HelixDesign-Binder: A Scalable Production-Grade Platform for Binder Design Built on HelixFold3

Protein binder design is central to therapeutics, diagnostics, and synthetic biology, yet practical deployment remains challenging due to fragmented workflows, high computational costs, and complex tool integration. We present HelixDesign-Binder, a production-grade, high-throughput platform built on HelixFold3 that automates the full binder design pipeline, from backbone generation and sequence design to structural evaluation and multi-dimensional scoring. By unifying these stages into a scalable and user-friendly system, HelixDesign-Binder enables efficient exploration of binder candidates with favorable structural, energetic, and physicochemical properties. The platform leverages Baidu Cloud's high-performance infrastructure to support large-scale design and incorporates advanced scoring metrics, including ipTM, predicted binding free energy, and interface hydrophobicity. Benchmarking across six protein targets demonstrates that HelixDesign-Binder reliably produces diverse and high-quality binders, some of which match or exceed validated designs in predicted binding affinity. HelixDesign-Binder is accessible via an interactive web interface in PaddleHelix platform, supporting both academic research and industrial applications in antibody and protein binder development.

Improving Generalization of Medical Image Registration Foundation Model

Deformable registration is a fundamental task in medical image processing, aiming to achieve precise alignment by establishing nonlinear correspondences between images. Traditional methods offer good adaptability and interpretability but are limited by computational efficiency. Although deep learning approaches have significantly improved registration speed and accuracy, they often lack flexibility and generalizability across different datasets and tasks. In recent years, foundation models have emerged as a promising direction, leveraging large and diverse datasets to learn universal features and transformation patterns for image registration, thus demonstrating strong cross-task transferability. However, these models still face challenges in generalization and robustness when encountering novel anatomical structures, varying imaging conditions, or unseen modalities. To address these limitations, this paper incorporates Sharpness-Aware Minimization (SAM) into foundation models to enhance their generalization and robustness in medical image registration. By optimizing the flatness of the loss landscape, SAM improves model stability across diverse data distributions and strengthens its ability to handle complex clinical scenarios. Experimental results show that foundation models integrated with SAM achieve significant improvements in cross-dataset registration performance, offering new insights for the advancement of medical image registration technology. Our code is available at https://github.com/Promise13/fm_sam}{https://github.com/Promise13/fm\_sam.

RLMiniStyler: Light-weight RL Style Agent for Arbitrary Sequential Neural Style Generation

Arbitrary style transfer aims to apply the style of any given artistic image to another content image. Still, existing deep learning-based methods often require significant computational costs to generate diverse stylized results. Motivated by this, we propose a novel reinforcement learning-based framework for arbitrary style transfer RLMiniStyler. This framework leverages a unified reinforcement learning policy to iteratively guide the style transfer process by exploring and exploiting stylization feedback, generating smooth sequences of stylized results while achieving model lightweight. Furthermore, we introduce an uncertainty-aware multi-task learning strategy that automatically adjusts loss weights to adapt to the content and style balance requirements at different training stages, thereby accelerating model convergence. Through a series of experiments across image various resolutions, we have validated the advantages of RLMiniStyler over other state-of-the-art methods in generating high-quality, diverse artistic image sequences at a lower cost. Codes are available at https://github.com/fengxiaoming520/RLMiniStyler.

The Tenth NTIRE 2025 Efficient Super-Resolution Challenge Report

This paper presents a comprehensive review of the NTIRE 2025 Challenge on Single-Image Efficient Super-Resolution (ESR). The challenge aimed to advance the development of deep models that optimize key computational metrics, i.e., runtime, parameters, and FLOPs, while achieving a PSNR of at least 26.90 dB on the $\operatorname{DIV2K\_LSDIR\_valid}$ dataset and 26.99 dB on the $\operatorname{DIV2K\_LSDIR\_test}$ dataset. A robust participation saw \textbf{244} registered entrants, with \textbf{43} teams submitting valid entries. This report meticulously analyzes these methods and results, emphasizing groundbreaking advancements in state-of-the-art single-image ESR techniques. The analysis highlights innovative approaches and establishes benchmarks for future research in the field.

VADMamba: Exploring State Space Models for Fast Video Anomaly Detection

Video anomaly detection (VAD) methods are mostly CNN-based or Transformer-based, achieving impressive results, but the focus on detection accuracy often comes at the expense of inference speed. The emergence of state space models in computer vision, exemplified by the Mamba model, demonstrates improved computational efficiency through selective scans and showcases the great potential for long-range modeling. Our study pioneers the application of Mamba to VAD, dubbed VADMamba, which is based on multi-task learning for frame prediction and optical flow reconstruction. Specifically, we propose the VQ-Mamba Unet (VQ-MaU) framework, which incorporates a Vector Quantization (VQ) layer and Mamba-based Non-negative Visual State Space (NVSS) block. Furthermore, two individual VQ-MaU networks separately predict frames and reconstruct corresponding optical flows, further boosting accuracy through a clip-level fusion evaluation strategy. Experimental results validate the efficacy of the proposed VADMamba across three benchmark datasets, demonstrating superior performance in inference speed compared to previous work. Code is available at https://github.com/jLooo/VADMamba.

