Drift-Adaptive Slicing-Based Resource Management for Cooperative ISAC Networks

In this paper, we propose a novel drift-adaptive slicing-based resource management scheme for cooperative integrated sensing and communication (ISAC) networks. Particularly, we establish two network slices to provide sensing and communication services, respectively. In the large-timescale planning for the slices, we partition the sensing region of interest (RoI) of each mobile device and reserve network resources accordingly, facilitating low-complexity distance-based sensing target assignment in small timescales. To cope with the non-stationary spatial distributions of mobile devices and sensing targets, which can result in the drift in modeling the distributions and ineffective planning decisions, we construct digital twins (DTs) of the slices. In each DT, a drift-adaptive statistical model and an emulation function are developed for the spatial distributions in the corresponding slice, which facilitates closed-form decision-making and efficient validation of a planning decision, respectively. Numerical results show that the proposed drift-adaptive slicing-based resource management scheme can increase the service satisfaction ratio by up to 18% and reduce resource consumption by up to 13.1% when compared with benchmark schemes.

HelixDesign-Binder: A Scalable Production-Grade Platform for Binder Design Built on HelixFold3

Protein binder design is central to therapeutics, diagnostics, and synthetic biology, yet practical deployment remains challenging due to fragmented workflows, high computational costs, and complex tool integration. We present HelixDesign-Binder, a production-grade, high-throughput platform built on HelixFold3 that automates the full binder design pipeline, from backbone generation and sequence design to structural evaluation and multi-dimensional scoring. By unifying these stages into a scalable and user-friendly system, HelixDesign-Binder enables efficient exploration of binder candidates with favorable structural, energetic, and physicochemical properties. The platform leverages Baidu Cloud's high-performance infrastructure to support large-scale design and incorporates advanced scoring metrics, including ipTM, predicted binding free energy, and interface hydrophobicity. Benchmarking across six protein targets demonstrates that HelixDesign-Binder reliably produces diverse and high-quality binders, some of which match or exceed validated designs in predicted binding affinity. HelixDesign-Binder is accessible via an interactive web interface in PaddleHelix platform, supporting both academic research and industrial applications in antibody and protein binder development.

On the Price of Differential Privacy for Hierarchical Clustering

Hierarchical clustering is a fundamental unsupervised machine learning task with the aim of organizing data into a hierarchy of clusters. Many applications of hierarchical clustering involve sensitive user information, therefore motivating recent studies on differentially private hierarchical clustering under the rigorous framework of Dasgupta's objective. However, it has been shown that any privacy-preserving algorithm under edge-level differential privacy necessarily suffers a large error. To capture practical applications of this problem, we focus on the weight privacy model, where each edge of the input graph is at least unit weight. We present a novel algorithm in the weight privacy model that shows significantly better approximation than known impossibility results in the edge-level DP setting. In particular, our algorithm achieves $O(\log^{1.5}n/\varepsilon)$ multiplicative error for $\varepsilon$-DP and runs in polynomial time, where $n$ is the size of the input graph, and the cost is never worse than the optimal additive error in existing work. We complement our algorithm by showing if the unit-weight constraint does not apply, the lower bound for weight-level DP hierarchical clustering is essentially the same as the edge-level DP, i.e. $\Omega(n^2/\varepsilon)$ additive error. As a result, we also obtain a new lower bound of $\tilde{\Omega}(1/\varepsilon)$ additive error for balanced sparsest cuts in the weight-level DP model, which may be of independent interest. Finally, we evaluate our algorithm on synthetic and real-world datasets. Our experimental results show that our algorithm performs well in terms of extra cost and has good scalability to large graphs.

Timing the Match: A Deep Reinforcement Learning Approach for Ride-Hailing and Ride-Pooling Services

Efficient timing in ride-matching is crucial for improving the performance of ride-hailing and ride-pooling services, as it determines the number of drivers and passengers considered in each matching process. Traditional batched matching methods often use fixed time intervals to accumulate ride requests before assigning matches. While this approach increases the number of available drivers and passengers for matching, it fails to adapt to real-time supply-demand fluctuations, often leading to longer passenger wait times and driver idle periods. To address this limitation, we propose an adaptive ride-matching strategy using deep reinforcement learning (RL) to dynamically determine when to perform matches based on real-time system conditions. Unlike fixed-interval approaches, our method continuously evaluates system states and executes matching at moments that minimize total passenger wait time. Additionally, we incorporate a potential-based reward shaping (PBRS) mechanism to mitigate sparse rewards, accelerating RL training and improving decision quality. Extensive empirical evaluations using a realistic simulator trained on real-world data demonstrate that our approach outperforms fixed-interval matching strategies, significantly reducing passenger waiting times and detour delays, thereby enhancing the overall efficiency of ride-hailing and ride-pooling systems.

Towards Robust Model Evolution with Algorithmic Recourse

Algorithmic Recourse is a way for users to modify their attributes to align with a model's expectations, thereby improving their outcomes after receiving unfavorable decisions. In real-world scenarios, users often need to strategically adjust their attributes to compete for limited resources. However, such strategic behavior induces users to "game" algorithms, causing model collapse due to distribution shifts. These shifts arise from user competition, resource constraints, and adaptive user responses. While prior research on Algorithmic Recourse has explored its effects on both systems and users, the impact of resource constraints and competition over time remains underexplored. In this work, we develop a general framework to model user strategic behaviors and their interactions with decision-making systems under resource constraints and competitive dynamics. Through theoretical analysis and empirical evaluation, we identify three key phenomena that arise consistently in both synthetic and real-world datasets: escalating decision boundaries, non-robust model predictions, and inequitable recourse actions. Finally, we discuss the broader social implications of these findings and present two algorithmic strategies aimed at mitigating these challenges.

