Dynamic High-frequency Convolution for Infrared Small Target Detection

Infrared small targets are typically tiny and locally salient, which belong to high-frequency components (HFCs) in images. Single-frame infrared small target (SIRST) detection is challenging, since there are many HFCs along with targets, such as bright corners, broken clouds, and other clutters. Current learning-based methods rely on the powerful capabilities of deep networks, but neglect explicit modeling and discriminative representation learning of various HFCs, which is important to distinguish targets from other HFCs. To address the aforementioned issues, we propose a dynamic high-frequency convolution (DHiF) to translate the discriminative modeling process into the generation of a dynamic local filter bank. Especially, DHiF is sensitive to HFCs, owing to the dynamic parameters of its generated filters being symmetrically adjusted within a zero-centered range according to Fourier transformation properties. Combining with standard convolution operations, DHiF can adaptively and dynamically process different HFC regions and capture their distinctive grayscale variation characteristics for discriminative representation learning. DHiF functions as a drop-in replacement for standard convolution and can be used in arbitrary SIRST detection networks without significant decrease in computational efficiency. To validate the effectiveness of our DHiF, we conducted extensive experiments across different SIRST detection networks on real-scene datasets. Compared to other state-of-the-art convolution operations, DHiF exhibits superior detection performance with promising improvement. Codes are available at https://github.com/TinaLRJ/DHiF.

Where to Attend: A Principled Vision-Centric Position Encoding with Parabolas

We propose Parabolic Position Encoding (PaPE), a parabola-based position encoding for vision modalities in attention-based architectures. Given a set of vision tokens-such as images, point clouds, videos, or event camera streams-our objective is to encode their positions while accounting for the characteristics of vision modalities. Prior works have largely extended position encodings from 1D-sequences in language to nD-structures in vision, but only with partial account of vision characteristics. We address this gap by designing PaPE from principles distilled from prior work: translation invariance, rotation invariance (PaPE-RI), distance decay, directionality, and context awareness. We evaluate PaPE on 8 datasets that span 4 modalities. We find that either PaPE or PaPE-RI achieves the top performance on 7 out of 8 datasets. Extrapolation experiments on ImageNet-1K show that PaPE extrapolates remarkably well, improving in absolute terms by up to 10.5% over the next-best position encoding. Code is available at https://github.com/DTU-PAS/parabolic-position-encoding.

InstructTime++: Time Series Classification with Multimodal Language Modeling via Implicit Feature Enhancement

Most existing time series classification methods adopt a discriminative paradigm that maps input sequences directly to one-hot encoded class labels. While effective, this paradigm struggles to incorporate contextual features and fails to capture semantic relationships among classes. To address these limitations, we propose InstructTime, a novel framework that reformulates time series classification as a multimodal generative task. Specifically, continuous numerical sequences, contextual textual features, and task instructions are treated as multimodal inputs, while class labels are generated as textual outputs by tuned language models. To bridge the modality gap, InstructTime introduces a time series discretization module that converts continuous sequences into discrete temporal tokens, together with an alignment projection layer and a generative self-supervised pre-training strategy to enhance cross-modal representation alignment. Building upon this framework, we further propose InstructTime++, which extends InstructTime by incorporating implicit feature modeling to compensate for the limited inductive bias of language models. InstructTime++ leverages specialized toolkits to mine informative implicit patterns from raw time series and contextual inputs, including statistical feature extraction and vision-language-based image captioning, and translates them into textual descriptions for seamless integration. Extensive experiments on multiple benchmark datasets demonstrate the superior performance of InstructTime++.

Translating Light-Sheet Microscopy Images to Virtual H&E Using CycleGAN

Histopathology analysis relies on Hematoxylin and Eosin (H&E) staining, but fluorescence microscopy offers complementary information. Converting fluorescence images to H&E-like appearance can aid interpretation and integration with standard workflows. We present a Cycle-Consistent Adversarial Network (CycleGAN) approach for unpaired image-to-image translation from multi-channel fluorescence microscopy to pseudo H&E stained histopathology images. The method combines C01 and C02 fluorescence channels into RGB and learns a bidirectional mapping between fluorescence and H&E domains without paired training data. The architecture uses ResNet-based generators with residual blocks and PatchGAN discriminators, trained with adversarial, cycle-consistency, and identity losses. Experiments on fluorescence microscopy datasets show the model generates realistic pseudo H&E images that preserve morphological structures while adopting H&E-like color characteristics. This enables visualization of fluorescence data in a format familiar to pathologists and supports integration with existing H&E-based analysis pipelines.

