Agentic Discovery of Non-Canonical Antimicrobial Peptides with AMPGAN v3

Antimicrobial resistance causes to over a million deaths annually. Antimicrobial peptides (AMPs) are a promising solution, but generative AMP models are not yet ready to design peptides with non-natural amino acids and/or chemical modifications, which are essential for real-world peptide drugs. We present AMPGAN v3, a multi-objective conditional GAN that expands the generative vocabulary to D-amino acids and N/C-terminus modifications such as amidation. By separating adversarial and activity-aware supervision across two specialized discriminators, AMPGAN v3 substantially improves training stability and outperforms prior generative AMP models on external classifiers. We validated five candidates spanning three structural classes in vitro; two showed activity against Gram-positive strains, with the best candidate reaching MIC 8 μg/mL against B. subtilis. To support downstream curation, we further present PepCraft, a multi-agent framework for end-to-end AMP discovery in which a Planning Agent orchestrates specialized executors for generation, filtering, and verification. Its prioritization recommendations align with our in vitro outcomes. Together, these contributions let us examine, on a small but real scale, how generative and agentic AI compose in therapeutic peptide discovery. Code: https://github.com/marszzibros/AMPGANv3

Scaling Short-Term Memory of Visuomotor Policies for Long-Horizon Tasks

Many robotic tasks require short-term memory, whether it's retrieving an object that's no longer visible or turning off an appliance after a set period. Yet, most visuomotor policies trained via imitation learning rely only on immediate sensory input without using past experiences to guide decisions. We present PRISM, a transformer-based architecture for visuomotor policies to effectively use short-term memory via two key components: (i) gated attention, which filters retrieved information to suppress irrelevant details, improving performance by reducing the spurious correlations between the history and current action prediction, (ii) a hierarchical architecture that first compresses local information into compact tokens and then integrates them to capture temporally extended dependencies, improving its compute and memory footprint. Together, these mechanisms enable us to scale short-term memory in visuomotor policies for up to two minutes. To systematically evaluate memory in visuomotor control, we introduce ReMemBench -- a benchmark of eight diverse household manipulation tasks spanning four categories of short-term memory -- designed to foster general memory mechanisms rather than siloed, task-specific solutions. PRISM consistently outperforms prior works, including recurrent architectures, transformers, and their variants -- achieving an absolute improvement of 5%--12% over the strongest baseline. On the RoboCasa and LIBERO benchmarks, it achieves absolute improvements of 11%--15% over its no-memory variant and fine-tuned Vision-Language-Action baselines such as GR00T-N1-3B and OpenVLA, despite not leveraging any large-scale pretraining. Together, PRISM and ReMemBench establish a foundation for developing and evaluating short-term memory-augmented visuomotor policies that scale to long-horizon tasks. Additional materials are available at https://shahrutav.github.io/short-term-memory

Description-Code Inconsistency in Real-world MCP Servers: Measurement, Detection, and Security Implications

The Model Context Protocol (MCP) has emerged as a critical standard empowering Large Language Models (LLMs) to utilize external tools. In this ecosystem, LLMs rely on natural language descriptions provided by MCP servers to select and execute functions. This interaction implicitly assumes that tool descriptions faithfully reflect their underlying implementations, while this assumption is not mandatorily verified in practice. As a result, MCP deployments may suffer from a problem named Description-Code Inconsistency (DCI), where a tool's description of its capabilities and security boundaries is not consistent with what the code actually does. In this paper, we present a comprehensive study of DCI in real-world MCP servers. We formally define the problem and propose a comprehensive taxonomy spanning functionality inconsistencies and undeclared side effects. Guided by this taxonomy, we develop DCIChecker, an automated framework that combines structure-aware static analysis with the Direct-Reverse-Arbitration prompting method to cross-validate tool descriptions against actual code implementations. We apply this framework to a large-scale dataset comprising 19,200 description-code pairs extracted from 2,214 real-world MCP servers. Our measurement reveals that DCI is widespread, with 9.93% of these pairs exhibiting inconsistencies. We further demonstrate that DCI creates a critical defense blind spot, facilitating varied risks from operational failures to stealthy malicious behaviors. Finally, we propose mitigation strategies to enforce semantic consistency and enhance the reliability of the emerging agentic ecosystem.

Can LLM Agents Sustain Long-Horizon Organizational Dynamics?

