General Methods Make Great Domain-specific Foundation Models: A Case-study on Fetal Ultrasound

With access to large-scale, unlabeled medical datasets, researchers are confronted with two questions: Should they attempt to pretrain a custom foundation model on this medical data, or use transfer-learning from an existing generalist model? And, if a custom model is pretrained, are novel methods required? In this paper we explore these questions by conducting a case-study, in which we train a foundation model on a large regional fetal ultrasound dataset of 2M images. By selecting the well-established DINOv2 method for pretraining, we achieve state-of-the-art results on three fetal ultrasound datasets, covering data from different countries, classification, segmentation, and few-shot tasks. We compare against a series of models pretrained on natural images, ultrasound images, and supervised baselines. Our results demonstrate two key insights: (i) Pretraining on custom data is worth it, even if smaller models are trained on less data, as scaling in natural image pretraining does not translate to ultrasound performance. (ii) Well-tuned methods from computer vision are making it feasible to train custom foundation models for a given medical domain, requiring no hyperparameter tuning and little methodological adaptation. Given these findings, we argue that a bias towards methodological innovation should be avoided when developing domain specific foundation models under common computational resource constraints.

NeoBabel: A Multilingual Open Tower for Visual Generation

Text-to-image generation advancements have been predominantly English-centric, creating barriers for non-English speakers and perpetuating digital inequities. While existing systems rely on translation pipelines, these introduce semantic drift, computational overhead, and cultural misalignment. We introduce NeoBabel, a novel multilingual image generation framework that sets a new Pareto frontier in performance, efficiency and inclusivity, supporting six languages: English, Chinese, Dutch, French, Hindi, and Persian. The model is trained using a combination of large-scale multilingual pretraining and high-resolution instruction tuning. To evaluate its capabilities, we expand two English-only benchmarks to multilingual equivalents: m-GenEval and m-DPG. NeoBabel achieves state-of-the-art multilingual performance while retaining strong English capability, scoring 0.75 on m-GenEval and 0.68 on m-DPG. Notably, it performs on par with leading models on English tasks while outperforming them by +0.11 and +0.09 on multilingual benchmarks, even though these models are built on multilingual base LLMs. This demonstrates the effectiveness of our targeted alignment training for preserving and extending crosslingual generalization. We further introduce two new metrics to rigorously assess multilingual alignment and robustness to code-mixed prompts. Notably, NeoBabel matches or exceeds English-only models while being 2-4x smaller. We release an open toolkit, including all code, model checkpoints, a curated dataset of 124M multilingual text-image pairs, and standardized multilingual evaluation protocols, to advance inclusive AI research. Our work demonstrates that multilingual capability is not a trade-off but a catalyst for improved robustness, efficiency, and cultural fidelity in generative AI.

ShapeEmbed: a self-supervised learning framework for 2D contour quantification

The shape of objects is an important source of visual information in a wide range of applications. One of the core challenges of shape quantification is to ensure that the extracted measurements remain invariant to transformations that preserve an object's intrinsic geometry, such as changing its size, orientation, and position in the image. In this work, we introduce ShapeEmbed, a self-supervised representation learning framework designed to encode the contour of objects in 2D images, represented as a Euclidean distance matrix, into a shape descriptor that is invariant to translation, scaling, rotation, reflection, and point indexing. Our approach overcomes the limitations of traditional shape descriptors while improving upon existing state-of-the-art autoencoder-based approaches. We demonstrate that the descriptors learned by our framework outperform their competitors in shape classification tasks on natural and biological images. We envision our approach to be of particular relevance to biological imaging applications.

Rethinking Multilingual Vision-Language Translation: Dataset, Evaluation, and Adaptation

Vision-Language Translation (VLT) is a challenging task that requires accurately recognizing multilingual text embedded in images and translating it into the target language with the support of visual context. While recent Large Vision-Language Models (LVLMs) have demonstrated strong multilingual and visual understanding capabilities, there is a lack of systematic evaluation and understanding of their performance on VLT. In this work, we present a comprehensive study of VLT from three key perspectives: data quality, model architecture, and evaluation metrics. (1) We identify critical limitations in existing datasets, particularly in semantic and cultural fidelity, and introduce AibTrans -- a multilingual, parallel, human-verified dataset with OCR-corrected annotations. (2) We benchmark 11 commercial LVLMs/LLMs and 6 state-of-the-art open-source models across end-to-end and cascaded architectures, revealing their OCR dependency and contrasting generation versus reasoning behaviors. (3) We propose Density-Aware Evaluation to address metric reliability issues under varying contextual complexity, introducing the DA Score as a more robust measure of translation quality. Building upon these findings, we establish a new evaluation benchmark for VLT. Notably, we observe that fine-tuning LVLMs on high-resource language pairs degrades cross-lingual performance, and we propose a balanced multilingual fine-tuning strategy that effectively adapts LVLMs to VLT without sacrificing their generalization ability.

