A Comprehensive Review of Multimodal Large Language Models: Performance and Challenges Across Different Tasks

In an era defined by the explosive growth of data and rapid technological advancements, Multimodal Large Language Models (MLLMs) stand at the forefront of artificial intelligence (AI) systems. Designed to seamlessly integrate diverse data types-including text, images, videos, audio, and physiological sequences-MLLMs address the complexities of real-world applications far beyond the capabilities of single-modality systems. In this paper, we systematically sort out the applications of MLLM in multimodal tasks such as natural language, vision, and audio. We also provide a comparative analysis of the focus of different MLLMs in the tasks, and provide insights into the shortcomings of current MLLMs, and suggest potential directions for future research. Through these discussions, this paper hopes to provide valuable insights for the further development and application of MLLM.

Potential of Multimodal Large Language Models for Data Mining of Medical Images and Free-text Reports

Medical images and radiology reports are crucial for diagnosing medical conditions, highlighting the importance of quantitative analysis for clinical decision-making. However, the diversity and cross-source heterogeneity of these data challenge the generalizability of current data-mining methods. Multimodal large language models (MLLMs) have recently transformed many domains, significantly affecting the medical field. Notably, Gemini-Vision-series (Gemini) and GPT-4-series (GPT-4) models have epitomized a paradigm shift in Artificial General Intelligence (AGI) for computer vision, showcasing their potential in the biomedical domain. In this study, we evaluated the performance of the Gemini, GPT-4, and 4 popular large models for an exhaustive evaluation across 14 medical imaging datasets, including 5 medical imaging categories (dermatology, radiology, dentistry, ophthalmology, and endoscopy), and 3 radiology report datasets. The investigated tasks encompass disease classification, lesion segmentation, anatomical localization, disease diagnosis, report generation, and lesion detection. Our experimental results demonstrated that Gemini-series models excelled in report generation and lesion detection but faces challenges in disease classification and anatomical localization. Conversely, GPT-series models exhibited proficiency in lesion segmentation and anatomical localization but encountered difficulties in disease diagnosis and lesion detection. Additionally, both the Gemini series and GPT series contain models that have demonstrated commendable generation efficiency. While both models hold promise in reducing physician workload, alleviating pressure on limited healthcare resources, and fostering collaboration between clinical practitioners and artificial intelligence technologies, substantial enhancements and comprehensive validations remain imperative before clinical deployment.

Embracing Federated Learning: Enabling Weak Client Participation via Partial Model Training

In Federated Learning (FL), clients may have weak devices that cannot train the full model or even hold it in their memory space. To implement large-scale FL applications, thus, it is crucial to develop a distributed learning method that enables the participation of such weak clients. We propose EmbracingFL, a general FL framework that allows all available clients to join the distributed training regardless of their system resource capacity. The framework is built upon a novel form of partial model training method in which each client trains as many consecutive output-side layers as its system resources allow. Our study demonstrates that EmbracingFL encourages each layer to have similar data representations across clients, improving FL efficiency. The proposed partial model training method guarantees convergence to a neighbor of stationary points for non-convex and smooth problems. We evaluate the efficacy of EmbracingFL under a variety of settings with a mixed number of strong, moderate (~40% memory), and weak (~15% memory) clients, datasets (CIFAR-10, FEMNIST, and IMDB), and models (ResNet20, CNN, and LSTM). Our empirical study shows that EmbracingFL consistently achieves high accuracy as like all clients are strong, outperforming the state-of-the-art width reduction methods (i.e. HeteroFL and FjORD).

Creating a Lens of Chinese Culture: A Multimodal Dataset for Chinese Pun Rebus Art Understanding

Large vision-language models (VLMs) have demonstrated remarkable abilities in understanding everyday content. However, their performance in the domain of art, particularly culturally rich art forms, remains less explored. As a pearl of human wisdom and creativity, art encapsulates complex cultural narratives and symbolism. In this paper, we offer the Pun Rebus Art Dataset, a multimodal dataset for art understanding deeply rooted in traditional Chinese culture. We focus on three primary tasks: identifying salient visual elements, matching elements with their symbolic meanings, and explanations for the conveyed messages. Our evaluation reveals that state-of-the-art VLMs struggle with these tasks, often providing biased and hallucinated explanations and showing limited improvement through in-context learning. By releasing the Pun Rebus Art Dataset, we aim to facilitate the development of VLMs that can better understand and interpret culturally specific content, promoting greater inclusiveness beyond English-based corpora.

Revisiting OPRO: The Limitations of Small-Scale LLMs as Optimizers

Numerous recent works aim to enhance the efficacy of Large Language Models (LLMs) through strategic prompting. In particular, the Optimization by PROmpting (OPRO) approach provides state-of-the-art performance by leveraging LLMs as optimizers where the optimization task is to find instructions that maximize the task accuracy. In this paper, we revisit OPRO for automated prompting with relatively small-scale LLMs, such as LLaMa-2 family and Mistral 7B. Our investigation reveals that OPRO shows limited effectiveness in small-scale LLMs, with limited inference capabilities constraining optimization ability. We suggest future automatic prompting engineering to consider both model capabilities and computational costs. Additionally, for small-scale LLMs, we recommend direct instructions that clearly outline objectives and methodologies as robust prompt baselines, ensuring efficient and effective prompt engineering in ongoing research.

