Latent Diffusion Model Based Denoising Receiver for 6G Semantic Communication: From Stochastic Differential Theory to Application

In this paper, a novel semantic communication framework empowered by generative artificial intelligence (GAI) is proposed, specifically leveraging the capabilities of diffusion models (DMs). A rigorous theoretical foundation is established based on stochastic differential equations (SDEs), which elucidates the denoising properties of DMs in mitigating additive white Gaussian noise (AWGN) in latent semantic representations. Crucially, a closed-form analytical relationship between the signal-to-noise ratio (SNR) and the denoising timestep is derived, enabling the optimal selection of diffusion parameters for any given channel condition. To address the distribution mismatch between the received signal and the DM's training data, a mathematically principled scaling mechanism is introduced, ensuring robust performance across a wide range of SNRs without requiring model fine-tuning. Built upon this theoretical insight, we develop a latent diffusion model (LDM)-based semantic transceiver, wherein a variational autoencoder (VAE) is employed for efficient semantic compression, and a pretrained DM serves as a universal denoiser. Notably, the proposed architecture is fully training-free at inference time, offering high modularity and compatibility with large-scale pretrained LDMs. This design inherently supports zero-shot generalization and mitigates the challenges posed by out-of-distribution inputs. Extensive experimental evaluations demonstrate that the proposed framework significantly outperforms conventional neural-network-based semantic communication baselines, particularly under low SNR conditions and distributional shifts, thereby establishing a promising direction for GAI-driven robust semantic transmission in future 6G systems.

Patient-Specific Dynamic Digital-Physical Twin for Coronary Intervention Training: An Integrated Mixed Reality Approach

Background and Objective: Precise preoperative planning and effective physician training for coronary interventions are increasingly important. Despite advances in medical imaging technologies, transforming static or limited dynamic imaging data into comprehensive dynamic cardiac models remains challenging. Existing training systems lack accurate simulation of cardiac physiological dynamics. This study develops a comprehensive dynamic cardiac model research framework based on 4D-CTA, integrating digital twin technology, computer vision, and physical model manufacturing to provide precise, personalized tools for interventional cardiology. Methods: Using 4D-CTA data from a 60-year-old female with three-vessel coronary stenosis, we segmented cardiac chambers and coronary arteries, constructed dynamic models, and implemented skeletal skinning weight computation to simulate vessel deformation across 20 cardiac phases. Transparent vascular physical models were manufactured using medical-grade silicone. We developed cardiac output analysis and virtual angiography systems, implemented guidewire 3D reconstruction using binocular stereo vision, and evaluated the system through angiography validation and CABG training applications. Results: Morphological consistency between virtual and real angiography reached 80.9%. Dice similarity coefficients for guidewire motion ranged from 0.741-0.812, with mean trajectory errors below 1.1 mm. The transparent model demonstrated advantages in CABG training, allowing direct visualization while simulating beating heart challenges. Conclusion: Our patient-specific digital-physical twin approach effectively reproduces both anatomical structures and dynamic characteristics of coronary vasculature, offering a dynamic environment with visual and tactile feedback valuable for education and clinical planning.

Anti-Intercept OFDM Waveform Design with Secure Coding for Satellite Networks

Low Earth Orbit (LEO) satellite networks are integral to next-generation communication systems, providing global coverage, low latency, and minimal signal loss. However, their unique characteristics, such as constrained onboard resources, Line-of-Sight (LoS) propagation, and vulnerability to eavesdropping over wide coverage areas, present significant challenges to physical layer security. To address these challenges, this paper focuses on the design of anti-intercept waveforms for satellite-ground links within Orthogonal Frequency Division Multiplexing (OFDM) systems, aiming to enhance security against eavesdropping threats. We formulate a secrecy rate maximization problem that aims to balance secrecy performance and communication reliability under eavesdropping constraints and sub-carrier power limitations. To solve this non-convex optimization problem, we propose a bisection search-activated neural network (BSA-Net) that integrates unsupervised learning for secure coding optimization and bisection search for dynamic power allocation. The proposed method is structured in two stages: the first optimizes secure coding under power constraints, while the second allocates power across sub-carriers under eavesdropping constraints. Extensive simulation results demonstrate the efficacy of our approach, showcasing significant improvements in secrecy rate performance.

