EXACT-Net:EHR-guided lung tumor auto-segmentation for non-small cell lung cancer radiotherapy

Lung cancer is a devastating disease with the highest mortality rate among cancer types. Over 60% of non-small cell lung cancer (NSCLC) patients, which accounts for 87% of diagnoses, require radiation therapy. Rapid treatment initiation significantly increases the patient's survival rate and reduces the mortality rate. Accurate tumor segmentation is a critical step in the diagnosis and treatment of NSCLC. Manual segmentation is time and labor-consuming and causes delays in treatment initiation. Although many lung nodule detection methods, including deep learning-based models, have been proposed, there is still a long-standing problem of high false positives (FPs) with most of these methods. Here, we developed an electronic health record (EHR) guided lung tumor auto-segmentation called EXACT-Net (EHR-enhanced eXACtitude in Tumor segmentation), where the extracted information from EHRs using a pre-trained large language model (LLM), was used to remove the FPs and keep the TP nodules only. The auto-segmentation model was trained on NSCLC patients' computed tomography (CT), and the pre-trained LLM was used with the zero-shot learning approach. Our approach resulted in a 250% boost in successful nodule detection using the data from ten NSCLC patients treated in our institution.

PARCv2: Physics-aware Recurrent Convolutional Neural Networks for Spatiotemporal Dynamics Modeling

Modeling unsteady, fast transient, and advection-dominated physics problems is a pressing challenge for physics-aware deep learning (PADL). The physics of complex systems is governed by large systems of partial differential equations (PDEs) and ancillary constitutive models with nonlinear structures, as well as evolving state fields exhibiting sharp gradients and rapidly deforming material interfaces. Here, we investigate an inductive bias approach that is versatile and generalizable to model generic nonlinear field evolution problems. Our study focuses on the recent physics-aware recurrent convolutions (PARC), which incorporates a differentiator-integrator architecture that inductively models the spatiotemporal dynamics of generic physical systems. We extend the capabilities of PARC to simulate unsteady, transient, and advection-dominant systems. The extended model, referred to as PARCv2, is equipped with differential operators to model advection-reaction-diffusion equations, as well as a hybrid integral solver for stable, long-time predictions. PARCv2 is tested on both standard benchmark problems in fluid dynamics, namely Burgers and Navier-Stokes equations, and then applied to more complex shock-induced reaction problems in energetic materials. We evaluate the behavior of PARCv2 in comparison to other physics-informed and learning bias models and demonstrate its potential to model unsteady and advection-dominant dynamics regimes.

StyleDubber: Towards Multi-Scale Style Learning for Movie Dubbing

Given a script, the challenge in Movie Dubbing (Visual Voice Cloning, V2C) is to generate speech that aligns well with the video in both time and emotion, based on the tone of a reference audio track. Existing state-of-the-art V2C models break the phonemes in the script according to the divisions between video frames, which solves the temporal alignment problem but leads to incomplete phoneme pronunciation and poor identity stability. To address this problem, we propose StyleDubber, which switches dubbing learning from the frame level to phoneme level. It contains three main components: (1) A multimodal style adaptor operating at the phoneme level to learn pronunciation style from the reference audio, and generate intermediate representations informed by the facial emotion presented in the video; (2) An utterance-level style learning module, which guides both the mel-spectrogram decoding and the refining processes from the intermediate embeddings to improve the overall style expression; And (3) a phoneme-guided lip aligner to maintain lip sync. Extensive experiments on two of the primary benchmarks, V2C and Grid, demonstrate the favorable performance of the proposed method as compared to the current state-of-the-art. The source code and trained models will be released to the public.

Explaining generative diffusion models via visual analysis for interpretable decision-making process

Diffusion models have demonstrated remarkable performance in generation tasks. Nevertheless, explaining the diffusion process remains challenging due to it being a sequence of denoising noisy images that are difficult for experts to interpret. To address this issue, we propose the three research questions to interpret the diffusion process from the perspective of the visual concepts generated by the model and the region where the model attends in each time step. We devise tools for visualizing the diffusion process and answering the aforementioned research questions to render the diffusion process human-understandable. We show how the output is progressively generated in the diffusion process by explaining the level of denoising and highlighting relationships to foundational visual concepts at each time step through the results of experiments with various visual analyses using the tools. Throughout the training of the diffusion model, the model learns diverse visual concepts corresponding to each time-step, enabling the model to predict varying levels of visual concepts at different stages. We substantiate our tools using Area Under Cover (AUC) score, correlation quantification, and cross-attention mapping. Our findings provide insights into the diffusion process and pave the way for further research into explainable diffusion mechanisms.

FlashTex: Fast Relightable Mesh Texturing with LightControlNet

Manually creating textures for 3D meshes is time-consuming, even for expert visual content creators. We propose a fast approach for automatically texturing an input 3D mesh based on a user-provided text prompt. Importantly, our approach disentangles lighting from surface material/reflectance in the resulting texture so that the mesh can be properly relit and rendered in any lighting environment. We introduce LightControlNet, a new text-to-image model based on the ControlNet architecture, which allows the specification of the desired lighting as a conditioning image to the model. Our text-to-texture pipeline then constructs the texture in two stages. The first stage produces a sparse set of visually consistent reference views of the mesh using LightControlNet. The second stage applies a texture optimization based on Score Distillation Sampling (SDS) that works with LightControlNet to increase the texture quality while disentangling surface material from lighting. Our pipeline is significantly faster than previous text-to-texture methods, while producing high-quality and relightable textures.

