Towards Practical Alzheimer's Disease Diagnosis: A Lightweight and Interpretable Spiking Neural Model

Early diagnosis of Alzheimer's Disease (AD), especially at the mild cognitive impairment (MCI) stage, is vital yet hindered by subjective assessments and the high cost of multimodal imaging modalities. Although deep learning methods offer automated alternatives, their energy inefficiency and computational demands limit real-world deployment, particularly in resource-constrained settings. As a brain-inspired paradigm, spiking neural networks (SNNs) are inherently well-suited for modeling the sparse, event-driven patterns of neural degeneration in AD, offering a promising foundation for interpretable and low-power medical diagnostics. However, existing SNNs often suffer from weak expressiveness and unstable training, which restrict their effectiveness in complex medical tasks. To address these limitations, we propose FasterSNN, a hybrid neural architecture that integrates biologically inspired LIF neurons with region-adaptive convolution and multi-scale spiking attention. This design enables sparse, efficient processing of 3D MRI while preserving diagnostic accuracy. Experiments on benchmark datasets demonstrate that FasterSNN achieves competitive performance with substantially improved efficiency and stability, supporting its potential for practical AD screening. Our source code is available at https://github.com/wuchangw/FasterSNN.

Tool-Star: Empowering LLM-Brained Multi-Tool Reasoner via Reinforcement Learning

Recently, large language models (LLMs) have shown remarkable reasoning capabilities via large-scale reinforcement learning (RL). However, leveraging the RL algorithm to empower effective multi-tool collaborative reasoning in LLMs remains an open challenge. In this paper, we introduce Tool-Star, an RL-based framework designed to empower LLMs to autonomously invoke multiple external tools during stepwise reasoning. Tool-Star integrates six types of tools and incorporates systematic designs in both data synthesis and training. To address the scarcity of tool-use data, we propose a general tool-integrated reasoning data synthesis pipeline, which combines tool-integrated prompting with hint-based sampling to automatically and scalably generate tool-use trajectories. A subsequent quality normalization and difficulty-aware classification process filters out low-quality samples and organizes the dataset from easy to hard. Furthermore, we propose a two-stage training framework to enhance multi-tool collaborative reasoning by: (1) cold-start fine-tuning, which guides LLMs to explore reasoning patterns via tool-invocation feedback; and (2) a multi-tool self-critic RL algorithm with hierarchical reward design, which reinforces reward understanding and promotes effective tool collaboration. Experimental analyses on over 10 challenging reasoning benchmarks highlight the effectiveness and efficiency of Tool-Star. The code is available at https://github.com/dongguanting/Tool-Star.

Towards Accurate and Interpretable Neuroblastoma Diagnosis via Contrastive Multi-scale Pathological Image Analysis

Neuroblastoma, adrenal-derived, is among the most common pediatric solid malignancies, characterized by significant clinical heterogeneity. Timely and accurate pathological diagnosis from hematoxylin and eosin-stained whole slide images is critical for patient prognosis. However, current diagnostic practices primarily rely on subjective manual examination by pathologists, leading to inconsistent accuracy. Existing automated whole slide image classification methods encounter challenges such as poor interpretability, limited feature extraction capabilities, and high computational costs, restricting their practical clinical deployment. To overcome these limitations, we propose CMSwinKAN, a contrastive-learning-based multi-scale feature fusion model tailored for pathological image classification, which enhances the Swin Transformer architecture by integrating a Kernel Activation Network within its multilayer perceptron and classification head modules, significantly improving both interpretability and accuracy. By fusing multi-scale features and leveraging contrastive learning strategies, CMSwinKAN mimics clinicians' comprehensive approach, effectively capturing global and local tissue characteristics. Additionally, we introduce a heuristic soft voting mechanism guided by clinical insights to seamlessly bridge patch-level predictions to whole slide image-level classifications. We validate CMSwinKAN on the PpNTs dataset, which was collaboratively established with our partner hospital and the publicly accessible BreakHis dataset. Results demonstrate that CMSwinKAN performs better than existing state-of-the-art pathology-specific models pre-trained on large datasets. Our source code is available at https://github.com/JSLiam94/CMSwinKAN.