Innovative Integration of 4D Cardiovascular Reconstruction and Hologram: A New Visualization Tool for Coronary Artery Bypass Grafting Planning

Background: Coronary artery bypass grafting (CABG) planning requires advanced spatial visualization and consideration of coronary artery depth, calcification, and pericardial adhesions. Objective: To develop and evaluate a dynamic cardiovascular holographic visualization tool for preoperative CABG planning. Methods: Using 4D cardiac computed tomography angiography data from 14 CABG candidates, we developed a semi-automated workflow for time-resolved segmentation of cardiac structures, epicardial adipose tissue (EAT), and coronary arteries with calcium scoring. The workflow incorporated methods for cardiac segmentation, coronary calcification quantification, visualization of coronary depth within EAT, and pericardial adhesion assessment through motion analysis. Dynamic cardiovascular holograms were displayed using the Looking Glass platform. Thirteen cardiac surgeons evaluated the tool using a Likert scale. Additionally, pericardial adhesion scores from holograms of 21 patients (including seven undergoing secondary cardiac surgeries) were compared with intraoperative findings. Results: Surgeons rated the visualization tool highly for preoperative planning utility (mean Likert score: 4.57/5.0). Hologram-based pericardial adhesion scoring strongly correlated with intraoperative findings (r=0.786, P<0.001). Conclusion: This study establishes a visualization framework for CABG planning that produces clinically relevant dynamic holograms from patient-specific data, with clinical feedback confirming its effectiveness for preoperative planning.

RadioDiff-$k^2$: Helmholtz Equation Informed Generative Diffusion Model for Multi-Path Aware Radio Map Construction

In this paper, we propose a novel physics-informed generative learning approach, termed RadioDiff-$\bm{k^2}$, for accurate and efficient multipath-aware radio map (RM) construction. As wireless communication evolves towards environment-aware paradigms, driven by the increasing demand for intelligent and proactive optimization in sixth-generation (6G) networks, accurate construction of RMs becomes crucial yet highly challenging. Conventional electromagnetic (EM)-based methods, such as full-wave solvers and ray-tracing approaches, exhibit substantial computational overhead and limited adaptability to dynamic scenarios. Although, existing neural network (NN) approaches have efficient inferencing speed, they lack sufficient consideration of the underlying physics of EM wave propagation, limiting their effectiveness in accurately modeling critical EM singularities induced by complex multipath environments. To address these fundamental limitations, we propose a novel physics-inspired RM construction method guided explicitly by the Helmholtz equation, which inherently governs EM wave propagation. Specifically, we theoretically establish a direct correspondence between EM singularities, which correspond to the critical spatial features influencing wireless propagation, and regions defined by negative wave numbers in the Helmholtz equation. Based on this insight, we design an innovative dual generative diffusion model (DM) framework comprising one DM dedicated to accurately inferring EM singularities and another DM responsible for reconstructing the complete RM using these singularities along with environmental contextual information. Our physics-informed approach uniquely combines the efficiency advantages of data-driven methods with rigorous physics-based EM modeling, significantly enhancing RM accuracy, particularly in complex propagation environments dominated by multipath effects.

RadioDiff-Inverse: Diffusion Enhanced Bayesian Inverse Estimation for ISAC Radio Map Construction

Radio maps (RMs) are essential for environment-aware communication and sensing, providing location-specific wireless channel information. Existing RM construction methods often rely on precise environmental data and base station (BS) locations, which are not always available in dynamic or privacy-sensitive environments. While sparse measurement techniques reduce data collection, the impact of noise in sparse data on RM accuracy is not well understood. This paper addresses these challenges by formulating RM construction as a Bayesian inverse problem under coarse environmental knowledge and noisy sparse measurements. Although maximum a posteriori (MAP) filtering offers an optimal solution, it requires a precise prior distribution of the RM, which is typically unavailable. To solve this, we propose RadioDiff-Inverse, a diffusion-enhanced Bayesian inverse estimation framework that uses an unconditional generative diffusion model to learn the RM prior. This approach not only reconstructs the spatial distribution of wireless channel features but also enables environmental structure perception, such as building outlines, and location of BS just relay on pathloss, through integrated sensing and communication (ISAC). Remarkably, RadioDiff-Inverse is training-free, leveraging a pre-trained model from Imagenet without task-specific fine-tuning, which significantly reduces the training cost of using generative large model in wireless networks. Experimental results demonstrate that RadioDiff-Inverse achieves state-of-the-art performance in accuracy of RM construction and environmental reconstruction, and robustness against noisy sparse sampling.

A Channel-Triggered Backdoor Attack on Wireless Semantic Image Reconstruction

Despite the transformative impact of deep learning (DL) on wireless communication systems through data-driven end-to-end (E2E) learning, the security vulnerabilities of these systems have been largely overlooked. Unlike the extensively studied image domain, limited research has explored the threat of backdoor attacks on the reconstruction of symbols in semantic communication (SemCom) systems. Previous work has investigated such backdoor attacks at the input level, but these approaches are infeasible in applications with strict input control. In this paper, we propose a novel attack paradigm, termed Channel-Triggered Backdoor Attack (CT-BA), where the backdoor trigger is a specific wireless channel. This attack leverages fundamental physical layer characteristics, making it more covert and potentially more threatening compared to previous input-level attacks. Specifically, we utilize channel gain with different fading distributions or channel noise with different power spectral densities as potential triggers. This approach establishes unprecedented attack flexibility as the adversary can select backdoor triggers from both fading characteristics and noise variations in diverse channel environments. Moreover, during the testing phase, CT-BA enables automatic trigger activation through natural channel variations without requiring active adversary participation. We evaluate the robustness of CT-BA on a ViT-based Joint Source-Channel Coding (JSCC) model across three datasets: MNIST, CIFAR-10, and ImageNet. Furthermore, we apply CT-BA to three typical E2E SemCom systems: BDJSCC, ADJSCC, and JSCCOFDM. Experimental results demonstrate that our attack achieves near-perfect attack success rate (ASR) while maintaining effective stealth. Finally, we discuss potential defense mechanisms against such attacks.