HS-FPN: High Frequency and Spatial Perception FPN for Tiny Object Detection

The introduction of Feature Pyramid Network (FPN) has significantly improved object detection performance. However, substantial challenges remain in detecting tiny objects, as their features occupy only a very small proportion of the feature maps. Although FPN integrates multi-scale features, it does not directly enhance or enrich the features of tiny objects. Furthermore, FPN lacks spatial perception ability. To address these issues, we propose a novel High Frequency and Spatial Perception Feature Pyramid Network (HS-FPN) with two innovative modules. First, we designed a high frequency perception module (HFP) that generates high frequency responses through high pass filters. These high frequency responses are used as mask weights from both spatial and channel perspectives to enrich and highlight the features of tiny objects in the original feature maps. Second, we developed a spatial dependency perception module (SDP) to capture the spatial dependencies that FPN lacks. Our experiments demonstrate that detectors based on HS-FPN exhibit competitive advantages over state-of-the-art models on the AI-TOD dataset for tiny object detection.

Precise Antigen-Antibody Structure Predictions Enhance Antibody Development with HelixFold-Multimer

The accurate prediction of antigen-antibody structures is essential for advancing immunology and therapeutic development, as it helps elucidate molecular interactions that underlie immune responses. Despite recent progress with deep learning models like AlphaFold and RoseTTAFold, accurately modeling antigen-antibody complexes remains a challenge due to their unique evolutionary characteristics. HelixFold-Multimer, a specialized model developed for this purpose, builds on the framework of AlphaFold-Multimer and demonstrates improved precision for antigen-antibody structures. HelixFold-Multimer not only surpasses other models in accuracy but also provides essential insights into antibody development, enabling more precise identification of binding sites, improved interaction prediction, and enhanced design of therapeutic antibodies. These advances underscore HelixFold-Multimer's potential in supporting antibody research and therapeutic innovation.

Goal-Conditioned Supervised Learning for Multi-Objective Recommendation

Multi-objective learning endeavors to concurrently optimize multiple objectives using a single model, aiming to achieve high and balanced performance across these diverse objectives. However, it often involves a more complex optimization problem, particularly when navigating potential conflicts between objectives, leading to solutions with higher memory requirements and computational complexity. This paper introduces a Multi-Objective Goal-Conditioned Supervised Learning (MOGCSL) framework for automatically learning to achieve multiple objectives from offline sequential data. MOGCSL extends the conventional Goal-Conditioned Supervised Learning (GCSL) method to multi-objective scenarios by redefining goals from one-dimensional scalars to multi-dimensional vectors. The need for complex architectures and optimization constraints can be naturally eliminated. MOGCSL benefits from filtering out uninformative or noisy instances that do not achieve desirable long-term rewards. It also incorporates a novel goal-choosing algorithm to model and select "high" achievable goals for inference. While MOGCSL is quite general, we focus on its application to the next action prediction problem in commercial-grade recommender systems. In this context, any viable solution needs to be reasonably scalable and also be robust to large amounts of noisy data that is characteristic of this application space. We show that MOGCSL performs admirably on both counts. Specifically, extensive experiments conducted on real-world recommendation datasets validate its efficacy and efficiency. Also, analysis and experiments are included to explain its strength in discounting the noisier portions of training data in recommender systems.

Appearance Blur-driven AutoEncoder and Motion-guided Memory Module for Video Anomaly Detection

Video anomaly detection (VAD) often learns the distribution of normal samples and detects the anomaly through measuring significant deviations, but the undesired generalization may reconstruct a few anomalies thus suppressing the deviations. Meanwhile, most VADs cannot cope with cross-dataset validation for new target domains, and few-shot methods must laboriously rely on model-tuning from the target domain to complete domain adaptation. To address these problems, we propose a novel VAD method with a motion-guided memory module to achieve cross-dataset validation with zero-shot. First, we add Gaussian blur to the raw appearance images, thereby constructing the global pseudo-anomaly, which serves as the input to the network. Then, we propose multi-scale residual channel attention to deblur the pseudo-anomaly in normal samples. Next, memory items are obtained by recording the motion features in the training phase, which are used to retrieve the motion features from the raw information in the testing phase. Lastly, our method can ignore the blurred real anomaly through attention and rely on motion memory items to increase the normality gap between normal and abnormal motion. Extensive experiments on three benchmark datasets demonstrate the effectiveness of the proposed method. Compared with cross-domain methods, our method achieves competitive performance without adaptation during testing.

An Explainable Non-local Network for COVID-19 Diagnosis

The CNN has achieved excellent results in the automatic classification of medical images. In this study, we propose a novel deep residual 3D attention non-local network (NL-RAN) to classify CT images included COVID-19, common pneumonia, and normal to perform rapid and explainable COVID-19 diagnosis. We built a deep residual 3D attention non-local network that could achieve end-to-end training. The network is embedded with a nonlocal module to capture global information, while a 3D attention module is embedded to focus on the details of the lesion so that it can directly analyze the 3D lung CT and output the classification results. The output of the attention module can be used as a heat map to increase the interpretability of the model. 4079 3D CT scans were included in this study. Each scan had a unique label (novel coronavirus pneumonia, common pneumonia, and normal). The CT scans cohort was randomly split into a training set of 3263 scans, a validation set of 408 scans, and a testing set of 408 scans. And compare with existing mainstream classification methods, such as CovNet, CBAM, ResNet, etc. Simultaneously compare the visualization results with visualization methods such as CAM. Model performance was evaluated using the Area Under the ROC Curve(AUC), precision, and F1-score. The NL-RAN achieved the AUC of 0.9903, the precision of 0.9473, and the F1-score of 0.9462, surpass all the classification methods compared. The heat map output by the attention module is also clearer than the heat map output by CAM. Our experimental results indicate that our proposed method performs significantly better than existing methods. In addition, the first attention module outputs a heat map containing detailed outline information to increase the interpretability of the model. Our experiments indicate that the inference of our model is fast. It can provide real-time assistance with diagnosis.