UniLGL: Learning Uniform Place Recognition for FOV-limited/Panoramic LiDAR Global Localization

Existing LGL methods typically consider only partial information (e.g., geometric features) from LiDAR observations or are designed for homogeneous LiDAR sensors, overlooking the uniformity in LGL. In this work, a uniform LGL method is proposed, termed UniLGL, which simultaneously achieves spatial and material uniformity, as well as sensor-type uniformity. The key idea of the proposed method is to encode the complete point cloud, which contains both geometric and material information, into a pair of BEV images (i.e., a spatial BEV image and an intensity BEV image). An end-to-end multi-BEV fusion network is designed to extract uniform features, equipping UniLGL with spatial and material uniformity. To ensure robust LGL across heterogeneous LiDAR sensors, a viewpoint invariance hypothesis is introduced, which replaces the conventional translation equivariance assumption commonly used in existing LPR networks and supervises UniLGL to achieve sensor-type uniformity in both global descriptors and local feature representations. Finally, based on the mapping between local features on the 2D BEV image and the point cloud, a robust global pose estimator is derived that determines the global minimum of the global pose on SE(3) without requiring additional registration. To validate the effectiveness of the proposed uniform LGL, extensive benchmarks are conducted in real-world environments, and the results show that the proposed UniLGL is demonstratively competitive compared to other State-of-the-Art LGL methods. Furthermore, UniLGL has been deployed on diverse platforms, including full-size trucks and agile Micro Aerial Vehicles (MAVs), to enable high-precision localization and mapping as well as multi-MAV collaborative exploration in port and forest environments, demonstrating the applicability of UniLGL in industrial and field scenarios.

Synthetic multi-inversion time magnetic resonance images for visualization of subcortical structures

Purpose: Visualization of subcortical gray matter is essential in neuroscience and clinical practice, particularly for disease understanding and surgical planning.While multi-inversion time (multi-TI) T$_1$-weighted (T$_1$-w) magnetic resonance (MR) imaging improves visualization, it is rarely acquired in clinical settings. Approach: We present SyMTIC (Synthetic Multi-TI Contrasts), a deep learning method that generates synthetic multi-TI images using routinely acquired T$_1$-w, T$_2$-weighted (T$_2$-w), and FLAIR images. Our approach combines image translation via deep neural networks with imaging physics to estimate longitudinal relaxation time (T$_1$) and proton density (PD) maps. These maps are then used to compute multi-TI images with arbitrary inversion times. Results: SyMTIC was trained using paired MPRAGE and FGATIR images along with T$_2$-w and FLAIR images. It accurately synthesized multi-TI images from standard clinical inputs, achieving image quality comparable to that from explicitly acquired multi-TI data.The synthetic images, especially for TI values between 400-800 ms, enhanced visualization of subcortical structures and improved segmentation of thalamic nuclei. Conclusion: SyMTIC enables robust generation of high-quality multi-TI images from routine MR contrasts. It generalizes well to varied clinical datasets, including those with missing FLAIR images or unknown parameters, offering a practical solution for improving brain MR image visualization and analysis.

MetricHMR: Metric Human Mesh Recovery from Monocular Images

We introduce MetricHMR (Metric Human Mesh Recovery), an approach for metric human mesh recovery with accurate global translation from monocular images. In contrast to existing HMR methods that suffer from severe scale and depth ambiguity, MetricHMR is able to produce geometrically reasonable body shape and global translation in the reconstruction results. To this end, we first systematically analyze previous HMR methods on camera models to emphasize the critical role of the standard perspective projection model in enabling metric-scale HMR. We then validate the acceptable ambiguity range of metric HMR under the standard perspective projection model. Finally, we contribute a novel approach that introduces a ray map based on the standard perspective projection to jointly encode bounding-box information, camera parameters, and geometric cues for End2End metric HMR without any additional metric-regularization modules. Extensive experiments demonstrate that our method achieves state-of-the-art performance, even compared with sequential HMR methods, in metric pose, shape, and global translation estimation across both indoor and in-the-wild scenarios.

