Carnegie Mellon University
Abstract:Reconstructing 4D (3D+t) cardiac geometry from sparse 2D echocardiography is highly desirable yet fundamentally challenged by geometric ambiguity and temporal discontinuity. To tackle these issues, we propose Echo4DIR, a novel test-time 4D implicit reconstruction framework. Specifically, we learn robust 3D shape priors from statistical shape models (SSMs) via a cardiac conditional SDF, constructing an Epipolar Mask Encoder module with epipolar cross attention to effectively fuse multi-view features. To bridge the synthetic-to-real domain gap, we introduce a self-supervised SDF-tailored differentiable rendering strategy for patient-specific 3D shape adaptation using uncalibrated clinical masks without requiring 3D ground truth. Crucially, the inherent continuity of implicit representation overcomes sparse observations, enabling anatomically reliable geometry at arbitrary resolutions. Furthermore, to empower our framework with physically continuous 4D extension, we introduce a Radial SDF Alignment strategy that strictly locks shape evolution to the predicted velocity field, fundamentally eliminating mesh drift. Extensive experiments on synthetic benchmarks and real clinical datasets demonstrate that Echo4DIR achieves state-of-the-art 4D cardiac mesh reconstruction, notably yielding an impressive clinical overlap of up to 98.35% Dice and 96.75% IoU.
Abstract:Accurate localization of myocardial infarction is essential for risk stratification. While LGE-MRI remains the gold standard, it is resource-intensive. Integrating cine MRI with ECG enables a more detailed representation of infarct properties. Existing inverse MI inference methods overlook realistic scar morphology and cardiac repolarization, reducing sensitivity to subtle ECG variations and interpretability of infarct-induced electrophysiological changes. In this paper, we propose a novel framework for noninvasive MI localization using cardiac digital twins. To bridge the domain gap between simulation and reality, we introduce an anatomy-aware stochastic infarct synthesis strategy to synthesize realistic, irregular scars with border zones, mimicking ischemic transmural progression. We then construct a virtual cohort to simulate QRS-T waveforms, capturing both depolarization and repolarization dynamics. Furthermore, we design a Physiology and Anatomy Aware Network (PAA-Net) that jointly encodes 3D myocardial geometry and multi-lead ECGs to infer infarct areas with varying localizations, sizes, spatial extents, and transmuralities. Experimental results demonstrate that our framework significantly outperforms existing methods in inverse inference, achieving Dice scores of 0.7391 and 0.5503 for scar and border zone segmentation, respectively, while further enhancing the interpretability of the ECG-infarct relationship. Our code will be released upon acceptance.
Abstract:Multimodal large language models (MLLMs) and diffusion models have each reached remarkable maturity: MLLMs excel at reasoning over heterogeneous multimodal inputs with strong semantic grounding, while diffusion models synthesize images and videos with photorealistic fidelity. We argue that these two families can be unified through a simple division of labor: MLLMs perform semantic planning, while diffusion models render pixels from high-level semantic guidance and low-level visual features. Building on this idea, we propose Bernini, a unified framework for video generation and editing. An MLLM-based planner predicts the target semantic representation directly in the ViT embedding space, and a DiT-based renderer synthesizes pixels conditioned on this plan, augmented by text features and, for editing, source VAE features for detail preservation. Because semantics serve as the interface, the planner and renderer can be trained separately and only lightly co-trained, preserving the pretrained strengths of both components while keeping training efficient. To better handle multiple visual inputs, we introduce Segment-Aware 3D Rotary Positional Embedding (SA-3D RoPE), and further incorporate chain-of-thought reasoning in the planner to better transfer understanding into generation. Bernini achieves state-of-the-art performance across a wide range of video generation and editing benchmarks, with the MLLM's pretrained understanding translating into strong generalization on challenging editing tasks.