Large language agents are increasingly used for social simulation, yet it remains unclear whether they can sustain coherent behavior in structured organizations, where goals must propagate through hierarchy, tasks depend on prior execution, and artifacts accumulate over long horizons. We formulate long-horizon organizational simulation as a memory-centered coordination problem and introduce TaskWeave, a hierarchical agentic framework that maintains planning states through a Formulate-Partition-Diagnose-Align cycle and grounds execution through dependency-aware trace memory. We evaluate TaskWeave in a year-long IT company simulation and compare it with other multi-agent frameworks on organizational coherence, execution grounding, and downstream enterprise NLP utility. Experiments show that TaskWeave supports coherent and long-horizon organizational dynamics while producing grounded artifacts and adapting to external environments. These findings suggest that structured simulation memory is a key mechanism for building reliable LLM-based organizational simulators.

LongAV-Compass: Towards Unified Evaluation of Minute-Scale Audio-Visual Generation Across T2AV, I2AV, and V2AV

Audio-visual generation is rapidly advancing from short clips to minute-long content, while existing evaluation protocols remain largely confined to short-form settings. Existing benchmarks primarily focus on 5--10 second text-conditioned generation and rarely support unified evaluation across text, image, and video conditioning modalities. Moreover, they provide limited insight into how identity consistency, narrative coherence, and audio-visual alignment degrade over extended temporal horizons. To bridge this gap, we introduce LongAV-Compass, a systematic benchmark for minute-long audio-visual generation. LongAV-Compass contains 284 curated test cases spanning text-to-audio-video (T2AV), image-to-audio-video (I2AV), and video-to-audio-video (V2AV), organized by application scenario and generation complexity. The benchmark combines taxonomy-guided benchmark construction with a unified evaluation framework that integrates MLLM-assisted assessment with complementary perceptual and multimodal metrics, including DINO-v2, ArcFace, CLIP, and ImageBind. The framework evaluates more than 20 fine-grained dimensions covering within-segment quality, cross-segment consistency, global narrative coherence, semantic alignment, and audio-visual synchronization. Through experiments on 11 representative models together with human-alignment validation, LongAV-Compass provides a diagnostic testbed for analyzing the limitations of current systems in sustaining coherent, semantically aligned, and temporally consistent minute-scale audio-visual generation across diverse input modalities.

Trusted Weights, Treacherous Optimizations? Optimization-Triggered Backdoor Attacks on LLMs

Inference optimization is a vital technique for deploying LLMs at scale. Compilation is the most widely adopted optimization technique for LLMs. While it assumes semantic equivalence between the original and compiled graphs, we first uncover its numerical side effects can be maliciously exploited to implant stealthy backdoors in LLMs. We propose a unified optimization-triggered attack framework comprising two complementary strategies. Without any modification to the compiler or hardware, one strategy flips predictions for specific inputs only when the model is compiled, while the other uses a universal trigger that remains dormant under uncompiled execution but hijacks arbitrary inputs once compilation optimization is applied. Both attacks bypass standard safety evaluations run without compilation. We empirically demonstrate that these optimization-triggered backdoors achieve attack success rates averaging 90% across four mainstream open-source LLMs and four tasks, while clean accuracy is preserved at nearly 100% under all settings. Our findings reveal a novel attack surface at the intersection of optimization and security in the LLM deployment pipeline, and we investigate practical defenses to mitigate this threat.

Turning Generators into Retrievers: Unlocking MLLMs for Natural Language-Guided Geo-Localization

Natural-language Guided Cross-view Geo-localization (NGCG) aims to retrieve geo-tagged satellite imagery using textual descriptions of ground scenes. While recent NGCG methods commonly rely on CLIP-style dual-encoder architectures, they often suffer from weak cross-modal generalization and require complex architectural designs. In contrast, Multimodal Large Language Models (MLLMs) offer powerful semantic reasoning capabilities but are not directly optimized for retrieval tasks. In this work, we present a simple yet effective framework to adapt MLLMs for NGCG via parameter-efficient finetuning. Our approach optimizes latent representations within the MLLM while preserving its pretrained multimodal knowledge, enabling strong cross-modal alignment without redesigning model architectures. Through systematic analysis of diverse variables, from model backbone to feature aggregation, we provide practical and generalizable insights for leveraging MLLMs in NGCG. Our method achieves SOTA on GeoText-1652 with a 12.2% improvement in Text-to-Image Recall@1 and secures top performance in 5 out of 12 subtasks on CVG-Text, all while surpassing baselines with far fewer trainable parameters. These results position MLLMs as a robust foundation for semantic cross-view retrieval and pave the way for MLLM-based NGCG to be adopted as a scalable, powerful alternative to traditional dual-encoder designs. Project page and code are available at https://yuqichen888.github.io/NGCG-MLLMs-web/.

