Self-Supervised Noise Adaptive MRI Denoising via Repetition to Repetition (Rep2Rep) Learning

Purpose: This work proposes a novel self-supervised noise-adaptive image denoising framework, called Repetition to Repetition (Rep2Rep) learning, for low-field (<1T) MRI applications. Methods: Rep2Rep learning extends the Noise2Noise framework by training a neural network on two repeated MRI acquisitions, using one repetition as input and another as target, without requiring ground-truth data. It incorporates noise-adaptive training, enabling denoising generalization across varying noise levels and flexible inference with any number of repetitions. Performance was evaluated on both synthetic noisy brain MRI and 0.55T prostate MRI data, and compared against supervised learning and Monte Carlo Stein's Unbiased Risk Estimator (MC-SURE). Results: Rep2Rep learning outperforms MC-SURE on both synthetic and 0.55T MRI datasets. On synthetic brain data, it achieved denoising quality comparable to supervised learning and surpassed MC-SURE, particularly in preserving structural details and reducing residual noise. On the 0.55T prostate MRI dataset, a reader study showed radiologists preferred Rep2Rep-denoised 2-average images over 8-average noisy images. Rep2Rep demonstrated robustness to noise-level discrepancies between training and inference, supporting its practical implementation. Conclusion: Rep2Rep learning offers an effective self-supervised denoising for low-field MRI by leveraging routinely acquired multi-repetition data. Its noise-adaptivity enables generalization to different SNR regimes without clean reference images. This makes Rep2Rep learning a promising tool for improving image quality and scan efficiency in low-field MRI.

Learned Primal Dual Splitting for Self-Supervised Noise-Adaptive MRI Reconstruction

Magnetic resonance imaging (MRI) reconstruction has largely been dominated by deep neural networks (DNN); however, many state-of-the-art architectures use black-box structures, which hinder interpretability and improvement. Here, we propose an interpretable DNN architecture for self-supervised MRI reconstruction and denoising by directly parameterizing and learning the classical primal-dual splitting, dubbed LPDSNet. This splitting algorithm allows us to decouple the observation model from the signal prior. Experimentally, we show other interpretable architectures without this decoupling property exhibit failure in the self-supervised learning regime. We report state-of-the-art self-supervised joint MRI reconstruction and denoising performance and novel noise-level generalization capabilities, where in contrast black-box networks fail to generalize.

HQViT: Hybrid Quantum Vision Transformer for Image Classification

Transformer-based architectures have revolutionized the landscape of deep learning. In computer vision domain, Vision Transformer demonstrates remarkable performance on par with or even surpassing that of convolutional neural networks. However, the quadratic computational complexity of its self-attention mechanism poses challenges for classical computing, making model training with high-dimensional input data, e.g., images, particularly expensive. To address such limitations, we propose a Hybrid Quantum Vision Transformer (HQViT), that leverages the principles of quantum computing to accelerate model training while enhancing model performance. HQViT introduces whole-image processing with amplitude encoding to better preserve global image information without additional positional encoding. By leveraging quantum computation on the most critical steps and selectively handling other components in a classical way, we lower the cost of quantum resources for HQViT. The qubit requirement is minimized to $O(log_2N)$ and the number of parameterized quantum gates is only $O(log_2d)$, making it well-suited for Noisy Intermediate-Scale Quantum devices. By offloading the computationally intensive attention coefficient matrix calculation to the quantum framework, HQViT reduces the classical computational load by $O(T^2d)$. Extensive experiments across various computer vision datasets demonstrate that HQViT outperforms existing models, achieving a maximum improvement of up to $10.9\%$ (on the MNIST 10-classification task) over the state of the art. This work highlights the great potential to combine quantum and classical computing to cope with complex image classification tasks.

Quantum Complex-Valued Self-Attention Model

The self-attention mechanism has revolutionized classical machine learning, yet its quantum counterpart remains underexplored in fully harnessing the representational power of quantum states. Current quantum self-attention models exhibit a critical limitation by neglecting the indispensable phase information inherent in quantum systems when compressing attention weights into real-valued overlaps. To address this fundamental gap, we propose the Quantum Complex-Valued Self-Attention Model (QCSAM), the first framework that explicitly leverages complex-valued similarities between quantum states to capture both amplitude and phase relationships. Simultaneously, we enhance the standard Linear Combination of Unitaries (LCUs) method by introducing a Complex LCUs (CLCUs) framework that natively supports complex-valued coefficients. This framework enables the weighting of corresponding quantum values using fixed quantum complex self-attention weights, while also supporting trainable complex-valued parameters for value aggregation and quantum multi-head attention. Experimental evaluations on MNIST and Fashion-MNIST demonstrate our model's superiority over recent quantum self-attention architectures including QKSAN, QSAN, and GQHAN, with multi-head configurations showing consistent advantages over single-head variants. We systematically evaluate model scalability through qubit configurations ranging from 3 to 8 qubits and multi-class classification tasks spanning 2 to 4 categories. Through comprehensive ablation studies, we establish the critical advantage of complex-valued quantum attention weights over real-valued alternatives.