Abstract:How can we distinguish whether a peer review was written by a human or generated by an AI model? We argue that, in this setting, authorship should not be attributed solely from the textual features of a review, but also from the ideas, judgments, and claims it expresses. To this end, we propose Sem-Detect, an authorship detection method for peer reviews that operationalizes this principle by combining textual features with claim-level semantic analysis. Sem-Detect compares a target review against multiple AI-generated reviews of the same paper, leveraging the observation that different AI models tend to converge on similar points, while human reviewers introduce more unique and diverse ones. As a result, Sem-Detect is able to distinguish fully AI reviews from authentic human-written ones, including those that have been refined using an LLM but still reflect human judgment. Across a dataset of over 20,000 peer reviews from ICLR and NeurIPS conferences, Sem-Detect improves over the strongest baseline by 25.5% in TPR@0.1% FPR in the binary setting. Moreover, in the three-class scenario, we empirically show that LLM refinement preserves the semantic signals of human reviews, which remain distinct from the patterns exhibited by fully AI-generated text; as a result, fewer than 3.5% of LLM-refined human reviews are misclassified as AI-generated.
Abstract:Cardiac motion over a cardiac cycle is crucial for quantifying regional function and is strongly affected by cardiovascular diseases. Since temporally dense mesh sequences are difficult to obtain in practice, we focus on leveraging the more accessible end-diastolic frame to infer a full-cycle sequence. Due to strong regional and disease-specific differences, traditional methods often oversmooth the data by relying on generative models that are optimized for global patterns. To address this problem, we propose Region-Aware and Phenotype-Adaptive Bi-Ventricular Cardiac Motion Synthesis (RePCM) for single frame Bi-ventricular mesh motion completion. In Stage I, a reconstruction network learns vertex wise motion descriptors and clustering yields a data driven functional partition, providing an explicit motion derived region structure. In Stage II, a Region-Specific Injection Module enforces masked, synchronized region exchange within a conditional VAE, preserving localized specific dynamics and restricting cross-region mixing. A Phenotype-Adaptive Mixture-of-Experts prior conditioned on ED shape uses anatomy-guided cues to model latent motion trends and capture inter-disease variability. Experiments on three datasets covering different cardiovascular diseases show consistent gains in geometric and functional metrics and improved preservation of region specific dynamics.
Abstract:Vision-Language Models (VLMs) have demonstrated remarkable proficiency in general multi-modal understanding; yet they struggle to efficiently acquire continually evolving domain-specific skills. Conventional approaches to enhancing VLM capabilities, such as Supervised Fine-Tuning (SFT), require extensive dataset curation and substantial computational resources. Model merging has emerged as an efficient alternative that enables the transfer of domain-specific expertise from Large Language Models (LLMs) to VLMs without incurring additional training data requirements or significant computational overhead. Unlike conventional merging of homogeneous LLMs, which mainly aggregates existing capabilities, cross-modal skill injection aims to induce emergent cross-modal capabilities by integrating a domain-expert LLM into a VLM. However, existing research lacks a systematic analysis of the applicability and methodology of cross-modal skill injection. In this study, we investigate cross-modal skill injection across three main aspects: scenarios, methods, and hyperparameters. For scenarios, we find that cross-modal skill injection generally performs well in instruction-following and cross-lingual settings, yet struggles with mathematical reasoning. For methods, we find that classic approaches such as TA and DARE consistently achieve superior performance over alternative merging methods. We also provide a systematic and quantitative analysis of the hyperparameter tuning that these classic methods critically depend on.