Geo$^\textbf{2}$: Geometry-Guided Cross-view Geo-Localization and Image Synthesis

Cross-view geo-spatial learning consists of two important tasks: Cross-View Geo-Localization (CVGL) and Cross-View Image Synthesis (CVIS), both of which rely on establishing geometric correspondences between ground and aerial views. Recent Geometric Foundation Models (GFMs) have demonstrated strong capabilities in extracting generalizable 3D geometric features from images, but their potential in cross-view geo-spatial tasks remains underexplored. In this work, we present Geo^2, a unified framework that leverages Geometric priors from GFMs (e.g., VGGT) to jointly perform geo-spatial tasks, CVGL and bidirectional CVIS. Despite the 3D reconstruction ability of GFMs, directly applying them to CVGL and CVIS remains challenging due to the large viewpoint gap between ground and aerial imagery. We propose GeoMap, which embeds ground and aerial features into a shared 3D-aware latent space, effectively reducing cross-view discrepancies for localization. This shared latent space naturally bridges cross-view image synthesis in both directions. To exploit this, we propose GeoFlow, a flow-matching model conditioned on geometry-aware latent embeddings. We further introduce a consistency loss to enforce latent alignment between the two synthesis directions, ensuring bidirectional coherence. Extensive experiments on standard benchmarks, including CVUSA, CVACT, and VIGOR, demonstrate that Geo^2 achieves state-of-the-art performance in both localization and synthesis, highlighting the effectiveness of 3D geometric priors for cross-view geo-spatial learning.

GeoFlow: Real-Time Fine-Grained Cross-View Geolocalization via Iterative Flow Prediction

Accurate and fast localization is vital for safe autonomous navigation in GPS-denied areas. Fine-Grained Cross-View Geolocalization (FG-CVG) aims to estimate the precise 2-Degree-of-Freedom (2-DoF) location of a ground image relative to a satellite image. However, current methods force a difficult trade-off, with high-accuracy models being slow for real-time use. In this paper, we introduce GeoFlow, a new approach that offers a lightweight and highly efficient framework that breaks this accuracy-speed trade-off. Our technique learns a direct probabilistic mapping, predicting the displacement (in distance and direction) required to correct any given location hypothesis. This is complemented by our novel inference algorithm, Iterative Refinement Sampling (IRS). Instead of trusting a single prediction, IRS refines a population of hypotheses, allowing them to iteratively 'flow' from random starting points to a robust, converged consensus. Even its iterative nature, this approach offers flexible inference-time scaling, allowing a direct trade-off between performance and computation without any re-training. Experiments on the KITTI and VIGOR datasets show that GeoFlow achieves state-of-the-art efficiency, running at real-time speeds of 29 FPS while maintaining competitive localization accuracy. This work opens a new path for the development of practical real-time geolocalization systems.

You've Got a Golden Ticket: Improving Generative Robot Policies With A Single Noise Vector

What happens when a pretrained generative robot policy is provided a constant initial noise as input, rather than repeatedly sampling it from a Gaussian? We demonstrate that the performance of a pretrained, frozen diffusion or flow matching policy can be improved with respect to a downstream reward by swapping the sampling of initial noise from the prior distribution (typically isotropic Gaussian) with a well-chosen, constant initial noise input -- a golden ticket. We propose a search method to find golden tickets using Monte-Carlo policy evaluation that keeps the pretrained policy frozen, does not train any new networks, and is applicable to all diffusion/flow matching policies (and therefore many VLAs). Our approach to policy improvement makes no assumptions beyond being able to inject initial noise into the policy and calculate (sparse) task rewards of episode rollouts, making it deployable with no additional infrastructure or models. Our method improves the performance of policies in 38 out of 43 tasks across simulated and real-world robot manipulation benchmarks, with relative improvements in success rate by up to 58% for some simulated tasks, and 60% within 50 search episodes for real-world tasks. We also show unique benefits of golden tickets for multi-task settings: the diversity of behaviors from different tickets naturally defines a Pareto frontier for balancing different objectives (e.g., speed, success rates); in VLAs, we find that a golden ticket optimized for one task can also boost performance in other related tasks. We release a codebase with pretrained policies and golden tickets for simulation benchmarks using VLAs, diffusion policies, and flow matching policies.