EmbodiedAgent: A Scalable Hierarchical Approach to Overcome Practical Challenge in Multi-Robot Control

This paper introduces EmbodiedAgent, a hierarchical framework for heterogeneous multi-robot control. EmbodiedAgent addresses critical limitations of hallucination in impractical tasks. Our approach integrates a next-action prediction paradigm with a structured memory system to decompose tasks into executable robot skills while dynamically validating actions against environmental constraints. We present MultiPlan+, a dataset of more than 18,000 annotated planning instances spanning 100 scenarios, including a subset of impractical cases to mitigate hallucination. To evaluate performance, we propose the Robot Planning Assessment Schema (RPAS), combining automated metrics with LLM-aided expert grading. Experiments demonstrate EmbodiedAgent's superiority over state-of-the-art models, achieving 71.85% RPAS score. Real-world validation in an office service task highlights its ability to coordinate heterogeneous robots for long-horizon objectives.

VADMamba: Exploring State Space Models for Fast Video Anomaly Detection

Video anomaly detection (VAD) methods are mostly CNN-based or Transformer-based, achieving impressive results, but the focus on detection accuracy often comes at the expense of inference speed. The emergence of state space models in computer vision, exemplified by the Mamba model, demonstrates improved computational efficiency through selective scans and showcases the great potential for long-range modeling. Our study pioneers the application of Mamba to VAD, dubbed VADMamba, which is based on multi-task learning for frame prediction and optical flow reconstruction. Specifically, we propose the VQ-Mamba Unet (VQ-MaU) framework, which incorporates a Vector Quantization (VQ) layer and Mamba-based Non-negative Visual State Space (NVSS) block. Furthermore, two individual VQ-MaU networks separately predict frames and reconstruct corresponding optical flows, further boosting accuracy through a clip-level fusion evaluation strategy. Experimental results validate the efficacy of the proposed VADMamba across three benchmark datasets, demonstrating superior performance in inference speed compared to previous work. Code is available at https://github.com/jLooo/VADMamba.

Can Multi-modal (reasoning) LLMs work as deepfake detectors?

Deepfake detection remains a critical challenge in the era of advanced generative models, particularly as synthetic media becomes more sophisticated. In this study, we explore the potential of state of the art multi-modal (reasoning) large language models (LLMs) for deepfake image detection such as (OpenAI O1/4o, Gemini thinking Flash 2, Deepseek Janus, Grok 3, llama 3.2, Qwen 2/2.5 VL, Mistral Pixtral, Claude 3.5/3.7 sonnet) . We benchmark 12 latest multi-modal LLMs against traditional deepfake detection methods across multiple datasets, including recently published real-world deepfake imagery. To enhance performance, we employ prompt tuning and conduct an in-depth analysis of the models' reasoning pathways to identify key contributing factors in their decision-making process. Our findings indicate that best multi-modal LLMs achieve competitive performance with promising generalization ability with zero shot, even surpass traditional deepfake detection pipelines in out-of-distribution datasets while the rest of the LLM families performs extremely disappointing with some worse than random guess. Furthermore, we found newer model version and reasoning capabilities does not contribute to performance in such niche tasks of deepfake detection while model size do help in some cases. This study highlights the potential of integrating multi-modal reasoning in future deepfake detection frameworks and provides insights into model interpretability for robustness in real-world scenarios.

MMLNB: Multi-Modal Learning for Neuroblastoma Subtyping Classification Assisted with Textual Description Generation

Neuroblastoma (NB), a leading cause of childhood cancer mortality, exhibits significant histopathological variability, necessitating precise subtyping for accurate prognosis and treatment. Traditional diagnostic methods rely on subjective evaluations that are time-consuming and inconsistent. To address these challenges, we introduce MMLNB, a multi-modal learning (MML) model that integrates pathological images with generated textual descriptions to improve classification accuracy and interpretability. The approach follows a two-stage process. First, we fine-tune a Vision-Language Model (VLM) to enhance pathology-aware text generation. Second, the fine-tuned VLM generates textual descriptions, using a dual-branch architecture to independently extract visual and textual features. These features are fused via Progressive Robust Multi-Modal Fusion (PRMF) Block for stable training. Experimental results show that the MMLNB model is more accurate than the single modal model. Ablation studies demonstrate the importance of multi-modal fusion, fine-tuning, and the PRMF mechanism. This research creates a scalable AI-driven framework for digital pathology, enhancing reliability and interpretability in NB subtyping classification. Our source code is available at https://github.com/HovChen/MMLNB.

