AiSocrates: Towards Answering Ethical Quandary Questions

Considerable advancements have been made in various NLP tasks based on the impressive power of large pre-trained language models (LLMs). These results have inspired efforts to understand the limits of LLMs so as to evaluate how far we are from achieving human level general natural language understanding. In this work, we challenge the capability of LLMs with the new task of Ethical Quandary Generative Question Answering. Ethical quandary questions are more challenging to address because multiple conflicting answers may exist to a single quandary. We propose a system, AiSocrates, that provides an answer with a deliberative exchange of different perspectives to an ethical quandary, in the approach of Socratic philosophy, instead of providing a closed answer like an oracle. AiSocrates searches for different ethical principles applicable to the ethical quandary and generates an answer conditioned on the chosen principles through prompt-based few-shot learning. We also address safety concerns by providing a human controllability option in choosing ethical principles. We show that AiSocrates generates promising answers to ethical quandary questions with multiple perspectives, 6.92% more often than answers written by human philosophers by one measure, but the system still needs improvement to match the coherence of human philosophers fully. We argue that AiSocrates is a promising step toward developing an NLP system that incorporates human values explicitly by prompt instructions. We are releasing the code for research purposes.

3D Segmentation Guided Style-based Generative Adversarial Networks for PET Synthesis

Potential radioactive hazards in full-dose positron emission tomography (PET) imaging remain a concern, whereas the quality of low-dose images is never desirable for clinical use. So it is of great interest to translate low-dose PET images into full-dose. Previous studies based on deep learning methods usually directly extract hierarchical features for reconstruction. We notice that the importance of each feature is different and they should be weighted dissimilarly so that tiny information can be captured by the neural network. Furthermore, the synthesis on some regions of interest is important in some applications. Here we propose a novel segmentation guided style-based generative adversarial network (SGSGAN) for PET synthesis. (1) We put forward a style-based generator employing style modulation, which specifically controls the hierarchical features in the translation process, to generate images with more realistic textures. (2) We adopt a task-driven strategy that couples a segmentation task with a generative adversarial network (GAN) framework to improve the translation performance. Extensive experiments show the superiority of our overall framework in PET synthesis, especially on those regions of interest.

Transformer based multiple instance learning for weakly supervised histopathology image segmentation

Hispathological image segmentation algorithms play a critical role in computer aided diagnosis technology. The development of weakly supervised segmentation algorithm alleviates the problem of medical image annotation that it is time-consuming and labor-intensive. As a subset of weakly supervised learning, Multiple Instance Learning (MIL) has been proven to be effective in segmentation. However, there is a lack of related information between instances in MIL, which limits the further improvement of segmentation performance. In this paper, we propose a novel weakly supervised method for pixel-level segmentation in histopathology images, which introduces Transformer into the MIL framework to capture global or long-range dependencies. The multi-head self-attention in the Transformer establishes the relationship between instances, which solves the shortcoming that instances are independent of each other in MIL. In addition, deep supervision is introduced to overcome the limitation of annotations in weakly supervised methods and make the better utilization of hierarchical information. The state-of-the-art results on the colon cancer dataset demonstrate the superiority of the proposed method compared with other weakly supervised methods. It is worth believing that there is a potential of our approach for various applications in medical images.

Improving Visual Grounding with Visual-Linguistic Verification and Iterative Reasoning

Visual grounding is a task to locate the target indicated by a natural language expression. Existing methods extend the generic object detection framework to this problem. They base the visual grounding on the features from pre-generated proposals or anchors, and fuse these features with the text embeddings to locate the target mentioned by the text. However, modeling the visual features from these predefined locations may fail to fully exploit the visual context and attribute information in the text query, which limits their performance. In this paper, we propose a transformer-based framework for accurate visual grounding by establishing text-conditioned discriminative features and performing multi-stage cross-modal reasoning. Specifically, we develop a visual-linguistic verification module to focus the visual features on regions relevant to the textual descriptions while suppressing the unrelated areas. A language-guided feature encoder is also devised to aggregate the visual contexts of the target object to improve the object's distinctiveness. To retrieve the target from the encoded visual features, we further propose a multi-stage cross-modal decoder to iteratively speculate on the correlations between the image and text for accurate target localization. Extensive experiments on five widely used datasets validate the efficacy of our proposed components and demonstrate state-of-the-art performance. Our code is public at https://github.com/yangli18/VLTVG.