Formal Synthesis of Controllers for Safety-Critical Autonomous Systems: Developments and Challenges

In recent years, formal methods have been extensively used in the design of autonomous systems. By employing mathematically rigorous techniques, formal methods can provide fully automated reasoning processes with provable safety guarantees for complex dynamic systems with intricate interactions between continuous dynamics and discrete logics. This paper provides a comprehensive review of formal controller synthesis techniques for safety-critical autonomous systems. Specifically, we categorize the formal control synthesis problem based on diverse system models, encompassing deterministic, non-deterministic, and stochastic, and various formal safety-critical specifications involving logic, real-time, and real-valued domains. The review covers fundamental formal control synthesis techniques, including abstraction-based approaches and abstraction-free methods. We explore the integration of data-driven synthesis approaches in formal control synthesis. Furthermore, we review formal techniques tailored for multi-agent systems (MAS), with a specific focus on various approaches to address the scalability challenges in large-scale systems. Finally, we discuss some recent trends and highlight research challenges in this area.

PANDA: Preference Adaptation for Enhancing Domain-Specific Abilities of LLMs

While Large language models (LLMs) have demonstrated considerable capabilities across various natural language tasks, they often fall short of the performance achieved by domain-specific state-of-the-art models. One potential approach to enhance domain-specific capabilities of LLMs involves fine-tuning them using corresponding datasets. However, this method can be both resource and time-intensive, and not applicable to closed-source commercial LLMs. In this paper, we propose Preference Adaptation for Enhancing Domain-specific Abilities of LLMs (PANDA), a method designed to augment the domain-specific capabilities of LLMs by leveraging insights from the response preference of expert models without requiring fine-tuning. Our experimental results reveal that PANDA significantly enhances the domain-specific ability of LLMs on text classification and interactive decision tasks. Moreover, LLM with PANDA even outperforms the expert model that being learned on 4 tasks of ScienceWorld. This finding highlights the potential of exploring tuning-free approaches to achieve weak-to-strong generalization.

Federated Multi-Task Learning on Non-IID Data Silos: An Experimental Study

The innovative Federated Multi-Task Learning (FMTL) approach consolidates the benefits of Federated Learning (FL) and Multi-Task Learning (MTL), enabling collaborative model training on multi-task learning datasets. However, a comprehensive evaluation method, integrating the unique features of both FL and MTL, is currently absent in the field. This paper fills this void by introducing a novel framework, FMTL-Bench, for systematic evaluation of the FMTL paradigm. This benchmark covers various aspects at the data, model, and optimization algorithm levels, and comprises seven sets of comparative experiments, encapsulating a wide array of non-independent and identically distributed (Non-IID) data partitioning scenarios. We propose a systematic process for comparing baselines of diverse indicators and conduct a case study on communication expenditure, time, and energy consumption. Through our exhaustive experiments, we aim to provide valuable insights into the strengths and limitations of existing baseline methods, contributing to the ongoing discourse on optimal FMTL application in practical scenarios. The source code will be made available for results replication.

Stochastic Graph Heat Modelling for Diffusion-based Connectivity Retrieval

Heat diffusion describes the process by which heat flows from areas with higher temperatures to ones with lower temperatures. This concept was previously adapted to graph structures, whereby heat flows between nodes of a graph depending on the graph topology. Here, we combine the graph heat equation with the stochastic heat equation, which ultimately yields a model for multivariate time signals on a graph. We show theoretically how the model can be used to directly compute the diffusion-based connectivity structure from multivariate signals. Unlike other connectivity measures, our heat model-based approach is inherently multivariate and yields an absolute scaling factor, namely the graph thermal diffusivity, which captures the extent of heat-like graph propagation in the data. On two datasets, we show how the graph thermal diffusivity can be used to characterise Alzheimer's disease. We find that the graph thermal diffusivity is lower for Alzheimer's patients than healthy controls and correlates with dementia scores, suggesting structural impairment in patients in line with previous findings.

BMLP: Behavior-aware MLP for Heterogeneous Sequential Recommendation

In real recommendation scenarios, users often have different types of behaviors, such as clicking and buying. Existing research methods show that it is possible to capture the heterogeneous interests of users through different types of behaviors. However, most multi-behavior approaches have limitations in learning the relationship between different behaviors. In this paper, we propose a novel multilayer perceptron (MLP)-based heterogeneous sequential recommendation method, namely behavior-aware multilayer perceptron (BMLP). Specifically, it has two main modules, including a heterogeneous interest perception (HIP) module, which models behaviors at multiple granularities through behavior types and transition relationships, and a purchase intent perception (PIP) module, which adaptively fuses subsequences of auxiliary behaviors to capture users' purchase intent. Compared with mainstream sequence models, MLP is competitive in terms of accuracy and has unique advantages in simplicity and efficiency. Extensive experiments show that BMLP achieves significant improvement over state-of-the-art algorithms on four public datasets. In addition, its pure MLP architecture leads to a linear time complexity.