Domain-conditioned and Temporal-guided Diffusion Modeling for Accelerated Dynamic MRI Reconstruction

Purpose: To propose a domain-conditioned and temporal-guided diffusion modeling method, termed dynamic Diffusion Modeling (dDiMo), for accelerated dynamic MRI reconstruction, enabling diffusion process to characterize spatiotemporal information for time-resolved multi-coil Cartesian and non-Cartesian data. Methods: The dDiMo framework integrates temporal information from time-resolved dimensions, allowing for the concurrent capture of intra-frame spatial features and inter-frame temporal dynamics in diffusion modeling. It employs additional spatiotemporal ($x$-$t$) and self-consistent frequency-temporal ($k$-$t$) priors to guide the diffusion process. This approach ensures precise temporal alignment and enhances the recovery of fine image details. To facilitate a smooth diffusion process, the nonlinear conjugate gradient algorithm is utilized during the reverse diffusion steps. The proposed model was tested on two types of MRI data: Cartesian-acquired multi-coil cardiac MRI and Golden-Angle-Radial-acquired multi-coil free-breathing lung MRI, across various undersampling rates. Results: dDiMo achieved high-quality reconstructions at various acceleration factors, demonstrating improved temporal alignment and structural recovery compared to other competitive reconstruction methods, both qualitatively and quantitatively. This proposed diffusion framework exhibited robust performance in handling both Cartesian and non-Cartesian acquisitions, effectively reconstructing dynamic datasets in cardiac and lung MRI under different imaging conditions. Conclusion: This study introduces a novel diffusion modeling method for dynamic MRI reconstruction.

GroupCDL: Interpretable Denoising and Compressed Sensing MRI via Learned Group-Sparsity and Circulant Attention

Nonlocal self-similarity within images has become an increasingly popular prior in deep-learning models. Despite their successful image restoration performance, such models remain largely uninterpretable due to their black-box construction. Our previous studies have shown that interpretable construction of a fully convolutional denoiser (CDLNet), with performance on par with state-of-the-art black-box counterparts, is achievable by unrolling a convolutional dictionary learning algorithm. In this manuscript, we seek an interpretable construction of a convolutional network with a nonlocal self-similarity prior that performs on par with black-box nonlocal models. We show that such an architecture can be effectively achieved by upgrading the L1 sparsity prior (soft-thresholding) of CDLNet to an image-adaptive group-sparsity prior (group-thresholding). The proposed learned group-thresholding makes use of nonlocal attention to perform spatially varying soft-thresholding on the latent representation. To enable effective training and inference on large images with global artifacts, we propose a novel circulant-sparse attention. We achieve competitive natural-image denoising performance compared to black-box nonlocal DNNs and transformers. The interpretable construction of our network allows for a straightforward extension to Compressed Sensing MRI (CS-MRI), yielding state-of-the-art performance. Lastly, we show robustness to noise-level mismatches between training and inference for denoising and CS-MRI reconstruction.

IIP-Mixer:Intra-Inter Patch Mixing Architecture for Battery Remaining Useful Life Prediction

Accurately estimating the Remaining Useful Life (RUL) of lithium-ion batteries is crucial for maintaining the safe and stable operation of rechargeable battery management systems. However, this task is often challenging due to the complex temporal dynamics involved. Recently, attention-based networks, such as Transformers and Informer, have been the popular architecture in time series forecasting. Despite their effectiveness, these models with abundant parameters necessitate substantial training time to unravel temporal patterns. To tackle these challenges, we propose a simple MLP-Mixer-based architecture named 'Intra-Inter Patch Mixer' (IIP-Mixer), which is an architecture based exclusively on multi-layer perceptrons (MLPs), extracting information by mixing operations along both intra-patch and inter-patch dimensions for battery RUL prediction. The proposed IIP-Mixer comprises parallel dual-head mixer layers: the intra-patch mixing MLP, capturing local temporal patterns in the short-term period, and the inter-patch mixing MLP, capturing global temporal patterns in the long-term period. Notably, to address the varying importance of features in RUL prediction, we introduce a weighted loss function in the MLP-Mixer-based architecture, marking the first time such an approach has been employed. Our experiments demonstrate that IIP-Mixer achieves competitive performance in battery RUL prediction, outperforming other popular time-series frameworks