Abstract:Current hierarchical attention methods, such as NSA and InfLLMv2, select the top-k relevant key-value (KV) blocks based on coarse attention scores and subsequently apply fine-grained softmax attention on the selected tokens. However, the top-k operation assumes the number of relevant tokens for any query is fixed and it precludes the gradient flow between the sparse and dense stages. In this work, we propose DashAttention (Differentiable and Adaptive Sparse Hierarchical Attention), which leverages the adaptively sparse $α$-entmax transformation to select a variable number of blocks according to the current query in the first stage. This in turn provides a prior for the second-stage softmax attention, keeping the entire hierarchy fully differentiable. Contrary to other hierarchical attention methods, we show that DashAttention is non-dispersive, translating to better long-context modeling ability. Experiments with large language models (LLMs) show that DashAttention achieves comparable accuracy as full attention with 75% sparsity and a better Pareto frontier than NSA and InfLLMv2, especially in high-sparsity regimes. We also provide an efficient, GPU-aware implementation of DashAttention in Triton, which achieves a speedup of up to over FlashAttention-3 at inference time. Overall, DashAttention offers a cost-effective strategy to model long contexts.
Abstract:Recent advances in multimodal large language models have driven growing interest in graphical user interface (GUI) agents, yet their generalization remains constrained by the scarcity of large-scale training data spanning diverse real-world applications. Existing datasets rely heavily on costly manual annotations and are typically confined to narrow domains. To address this challenge, we propose Video2GUI, a fully automated framework that extracts grounded GUI interaction trajectories directly from unlabeled Internet videos. Video2GUI employs a coarse-to-fine filtering strategy to identify high-quality GUI tutorial videos and convert them into structured agent trajectories. Applying this pipeline to 500 million video metadata entries, we construct WildGUI, a large-scale dataset containing 12 million interaction trajectories spanning over 1,500 applications and websites. Pre-training Qwen2.5-VL and Mimo-VL on WildGUI yields consistent improvements of 5-20% across multiple GUI grounding and action benchmarks, matching or surpassing state-of-the-art performance. We will release both the WildGUI dataset and the Video2GUI pipeline to support future research of GUI agents.
Abstract:Accurate 3D+t whole-heart mesh reconstruction from cine MRI is a clinically crucial yet technically challenging task. The difficulty of this task arises from two coupled factors: inherently sparse sampling of 3D cardiac anatomy by 2D image slices and the tight coupling between cardiac shape and motion. Current cardiac image-to-mesh approaches typically reconstruct only a subset of cardiac chambers or a single phase of the cardiac cycle. In this work, we propose CineMesh4D, a novel end-to-end 4D (3D+t) pipeline that directly reconstructs patient-specific whole-heart mesh from multi-view 2D cine MRI via cross-domain mapping. Specifically, we introduce a differentiable rendering loss that enables supervision of 3D+t whole-heart mesh from multi-view sparse contours of cine MRI. Furthermore, we develop a dual-context temporal block that fuses global and local cardiac temporal information to capture high-dimensional sequential patterns. In quantitative and qualitative evaluations, CineMesh4D outperforms existing approaches in terms of reconstruction quality and motion consistency, providing a practical pathway for personalized real-time cardiac assessment. The code will be publicly released once the manuscript is accepted.
Abstract:Large language model (LLM)-enhanced sequential recommendation typically aims to improve two core components: user semantic embedding extraction and utilization. Despite promising results, existing methods still have two limitations: 1) In the extraction stage, most methods directly input long interaction sequence fragments into LLM for preference summarization. However, excessively long sequences increase inference difficulty, making it challenging to reliably infer accurate user embeddings. 2) In the utilization stage, most methods employ the same semantic embedding utilization strategy for all users, neglecting the differences caused by user activity levels, leading to suboptimal performance. To address these issues, we propose HSUGA, which introduces a simple yet effective plugin for each of the two core components: Hierarchical Semantic Understanding (HSU) and Group-Aware Alignment (GAA). HSU performs a staged two-phase preference mining and models preference evolution through constrained editing operations, thereby improving the reliability of user semantic extraction. GAA adjusts the intensity of semantic utilization based on user activity levels, providing weaker alignment for active users and stronger guidance for users with sparse historical data. Finally, extensive experiments on three benchmark datasets demonstrate the effectiveness and compatibility of HSUGA.