Label-free Prediction of Vascular Connectivity in Perfused Microvascular Networks in vitro

Continuous monitoring and in-situ assessment of microvascular connectivity have significant implications for culturing vascularized organoids and optimizing the therapeutic strategies. However, commonly used methods for vascular connectivity assessment heavily rely on fluorescent labels that may either raise biocompatibility concerns or interrupt the normal cell growth process. To address this issue, a Vessel Connectivity Network (VC-Net) was developed for label-free assessment of vascular connectivity. To validate the VC-Net, microvascular networks (MVNs) were cultured in vitro and their microscopic images were acquired at different culturing conditions as a training dataset. The VC-Net employs a Vessel Queue Contrastive Learning (VQCL) method and a class imbalance algorithm to address the issues of limited sample size, indistinctive class features and imbalanced class distribution in the dataset. The VC-Net successfully evaluated the vascular connectivity with no significant deviation from that by fluorescence imaging. In addition, the proposed VC-Net successfully differentiated the connectivity characteristics between normal and tumor-related MVNs. In comparison with those cultured in the regular microenvironment, the averaged connectivity of MVNs cultured in the tumor-related microenvironment decreased by 30.8%, whereas the non-connected area increased by 37.3%. This study provides a new avenue for label-free and continuous assessment of organoid or tumor vascularization in vitro.

Focusing Image Generation to Mitigate Spurious Correlations

Instance features in images exhibit spurious correlations with background features, affecting the training process of deep neural classifiers. This leads to insufficient attention to instance features by the classifier, resulting in erroneous classification outcomes. In this paper, we propose a data augmentation method called Spurious Correlations Guided Synthesis (SCGS) that mitigates spurious correlations through image generation model. This approach does not require expensive spurious attribute (group) labels for the training data and can be widely applied to other debiasing methods. Specifically, SCGS first identifies the incorrect attention regions of a pre-trained classifier on the training images, and then uses an image generation model to generate new training data based on these incorrect attended regions. SCGS increases the diversity and scale of the dataset to reduce the impact of spurious correlations on classifiers. Changes in the classifier's attention regions and experimental results on three different domain datasets demonstrate that this method is effective in reducing the classifier's reliance on spurious correlations.

Precise Antigen-Antibody Structure Predictions Enhance Antibody Development with HelixFold-Multimer

The accurate prediction of antigen-antibody structures is essential for advancing immunology and therapeutic development, as it helps elucidate molecular interactions that underlie immune responses. Despite recent progress with deep learning models like AlphaFold and RoseTTAFold, accurately modeling antigen-antibody complexes remains a challenge due to their unique evolutionary characteristics. HelixFold-Multimer, a specialized model developed for this purpose, builds on the framework of AlphaFold-Multimer and demonstrates improved precision for antigen-antibody structures. HelixFold-Multimer not only surpasses other models in accuracy but also provides essential insights into antibody development, enabling more precise identification of binding sites, improved interaction prediction, and enhanced design of therapeutic antibodies. These advances underscore HelixFold-Multimer's potential in supporting antibody research and therapeutic innovation.

CP-UNet: Contour-based Probabilistic Model for Medical Ultrasound Images Segmentation

Deep learning-based segmentation methods are widely utilized for detecting lesions in ultrasound images. Throughout the imaging procedure, the attenuation and scattering of ultrasound waves cause contour blurring and the formation of artifacts, limiting the clarity of the acquired ultrasound images. To overcome this challenge, we propose a contour-based probabilistic segmentation model CP-UNet, which guides the segmentation network to enhance its focus on contour during decoding. We design a novel down-sampling module to enable the contour probability distribution modeling and encoding stages to acquire global-local features. Furthermore, the Gaussian Mixture Model utilizes optimized features to model the contour distribution, capturing the uncertainty of lesion boundaries. Extensive experiments with several state-of-the-art deep learning segmentation methods on three ultrasound image datasets show that our method performs better on breast and thyroid lesions segmentation.

Neuc-MDS: Non-Euclidean Multidimensional Scaling Through Bilinear Forms

We introduce Non-Euclidean-MDS (Neuc-MDS), an extension of classical Multidimensional Scaling (MDS) that accommodates non-Euclidean and non-metric inputs. The main idea is to generalize the standard inner product to symmetric bilinear forms to utilize the negative eigenvalues of dissimilarity Gram matrices. Neuc-MDS efficiently optimizes the choice of (both positive and negative) eigenvalues of the dissimilarity Gram matrix to reduce STRESS, the sum of squared pairwise error. We provide an in-depth error analysis and proofs of the optimality in minimizing lower bounds of STRESS. We demonstrate Neuc-MDS's ability to address limitations of classical MDS raised by prior research, and test it on various synthetic and real-world datasets in comparison with both linear and non-linear dimension reduction methods.