APTOS-2024 challenge report: Generation of synthetic 3D OCT images from fundus photographs

Optical Coherence Tomography (OCT) provides high-resolution, 3D, and non-invasive visualization of retinal layers in vivo, serving as a critical tool for lesion localization and disease diagnosis. However, its widespread adoption is limited by equipment costs and the need for specialized operators. In comparison, 2D color fundus photography offers faster acquisition and greater accessibility with less dependence on expensive devices. Although generative artificial intelligence has demonstrated promising results in medical image synthesis, translating 2D fundus images into 3D OCT images presents unique challenges due to inherent differences in data dimensionality and biological information between modalities. To advance generative models in the fundus-to-3D-OCT setting, the Asia Pacific Tele-Ophthalmology Society (APTOS-2024) organized a challenge titled Artificial Intelligence-based OCT Generation from Fundus Images. This paper details the challenge framework (referred to as APTOS-2024 Challenge), including: the benchmark dataset, evaluation methodology featuring two fidelity metrics-image-based distance (pixel-level OCT B-scan similarity) and video-based distance (semantic-level volumetric consistency), and analysis of top-performing solutions. The challenge attracted 342 participating teams, with 42 preliminary submissions and 9 finalists. Leading methodologies incorporated innovations in hybrid data preprocessing or augmentation (cross-modality collaborative paradigms), pre-training on external ophthalmic imaging datasets, integration of vision foundation models, and model architecture improvement. The APTOS-2024 Challenge is the first benchmark demonstrating the feasibility of fundus-to-3D-OCT synthesis as a potential solution for improving ophthalmic care accessibility in under-resourced healthcare settings, while helping to expedite medical research and clinical applications.

SPC to 3D: Novel View Synthesis from Binary SPC via I2I translation

Single Photon Avalanche Diodes (SPADs) represent a cutting-edge imaging technology, capable of detecting individual photons with remarkable timing precision. Building on this sensitivity, Single Photon Cameras (SPCs) enable image capture at exceptionally high speeds under both low and high illumination. Enabling 3D reconstruction and radiance field recovery from such SPC data holds significant promise. However, the binary nature of SPC images leads to severe information loss, particularly in texture and color, making traditional 3D synthesis techniques ineffective. To address this challenge, we propose a modular two-stage framework that converts binary SPC images into high-quality colorized novel views. The first stage performs image-to-image (I2I) translation using generative models such as Pix2PixHD, converting binary SPC inputs into plausible RGB representations. The second stage employs 3D scene reconstruction techniques like Neural Radiance Fields (NeRF) or Gaussian Splatting (3DGS) to generate novel views. We validate our two-stage pipeline (Pix2PixHD + Nerf/3DGS) through extensive qualitative and quantitative experiments, demonstrating significant improvements in perceptual quality and geometric consistency over the alternative baseline.

SparseC-AFM: a deep learning method for fast and accurate characterization of MoS$_2$ with C-AFM

The increasing use of two-dimensional (2D) materials in nanoelectronics demands robust metrology techniques for electrical characterization, especially for large-scale production. While atomic force microscopy (AFM) techniques like conductive AFM (C-AFM) offer high accuracy, they suffer from slow data acquisition speeds due to the raster scanning process. To address this, we introduce SparseC-AFM, a deep learning model that rapidly and accurately reconstructs conductivity maps of 2D materials like MoS$_2$ from sparse C-AFM scans. Our approach is robust across various scanning modes, substrates, and experimental conditions. We report a comparison between (a) classic flow implementation, where a high pixel density C-AFM image (e.g., 15 minutes to collect) is manually parsed to extract relevant material parameters, and (b) our SparseC-AFM method, which achieves the same operation using data that requires substantially less acquisition time (e.g., under 5 minutes). SparseC-AFM enables efficient extraction of critical material parameters in MoS$_2$, including film coverage, defect density, and identification of crystalline island boundaries, edges, and cracks. We achieve over 11x reduction in acquisition time compared to manual extraction from a full-resolution C-AFM image. Moreover, we demonstrate that our model-predicted samples exhibit remarkably similar electrical properties to full-resolution data gathered using classic-flow scanning. This work represents a significant step toward translating AI-assisted 2D material characterization from laboratory research to industrial fabrication. Code and model weights are available at github.com/UNITES-Lab/sparse-cafm.