Quantum Mixed-State Self-Attention Network

The rapid advancement of quantum computing has increasingly highlighted its potential in the realm of machine learning, particularly in the context of natural language processing (NLP) tasks. Quantum machine learning (QML) leverages the unique capabilities of quantum computing to offer novel perspectives and methodologies for complex data processing and pattern recognition challenges. This paper introduces a novel Quantum Mixed-State Attention Network (QMSAN), which integrates the principles of quantum computing with classical machine learning algorithms, especially self-attention networks, to enhance the efficiency and effectiveness in handling NLP tasks. QMSAN model employs a quantum attention mechanism based on mixed states, enabling efficient direct estimation of similarity between queries and keys within the quantum domain, leading to more effective attention weight acquisition. Additionally, we propose an innovative quantum positional encoding scheme, implemented through fixed quantum gates within the quantum circuit, to enhance the model's accuracy. Experimental validation on various datasets demonstrates that QMSAN model outperforms existing quantum and classical models in text classification, achieving significant performance improvements. QMSAN model not only significantly reduces the number of parameters but also exceeds classical self-attention networks in performance, showcasing its strong capability in data representation and information extraction. Furthermore, our study investigates the model's robustness in different quantum noise environments, showing that QMSAN possesses commendable robustness to low noise.

DeepEMC-T2 Mapping: Deep Learning-Enabled T2 Mapping Based on Echo Modulation Curve Modeling

Purpose: Echo modulation curve (EMC) modeling can provide accurate and reproducible quantification of T2 relaxation times. The standard EMC-T2 mapping framework, however, requires sufficient echoes and cumbersome pixel-wise dictionary-matching steps. This work proposes a deep learning version of EMC-T2 mapping, called DeepEMC-T2 mapping, to efficiently estimate accurate T2 maps from fewer echoes without a dictionary. Methods: DeepEMC-T2 mapping was developed using a modified U-Net to estimate both T2 and Proton Density (PD) maps directly from multi-echo spin-echo (MESE) images. The modified U-Net employs several new features to improve the accuracy of T2/PD estimation. MESE datasets from 68 subjects were used for training and evaluation of the DeepEMC-T2 mapping technique. Multiple experiments were conducted to evaluate the impact of the proposed new features on DeepEMC-T2 mapping. Results: DeepEMC-T2 mapping achieved T2 estimation errors ranging from 3%-12% in different T2 ranges and 0.8%-1.7% for PD estimation with 10/7/5/3 echoes, which yielded more accurate parameter estimation than standard EMC-T2 mapping. The new features proposed in DeepEMC-T2 mapping enabled improved parameter estimation. The use of a larger echo spacing with fewer echoes can maintain the accuracy of T2 and PD estimations while reducing the number of 180-degree refocusing pulses. Conclusions: DeepEMC-T2 mapping enables simplified, efficient, and accurate T2 quantification directly from MESE images without a time-consuming dictionary-matching step and requires fewer echoes. This allows for increased volumetric coverage and/or decreased SAR by reducing the number of 180-degree refocusing pulses.

1D-Touch: NLP-Assisted Coarse Text Selection via a Semi-Direct Gesture

Existing text selection techniques on touchscreen focus on improving the control for moving the carets. Coarse-grained text selection on word and phrase levels has not received much support beyond word-snapping and entity recognition. We introduce 1D-Touch, a novel text selection method that complements the carets-based sub-word selection by facilitating the selection of semantic units of words and above. This method employs a simple vertical slide gesture to expand and contract a selection area from a word. The expansion can be by words or by semantic chunks ranging from sub-phrases to sentences. This technique shifts the concept of text selection, from defining a range by locating the first and last words, towards a dynamic process of expanding and contracting a textual semantic entity. To understand the effects of our approach, we prototyped and tested two variants: WordTouch, which offers a straightforward word-by-word expansion, and ChunkTouch, which leverages NLP to chunk text into syntactic units, allowing the selection to grow by semantically meaningful units in response to the sliding gesture. Our evaluation, focused on the coarse-grained selection tasks handled by 1D-Touch, shows a 20% improvement over the default word-snapping selection method on Android.