The identification of compound-protein interactions (CPI) plays a critical role in drug screening, drug repurposing, and combination therapy studies. The effectiveness of CPI prediction relies heavily on the features extracted from both compounds and target proteins. While various prediction methods employ different feature combinations, both molecular-based and network-based models encounter the common obstacle of incomplete feature representations. Thus, a promising solution to this issue is to fully integrate all relevant CPI features. This study proposed a novel model named MCPI, which is designed to improve the prediction performance of CPI by integrating multiple sources of information, including the PPI network, CCI network, and structural features of CPI. The results of the study indicate that the MCPI model outperformed other existing methods for predicting CPI on public datasets. Furthermore, the study has practical implications for drug development, as the model was applied to search for potential inhibitors among FDA-approved drugs in response to the SARS-CoV-2 pandemic. The prediction results were then validated through the literature, suggesting that the MCPI model could be a useful tool for identifying potential drug candidates. Overall, this study has the potential to advance our understanding of CPI and guide drug development efforts.
Clouds in remote sensing images inevitably affect information extraction, which hinder the following analysis of satellite images. Hence, cloud detection is a necessary preprocessing procedure. However, the existing methods have numerous calculations and parameters. In this letter, a lightweight CNN-Transformer network, CD-CTFM, is proposed to solve the problem. CD-CTFM is based on encoder-decoder architecture and incorporates the attention mechanism. In the decoder part, we utilize a lightweight network combing CNN and Transformer as backbone, which is conducive to extract local and global features simultaneously. Moreover, a lightweight feature pyramid module is designed to fuse multiscale features with contextual information. In the decoder part, we integrate a lightweight channel-spatial attention module into each skip connection between encoder and decoder, extracting low-level features while suppressing irrelevant information without introducing many parameters. Finally, the proposed model is evaluated on two cloud datasets, 38-Cloud and MODIS. The results demonstrate that CD-CTFM achieves comparable accuracy as the state-of-art methods. At the same time, CD-CTFM outperforms state-of-art methods in terms of efficiency.
Most video platforms provide video streaming services with different qualities, and the quality of the services is usually adjusted by the resolution of the videos. So high-resolution videos need to be downsampled for compression. In order to solve the problem of video coding at different resolutions, we propose a rate-guided arbitrary rescaling network (RARN) for video resizing before encoding. To help the RARN be compatible with standard codecs and generate compression-friendly results, an iteratively optimized transformer-based virtual codec (TVC) is introduced to simulate the key components of video encoding and perform bitrate estimation. By iteratively training the TVC and the RARN, we achieved 5%-29% BD-Rate reduction anchored by linear interpolation under different encoding configurations and resolutions, exceeding the previous methods on most test videos. Furthermore, the lightweight RARN structure can process FHD (1080p) content at real-time speed (91 FPS) and obtain a considerable rate reduction.
The need to compactly and robustly represent item-attribute relations arises in many important tasks, such as faceted browsing and recommendation systems. A popular machine learning approach for this task denotes that an item has an attribute by a high dot-product between vectors for the item and attribute -- a representation that is not only dense, but also tends to correct noisy and incomplete data. While this method works well for queries retrieving items by a single attribute (such as \emph{movies that are comedies}), we find that vector embeddings do not so accurately support compositional queries (such as movies that are comedies and British but not romances). To address these set-theoretic compositions, this paper proposes to replace vectors with box embeddings, a region-based representation that can be thought of as learnable Venn diagrams. We introduce a new benchmark dataset for compositional queries, and present experiments and analysis providing insights into the behavior of both. We find that, while vector and box embeddings are equally suited to single attribute queries, for compositional queries box embeddings provide substantial advantages over vectors, particularly at the moderate and larger retrieval set sizes that are most useful for users' search and browsing.
Building robust, interpretable, and secure artificial intelligence system requires some degree of quantifying and representing uncertainty via a probabilistic perspective, as it allows to mimic human cognitive abilities. However, probabilistic computation presents significant challenges due to its inherent complexity. In this paper, we develop an efficient and interpretable probabilistic computation framework by truncating the probabilistic representation up to its first two moments, i.e., mean and covariance. We instantiate the framework by training a deterministic surrogate of a stochastic network that learns the complex probabilistic representation via combinations of simple activations, encapsulating the non-linearities coupling of the mean and covariance. We show that when the mean is supervised for optimizing the task objective, the unsupervised covariance spontaneously emerging from the non-linear coupling with the mean faithfully captures the uncertainty associated with model predictions. Our research highlights the inherent computability and simplicity of probabilistic computation, enabling its wider application in large-scale settings.
