Improving Generalization of Medical Image Registration Foundation Model

Deformable registration is a fundamental task in medical image processing, aiming to achieve precise alignment by establishing nonlinear correspondences between images. Traditional methods offer good adaptability and interpretability but are limited by computational efficiency. Although deep learning approaches have significantly improved registration speed and accuracy, they often lack flexibility and generalizability across different datasets and tasks. In recent years, foundation models have emerged as a promising direction, leveraging large and diverse datasets to learn universal features and transformation patterns for image registration, thus demonstrating strong cross-task transferability. However, these models still face challenges in generalization and robustness when encountering novel anatomical structures, varying imaging conditions, or unseen modalities. To address these limitations, this paper incorporates Sharpness-Aware Minimization (SAM) into foundation models to enhance their generalization and robustness in medical image registration. By optimizing the flatness of the loss landscape, SAM improves model stability across diverse data distributions and strengthens its ability to handle complex clinical scenarios. Experimental results show that foundation models integrated with SAM achieve significant improvements in cross-dataset registration performance, offering new insights for the advancement of medical image registration technology. Our code is available at https://github.com/Promise13/fm_sam}{https://github.com/Promise13/fm\_sam.

RLMiniStyler: Light-weight RL Style Agent for Arbitrary Sequential Neural Style Generation

Arbitrary style transfer aims to apply the style of any given artistic image to another content image. Still, existing deep learning-based methods often require significant computational costs to generate diverse stylized results. Motivated by this, we propose a novel reinforcement learning-based framework for arbitrary style transfer RLMiniStyler. This framework leverages a unified reinforcement learning policy to iteratively guide the style transfer process by exploring and exploiting stylization feedback, generating smooth sequences of stylized results while achieving model lightweight. Furthermore, we introduce an uncertainty-aware multi-task learning strategy that automatically adjusts loss weights to adapt to the content and style balance requirements at different training stages, thereby accelerating model convergence. Through a series of experiments across image various resolutions, we have validated the advantages of RLMiniStyler over other state-of-the-art methods in generating high-quality, diverse artistic image sequences at a lower cost. Codes are available at https://github.com/fengxiaoming520/RLMiniStyler.

Robust Fairness Vision-Language Learning for Medical Image Analysis

The advent of Vision-Language Models (VLMs) in medical image analysis has the potential to help process multimodal inputs and increase performance over traditional inference methods. However, when considering the domain in which these models will be implemented, fairness and robustness are important to ensure the model stays true for any patient. In this paper, we introduce a framework for ensuring robustness and fairness of VLM models. This framework modifies the loss function at training by identifying and adjusting faulty image-text pairs through a Dynamic Bad Pair Mining algorithm and also utilizing Sinkhorn distance to ensure the loss distributions of protected groups do not deviate from the total loss. Experimental testing of our framework shows up to a 8.6\% improvement when looking at equity-scaled AUC.

Lane-Wise Highway Anomaly Detection

This paper proposes a scalable and interpretable framework for lane-wise highway traffic anomaly detection, leveraging multi-modal time series data extracted from surveillance cameras. Unlike traditional sensor-dependent methods, our approach uses AI-powered vision models to extract lane-specific features, including vehicle count, occupancy, and truck percentage, without relying on costly hardware or complex road modeling. We introduce a novel dataset containing 73,139 lane-wise samples, annotated with four classes of expert-validated anomalies: three traffic-related anomalies (lane blockage and recovery, foreign object intrusion, and sustained congestion) and one sensor-related anomaly (camera angle shift). Our multi-branch detection system integrates deep learning, rule-based logic, and machine learning to improve robustness and precision. Extensive experiments demonstrate that our framework outperforms state-of-the-art methods in precision, recall, and F1-score, providing a cost-effective and scalable solution for real-world intelligent transportation systems.

Robust AI-Generated Face Detection with Imbalanced Data

Deepfakes, created using advanced AI techniques such as Variational Autoencoder and Generative Adversarial Networks, have evolved from research and entertainment applications into tools for malicious activities, posing significant threats to digital trust. Current deepfake detection techniques have evolved from CNN-based methods focused on local artifacts to more advanced approaches using vision transformers and multimodal models like CLIP, which capture global anomalies and improve cross-domain generalization. Despite recent progress, state-of-the-art deepfake detectors still face major challenges in handling distribution shifts from emerging generative models and addressing severe class imbalance between authentic and fake samples in deepfake datasets, which limits their robustness and detection accuracy. To address these challenges, we propose a framework that combines dynamic loss reweighting and ranking-based optimization, which achieves superior generalization and performance under imbalanced dataset conditions. The code is available at https://github.com/Purdue-M2/SP_CUP.