WSSS4LUAD: Grand Challenge on Weakly-supervised Tissue Semantic Segmentation for Lung Adenocarcinoma

Lung cancer is the leading cause of cancer death worldwide, and adenocarcinoma (LUAD) is the most common subtype. Exploiting the potential value of the histopathology images can promote precision medicine in oncology. Tissue segmentation is the basic upstream task of histopathology image analysis. Existing deep learning models have achieved superior segmentation performance but require sufficient pixel-level annotations, which is time-consuming and expensive. To enrich the label resources of LUAD and to alleviate the annotation efforts, we organize this challenge WSSS4LUAD to call for the outstanding weakly-supervised semantic segmentation (WSSS) techniques for histopathology images of LUAD. Participants have to design the algorithm to segment tumor epithelial, tumor-associated stroma and normal tissue with only patch-level labels. This challenge includes 10,091 patch-level annotations (the training set) and over 130 million labeled pixels (the validation and test sets), from 87 WSIs (67 from GDPH, 20 from TCGA). All the labels were generated by a pathologist-in-the-loop pipeline with the help of AI models and checked by the label review board. Among 532 registrations, 28 teams submitted the results in the test phase with over 1,000 submissions. Finally, the first place team achieved mIoU of 0.8413 (tumor: 0.8389, stroma: 0.7931, normal: 0.8919). According to the technical reports of the top-tier teams, CAM is still the most popular approach in WSSS. Cutmix data augmentation has been widely adopted to generate more reliable samples. With the success of this challenge, we believe that WSSS approaches with patch-level annotations can be a complement to the traditional pixel annotations while reducing the annotation efforts. The entire dataset has been released to encourage more researches on computational pathology in LUAD and more novel WSSS techniques.

Can Question Rewriting Help Conversational Question Answering?

Question rewriting (QR) is a subtask of conversational question answering (CQA) aiming to ease the challenges of understanding dependencies among dialogue history by reformulating questions in a self-contained form. Despite seeming plausible, little evidence is available to justify QR as a mitigation method for CQA. To verify the effectiveness of QR in CQA, we investigate a reinforcement learning approach that integrates QR and CQA tasks and does not require corresponding QR datasets for targeted CQA. We find, however, that the RL method is on par with the end-to-end baseline. We provide an analysis of the failure and describe the difficulty of exploiting QR for CQA.

RNNPose: Recurrent 6-DoF Object Pose Refinement with Robust Correspondence Field Estimation and Pose Optimization

6-DoF object pose estimation from a monocular image is challenging, and a post-refinement procedure is generally needed for high-precision estimation. In this paper, we propose a framework based on a recurrent neural network (RNN) for object pose refinement, which is robust to erroneous initial poses and occlusions. During the recurrent iterations, object pose refinement is formulated as a non-linear least squares problem based on the estimated correspondence field (between a rendered image and the observed image). The problem is then solved by a differentiable Levenberg-Marquardt (LM) algorithm enabling end-to-end training. The correspondence field estimation and pose refinement are conducted alternatively in each iteration to recover the object poses. Furthermore, to improve the robustness to occlusion, we introduce a consistency-check mechanism based on the learned descriptors of the 3D model and observed 2D images, which downweights the unreliable correspondences during pose optimization. Extensive experiments on LINEMOD, Occlusion-LINEMOD, and YCB-Video datasets validate the effectiveness of our method and demonstrate state-of-the-art performance.

VScript: Controllable Script Generation with Audio-Visual Presentation

Automatic script generation could save a considerable amount of resources and offer inspiration to professional scriptwriters. We present VScript, a controllable pipeline that generates complete scripts including dialogues and scene descriptions, and presents visually using video retrieval and aurally using text-to-speech for spoken dialogue. With an interactive interface, our system allows users to select genres and input starting words that control the theme and development of the generated script. We adopt a hierarchical structure, which generates the plot, then the script and its audio-visual presentation. We also introduce a novel approach to plot-guided dialogue generation by treating it as an inverse dialogue summarization. Experiment results show that our approach outperforms the baselines on both automatic and human evaluations, especially in terms of genre control.