Revealing Modular Gradient Noise Imbalance in LLMs: Calibrating Adam via Signal-to-Noise Ratio

The impressive performance of large language models (LLMs) arises from their massive scale and heterogeneous module composition. However, this structural heterogeneity introduces additional optimization challenges. While adaptive optimizers such as Adam(W) provide per-parameter adaptivity, they do not explicitly account for module-level gradient heterogeneity, resulting in slower convergence, suboptimal performance, or training instability. Existing approaches typically rely on manually tuned module-specific learning rates or specific optimization strategies, which are computationally costly and difficult to generalize across tasks or models. To establish a more principled approach, we first analyze the noise-damping behavior of Adam in high-noise modules and introduce \textbf{Module-wise Learning Rate Scaling via SNR (MoLS)}. MoLS estimates module-level SNRs to scale Adam updates, allowing automated module-wise learning rate allocation without manual tuning. Empirical results through multiple LLM training benchmarks demonstrate that MoLS improves convergence speed and generalization, achieving performance comparable to carefully tuned module-specific learning rates, while remaining compatible with memory-efficient training algorithms.

Stability and Generalization for Decentralized Markov SGD

Stochastic gradient methods are central to large-scale learning, yet their generalization theory typically relies on independent sampling assumptions. In many practical applications, data are generated by Markov chains and learning is performed in a decentralized manner, which introduces significant analytical challenges. In this work, we investigate the stability and generalization of decentralized stochastic gradient descent (SGD) and stochastic gradient descent ascent (SGDA) under Markov chain sampling. Leveraging a stability-based framework, we characterize how Markovian dependence and decentralized communication jointly influence generalization behavior. Our analysis captures the effects of network topology, Markov chain mixing properties, and primal-dual dynamics. We establish non-asymptotic generalization bounds for both algorithms, extending existing results on Markov stochastic gradient methods to decentralized and minimax settings.

MAny: Merge Anything for Multimodal Continual Instruction Tuning

Multimodal Continual Instruction Tuning (MCIT) is essential for sequential task adaptation of Multimodal Large Language Models (MLLMs) but is severely restricted by catastrophic forgetting. While existing literature focuses on the reasoning language backbone, in this work, we expose a critical yet neglected dual-forgetting phenomenon across both perception drift in Cross-modal Projection Space and reasoning collapse in Low-rank Parameter Space. To resolve this, we present \textbf{MAny} (\textbf{M}erge \textbf{Any}thing), a framework that merges task-specific knowledge through \textbf{C}ross-modal \textbf{P}rojection \textbf{M}erging (\textbf{CPM}) and \textbf{L}ow-rank \textbf{P}arameter \textbf{M}erging (\textbf{LPM}). Specifically, CPM recovers perceptual alignment by adaptively merging cross-modal visual representations via visual-prototype guidance, ensuring accurate feature recovery during inference. Simultaneously, LPM eliminates mutual interference among task-specific low-rank modules by recursively merging low-rank weight matrices. By leveraging recursive least squares, LPM provides a closed-form solution that mathematically guarantees an optimal fusion trajectory for reasoning stability. Notably, MAny operates as a training-free paradigm that achieves knowledge merging via efficient CPU-based algebraic operations, eliminating additional gradient-based optimization beyond initial tuning. Our extensive evaluations confirm the superior performance and robustness of MAny across multiple MLLMs and benchmarks. Specifically, on the UCIT benchmark, MAny achieves significant leads of up to 8.57\% and 2.85\% in final average accuracy over state-of-the-art methods across two different MLLMs, respectively.