Eye-gaze Guided Multi-modal Alignment Framework for Radiology

In multi-modal frameworks, the alignment of cross-modal features presents a significant challenge. The predominant approach in multi-modal pre-training emphasizes either global or local alignment between modalities, utilizing extensive datasets. This bottom-up driven method often suffers from a lack of interpretability, a critical concern in radiology. Previous studies have integrated high-level labels in medical images or text, but these still rely on manual annotation, a costly and labor-intensive process. Our work introduces a novel approach by using eye-gaze data, collected synchronously by radiologists during diagnostic evaluations. This data, indicating radiologists' focus areas, naturally links chest X-rays to diagnostic texts. We propose the Eye-gaze Guided Multi-modal Alignment (EGMA) framework to harness eye-gaze data for better alignment of image and text features, aiming to reduce reliance on manual annotations and thus cut training costs. Our model demonstrates robust performance, outperforming other state-of-the-art methods in zero-shot classification and retrieval tasks. The incorporation of easily-obtained eye-gaze data during routine radiological diagnoses signifies a step towards minimizing manual annotation dependency. Additionally, we explore the impact of varying amounts of eye-gaze data on model performance, highlighting the feasibility and utility of integrating this auxiliary data into multi-modal pre-training.

Understanding LLMs: A Comprehensive Overview from Training to Inference

The introduction of ChatGPT has led to a significant increase in the utilization of Large Language Models (LLMs) for addressing downstream tasks. There's an increasing focus on cost-efficient training and deployment within this context. Low-cost training and deployment of LLMs represent the future development trend. This paper reviews the evolution of large language model training techniques and inference deployment technologies aligned with this emerging trend. The discussion on training includes various aspects, including data preprocessing, training architecture, pre-training tasks, parallel training, and relevant content related to model fine-tuning. On the inference side, the paper covers topics such as model compression, parallel computation, memory scheduling, and structural optimization. It also explores LLMs' utilization and provides insights into their future development.

High Efficiency Inference Accelerating Algorithm for NOMA-based Mobile Edge Computing

Splitting the inference model between device, edge server, and cloud can improve the performance of EI greatly. Additionally, the non-orthogonal multiple access (NOMA), which is the key supporting technologies of B5G/6G, can achieve massive connections and high spectrum efficiency. Motivated by the benefits of NOMA, integrating NOMA with model split in MEC to reduce the inference latency further becomes attractive. However, the NOMA based communication during split inference has not been properly considered in previous works. Therefore, in this paper, we integrate the NOMA into split inference in MEC, and propose the effective communication and computing resource allocation algorithm to accelerate the model inference at edge. Specifically, when the mobile user has a large model inference task needed to be calculated in the NOMA-based MEC, it will take the energy consumption of both device and edge server and the inference latency into account to find the optimal model split strategy, subchannel allocation strategy (uplink and downlink), and transmission power allocation strategy (uplink and downlink). Since the minimum inference delay and energy consumption cannot be satisfied simultaneously, and the variables of subchannel allocation and model split are discrete, the gradient descent (GD) algorithm is adopted to find the optimal tradeoff between them. Moreover, the loop iteration GD approach (Li-GD) is proposed to reduce the complexity of GD algorithm that caused by the parameter discrete. Additionally, the properties of the proposed algorithm are also investigated, which demonstrate the effectiveness of the proposed algorithms.

The DURel Annotation Tool: Human and Computational Measurement of Semantic Proximity, Sense Clusters and Semantic Change

We present the DURel tool that implements the annotation of semantic proximity between uses of words into an online, open source interface. The tool supports standardized human annotation as well as computational annotation, building on recent advances with Word-in-Context models. Annotator judgments are clustered with automatic graph clustering techniques and visualized for analysis. This allows to measure word senses with simple and intuitive micro-task judgments between use pairs, requiring minimal preparation efforts. The tool offers additional functionalities to compare the agreement between annotators to guarantee the inter-subjectivity of the obtained judgments and to calculate summary statistics giving insights into sense frequency distributions, semantic variation or changes of senses over time.

ChatRadio-Valuer: A Chat Large Language Model for Generalizable Radiology Report Generation Based on Multi-institution and Multi-system Data

Radiology report generation, as a key step in medical image analysis, is critical to the quantitative analysis of clinically informed decision-making levels. However, complex and diverse radiology reports with cross-source heterogeneity pose a huge generalizability challenge to the current methods under massive data volume, mainly because the style and normativity of radiology reports are obviously distinctive among institutions, body regions inspected and radiologists. Recently, the advent of large language models (LLM) offers great potential for recognizing signs of health conditions. To resolve the above problem, we collaborate with the Second Xiangya Hospital in China and propose ChatRadio-Valuer based on the LLM, a tailored model for automatic radiology report generation that learns generalizable representations and provides a basis pattern for model adaptation in sophisticated analysts' cases. Specifically, ChatRadio-Valuer is trained based on the radiology reports from a single institution by means of supervised fine-tuning, and then adapted to disease diagnosis tasks for human multi-system evaluation (i.e., chest, abdomen, muscle-skeleton, head, and maxillofacial $\&$ neck) from six different institutions in clinical-level events. The clinical dataset utilized in this study encompasses a remarkable total of \textbf{332,673} observations. From the comprehensive results on engineering indicators, clinical efficacy and deployment cost metrics, it can be shown that ChatRadio-Valuer consistently outperforms state-of-the-art models, especially ChatGPT (GPT-3.5-Turbo) and GPT-4 et al., in terms of the diseases diagnosis from radiology reports. ChatRadio-Valuer provides an effective avenue to boost model generalization performance and alleviate the annotation workload of experts to enable the promotion of clinical AI applications in radiology reports.