perturbation-based defense method. Experimental results on sentiment analysis and toxic detection tasks show that our method achieves better defending performance and much lower computational costs than existing online defense methods. Our code is available at https://github.com/lancopku/RAP.