**Background:** Accurate 3D CT scan segmentation of gastric tumors is pivotal for diagnosis and treatment. The challenges lie in the irregular shapes, blurred boundaries of tumors, and the inefficiency of existing methods. **Purpose:** We conducted a study to introduce a model, utilizing human-guided knowledge and unique modules, to address the challenges of 3D tumor segmentation. **Methods:** We developed the PropNet framework, propagating radiologists' knowledge from 2D annotations to the entire 3D space. This model consists of a proposing stage for coarse segmentation and a refining stage for improved segmentation, using two-way branches for enhanced performance and an up-down strategy for efficiency. **Results:** With 98 patient scans for training and 30 for validation, our method achieves a significant agreement with manual annotation (Dice of 0.803) and improves efficiency. The performance is comparable in different scenarios and with various radiologists' annotations (Dice between 0.785 and 0.803). Moreover, the model shows improved prognostic prediction performance (C-index of 0.620 vs. 0.576) on an independent validation set of 42 patients with advanced gastric cancer. **Conclusions:** Our model generates accurate tumor segmentation efficiently and stably, improving prognostic performance and reducing high-throughput image reading workload. This model can accelerate the quantitative analysis of gastric tumors and enhance downstream task performance.
Representing texts as information about entities has long been deemed effective in event reasoning. We propose OpenPI2.0, an improved dataset for tracking entity states in procedural texts. OpenPI2.0 features not only canonicalized entities that facilitate evaluation, but also salience annotations including both manual labels and automatic predictions. Regarding entity salience, we provide a survey on annotation subjectivity, modeling feasibility, and downstream applications in tasks such as question answering and classical planning.
Multi-stage strategies are frequently employed in image restoration tasks. While transformer-based methods have exhibited high efficiency in single-image super-resolution tasks, they have not yet shown significant advantages over CNN-based methods in stereo super-resolution tasks. This can be attributed to two key factors: first, current single-image super-resolution transformers are unable to leverage the complementary stereo information during the process; second, the performance of transformers is typically reliant on sufficient data, which is absent in common stereo-image super-resolution algorithms. To address these issues, we propose a Hybrid Transformer and CNN Attention Network (HTCAN), which utilizes a transformer-based network for single-image enhancement and a CNN-based network for stereo information fusion. Furthermore, we employ a multi-patch training strategy and larger window sizes to activate more input pixels for super-resolution. We also revisit other advanced techniques, such as data augmentation, data ensemble, and model ensemble to reduce overfitting and data bias. Finally, our approach achieved a score of 23.90dB and emerged as the winner in Track 1 of the NTIRE 2023 Stereo Image Super-Resolution Challenge.
Labeling LiDAR point clouds for training autonomous driving is extremely expensive and difficult. LiDAR simulation aims at generating realistic LiDAR data with labels for training and verifying self-driving algorithms more efficiently. Recently, Neural Radiance Fields (NeRF) have been proposed for novel view synthesis using implicit reconstruction of 3D scenes. Inspired by this, we present NeRF-LIDAR, a novel LiDAR simulation method that leverages real-world information to generate realistic LIDAR point clouds. Different from existing LiDAR simulators, we use real images and point cloud data collected by self-driving cars to learn the 3D scene representation, point cloud generation and label rendering. We verify the effectiveness of our NeRF-LiDAR by training different 3D segmentation models on the generated LiDAR point clouds. It reveals that the trained models are able to achieve similar accuracy when compared with the same model trained on the real LiDAR data. Besides, the generated data is capable of boosting the accuracy through pre-training which helps reduce the requirements of the real labeled data.
360{\deg} omnidirectional images have gained research attention due to their immersive and interactive experience, particularly in AR/VR applications. However, they suffer from lower angular resolution due to being captured by fisheye lenses with the same sensor size for capturing planar images. To solve the above issues, we propose a two-stage framework for 360{\deg} omnidirectional image superresolution. The first stage employs two branches: model A, which incorporates omnidirectional position-aware deformable blocks (OPDB) and Fourier upsampling, and model B, which adds a spatial frequency fusion module (SFF) to model A. Model A aims to enhance the feature extraction ability of 360{\deg} image positional information, while Model B further focuses on the high-frequency information of 360{\deg} images. The second stage performs same-resolution enhancement based on the structure of model A with a pixel unshuffle operation. In addition, we collected data from YouTube to improve the fitting ability of the transformer, and created pseudo low-resolution images using a degradation network. Our proposed method achieves superior performance and wins the NTIRE 2023 challenge of 360{\deg} omnidirectional image super-resolution.