ECHO: Efficient Chest X-ray Report Generation with One-step Block Diffusion

Chest X-ray report generation (CXR-RG) has the potential to substantially alleviate radiologists' workload. However, conventional autoregressive vision--language models (VLMs) suffer from high inference latency due to sequential token decoding. Diffusion-based models offer a promising alternative through parallel generation, but they still require multiple denoising iterations. Compressing multi-step denoising to a single step could further reduce latency, but often degrades textual coherence due to the mean-field bias introduced by token-factorized denoisers. To address this challenge, we propose \textbf{ECHO}, an efficient diffusion-based VLM (dVLM) for chest X-ray report generation. ECHO enables stable one-step-per-block inference via a novel Direct Conditional Distillation (DCD) framework, which mitigates the mean-field limitation by constructing unfactorized supervision from on-policy diffusion trajectories to encode joint token dependencies. In addition, we introduce a Response-Asymmetric Diffusion (RAD) training strategy that further improves training efficiency while maintaining model effectiveness. Extensive experiments demonstrate that ECHO surpasses state-of-the-art autoregressive methods, improving RaTE and SemScore by \textbf{64.33\%} and \textbf{60.58\%} respectively, while achieving an \textbf{$8\times$} inference speedup without compromising clinical accuracy.

ICODEN: Ordinary Differential Equation Neural Networks for Interval-Censored Data

Predicting time-to-event outcomes when event times are interval censored is challenging because the exact event time is unobserved. Many existing survival analysis approaches for interval-censored data rely on strong model assumptions or cannot handle high-dimensional predictors. We develop ICODEN, an ordinary differential equation-based neural network for interval-censored data that models the hazard function through deep neural networks and obtains the cumulative hazard by solving an ordinary differential equation. ICODEN does not require the proportional hazards assumption or a prespecified parametric form for the hazard function, thereby permitting flexible survival modeling. Across simulation settings with proportional or non-proportional hazards and both linear and nonlinear covariate effects, ICODEN consistently achieves satisfactory predictive accuracy and remains stable as the number of predictors increases. Applications to data from multiple phases of the Alzheimer's Disease Neuroimaging Initiative (ADNI) and to two Age-Related Eye Disease Studies (AREDS and AREDS2) for age-related macular degeneration (AMD) demonstrate ICODEN's robust prediction performance. In both applications, predicting time-to-AD or time-to-late AMD, ICODEN effectively uses hundreds to more than 1,000 SNPs and supports data-driven subgroup identification with differential progression risk profiles. These results establish ICODEN as a practical assumption-lean tool for prediction with interval-censored survival data in high-dimensional biomedical settings.

Refining Strokes by Learning Offset Attributes between Strokes for Flexible Sketch Edit at Stroke-Level

Sketch edit at stroke-level aims to transplant source strokes onto a target sketch via stroke expansion or replacement, while preserving semantic consistency and visual fidelity with the target sketch. Recent studies addressed it by relocating source strokes at appropriate canvas positions. However, as source strokes could exhibit significant variations in both size and orientation, we may fail to produce plausible sketch editing results by merely repositioning them without further adjustments. For example, anchoring an oversized source stroke onto the target without proper scaling would fail to produce a semantically coherent outcome. In this paper, we propose SketchMod to refine the source stroke through transformation so as to align it with the target sketch's patterns, further realize flexible sketch edit at stroke-level. As the source stroke refinement is governed by the patterns of the target sketch, we learn three key offset attributes (scale, orientation and position) from the source stroke to another, and align it with the target by: 1) resizing to match spatial proportions by scale, 2) rotating to align with local geometry by orientation, and 3) displacing to meet with semantic layout by position. Besides, a stroke's profiles can be precisely controlled during sketch edit via the exposed captured stroke attributes. Experimental results indicate that SketchMod achieves precise and flexible performances on stroke-level sketch edit.

Reliable Brain Tumor Segmentation Based on Spiking Neural Networks with Efficient Training

We propose a reliable and energy-efficient framework for 3D brain tumor segmentation using spiking neural networks (SNNs). A multi-view ensemble of sagittal, coronal, and axial SNN models provides voxel-wise uncertainty estimation and enhances segmentation robustness. To address the high computational cost in training SNN models for semantic image segmentation, we employ Forward Propagation Through Time (FPTT), which maintains temporal learning efficiency with significantly reduced computational cost. Experiments on the Multimodal Brain Tumor Segmentation Challenges (BraTS 2017 and BraTS 2023) demonstrate competitive accuracy, well-calibrated uncertainty, and an 87% reduction in FLOPs, underscoring the potential of SNNs for reliable, low-power medical IoT and Point-of-Care systems.