TranslateGemma Technical Report

We present TranslateGemma, a suite of open machine translation models based on the Gemma 3 foundation models. To enhance the inherent multilingual capabilities of Gemma 3 for the translation task, we employ a two-stage fine-tuning process. First, supervised fine-tuning is performed using a rich mixture of high-quality large-scale synthetic parallel data generated via state-of-the-art models and human-translated parallel data. This is followed by a reinforcement learning phase, where we optimize translation quality using an ensemble of reward models, including MetricX-QE and AutoMQM, targeting translation quality. We demonstrate the effectiveness of TranslateGemma with human evaluation on the WMT25 test set across 10 language pairs and with automatic evaluation on the WMT24++ benchmark across 55 language pairs. Automatic metrics show consistent and substantial gains over the baseline Gemma 3 models across all sizes. Notably, smaller TranslateGemma models often achieve performance comparable to larger baseline models, offering improved efficiency. We also show that TranslateGemma models retain strong multimodal capabilities, with enhanced performance on the Vistra image translation benchmark. The release of the open TranslateGemma models aims to provide the research community with powerful and adaptable tools for machine translation.

PyHealth 2.0: A Comprehensive Open-Source Toolkit for Accessible and Reproducible Clinical Deep Learning

Difficulty replicating baselines, high computational costs, and required domain expertise create persistent barriers to clinical AI research. To address these challenges, we introduce PyHealth 2.0, an enhanced clinical deep learning toolkit that enables predictive modeling in as few as 7 lines of code. PyHealth 2.0 offers three key contributions: (1) a comprehensive toolkit addressing reproducibility and compatibility challenges by unifying 15+ datasets, 20+ clinical tasks, 25+ models, 5+ interpretability methods, and uncertainty quantification including conformal prediction within a single framework that supports diverse clinical data modalities - signals, imaging, and electronic health records - with translation of 5+ medical coding standards; (2) accessibility-focused design accommodating multimodal data and diverse computational resources with up to 39x faster processing and 20x lower memory usage, enabling work from 16GB laptops to production systems; and (3) an active open-source community of 400+ members lowering domain expertise barriers through extensive documentation, reproducible research contributions, and collaborations with academic health systems and industry partners, including multi-language support via RHealth. PyHealth 2.0 establishes an open-source foundation and community advancing accessible, reproducible healthcare AI. Available at pip install pyhealth.

From Perception to Action: Spatial AI Agents and World Models

While large language models have become the prevailing approach for agentic reasoning and planning, their success in symbolic domains does not readily translate to the physical world. Spatial intelligence, the ability to perceive 3D structure, reason about object relationships, and act under physical constraints, is an orthogonal capability that proves important for embodied agents. Existing surveys address either agentic architectures or spatial domains in isolation. None provide a unified framework connecting these complementary capabilities. This paper bridges that gap. Through a thorough review of over 2,000 papers, citing 742 works from top-tier venues, we introduce a unified three-axis taxonomy connecting agentic capabilities with spatial tasks across scales. Crucially, we distinguish spatial grounding (metric understanding of geometry and physics) from symbolic grounding (associating images with text), arguing that perception alone does not confer agency. Our analysis reveals three key findings mapped to these axes: (1) hierarchical memory systems (Capability axis) are important for long-horizon spatial tasks. (2) GNN-LLM integration (Task axis) is a promising approach for structured spatial reasoning. (3) World models (Scale axis) are essential for safe deployment across micro-to-macro spatial scales. We conclude by identifying six grand challenges and outlining directions for future research, including the need for unified evaluation frameworks to standardize cross-domain assessment. This taxonomy provides a foundation for unifying fragmented research efforts and enabling the next generation of spatially-aware autonomous systems in robotics, autonomous vehicles, and geospatial intelligence.