APF+: Boosting adaptive-potential function reinforcement learning methods with a W-shaped network for high-dimensional games

Studies in reward shaping for reinforcement learning (RL) have flourished in recent years due to its ability to speed up training. Our previous work proposed an adaptive potential function (APF) and showed that APF can accelerate the Q-learning with a Multi-layer Perceptron algorithm in the low-dimensional domain. This paper proposes to extend APF with an encoder (APF+) for RL state representation, allowing applying APF to the pixel-based Atari games using a state-encoding method that projects high-dimensional game's pixel frames to low-dimensional embeddings. We approach by designing the state-representation encoder as a W-shaped network (W-Net), by using which we are able to encode both the background as well as the moving entities in the game frames. Specifically, the embeddings derived from the pre-trained W-Net consist of two latent vectors: One represents the input state, and the other represents the deviation of the input state's representation from itself. We then incorporate W-Net into APF to train a downstream Dueling Deep Q-Network (DDQN), obtain the APF-WNet-DDQN, and demonstrate its effectiveness in Atari game-playing tasks. To evaluate the APF+W-Net module in such high-dimensional tasks, we compare with two types of baseline methods: (i) the basic DDQN; and (ii) two encoder-replaced APF-DDQN methods where we replace W-Net by (a) an unsupervised state representation method called Spatiotemporal Deep Infomax (ST-DIM) and (b) a ground truth state representation provided by the Atari Annotated RAM Interface (ARI). The experiment results show that out of 20 Atari games, APF-WNet-DDQN outperforms DDQN (14/20 games) and APF-STDIM-DDQN (13/20 games) significantly. In comparison against the APF-ARI-DDQN which employs embeddings directly of the detailed game-internal state information, the APF-WNet-DDQN achieves a comparable performance.

Cross-Layer-Optimized Link Selection for Hologram Video Streaming over Millimeter Wave Networks

Holographic-type communication brings an immersive tele-holography experience by delivering holographic contents to users. As the direct representation of holographic contents, hologram videos are naturally three-dimensional representation, which consist of a huge volume of data. Advanced multi-connectivity (MC) millimeter-wave (mmWave) networks are now available to transmit hologram videos by providing the necessary bandwidth. However, the existing link selection schemes in MC-based mmWave networks neglect the source content characteristics of hologram videos and the coordination among the parameters of different protocol layers in each link, leading to sub-optimal streaming performance. To address this issue, we propose a cross-layer-optimized link selection scheme for hologram video streaming over mmWave networks. This scheme optimizes link selection by jointly adjusting the video coding bitrate, the modulation and channel coding schemes (MCS), and link power allocation to minimize the end-to-end hologram distortion while guaranteeing the synchronization and quality balance between real and imaginary components of the hologram. Results show that the proposed scheme can effectively improve the hologram video streaming performance in terms of PSNR by 1.2dB to 6.4dB against the non-cross-layer scheme.

XLSTM-HVED: Cross-Modal Brain Tumor Segmentation and MRI Reconstruction Method Using Vision XLSTM and Heteromodal Variational Encoder-Decoder

Neurogliomas are among the most aggressive forms of cancer, presenting considerable challenges in both treatment and monitoring due to their unpredictable biological behavior. Magnetic resonance imaging (MRI) is currently the preferred method for diagnosing and monitoring gliomas. However, the lack of specific imaging techniques often compromises the accuracy of tumor segmentation during the imaging process. To address this issue, we introduce the XLSTM-HVED model. This model integrates a hetero-modal encoder-decoder framework with the Vision XLSTM module to reconstruct missing MRI modalities. By deeply fusing spatial and temporal features, it enhances tumor segmentation performance. The key innovation of our approach is the Self-Attention Variational Encoder (SAVE) module, which improves the integration of modal features. Additionally, it optimizes the interaction of features between segmentation and reconstruction tasks through the Squeeze-Fusion-Excitation Cross Awareness (SFECA) module. Our experiments using the BraTS 2024 dataset demonstrate that our model significantly outperforms existing advanced methods in handling cases where modalities are missing. Our source code is available at https://github.com/Quanato607/XLSTM-HVED.