Time-Varying Coronary Artery Deformation: A Dynamic Skinning Framework for Surgical Training

Purpose: This study proposes a novel anatomically-driven dynamic modeling framework for coronary arteries using skeletal skinning weights computation, aiming to achieve precise control over vessel deformation while maintaining real-time performance for surgical simulation applications. Methods: We developed a computational framework based on biharmonic energy minimization for skinning weight calculation, incorporating volumetric discretization through tetrahedral mesh generation. The method implements temporal sampling and interpolation for continuous vessel deformation throughout the cardiac cycle, with mechanical constraints and volume conservation enforcement. The framework was validated using clinical datasets from 5 patients, comparing interpolated deformation results against ground truth data obtained from frame-by-frame segmentation across cardiac phases. Results: The proposed framework effectively handled interactive vessel manipulation. Geometric accuracy evaluation showed mean Hausdorff distance of 4.96 +- 1.78 mm and mean surface distance of 1.78 +- 0.75 mm between interpolated meshes and ground truth models. The Branch Completeness Ratio achieved 1.82 +- 0.46, while Branch Continuity Score maintained 0.84 +- 0.06 (scale 0-1) across all datasets. The system demonstrated capability in supporting real-time guidewire-vessel collision detection and contrast medium flow simulation throughout the complete coronary tree structure. Conclusion: Our skinning weight-based methodology enhances model interactivity and applicability while maintaining geometric accuracy. The framework provides a more flexible technical foundation for virtual surgical training systems, demonstrating promising potential for both clinical practice and medical education applications. The code is available at https://github.com/ipoirot/DynamicArtery.

Rethinking Fine-Tuning when Scaling Test-Time Compute: Limiting Confidence Improves Mathematical Reasoning

Recent progress in large language models (LLMs) highlights the power of scaling test-time compute to achieve strong performance on complex tasks, such as mathematical reasoning and code generation. This raises a critical question: how should model training be modified to optimize performance under a subsequent test-time compute strategy and budget? To explore this, we focus on pass@N, a simple test-time strategy that searches for a correct answer in $N$ independent samples. We show, surprisingly, that training with cross-entropy (CE) loss can be ${\it misaligned}$ with pass@N in that pass@N accuracy ${\it decreases}$ with longer training. We explain the origins of this misalignment in terms of model overconfidence induced by CE, and experimentally verify our prediction of overconfidence as an impediment to scaling test-time compute via pass@N. Furthermore we suggest a principled, modified training loss that is better aligned to pass@N by limiting model confidence and rescuing pass@N test performance. Our algorithm demonstrates improved mathematical reasoning on MATH and MiniF2F benchmarks under several scenarios: (1) providing answers to math questions; and (2) proving theorems by searching over proof trees of varying shapes. Overall our work underscores the importance of co-designing two traditionally separate phases of LLM development: training-time protocols and test-time search and reasoning strategies.

Erasing Noise in Signal Detection with Diffusion Model: From Theory to Application

In this paper, a signal detection method based on the denoise diffusion model (DM) is proposed, which outperforms the maximum likelihood (ML) estimation method that has long been regarded as the optimal signal detection technique. Theoretically, a novel mathematical theory for intelligent signal detection based on stochastic differential equations (SDEs) is established in this paper, demonstrating the effectiveness of DM in reducing the additive white Gaussian noise in received signals. Moreover, a mathematical relationship between the signal-to-noise ratio (SNR) and the timestep in DM is established, revealing that for any given SNR, a corresponding optimal timestep can be identified. Furthermore, to address potential issues with out-of-distribution inputs in the DM, we employ a mathematical scaling technique that allows the trained DM to handle signal detection across a wide range of SNRs without any fine-tuning. Building on the above theoretical foundation, we propose a DM-based signal detection method, with the diffusion transformer (DiT) serving as the backbone neural network, whose computational complexity of this method is $\mathcal{O}(n^2)$. Simulation results demonstrate that, for BPSK and QAM modulation schemes, the DM-based method achieves a significantly lower symbol error rate (SER) compared to ML estimation, while maintaining a much lower computational complexity.