Toward Autonomous Laboratory Safety Monitoring with Vision Language Models: Learning to See Hazards Through Scene Structure

Laboratories are prone to severe injuries from minor unsafe actions, yet continuous safety monitoring -- beyond mandatory pre-lab safety training -- is limited by human availability. Vision language models (VLMs) offer promise for autonomous laboratory safety monitoring, but their effectiveness in realistic settings is unclear due to the lack of visual evaluation data, as most safety incidents are documented primarily as unstructured text. To address this gap, we first introduce a structured data generation pipeline that converts textual laboratory scenarios into aligned triples of (image, scene graph, ground truth), using large language models as scene graph architects and image generation models as renderers. Our experiments on the synthetic dataset of 1,207 samples across 362 unique scenarios and seven open- and closed-source models show that VLMs perform effectively given textual scene graph, but degrade substantially in visual-only settings indicating difficulty in extracting structured object relationships directly from pixels. To overcome this, we propose a post-training context-engineering approach, scene-graph-guided alignment, to bridge perceptual gaps in VLMs by translating visual inputs into structured scene graphs better aligned with VLM reasoning, improving hazard detection performance in visual only settings.

Advanced Geometric Correction Algorithms for 3D Medical Reconstruction: Comparison of Computed Tomography and Macroscopic Imaging

This paper introduces a hybrid two-stage registration framework for reconstructing three-dimensional (3D) kidney anatomy from macroscopic slices, using CT-derived models as the geometric reference standard. The approach addresses the data-scarcity and high-distortion challenges typical of macroscopic imaging, where fully learning-based registration (e.g., VoxelMorph) often fails to generalize due to limited training diversity and large nonrigid deformations that exceed the capture range of unconstrained convolutional filters. In the proposed pipeline, the Optimal Cross-section Matching (OCM) algorithm first performs constrained global alignment: translation, rotation, and uniform scaling to establish anatomically consistent slice initialization. Next, a lightweight deep-learning refinement network, inspired by VoxelMorph, predicts residual local deformations between consecutive slices. The core novelty of this architecture lies in its hierarchical decomposition of the registration manifold. This hybrid OCM+DL design integrates explicit geometric priors with the flexible learning capacity of neural networks, ensuring stable optimization and plausible deformation fields even with few training examples. Experiments on an original dataset of 40 kidneys demonstrated better results compared to single-stage baselines. The pipeline maintains physical calibration via Hough-based grid detection and employs Bezier-based contour smoothing for robust meshing and volume estimation. Although validated on kidney data, the proposed framework generalizes to other soft-tissue organs reconstructed from optical or photographic cross-sections. By decoupling interpretable global optimization from data-efficient deep refinement, the method advances the precision, reproducibility, and anatomical realism of multimodal 3D reconstructions for surgical planning, morphological assessment, and medical education.

Sim-to-Real Transfer via a Style-Identified Cycle Consistent Generative Adversarial Network: Zero-Shot Deployment on Robotic Manipulators through Visual Domain Adaptation

The sample efficiency challenge in Deep Reinforcement Learning (DRL) compromises its industrial adoption due to the high cost and time demands of real-world training. Virtual environments offer a cost-effective alternative for training DRL agents, but the transfer of learned policies to real setups is hindered by the sim-to-real gap. Achieving zero-shot transfer, where agents perform directly in real environments without additional tuning, is particularly desirable for its efficiency and practical value. This work proposes a novel domain adaptation approach relying on a Style-Identified Cycle Consistent Generative Adversarial Network (StyleID-CycleGAN or SICGAN), an original Cycle Consistent Generative Adversarial Network (CycleGAN) based model. SICGAN translates raw virtual observations into real-synthetic images, creating a hybrid domain for training DRL agents that combines virtual dynamics with real-like visual inputs. Following virtual training, the agent can be directly deployed, bypassing the need for real-world training. The pipeline is validated with two distinct industrial robots in the approaching phase of a pick-and-place operation. In virtual environments agents achieve success rates of 90 to 100\%, and real-world deployment confirms robust zero-shot transfer (i.e., without additional training in the physical environment) with accuracies above 95\% for most workspace regions. We use augmented reality targets to improve the evaluation process efficiency, and experimentally demonstrate that the agent successfully generalizes to real objects of varying colors and shapes, including LEGO\textsuperscript{\textregistered}~cubes and a mug. These results establish the proposed pipeline as an efficient, scalable solution to the sim-to-real problem.