Local Gradient Regulation Stabilizes Federated Learning under Client Heterogeneity

Federated learning (FL) enables collaborative model training across distributed clients without sharing raw data, yet its stability is fundamentally challenged by statistical heterogeneity in realistic deployments. Here, we show that client heterogeneity destabilizes FL primarily by distorting local gradient dynamics during client-side optimization, causing systematic drift that accumulates across communication rounds and impedes global convergence. This observation highlights local gradients as a key regulatory lever for stabilizing heterogeneous FL systems. Building on this insight, we develop a general client-side perspective that regulates local gradient contributions without incurring additional communication overhead. Inspired by swarm intelligence, we instantiate this perspective through Exploratory--Convergent Gradient Re-aggregation (ECGR), which balances well-aligned and misaligned gradient components to preserve informative updates while suppressing destabilizing effects. Theoretical analysis and extensive experiments, including evaluations on the LC25000 medical imaging dataset, demonstrate that regulating local gradient dynamics consistently stabilizes federated learning across state-of-the-art methods under heterogeneous data distributions.

Fine-tuning Small Language Models as Efficient Enterprise Search Relevance Labelers

In enterprise search, building high-quality datasets at scale remains a central challenge due to the difficulty of acquiring labeled data. To resolve this challenge, we propose an efficient approach to fine-tune small language models (SLMs) for accurate relevance labeling, enabling high-throughput, domain-specific labeling comparable or even better in quality to that of state-of-the-art large language models (LLMs). To overcome the lack of high-quality and accessible datasets in the enterprise domain, our method leverages on synthetic data generation. Specifically, we employ an LLM to synthesize realistic enterprise queries from a seed document, apply BM25 to retrieve hard negatives, and use a teacher LLM to assign relevance scores. The resulting dataset is then distilled into an SLM, producing a compact relevance labeler. We evaluate our approach on a high-quality benchmark consisting of 923 enterprise query-document pairs annotated by trained human annotators, and show that the distilled SLM achieves agreement with human judgments on par with or better than the teacher LLM. Furthermore, our fine-tuned labeler substantially improves throughput, achieving 17 times increase while also being 19 times more cost-effective. This approach enables scalable and cost-effective relevance labeling for enterprise-scale retrieval applications, supporting rapid offline evaluation and iteration in real-world settings.

A DeepSeek-Powered AI System for Automated Chest Radiograph Interpretation in Clinical Practice

A global shortage of radiologists has been exacerbated by the significant volume of chest X-ray workloads, particularly in primary care. Although multimodal large language models show promise, existing evaluations predominantly rely on automated metrics or retrospective analyses, lacking rigorous prospective clinical validation. Janus-Pro-CXR (1B), a chest X-ray interpretation system based on DeepSeek Janus-Pro model, was developed and rigorously validated through a multicenter prospective trial (NCT07117266). Our system outperforms state-of-the-art X-ray report generation models in automated report generation, surpassing even larger-scale models including ChatGPT 4o (200B parameters), while demonstrating reliable detection of six clinically critical radiographic findings. Retrospective evaluation confirms significantly higher report accuracy than Janus-Pro and ChatGPT 4o. In prospective clinical deployment, AI assistance significantly improved report quality scores, reduced interpretation time by 18.3% (P < 0.001), and was preferred by a majority of experts in 54.3% of cases. Through lightweight architecture and domain-specific optimization, Janus-Pro-CXR improves diagnostic reliability and workflow efficiency, particularly in resource-constrained settings. The model architecture and implementation framework will be open-sourced to facilitate the clinical translation of AI-assisted radiology solutions.