Advanced Multi-Architecture Deep Learning Framework for BIRADS-Based Mammographic Image Retrieval: Comprehensive Performance Analysis with Super-Ensemble Optimization

Content-based mammographic image retrieval systems require exact BIRADS categorical matching across five distinct classes, presenting significantly greater complexity than binary classification tasks commonly addressed in literature. Current medical image retrieval studies suffer from methodological limitations including inadequate sample sizes, improper data splitting, and insufficient statistical validation that hinder clinical translation. We developed a comprehensive evaluation framework systematically comparing CNN architectures (DenseNet121, ResNet50, VGG16) with advanced training strategies including sophisticated fine-tuning, metric learning, and super-ensemble optimization. Our evaluation employed rigorous stratified data splitting (50%/20%/30% train/validation/test), 602 test queries, and systematic validation using bootstrap confidence intervals with 1,000 samples. Advanced fine-tuning with differential learning rates achieved substantial improvements: DenseNet121 (34.79% precision@10, 19.64% improvement) and ResNet50 (34.54%, 19.58% improvement). Super-ensemble optimization combining complementary architectures achieved 36.33% precision@10 (95% CI: [34.78%, 37.88%]), representing 24.93% improvement over baseline and providing 3.6 relevant cases per query. Statistical analysis revealed significant performance differences between optimization strategies (p<0.001) with large effect sizes (Cohen's d>0.8), while maintaining practical search efficiency (2.8milliseconds). Performance significantly exceeds realistic expectations for 5-class medical retrieval tasks, where literature suggests 20-25% precision@10 represents achievable performance for exact BIRADS matching. Our framework establishes new performance benchmarks while providing evidence-based architecture selection guidelines for clinical deployment in diagnostic support and quality assurance applications.

Efficient Medical Image Retrieval Using DenseNet and FAISS for BIRADS Classification

That datasets that are used in todays research are especially vast in the medical field. Different types of medical images such as X-rays, MRI, CT scan etc. take up large amounts of space. This volume of data introduces challenges like accessing and retrieving specific images due to the size of the database. An efficient image retrieval system is essential as the database continues to grow to save time and resources. In this paper, we propose an approach to medical image retrieval using DenseNet for feature extraction and use FAISS for similarity search. DenseNet is well-suited for feature extraction in complex medical images and FAISS enables efficient handling of high-dimensional data in large-scale datasets. Unlike existing methods focused solely on classification accuracy, our method prioritizes both retrieval speed and diagnostic relevance, addressing a critical gap in real-time case comparison for radiologists. We applied the classification of breast cancer images using the BIRADS system. We utilized DenseNet's powerful feature representation and FAISSs efficient indexing capabilities to achieve high precision and recall in retrieving relevant images for diagnosis. We experimented on a dataset of 2006 images from the Categorized Digital Database for Low Energy and Subtracted Contrast Enhanced Spectral Mammography (CDD-CESM) images available on The Cancer Imaging Archive (TCIA). Our method outperforms conventional retrieval techniques, achieving a precision of 80% at k=5 for BIRADS classification. The dataset includes annotated CESM images and medical reports, providing a comprehensive foundation for our research.