Teacher Encoder-Student Decoder Denoising Guided Segmentation Network for Anomaly Detection

Visual anomaly detection is a highly challenging task, often categorized as a one-class classification and segmentation problem. Recent studies have demonstrated that the student-teacher (S-T) framework effectively addresses this challenge. However, most S-T frameworks rely solely on pre-trained teacher networks to guide student networks in learning multi-scale similar features, overlooking the potential of the student networks to enhance learning through multi-scale feature fusion. In this study, we propose a novel model named PFADSeg, which integrates a pre-trained teacher network, a denoising student network with multi-scale feature fusion, and a guided anomaly segmentation network into a unified framework. By adopting a unique teacher-encoder and student-decoder denoising mode, the model improves the student network's ability to learn from teacher network features. Furthermore, an adaptive feature fusion mechanism is introduced to train a self-supervised segmentation network that synthesizes anomaly masks autonomously, significantly increasing detection performance. Evaluated on the MVTec AD dataset, PFADSeg achieves state-of-the-art results with an image-level AUC of 98.9%, a pixel-level mean precision of 76.4%, and an instance-level mean precision of 78.7%.

Improving Generalization for AI-Synthesized Voice Detection

AI-synthesized voice technology has the potential to create realistic human voices for beneficial applications, but it can also be misused for malicious purposes. While existing AI-synthesized voice detection models excel in intra-domain evaluation, they face challenges in generalizing across different domains, potentially becoming obsolete as new voice generators emerge. Current solutions use diverse data and advanced machine learning techniques (e.g., domain-invariant representation, self-supervised learning), but are limited by predefined vocoders and sensitivity to factors like background noise and speaker identity. In this work, we introduce an innovative disentanglement framework aimed at extracting domain-agnostic artifact features related to vocoders. Utilizing these features, we enhance model learning in a flat loss landscape, enabling escape from suboptimal solutions and improving generalization. Extensive experiments on benchmarks show our approach outperforms state-of-the-art methods, achieving up to 5.12% improvement in the equal error rate metric in intra-domain and 7.59% in cross-domain evaluations.

A Self-Learning Multimodal Approach for Fake News Detection

The rapid growth of social media has resulted in an explosion of online news content, leading to a significant increase in the spread of misleading or false information. While machine learning techniques have been widely applied to detect fake news, the scarcity of labeled datasets remains a critical challenge. Misinformation frequently appears as paired text and images, where a news article or headline is accompanied by a related visuals. In this paper, we introduce a self-learning multimodal model for fake news classification. The model leverages contrastive learning, a robust method for feature extraction that operates without requiring labeled data, and integrates the strengths of Large Language Models (LLMs) to jointly analyze both text and image features. LLMs are excel at this task due to their ability to process diverse linguistic data drawn from extensive training corpora. Our experimental results on a public dataset demonstrate that the proposed model outperforms several state-of-the-art classification approaches, achieving over 85% accuracy, precision, recall, and F1-score. These findings highlight the model's effectiveness in tackling the challenges of multimodal fake news detection.

Meta-Learning with Heterogeneous Tasks

Meta-learning is a general approach to equip machine learning models with the ability to handle few-shot scenarios when dealing with many tasks. Most existing meta-learning methods work based on the assumption that all tasks are of equal importance. However, real-world applications often present heterogeneous tasks characterized by varying difficulty levels, noise in training samples, or being distinctively different from most other tasks. In this paper, we introduce a novel meta-learning method designed to effectively manage such heterogeneous tasks by employing rank-based task-level learning objectives, Heterogeneous Tasks Robust Meta-learning (HeTRoM). HeTRoM is proficient in handling heterogeneous tasks, and it prevents easy tasks from overwhelming the meta-learner. The approach allows for an efficient iterative optimization algorithm based on bi-level optimization, which is then improved by integrating statistical guidance. Our experimental results demonstrate that our method provides flexibility, enabling users to adapt to diverse task settings and enhancing the meta-learner's overall performance.

An Explainable Non-local Network for COVID-19 Diagnosis

The CNN has achieved excellent results in the automatic classification of medical images. In this study, we propose a novel deep residual 3D attention non-local network (NL-RAN) to classify CT images included COVID-19, common pneumonia, and normal to perform rapid and explainable COVID-19 diagnosis. We built a deep residual 3D attention non-local network that could achieve end-to-end training. The network is embedded with a nonlocal module to capture global information, while a 3D attention module is embedded to focus on the details of the lesion so that it can directly analyze the 3D lung CT and output the classification results. The output of the attention module can be used as a heat map to increase the interpretability of the model. 4079 3D CT scans were included in this study. Each scan had a unique label (novel coronavirus pneumonia, common pneumonia, and normal). The CT scans cohort was randomly split into a training set of 3263 scans, a validation set of 408 scans, and a testing set of 408 scans. And compare with existing mainstream classification methods, such as CovNet, CBAM, ResNet, etc. Simultaneously compare the visualization results with visualization methods such as CAM. Model performance was evaluated using the Area Under the ROC Curve(AUC), precision, and F1-score. The NL-RAN achieved the AUC of 0.9903, the precision of 0.9473, and the F1-score of 0.9462, surpass all the classification methods compared. The heat map output by the attention module is also clearer than the heat map output by CAM. Our experimental results indicate that our proposed method performs significantly better than existing methods. In addition, the first attention module outputs a heat map containing detailed outline information to increase the interpretability of the model. Our experiments indicate that the inference of our model is fast. It can provide real-time assistance with diagnosis.